{"id":"https://openalex.org/W3206080628","doi":"https://doi.org/10.7150/jca.62555","title":"SYT12 is a novel oncogene that promotes thyroid carcinoma progression and metastasis","display_name":"SYT12 is a novel oncogene that promotes thyroid carcinoma progression and metastasis","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3206080628","doi":"https://doi.org/10.7150/jca.62555","mag":"3206080628","pmid":"https://pubmed.ncbi.nlm.nih.gov/34659573","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8518017"},"language":"en","primary_location":{"id":"doi:10.7150/jca.62555","doi":"https://doi.org/10.7150/jca.62555","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.62555","pdf_url":"https://www.jcancer.org/v12p6851.pdf","source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jcancer.org/v12p6851.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102705130","display_name":"Lingli Jin","orcid":"https://orcid.org/0009-0006-4970-8335","observed_orcids":["https://orcid.org/0009-0006-4970-8335","https://orcid.org/0000-0001-9256-7271"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingli Jin","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020662612","display_name":"Danni Zheng","orcid":"https://orcid.org/0000-0001-5390-0211","observed_orcids":["https://orcid.org/0000-0001-5390-0211"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danni Zheng","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001303079","display_name":"Danxiang Chen","orcid":"https://orcid.org/0000-0002-9241-6841","observed_orcids":["https://orcid.org/0000-0002-9241-6841"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danxiang Chen","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070275317","display_name":"Erjie Xia","orcid":"https://orcid.org/0000-0003-0036-0703","observed_orcids":["https://orcid.org/0000-0003-0036-0703"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erjie Xia","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110850203","display_name":"Yaoyao Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaoyao Guan","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005846806","display_name":"Jialiang Wen","orcid":"https://orcid.org/0000-0003-1493-1757","observed_orcids":["https://orcid.org/0000-0003-1493-1757"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jialiang Wen","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052611964","display_name":"Adheesh Bhandari","orcid":"https://orcid.org/0000-0002-0406-2685","observed_orcids":["https://orcid.org/0000-0002-0406-2685"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Adheesh Bhandari","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041509753","display_name":"Ouchen Wang","orcid":"https://orcid.org/0000-0001-5230-379X","observed_orcids":["https://orcid.org/0000-0001-5230-379X"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ouchen Wang","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China","institution_ids":["https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I2801769982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052611964"],"corresponding_institution_ids":["https://openalex.org/I2801769982"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":0.9333,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.74990857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"22","first_page":"6851","last_page":"6860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.824999988079071},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.9539999961853027},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.6729999780654907},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tcga-cohort","display_name":"TCGA cohort","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6507031321525574},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6092240214347839},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.576102077960968},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.542498767375946},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.527474582195282},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5079262852668762},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49008452892303467},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.48743537068367004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46276822686195374},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.45603808760643005},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3980931043624878},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.396804541349411},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3396967053413391},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3046470284461975},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11900269985198975}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7150/jca.62555","doi":"https://doi.org/10.7150/jca.62555","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.62555","pdf_url":"https://www.jcancer.org/v12p6851.pdf","source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8518017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8518017","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer","raw_type":"Text"},{"id":"pmid:34659573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34659573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/jca.62555","doi":"https://doi.org/10.7150/jca.62555","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.62555","pdf_url":"https://www.jcancer.org/v12p6851.pdf","source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1374291085","display_name":null,"funder_award_id":"LY18H160053","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320310111","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3206080628.pdf","grobid_xml":"https://content.openalex.org/works/W3206080628.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1965481481","https://openalex.org/W1968812902","https://openalex.org/W1976283234","https://openalex.org/W1994933955","https://openalex.org/W1999324180","https://openalex.org/W2002936490","https://openalex.org/W2005824313","https://openalex.org/W2032840486","https://openalex.org/W2055599569","https://openalex.org/W2094783213","https://openalex.org/W2103523670","https://openalex.org/W2119156172","https://openalex.org/W2145150141","https://openalex.org/W2221837786","https://openalex.org/W2272984102","https://openalex.org/W2758700166","https://openalex.org/W2889646458","https://openalex.org/W2972349347","https://openalex.org/W2999417355","https://openalex.org/W3001702731","https://openalex.org/W3011971918","https://openalex.org/W3012017822","https://openalex.org/W3031624337","https://openalex.org/W3086473620","https://openalex.org/W3137724390","https://openalex.org/W4236146633","https://openalex.org/W6633658626","https://openalex.org/W6658641564","https://openalex.org/W6693972512","https://openalex.org/W6782158152"],"related_works":["https://openalex.org/W2606084514","https://openalex.org/W2758700166","https://openalex.org/W4412163762","https://openalex.org/W3003406165","https://openalex.org/W4281612021","https://openalex.org/W4392830947","https://openalex.org/W3022228189","https://openalex.org/W2989946500","https://openalex.org/W3051060720","https://openalex.org/W4411844359"],"abstract_inverted_index":{"Background:":[0],"Thyroid":[1],"malignancy":[2],"is":[3,12,31,163],"the":[4,22,36,89,95,107,123,138,158,172,199,210],"most":[5],"frequent":[6],"endocrine":[7],"malignant":[8,72],"tumor":[9],"whose":[10],"incidence":[11,179],"still":[13,61],"increasing.Mechanisms":[14],"genomic":[15],"variations":[16],"play":[17],"a":[18,32,231,243],"major":[19],"part":[20],"in":[21,57,84,103,106,142,194,225,250],"pathogenesis":[23],"of":[24,27,35,68,92,112,140,160,169,174,181,201,207],"many":[25],"types":[26],"malignancy.Synaptotagmin":[28],"12":[29],"(SYT12)":[30],"member":[33],"gene":[34],"synaptotagmins":[37],"family":[38],"and":[39,53,74,94,100,126,151,166,178,187,218,221,239,242,248],"SYT12's":[40,50],"variants":[41],"were":[42,60,154],"shown":[43],"to":[44,121,135,156],"be":[45],"associated":[46],"with":[47],"some":[48],"malignancies.Nevertheless,":[49],"specific":[51],"function":[52,159],"probable":[54],"clinical":[55,98],"value":[56],"papillary":[58],"cancer":[59,105],"unknown.Methods:":[62],"We":[63],"conducted":[64],"complete":[65],"genome":[66],"sequence":[67],"39":[69],"pairs":[70,115],"PTC":[71,143,192,226],"neoplasm":[73,183],"matched":[75],"non-neoplastic":[76],"tissues.We":[77],"found":[78],"that":[79,205,234],"SYT12":[80,93,101,141,162,170,208,229],"was":[81,119,230],"significantly":[82,164],"overexpressed":[83,165],"thyroid":[85,104,236],"malignancy.Next,":[86],"we":[87,129],"investigated":[88],"expression":[90,102,139,168],"level":[91],"relation":[96],"between":[97],"information":[99],"Cancer":[108],"Genome":[109],"Atlas":[110],"(TCGA).QRt-PCR":[111],"else":[113],"40":[114],"local":[116],"verified":[117],"cohort":[118],"performed":[120],"confirm":[122],"sequencing":[124],"data":[125],"TCGA":[127,195],"cohort.Then,":[128],"used":[130],"small":[131],"interfering":[132],"RNA":[133],"(si-RNA)":[134],"knock":[136],"down":[137],"cells.Finally,":[144],"proliferation,":[145,212],"cell":[146,211,213,223,227],"colony":[147,214],"formation,":[148,215],"migration,":[149,217],"invasion,":[150],"apoptosis":[152],"assays":[153,203],"done":[155],"demonstrate":[157],"SYT12.Results:":[161],"higher":[167],"upsurges":[171],"risk":[173],"lymph":[175],"node":[176],"metastatic":[177],"rate":[180],"primary":[182],"multivariate":[184],"focus":[185],"type":[186,190],"classical":[188],"histological":[189],"for":[191,246],"patients":[193],"cohort.In":[196],"vitro":[197],"experiments,":[198],"results":[200],"functional":[202],"presented":[204],"knock-down":[206],"inhibited":[209],"trans-well":[216,219],"invasion":[220],"promoted":[222],"apoptotic":[224],"lines.Conclusion:":[228],"novel":[232],"oncogene":[233],"promotes":[235],"carcinoma":[237],"progression":[238],"metastasis":[240],"potential":[241,244],"biomarker":[245],"diagnosis":[247],"treatment":[249],"PTC.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-10-25T00:00:00"}