{"id":"https://openalex.org/W3206483271","doi":"https://doi.org/10.3390/ijms222111383","title":"The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice","display_name":"The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice","publication_year":2021,"publication_date":"2021-10-21","ids":{"openalex":"https://openalex.org/W3206483271","doi":"https://doi.org/10.3390/ijms222111383","mag":"3206483271","pmid":"https://pubmed.ncbi.nlm.nih.gov/34768813","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8583725"},"language":"en","primary_location":{"id":"doi:10.3390/ijms222111383","doi":"https://doi.org/10.3390/ijms222111383","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222111383","pdf_url":"https://www.mdpi.com/1422-0067/22/21/11383/pdf?version=1635237556","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/21/11383/pdf?version=1635237556","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060503044","display_name":"Geng\u2010Ruei Chang","orcid":"https://orcid.org/0000-0003-0577-3339","observed_orcids":["https://orcid.org/0000-0003-0577-3339"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Geng-Ruei Chang","raw_affiliation_strings":["Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061833746","display_name":"Weili Lin","orcid":"https://orcid.org/0000-0003-4914-2707","observed_orcids":["https://orcid.org/0000-0003-4914-2707"]},"institutions":[{"id":"https://openalex.org/I126145234","display_name":"Chaoyang University of Technology","ror":"https://ror.org/04xwksx09","country_code":"TW","type":"education","lineage":["https://openalex.org/I126145234"]},{"id":"https://openalex.org/I95858998","display_name":"Hungkuang University","ror":"https://ror.org/02f2vsx71","country_code":"TW","type":"education","lineage":["https://openalex.org/I95858998"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Li Lin","raw_affiliation_strings":["Bachelor Degree Program in Animal Healthcare, Hungkuang University, 6 Section, 1018 Taiwan Boulevard, Shalu District, Taichung 433304, Taiwan","General Education Center, Chaoyang University of Technology, 168 Jifeng Eastern Road, Taichung 413310, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bachelor Degree Program in Animal Healthcare, Hungkuang University, 6 Section, 1018 Taiwan Boulevard, Shalu District, Taichung 433304, Taiwan","institution_ids":["https://openalex.org/I95858998"]},{"raw_affiliation_string":"General Education Center, Chaoyang University of Technology, 168 Jifeng Eastern Road, Taichung 413310, Taiwan","institution_ids":["https://openalex.org/I126145234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102417429","display_name":"Tzu-Chun Lin","orcid":"https://orcid.org/0000-0002-6140-1882","observed_orcids":["https://orcid.org/0000-0002-6140-1882"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tzu-Chun Lin","raw_affiliation_strings":["Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002060006","display_name":"Huei-Jyuan Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Huei-Jyuan Liao","raw_affiliation_strings":["Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yu-Wen Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124028","display_name":"Chang Bing Show Chwan Memorial Hospital","ror":"https://ror.org/02ntc9t93","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210124028"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yu-Wen Lu","raw_affiliation_strings":["Department of Chinese Medicine, Chang Bing Show Chwan Memorial Hospital, 6 Lugong Road, Lukang Township, Changhua 50544, Taiwan","Department of Chinese Medicine, Show Chwan Memorial Hospital, 1 Section, 542 Chung-Shan Road, Lukang Township, Changhua 50008, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chinese Medicine, Chang Bing Show Chwan Memorial Hospital, 6 Lugong Road, Lukang Township, Changhua 50544, Taiwan","institution_ids":["https://openalex.org/I4210124028"]},{"raw_affiliation_string":"Department of Chinese Medicine, Show Chwan Memorial Hospital, 1 Section, 542 Chung-Shan Road, Lukang Township, Changhua 50008, Taiwan","institution_ids":["https://openalex.org/I4210124028"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060503044"],"corresponding_institution_ids":["https://openalex.org/I183570559","https://openalex.org/I4210124028"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":4.4352,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.96129321,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"22","issue":"21","first_page":"11383","last_page":"11383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saikosaponin-d","display_name":"saikosaponin D","score":0.8960000276565552},{"id":"https://openalex.org/keywords/bupleurum-falcatum","display_name":"Bupleurum falcatum","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8289999961853027},{"id":"https://openalex.org/keywords/thioacetamide-induced-liver-injury","display_name":"thioacetamide-induced liver injury","score":0.9900000095367432},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8029999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6359999775886536},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5440000295639038},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9150000214576721},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8550000190734863},{"id":"https://openalex.org/keywords/fgf21","display_name":"FGF21","score":0.8489999771118164},{"id":"https://openalex.org/keywords/fabp4","display_name":"FABP4","score":0.7730000019073486},{"id":"https://openalex.org/keywords/srebp-1","display_name":"SREBP1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2781057625","wikidata":"https://www.wikidata.org/wiki/Q416253","display_name":"Thioacetamide","level":2,"score":0.6997623443603516},{"id":"https://openalex.org/C48289651","wikidata":"https://www.wikidata.org/wiki/Q106916817","display_name":"Fatty acid synthase","level":3,"score":0.6777113080024719},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5727971792221069},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5676049590110779},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5517364740371704},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4966462254524231},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.4961465299129486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49605998396873474},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.46846458315849304},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.46000248193740845},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.43303531408309937},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4197829067707062},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3446224331855774},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.33965539932250977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3365230858325958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2929633855819702},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.24351170659065247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20582228899002075},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.172660231590271},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.0835314393043518},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009828","descriptor_name":"Oleanolic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009828","descriptor_name":"Oleanolic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009828","descriptor_name":"Oleanolic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013853","descriptor_name":"Thioacetamide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms222111383","doi":"https://doi.org/10.3390/ijms222111383","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222111383","pdf_url":"https://www.mdpi.com/1422-0067/22/21/11383/pdf?version=1635237556","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7473874","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8583725","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34768813","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34768813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8583725","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8583725/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3238c32aba834798a99f7bf39ccb123a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3238c32aba834798a99f7bf39ccb123a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 11383, p 11383 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms222111383","doi":"https://doi.org/10.3390/ijms222111383","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222111383","pdf_url":"https://www.mdpi.com/1422-0067/22/21/11383/pdf?version=1635237556","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3206483271.pdf","grobid_xml":"https://content.openalex.org/works/W3206483271.grobid-xml"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W57763528","https://openalex.org/W78193575","https://openalex.org/W1417195398","https://openalex.org/W1734082729","https://openalex.org/W1813582158","https://openalex.org/W1854632697","https://openalex.org/W1970655448","https://openalex.org/W1987597166","https://openalex.org/W1988973837","https://openalex.org/W1992038268","https://openalex.org/W1993384072","https://openalex.org/W1996027317","https://openalex.org/W1996066410","https://openalex.org/W2002919415","https://openalex.org/W2007505836","https://openalex.org/W2009145361","https://openalex.org/W2011158403","https://openalex.org/W2015568641","https://openalex.org/W2016099094","https://openalex.org/W2020033336","https://openalex.org/W2020188836","https://openalex.org/W2024077873","https://openalex.org/W2025421728","https://openalex.org/W2027892232","https://openalex.org/W2034495928","https://openalex.org/W2039104165","https://openalex.org/W2052009601","https://openalex.org/W2052289997","https://openalex.org/W2054633072","https://openalex.org/W2065960646","https://openalex.org/W2072776570","https://openalex.org/W2077802449","https://openalex.org/W2085764996","https://openalex.org/W2090556647","https://openalex.org/W2092297684","https://openalex.org/W2094943794","https://openalex.org/W2098012175","https://openalex.org/W2101962482","https://openalex.org/W2102749034","https://openalex.org/W2111726298","https://openalex.org/W2116150143","https://openalex.org/W2124347139","https://openalex.org/W2131242458","https://openalex.org/W2133760334","https://openalex.org/W2139177452","https://openalex.org/W2139568257","https://openalex.org/W2139646168","https://openalex.org/W2144030722","https://openalex.org/W2158038310","https://openalex.org/W2159156852","https://openalex.org/W2160766754","https://openalex.org/W2163627238","https://openalex.org/W2163725144","https://openalex.org/W2165170143","https://openalex.org/W2166164361","https://openalex.org/W2169598496","https://openalex.org/W2182967339","https://openalex.org/W2188141302","https://openalex.org/W2207463207","https://openalex.org/W2230739551","https://openalex.org/W2303176459","https://openalex.org/W2309659182","https://openalex.org/W2397682060","https://openalex.org/W2410159898","https://openalex.org/W2410785063","https://openalex.org/W2411941307","https://openalex.org/W2467929007","https://openalex.org/W2521475965","https://openalex.org/W2531291721","https://openalex.org/W2557833949","https://openalex.org/W2561596885","https://openalex.org/W2610108725","https://openalex.org/W2618241602","https://openalex.org/W2621022753","https://openalex.org/W2746220486","https://openalex.org/W2757195376","https://openalex.org/W2774670446","https://openalex.org/W2791979965","https://openalex.org/W2797201060","https://openalex.org/W2797360746","https://openalex.org/W2800398142","https://openalex.org/W2805142669","https://openalex.org/W2810166530","https://openalex.org/W2810255809","https://openalex.org/W2885238244","https://openalex.org/W2899389750","https://openalex.org/W2938930184","https://openalex.org/W2947897354","https://openalex.org/W2950218642","https://openalex.org/W2955850417","https://openalex.org/W2994834689","https://openalex.org/W3005902244","https://openalex.org/W3006525569","https://openalex.org/W3014185994","https://openalex.org/W3014669719","https://openalex.org/W3022652730","https://openalex.org/W3025173203","https://openalex.org/W3042329397","https://openalex.org/W3049156115","https://openalex.org/W3080821369","https://openalex.org/W3118300923","https://openalex.org/W3119818074","https://openalex.org/W3133247272","https://openalex.org/W3136281660","https://openalex.org/W3136419409","https://openalex.org/W3147745593","https://openalex.org/W3157472913","https://openalex.org/W3163168546","https://openalex.org/W3173313323","https://openalex.org/W3177351253","https://openalex.org/W3178628179","https://openalex.org/W4211245332","https://openalex.org/W6720148634","https://openalex.org/W6750521631"],"related_works":["https://openalex.org/W2938930184","https://openalex.org/W2359996602","https://openalex.org/W3147745593","https://openalex.org/W2365963299","https://openalex.org/W3134262933","https://openalex.org/W2011158403","https://openalex.org/W4410756539","https://openalex.org/W2107035974","https://openalex.org/W2020236820","https://openalex.org/W3080821369"],"abstract_inverted_index":{"Liver":[0],"disorders":[1],"are":[2,35],"a":[3,18,184],"major":[4],"health":[5],"concern.":[6],"Saikosaponin-d":[7],"(SSd)":[8],"is":[9],"an":[10,197],"effective":[11],"active":[12],"ingredient":[13],"extracted":[14],"from":[15],"Bupleurum":[16],"falcatum,":[17],"traditional":[19],"Chinese":[20],"medicinal":[21],"plant,":[22],"with":[23,114],"anti-inflammatory":[24],"and":[25,32,41,52,74,83,87,108,129,152,160,177,194],"antioxidant":[26],"properties.":[27],"However,":[28],"its":[29],"hepatoprotective":[30,185],"properties":[31],"underlying":[33,42],"mechanisms":[34,43],"unknown.":[36],"We":[37],"investigated":[38],"the":[39],"effects":[40],"of":[44,121],"SSd":[45,65,141,182],"treatment":[46],"for":[47],"thioacetamide":[48],"(TAA)-induced":[49],"liver":[50,57,188],"injury":[51,189],"high-fat-diet":[53],"(HFD)-induced":[54],"non-alcoholic":[55],"fatty":[56,147],"disease":[58],"(NAFLD)":[59],"in":[60,187],"male":[61],"C57BL/6":[62],"mice.":[63],"The":[64],"group":[66],"showed":[67],"significantly":[68],"higher":[69],"food":[70],"intake,":[71],"body":[72],"weight,":[73],"hepatic":[75,89],"antioxidative":[76],"enzymes":[77],"(catalase":[78],"(CAT),":[79],"glutathione":[80],"peroxidase":[81],"(GPx),":[82],"superoxide":[84],"dismutase":[85],"(SOD))":[86],"lower":[88],"cyclooxygenase-2":[90],"(COX-2),":[91],"serum":[92,143],"alanine":[93],"aminotransferase":[94,97],"(ALT),":[95],"aspartate":[96],"(AST),":[98],"alkaline":[99],"phosphatase":[100],"(ALP),":[101],"interleukin":[102],"(IL)-1\u03b2,":[103],"tumor":[104],"necrosis":[105],"factor":[106,125,168,174],"(TNF)-\u03b1,":[107],"fibroblast":[109],"growth":[110],"factor-21":[111],"(FGF21)":[112],"compared":[113],"controls,":[115],"as":[116,118,196],"well":[117],"reduced":[119,142],"expression":[120],"inflammation-related":[122],"genes":[123],"(nuclear":[124],"kappa":[126],"B":[127],"(NF-\u03baB)":[128],"inducible":[130],"nitric":[131],"oxide":[132],"synthase":[133],"(iNOS))":[134],"messenger":[135],"RNA":[136],"(mRNA).":[137],"In":[138],"NAFLD":[139],"mice,":[140],"ALT,":[144],"AST,":[145],"triglycerides,":[146],"acid\u2013binding":[148],"protein":[149,156,180],"4":[150,175],"(FABP4)":[151],"sterol":[153],"regulatory":[154],"element\u2013binding":[155],"1":[157],"(SREBP1)":[158],"mRNA,":[159],"endoplasmic":[161],"reticulum":[162],"(ER)-stress-related":[163],"proteins":[164],"(phosphorylated":[165],"eukaryotic":[166],"initiation":[167],"2\u03b1":[169],"subunit":[170],"(p-eIF2\u03b1),":[171],"activating":[172],"transcription":[173],"(ATF4),":[176],"C/EBP":[178],"homologous":[179],"(CHOP).":[181],"has":[183],"effect":[186],"by":[190],"suppressing":[191],"inflammatory":[192],"responses":[193],"acting":[195],"antioxidant.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-10-25T00:00:00"}
