{"id":"https://openalex.org/W3205990930","doi":"https://doi.org/10.3389/fimmu.2021.752484","title":"Mechanisms by Which Obesity Promotes Acute Graft-Versus-Host Disease in Mice","display_name":"Mechanisms by Which Obesity Promotes Acute Graft-Versus-Host Disease in Mice","publication_year":2021,"publication_date":"2021-10-11","ids":{"openalex":"https://openalex.org/W3205990930","doi":"https://doi.org/10.3389/fimmu.2021.752484","mag":"3205990930","pmid":"https://pubmed.ncbi.nlm.nih.gov/34707616","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8542879"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2021.752484","doi":"https://doi.org/10.3389/fimmu.2021.752484","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.752484","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.752484/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.752484/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022992760","display_name":"Lam T. Khuat","orcid":"https://orcid.org/0000-0002-4223-8805","observed_orcids":["https://orcid.org/0000-0002-4223-8805"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lam T. Khuat","raw_affiliation_strings":["Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032279430","display_name":"Logan Vahid Vick","orcid":"https://orcid.org/0009-0006-9778-0120","observed_orcids":["https://orcid.org/0009-0006-9778-0120"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Logan V. Vick","raw_affiliation_strings":["Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eunju Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eunju Choi","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057966666","display_name":"Cordelia Dunai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cordelia Dunai","raw_affiliation_strings":["Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032164345","display_name":"Alexander A. Merleev","orcid":"https://orcid.org/0000-0002-5735-7233","observed_orcids":["https://orcid.org/0000-0002-5735-7233","https://orcid.org/0000-0002-5031-4775"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Merleev","raw_affiliation_strings":["Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030729248","display_name":"Emanual Michael Maverakis","orcid":"https://orcid.org/0000-0002-6294-6294","observed_orcids":["https://orcid.org/0000-0002-6294-6294"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanual Maverakis","raw_affiliation_strings":["Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058268746","display_name":"Bruce R. Blazar","orcid":"https://orcid.org/0000-0002-9608-9841","observed_orcids":["https://orcid.org/0000-0002-9608-9841"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce R. Blazar","raw_affiliation_strings":["Masonic Cancer Center and Division of Blood & Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center and Division of Blood & Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065634805","display_name":"Arta Monir Monjazeb","orcid":"https://orcid.org/0000-0001-5175-8004","observed_orcids":["https://orcid.org/0000-0001-5175-8004"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arta M. Monjazeb","raw_affiliation_strings":["Department of Radiation Oncology, School of Medicine, University of California, Davis, Sacramento, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, School of Medicine, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042070203","display_name":"William J. Murphy","orcid":"https://orcid.org/0000-0002-2793-401X","observed_orcids":["https://orcid.org/0000-0002-2793-401X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William J. Murphy","raw_affiliation_strings":["Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States","Department of Internal Medicine, School\u00a0of Medicine, University of California, Davis, Sacramento, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Internal Medicine, School\u00a0of Medicine, University of California, Davis, Sacramento, CA, United States","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042070203"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.6293,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84230355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"752484","last_page":"752484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.9259999990463257},{"id":"https://openalex.org/keywords/gastrointestinal-gvhd","display_name":"gastrointestinal GVHD","score":0.8140000104904175},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8140000104904175},{"id":"https://openalex.org/keywords/microbiota-diversity","display_name":"microbiome diversity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.6010000109672546},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.7649999856948853},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7765883207321167},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6633601784706116},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6355036497116089},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.627924919128418},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6165738105773926},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5876232981681824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5153824687004089},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5105487108230591},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5082699656486511},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.45809632539749146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3652641177177429},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2800370752811432},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.14948993921279907}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.3389/fimmu.2021.752484","doi":"https://doi.org/10.3389/fimmu.2021.752484","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.752484","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.752484/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7432733","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8542879","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8542879","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8542879","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:34707616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34707616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:496012","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.3389/fimmu.2021.752484>).","pdf_url":"https://eprints.soton.ac.uk/496012/1/fimmu-12-752484.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3fx730ms","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3fx730ms","pdf_url":"https://escholarship.org/content/qt3fx730ms/qt3fx730ms.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, vol 12","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:581f8689a69c4817a6e50c308b7a13b6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/581f8689a69c4817a6e50c308b7a13b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 12 (2021)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt3fx730ms","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3fx730ms","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2021.752484","doi":"https://doi.org/10.3389/fimmu.2021.752484","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.752484","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.752484/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1687387222","display_name":"T-Cell Targeting for GVHD","funder_award_id":"R01HL056067","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2896368367","display_name":"Exploiting the VISTA Pathway to Prevent Acute GVHD and Control Steroid Refractory Disease","funder_award_id":"R01HL155114","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6902756509","display_name":"Multispecies Comparison of the Impact of Obesity on GVHD/GVT","funder_award_id":"R01CA214048","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7938659809","display_name":null,"funder_award_id":"P30CA093373","funder_id":"https://openalex.org/F4320337900","funder_display_name":"Comprehensive Cancer Center, University of California, Davis"},{"id":"https://openalex.org/G8050863362","display_name":"T Cell Costimulatory Pathways:  Functions and Interactions","funder_award_id":"P01AI056299","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000015183","display_name":null,"funder_award_id":"CA093373","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000020151","display_name":null,"funder_award_id":"AI34495","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000263201","display_name":null,"funder_award_id":"HL56067","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000877125","display_name":"In Vivo Prevention of Murine GVHD","funder_award_id":"R37AI034495","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000885888","display_name":"Cancer Center Support Grant P30","funder_award_id":"P30CA093373","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000900684","display_name":"Enhancing Treg Therapeutic Efficacy in GVHD","funder_award_id":"R01HL118979","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000908608","display_name":"Off-the-Shelf Immune Effector Cells for Hematological Malignancies","funder_award_id":"P01CA065493","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337900","display_name":"Comprehensive Cancer Center, University of California, Davis","ror":"https://ror.org/02kcc1z29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205990930.pdf","grobid_xml":"https://content.openalex.org/works/W3205990930.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1480177881","https://openalex.org/W1544331058","https://openalex.org/W1592407962","https://openalex.org/W1843449358","https://openalex.org/W1971415551","https://openalex.org/W1988508853","https://openalex.org/W1995355078","https://openalex.org/W2001652786","https://openalex.org/W2012720431","https://openalex.org/W2036977806","https://openalex.org/W2084899273","https://openalex.org/W2091221156","https://openalex.org/W2100373006","https://openalex.org/W2118377433","https://openalex.org/W2131766513","https://openalex.org/W2133856765","https://openalex.org/W2151536540","https://openalex.org/W2169534511","https://openalex.org/W2179263776","https://openalex.org/W2310441748","https://openalex.org/W2514983123","https://openalex.org/W2517357121","https://openalex.org/W2546443007","https://openalex.org/W2582882943","https://openalex.org/W2594196841","https://openalex.org/W2625485505","https://openalex.org/W2727371443","https://openalex.org/W2884776261","https://openalex.org/W2904410891","https://openalex.org/W3107384662","https://openalex.org/W3110619918"],"related_works":["https://openalex.org/W2983767139","https://openalex.org/W4313355933","https://openalex.org/W3110619918","https://openalex.org/W4313383873","https://openalex.org/W2747943077","https://openalex.org/W4385686973","https://openalex.org/W6902533527","https://openalex.org/W4386161658","https://openalex.org/W4381850220","https://openalex.org/W3109877677"],"abstract_inverted_index":{"-host":[0],"disease":[1],"(GVHD).":[2],"We":[3,31,146],"have":[4],"recently":[5],"demonstrated":[6],"that":[7,111,167,214],"obesity":[8,68,219,243],"results":[9,212],"in":[10,15,42,132,142,190],"exacerbated":[11],"acute":[12,92,202,221,249],"gastrointestinal":[13],"GVHD":[14,56,185,203,223,250],"both":[16,133],"mouse":[17,63],"models":[18],"and":[19,28,50,152,204,238],"clinical":[20],"outcomes":[21],"due":[22],"to":[23,34,66,75,91,118,171,246],"increased":[24],"pro-inflammatory":[25],"cytokine":[26],"responses":[27],"microbiota":[29,141],"alterations.":[30],"therefore":[32],"wanted":[33],"delineate":[35],"the":[36,39,51,96,122,140,159,174,180,184,191,195,215,230,239],"role":[37,52],"of":[38,46,53,61,125,135,158,176,218],"various":[40],"parameters":[41],"obesity,":[43],"adiposity,":[44],"effects":[45,217],"high-fat":[47],"(HF)":[48],"diet,":[49],"microbiome":[54,182,240],"on":[55,113,220,227],"pathogenesis,":[57],"by":[58],"taking":[59],"advantage":[60],"a":[62,235],"strain":[64],"resistant":[65,74],"diet-induced":[67],"(DIO).":[69],"Female":[70],"BALB/c":[71],"mice":[72,143,199],"are":[73,105,224],"DIO":[76,82],"phenotype":[77],"with":[78,194,229,242],"approximately":[79],"50%":[80],"becoming":[81],"under":[83],"HF":[84,114,231],"diets.":[85],"The":[86],"DIO-susceptible":[87],"recipients":[88,206],"rapidly":[89],"succumb":[90],"gut":[93,222],"GVHD,":[94,109],"whereas":[95],"DIO-resistant":[97,205],"recipient":[98],"littermates,":[99],"which":[100],"do":[101],"not":[102,121],"become":[103],"obese,":[104],"partially":[106],"protected":[107],"from":[108,173],"indicating":[110],"being":[112],"diet":[115,232],"alone":[116],"contributes":[117],"but":[119,137],"is":[120],"primary":[123],"driver":[124],"GVHD.":[126],"Microbiome":[127],"assessment":[128],"revealed":[129],"restricted":[130,165,181],"diversity":[131,166],"cohorts":[134],"mice,":[136,193],"coprophagy":[138],"normalizes":[139],"housed":[144,149,161],"together.":[145],"then":[147],"individually":[148,160],"DIO-resistant,":[150],"DIO-susceptible,":[151],"lean":[153,196],"control":[154,197],"mice.":[155],"Notably,":[156],"each":[157],"groups":[162],"demonstrates":[163],"marked":[164],"has":[168],"been":[169],"shown":[170],"occur":[172],"stress":[175],"single":[177],"housing.":[178],"Despite":[179],"diversity,":[183],"pathogenesis":[186],"profile":[187],"remains":[188],"consistent":[189],"group-housed":[192],"single-housed":[198],"exhibiting":[200],"no":[201],"showing":[207],"again":[208],"partial":[209],"protection.":[210],"These":[211],"demonstrate":[213],"deleterious":[216],"critically":[225],"dependent":[226],"adiposity":[228],"also":[233],"playing":[234],"lesser":[236],"role,":[237],"alterations":[241],"instead":[244],"appear":[245],"fuel":[247],"ongoing":[248],"processes.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}
