{"id":"https://openalex.org/W3206428546","doi":"https://doi.org/10.7150/jca.62123","title":"Synergistic killing effects of PD-L1-CAR T cells and colorectal cancer stem cell-dendritic cell vaccine-sensitized T cells in ALDH1-positive colorectal cancer stem cells","display_name":"Synergistic killing effects of PD-L1-CAR T cells and colorectal cancer stem cell-dendritic cell vaccine-sensitized T cells in ALDH1-positive colorectal cancer stem cells","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3206428546","doi":"https://doi.org/10.7150/jca.62123","mag":"3206428546","pmid":"https://pubmed.ncbi.nlm.nih.gov/34659553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8517999"},"language":"en","primary_location":{"id":"doi:10.7150/jca.62123","doi":"https://doi.org/10.7150/jca.62123","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.62123","pdf_url":"https://www.jcancer.org/v12p6629.pdf","source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jcancer.org/v12p6629.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100324300","display_name":"Liu Liu","orcid":"https://orcid.org/0000-0003-3566-0212","observed_orcids":["https://orcid.org/0000-0003-3566-0212"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210165047","display_name":"Hefei First People's Hospital","ror":"https://ror.org/05qwgjd68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210165047"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu Liu","raw_affiliation_strings":["The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","Department of Oncology, The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Building 6, 390 Huaihe Road, Hefei, Anhui 230061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"Department of Oncology, The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Building 6, 390 Huaihe Road, Hefei, Anhui 230061, P.R. China","institution_ids":["https://openalex.org/I4210165047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405063","display_name":"Yuanyuan Liu","orcid":"https://orcid.org/0000-0003-0113-2438","observed_orcids":["https://orcid.org/0000-0003-0113-2438"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Liu","raw_affiliation_strings":["The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103654381","display_name":"Yang Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]},{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Xia","raw_affiliation_strings":["Taizhou People's Hospital/The Fifth Affiliated Hospital of Nantong University, Taizhou 225300, P.R. China",". The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taizhou People's Hospital/The Fifth Affiliated Hospital of Nantong University, Taizhou 225300, P.R. China","institution_ids":["https://openalex.org/I4210086801","https://openalex.org/I4210122818"]},{"raw_affiliation_string":". The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024846118","display_name":"Guanlong Wang","orcid":"https://orcid.org/0009-0008-8389-5271","observed_orcids":["https://orcid.org/0009-0008-8389-5271","https://orcid.org/0000-0002-9843-2623","https://orcid.org/0000-0003-0661-6597"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guanlong Wang","raw_affiliation_strings":["The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101764940","display_name":"Xiushan Zhang","orcid":"https://orcid.org/0009-0002-7175-8655","observed_orcids":["https://orcid.org/0009-0002-7175-8655"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiushan Zhang","raw_affiliation_strings":["The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356951","display_name":"Huan Zhang","orcid":"https://orcid.org/0000-0002-2289-7707","observed_orcids":["https://orcid.org/0000-0002-2289-7707","https://orcid.org/0009-0002-7251-1259"]},"institutions":[{"id":"https://openalex.org/I4405284357","display_name":"Linquan County People's Hospital","ror":"https://ror.org/03d8kx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405284357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Zhang","raw_affiliation_strings":["Linquan County People's Hospital, Linquan 236400, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Linquan County People's Hospital, Linquan 236400, P.R. China","institution_ids":["https://openalex.org/I4405284357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462099","display_name":"Yang Y. Xu","orcid":"https://orcid.org/0000-0003-4643-2098","observed_orcids":["https://orcid.org/0000-0003-4643-2098"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Xu","raw_affiliation_strings":["The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113577754","display_name":"Yuan Yuan","orcid":"https://orcid.org/0009-0002-9540-2100","observed_orcids":["https://orcid.org/0009-0002-9540-2100","https://orcid.org/0009-0006-5172-8570","https://orcid.org/0009-0008-8264-2205","https://orcid.org/0009-0009-1997-4343","https://orcid.org/0000-0002-2292-7339"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Yuan","raw_affiliation_strings":["The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072136791","display_name":"Shangquan Liu","orcid":"https://orcid.org/0000-0003-4069-4847","observed_orcids":["https://orcid.org/0000-0003-4069-4847"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shangquan Liu","raw_affiliation_strings":["The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100364910","display_name":"Yi Wang","orcid":"https://orcid.org/0000-0002-1043-7156","observed_orcids":["https://orcid.org/0000-0002-1043-7156"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Wang","raw_affiliation_strings":["The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China","institution_ids":["https://openalex.org/I197869895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024846118"],"corresponding_institution_ids":["https://openalex.org/I197869895"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":1.8298,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.85990263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"12","issue":"22","first_page":"6629","last_page":"6639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4643999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4643999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3837999999523163,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.08479999750852585,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer-stem-cells","display_name":"colorectal cancer stem cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.652999997138977},{"id":"https://openalex.org/keywords/dendritic-cell-vaccine","display_name":"dendritic cell vaccine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/aldh1","display_name":"ALDH1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.6079999804496765},{"id":"https://openalex.org/keywords/pd-1-pd-l1-axis","display_name":"PD-1/PD-L1 axis","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tumor-burden-reduction","display_name":"tumor burden reduction","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7002131938934326},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5957174301147461},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5927022695541382},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5701644420623779},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5489292144775391},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5101366639137268},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46151041984558105},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4567512273788452},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3902316391468048},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3451516330242157},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3300727605819702},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24462705850601196}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7150/jca.62123","doi":"https://doi.org/10.7150/jca.62123","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.62123","pdf_url":"https://www.jcancer.org/v12p6629.pdf","source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:34659553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34659553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8517999","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8517999/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7150/jca.62123","doi":"https://doi.org/10.7150/jca.62123","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.62123","pdf_url":"https://www.jcancer.org/v12p6629.pdf","source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3206428546.pdf","grobid_xml":"https://content.openalex.org/works/W3206428546.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1965180311","https://openalex.org/W1987052003","https://openalex.org/W2001393525","https://openalex.org/W2029231546","https://openalex.org/W2051055358","https://openalex.org/W2072100350","https://openalex.org/W2093350337","https://openalex.org/W2200958543","https://openalex.org/W2280403601","https://openalex.org/W2318101661","https://openalex.org/W2325048800","https://openalex.org/W2344915253","https://openalex.org/W2467919146","https://openalex.org/W2559268155","https://openalex.org/W2619959234","https://openalex.org/W2765190380","https://openalex.org/W2768497320","https://openalex.org/W2782676239","https://openalex.org/W2787775113","https://openalex.org/W2790337754","https://openalex.org/W2791880624","https://openalex.org/W2794396490","https://openalex.org/W2797465562","https://openalex.org/W2803801743","https://openalex.org/W2807110328","https://openalex.org/W2887150021","https://openalex.org/W2888146519","https://openalex.org/W2888676937","https://openalex.org/W2914626281","https://openalex.org/W2920256884","https://openalex.org/W2924339726","https://openalex.org/W2944657193","https://openalex.org/W2973023149","https://openalex.org/W3014986174","https://openalex.org/W3095051727","https://openalex.org/W4213385752","https://openalex.org/W4256449164"],"related_works":["https://openalex.org/W2886849359","https://openalex.org/W2496593931","https://openalex.org/W2467919146","https://openalex.org/W4210791802","https://openalex.org/W2788040536","https://openalex.org/W2573451002","https://openalex.org/W2564905673","https://openalex.org/W2460627364","https://openalex.org/W2078721111","https://openalex.org/W4286261453"],"abstract_inverted_index":{"Cancer":[0],"stem":[1],"cells":[2,74,80,87,145,165],"(CSCs)":[3],"are":[4,21,45],"characterized":[5],"by":[6,95],"self-renewal":[7],"and":[8,18,27,39,64,66,127,157,166],"unlimited":[9],"proliferation,":[10],"providing":[11],"a":[12,68,176],"basis":[13],"for":[14,81,179],"tumor":[15,125,152,169],"occurrence,":[16],"metastasis,":[17],"recurrence.Because":[19],"CSCs":[20,62],"highly":[22,133],"resistant":[23],"to":[24,97],"conventional":[25],"chemotherapy":[26],"radiotherapy,":[28],"various":[29],"immunotherapies,":[30],"particularly":[31],"chimeric":[32],"antigen":[33],"receptor":[34],"T":[35,79],"cell":[36,41,55,103,129],"(CAR-T)":[37],"therapy":[38,161],"dendritic":[40],"(DC)-based":[42],"vaccine":[43,106,148],"therapy,":[44],"currently":[46],"being":[47],"developed.Accordingly,":[48],"in":[49,60,121,135,141,155,158,171],"this":[50],"study,":[51],"we":[52],"evaluated":[53],"programmed":[54,102],"death":[56],"ligand-1":[57],"(PD-L1)":[58],"expression":[59],"colorectal":[61,85,184],"(CCSCs)":[63],"non-CCSCs":[65],"designed":[67],"combination":[69,160],"immunotherapy":[70],"synchronously":[71],"utilizing":[72],"PD-L1-CAR-T":[73,144],"together":[75],"with":[76,139,143],"CCSC-DC":[77,105,147],"vaccine-sensitized":[78],"the":[82,90,98,168,180],"treatment":[83,182],"of":[84,101,183],"cancer.PD-L1-CAR-T":[86],"specifically":[88],"recognized":[89],"PD-L1":[91,131],"molecule":[92],"on":[93],"CCSCs":[94,118,137],"binding":[96],"extracellular":[99],"domain":[100],"death-1.The":[104],"was":[107,132],"prepared":[108],"using":[109],"CCSC":[110],"lysates.We":[111],"found":[112],"that":[113,140],"aldehyde":[114],"dehydrogenase":[115],"1":[116],"(ALDH1)-positive":[117],"were":[119],"abundant":[120],"samples":[122],"from":[123],"patient":[124],"tissues":[126],"cancer":[128,164],"lines.Moreover,":[130],"expressed":[134],"ALDH1-positive":[136],"compared":[138],"non-CCSCs.Monotherapy":[142],"or":[146],"only":[149],"elicited":[150],"moderate":[151],"remission":[153],"both":[154],"vitro":[156],"vivo.However,":[159],"markedly":[162],"killed":[163],"relieved":[167],"burden":[170],"mice.Our":[172],"findings":[173],"may":[174],"provide":[175],"novel":[177],"strategy":[178],"clinical":[181],"malignancy.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-25T00:00:00"}
