{"id":"https://openalex.org/W3206099271","doi":"https://doi.org/10.61155/gen.v75i3.585","title":"Comentarios acerca de: \u201cValores de referencia de inmunoglobulina A s\u00e9rica total de utilidad para el diagn\u00f3stico y seguimiento de la enfermedad celiaca en venezolanos\u201d","display_name":"Comentarios acerca de: \u201cValores de referencia de inmunoglobulina A s\u00e9rica total de utilidad para el diagn\u00f3stico y seguimiento de la enfermedad celiaca en venezolanos\u201d","publication_year":2021,"publication_date":"2021-09-10","ids":{"openalex":"https://openalex.org/W3206099271","doi":"https://doi.org/10.61155/gen.v75i3.585","mag":"3206099271"},"language":"es","primary_location":{"id":"pmh:oai:ojs.genindex.ddns.net:article/585","doi":"https://doi.org/10.61155/gen.v75i3.585","is_oa":true,"landing_page_url":"https://revistagen.com/index.php/GEN/article/view/585","pdf_url":"https://revistagen.com/index.php/GEN/article/download/585/pdf","source":{"id":"https://openalex.org/S4387292041","display_name":"Revista GEN","issn_l":"0016-3503","issn":["0016-3503","2477-975X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0016-3503","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://revistagen.com/index.php/GEN/article/download/585/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062104203","display_name":"Nina Colina","orcid":"https://orcid.org/0000-0002-4052-5376","observed_orcids":["https://orcid.org/0000-0002-4052-5376"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nina Colina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062104203"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"3","first_page":"146","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10733","display_name":"Wheat and Barley Genetics and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12538","display_name":"Eosinophilic Esophagitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/celiac-disease","display_name":"celiac disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/reference-values","display_name":"reference values","score":0.968999981880188},{"id":"https://openalex.org/keywords/anti-tissue-transglutaminase-iga","display_name":"anti-tissue transglutaminase IgA","score":0.7850000262260437},{"id":"https://openalex.org/keywords/anti-gliadin-antibodies","display_name":"anti-gliadin antibodies","score":0.640999972820282},{"id":"https://openalex.org/keywords/selective-iga-deficiency","display_name":"selective IgA deficiency","score":0.8769999742507935},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/disease-surveillance","display_name":"disease surveillance","score":0.625},{"id":"https://openalex.org/keywords/hla-dq2-dq8","display_name":"HLA-DQ2/DQ8","score":0.8370000123977661},{"id":"https://openalex.org/keywords/intestinal-biopsy","display_name":"intestinal biopsy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/false-negative-serology","display_name":"false-negative serology","score":0.656000018119812},{"id":"https://openalex.org/keywords/dermatitis-herpetiformis","display_name":"dermatitis herpetiformis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hemolyzed-blood","display_name":"hemolyzed blood","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4291746914386749},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.39204925298690796},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3890892267227173}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ojs.genindex.ddns.net:article/585","doi":"https://doi.org/10.61155/gen.v75i3.585","is_oa":true,"landing_page_url":"https://revistagen.com/index.php/GEN/article/view/585","pdf_url":"https://revistagen.com/index.php/GEN/article/download/585/pdf","source":{"id":"https://openalex.org/S4387292041","display_name":"Revista GEN","issn_l":"0016-3503","issn":["0016-3503","2477-975X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0016-3503","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3206099271","doi":null,"is_oa":false,"landing_page_url":"http://saber.ucv.ve/ojs/index.php/rev_gen/article/view/23119/0","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista GEN","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ojs.genindex.ddns.net:article/585","doi":"https://doi.org/10.61155/gen.v75i3.585","is_oa":true,"landing_page_url":"https://revistagen.com/index.php/GEN/article/view/585","pdf_url":"https://revistagen.com/index.php/GEN/article/download/585/pdf","source":{"id":"https://openalex.org/S4387292041","display_name":"Revista GEN","issn_l":"0016-3503","issn":["0016-3503","2477-975X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0016-3503","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3206099271.pdf","grobid_xml":"https://content.openalex.org/works/W3206099271.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2973568916","https://openalex.org/W2998971955"],"related_works":["https://openalex.org/W7216122789","https://openalex.org/W1980298027","https://openalex.org/W2011809307","https://openalex.org/W2604478800","https://openalex.org/W7216400463","https://openalex.org/W4403293336","https://openalex.org/W2015905412","https://openalex.org/W4414396518","https://openalex.org/W2780287533","https://openalex.org/W2614571923"],"abstract_inverted_index":{"Comentarios":[0],"acerca":[1],"de:":[2],"\u201cValores":[3],"de":[4,6,11,18,44,51,66,79,86,98,104,109,119,127,130,140,146,158,167,176,178,188,207,217,219,233,240,248,263,280,288,315,318,326,335,379,389,414,420,430,436,450,456,473,475,486,512,522,545,548,562,579,602,605,645,648,672,689,700,705,713,737,749,753,759,763,774],"referencia":[5,513,683],"inmunoglobulina":[7],"A":[8,144,550],"s\u00e9rica":[9,121],"total":[10,755],"utilidad":[12],"para":[13,83,182,417,500,558,657,665,733,770],"el":[14,28,49,184,192,231,386,418,536,571,582,591,634,654,659,757],"diagn\u00f3stico":[15,419,688,712],"y":[16,74,196,353,355,446,504,614,708,745],"seguimiento":[17,580],"la":[19,84,92,95,106,165,174,197,203,234,238,267,273,289,294,370,380,383,390,412,421,434,454,476,489,501,543,559,587,593,600,618,646,690,703,709,714,735,747,751,761,764,771,775],"enfermedad":[20,502],"celiaca":[21],"en":[22,25,27,56,100,125,172,205,227,230,250,272,304,324,364,369,426,439,535,551,566,570,581,680,696,739,756],"venezolanos\u201d.":[23],"Publicado":[24],"GEN":[26],"Volumen":[29],"75":[30],"N\u00b0":[31],"2":[32],"abril-junio":[33],"2021,":[34],"p\u00e1gs.":[35],"50-54La":[36],"Enfermedad":[37],"Cel\u00edaca":[38],"(EC)":[39],"es":[40,180,266,361,620,661,674],"un":[41,214,251,642,675],"proceso":[42],"sist\u00e9mico":[43],"car\u00e1cter":[45],"inmunol\u00f3gico,":[46],"desencadenado":[47],"por":[48],"consumo":[50],"gluten,":[52],"que":[53,91,153,156,221,255,278,368,467,628,636,653],"se":[54,60,297,301,432,452,464,540,556,575,631,640],"da":[55],"sujetos":[57],"gen\u00e9ticamente":[58],"predispuestos,":[59],"expresa":[61],"con":[62,102,163,194,237,276,312,338,366,382,395,428,441,469,586,719,741],"una":[63,117,479,523,567,610,730],"gran":[64],"variedad":[65],"s\u00edntomas":[67],"cl\u00ednicos,":[68],"marcadores":[69,564],"serol\u00f3gicos":[70,416,565],"espec\u00edficos,":[71],"haplotipo":[72],"HLA-DQ2/DQ8":[73],"enteropat\u00eda(1).":[75],"La":[76,331],"elevada":[77],"precisi\u00f3n":[78],"los":[80,134,147,222,257,316,336,393,442,510,531,546,563,629,706,720],"test":[81,415],"utilizados":[82],"determinaci\u00f3n":[85,108,204,455,752],"estos":[87],"anticuerpos":[88,258,443,457,487,606,630],"ha":[89,465],"hecho":[90,635],"serolog\u00eda":[93,594,762],"sea":[94],"primera":[96,107,568,731],"l\u00ednea":[97],"investigaci\u00f3n":[99,673],"pacientes":[101,365,394,427,468,740],"sospecha":[103,429],"EC.Con":[105],"Anticuerpos":[110,137],"Antitransglutaminasa":[111],"(AATG)":[112],"IgA":[113,120,224,264,303,399,437,444,666,669,754],"debe":[114,541],"realizarse":[115],"siempre":[116],"cuantificaci\u00f3n":[118,239,435],"total,":[122,438],"ya":[123],"que,":[124],"caso":[126,758],"d\u00e9ficit":[128,247],"selectivo":[129],"IgA,":[131,149,249],"deben":[132,225,506],"usarse":[133],"AATG":[135,148,159,223],"IgG,":[136],"Peptidos":[138],"Desaminado":[139],"Gliadina":[141],"(PDG)":[142],"IgG.":[143],"diferencia":[145,529],"no":[150,397,495,505,539,574],"hay":[151,254],"estudios":[152,651,685],"hayan":[154],"valorado":[155],"niveles":[157,218,547],"IgG":[160,322,458],"pueden":[161],"predecir":[162],"fiabilidad":[164],"existencia":[166],"lesi\u00f3n":[168],"intestinal.":[169],"Por":[170,423],"tanto,":[171,425],"ni\u00f1os,":[173],"realizaci\u00f3n":[175,413],"Biopsia":[177],"intestino":[179],"obligatoria":[181],"confirmar":[183],"diagn\u00f3stico.":[185],"Otras":[186],"causas":[187],"falsos":[189,409],"negativos":[190,410],"son":[191,340,496],"tratamiento":[193],"inmunosupresores":[195],"dermatitis":[198],"herpetiforme,":[199],"frecuentemente":[200],"seronegativa.":[201],"Tambi\u00e9n":[202],"muestras":[206],"sangre":[208],"hemolizada":[209],"puede":[210,344,405,596],"dar":[211],"lugar":[212,229],"a":[213,282,293,307,347,356,407,638,677,684,702],"falso":[215],"descenso":[216],"anticuerpos(2).Confirman":[220],"determinarse":[226],"primer":[228],"estudio":[232],"EC":[235,367,381,431,742,765],"junto":[236],"Inmunoglobulina":[241],"gA":[242],"(Ig)":[243],"s\u00e9rica.":[244],"Si":[245],"existe":[246,528],"segundo":[252],"paso":[253],"estudiar":[256],"isotipo":[259],"IgG.La":[260],"deficiencia":[261],"selectiva":[262],"(DSIgA)":[265],"inmunodeficiencia":[268],"primaria":[269],"m\u00e1s":[270,362,573],"frecuente":[271],"poblaci\u00f3n":[274,371],"general,":[275],"incidencias":[277],"va":[279],"1:163":[281],"1:965":[283],"(menor":[284],"al":[285,687,698,717],"1%),":[286],"dependiendo":[287],"poblaci\u00f3n(3).":[290],"De":[291,518],"acuerdo":[292],"definici\u00f3n":[295],"actual,":[296],"considera":[298,641],"DSIgA":[299,339,360,384,396,451,470,738],"cuando":[300],"presenta":[302],"suero":[305],"menor":[306],"7":[308],"mg/dL":[309],"(0,07":[310],"g/L),":[311],"concentraciones":[313,604],"s\u00e9ricas":[314],"isotipos":[317],"inmunoglobulinas":[319],"IgM":[320],"e":[321],"normales,":[323],"individuos":[325,337],"4":[327],"a\u00f1os":[328],"o":[329,493,668],"mayores(3).":[330],"mayor\u00eda":[332],"(dos":[333],"tercios)":[334],"asintom\u00e1ticos,":[341],"sin":[342,692],"embargo,":[343,693],"presentarse":[345],"asociada":[346],"infecciones":[348],"recurrentes":[349],"del":[350,515,584,612,711,743],"tracto":[351],"respiratorio":[352],"gastrointestinal":[354],"ciertas":[357],"enfermedades":[358],"autoinmunes.(4)La":[359],"prevalente":[363],"general":[372],"(aproximadamente":[373],"10":[374],"veces":[375],"m\u00e1s)(5,6).":[376],"Esta":[377],"asociaci\u00f3n":[378,480],"complica":[385],"diagnostico":[387],"serol\u00f3gico":[388],"enfermedad.":[391],"As\u00ed,":[392],"producen":[398],"antitTG2":[400],"ni":[401,498],"IgA-EMA,":[402],"lo":[403,424],"cual":[404],"llevar":[406],"resultados":[408],"durante":[411],"patolog\u00eda(7).":[422],"sugiere":[433],"conjunto":[440],"anti-tTG2":[445,459],"IgA-EMA.":[447],"En":[448,590],"casos":[449,725],"recomienda":[453],"y/o":[460],"anti-DGP(8).A":[461],"su":[462],"vez,":[463],"reportado":[466],"presentan":[471],"6,5%":[472],"prevalencia":[474],"EC(9),":[477],"demostrando":[478],"entre":[481,530],"ambas":[482],"entidades.":[483],"Las":[484],"pruebas":[485,663],"contra":[488],"gliadina":[490],"nativa":[491],"(AGA-IgA":[492],"AGA-IgG)":[494],"sensibles":[497],"espec\u00edficas":[499],"cel\u00edaca":[503,595],"utilizarse.(10)Es":[507],"importante":[508],"conocer":[509],"valores":[511],"estandarizados":[514],"instrumento":[516],"usado.":[517],"esta":[519],"forma":[520],"resultara":[521],"manera":[524],"objetiva":[525],"establecer":[526],"si":[527,617],"diferentes":[532,553],"grupos":[533,707],"categorizados":[534],"estudio.":[537],"Adem\u00e1s,":[538],"soslayar":[542],"variabilidad":[544],"Ig":[549],"las":[552,603,767],"edadesLa":[554],"Iga":[555],"usa":[557],"adecuada":[560,772],"interpretaci\u00f3n":[561,773],"muestra,":[569],"diagnostico,":[572],"establece":[576],"como":[577,682,724,729],"recurso":[578],"control":[583],"paciento":[585],"condici\u00f3n":[588],"cel\u00edaca.":[589],"seguimiento,":[592],"ser":[597,678],"\u00fatil,":[598],"pero":[599],"disminuci\u00f3n":[601],"cel\u00edacos":[607],"espec\u00edficos":[608],"indica":[609],"reducci\u00f3n":[611],"gluten":[613],"logra":[615],"definir":[616],"adherencia":[619],"completa":[621],"solo":[622],"hasta":[623],"cierto":[624],"punto.":[625],"Una":[626],"vez":[627],"han":[632],"normalizado,":[633],"vuelvan":[637],"aumentar":[639],"buen":[643],"indicador":[644],"ingesta":[647],"gluten.":[649],"Los":[650],"sugieren":[652],"m\u00e9todo":[655],"preferido":[656],"controlar":[658],"cumplimiento":[660],"realizar":[662,760],"peri\u00f3dicas":[664],"anti-tTG":[667],"anti-DGP.(11)Este":[670],"trabajo":[671,728],"aporte":[676],"tomado":[679],"cuenta":[681],"referenciales":[686],"celiaqu\u00eda,":[691],"tiene":[694],"limitaciones":[695],"cuanto":[697],"n\u00famero":[699],"pacientes,":[701],"heterogeneidad":[704],"confirmaci\u00f3n":[710],"celiaqu\u00eda":[715],"previo":[716],"estudio,":[718],"cuales":[721],"fueron":[722],"seleccionados":[723],"confirmados.Considero,":[726],"este":[727],"aproximaci\u00f3n":[732],"describir":[734],"frecuencia":[736],"pa\u00eds":[744],"plantea":[746],"importancia":[748],"incluir":[750],"seg\u00fan":[766],"\u00faltimas":[768],"pautas":[769],"misma.":[776]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-10-25T00:00:00"}
