{"id":"https://openalex.org/W3205804184","doi":"https://doi.org/10.1002/lary.29891","title":"A Scoping Review of Ongoing Fluorescence\u2010Guided Surgery Clinical Trials in Otolaryngology","display_name":"A Scoping Review of Ongoing Fluorescence\u2010Guided Surgery Clinical Trials in Otolaryngology","publication_year":2021,"publication_date":"2021-10-11","ids":{"openalex":"https://openalex.org/W3205804184","doi":"https://doi.org/10.1002/lary.29891","mag":"3205804184","pmid":"https://pubmed.ncbi.nlm.nih.gov/34633092"},"language":"en","primary_location":{"id":"doi:10.1002/lary.29891","doi":"https://doi.org/10.1002/lary.29891","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lary.29891","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022642304","display_name":"Kayva L. Crawford","orcid":"https://orcid.org/0000-0002-8744-7168","observed_orcids":["https://orcid.org/0000-0002-8744-7168"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayva L. Crawford","raw_affiliation_strings":["Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego  San Diego California U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-8744-7168","affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego  San Diego California U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fernanda V. Pacheco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernanda V. Pacheco","raw_affiliation_strings":["Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego  San Diego California U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego  San Diego California U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu\u2010Jin Lee","orcid":"https://orcid.org/0000-0001-7050-9185","observed_orcids":["https://orcid.org/0000-0001-7050-9185"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu\u2010Jin Lee","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto California U.S.A"],"raw_orcid":"https://orcid.org/0000-0001-7050-9185","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto California U.S.A","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012685021","display_name":"Marisa E. Hom","orcid":"https://orcid.org/0000-0003-1319-5110","observed_orcids":["https://orcid.org/0000-0003-1319-5110"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marisa Hom","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto California U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto California U.S.A","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086275218","display_name":"Eben Lloyd Rosenthal","orcid":"https://orcid.org/0000-0003-0294-5203","observed_orcids":["https://orcid.org/0000-0003-0294-5203"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eben L. Rosenthal","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto California U.S.A"],"raw_orcid":"https://orcid.org/0000-0003-0294-5203","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Palo Alto California U.S.A","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112331821","display_name":"Quyen T. Nguyen","orcid":"https://orcid.org/0009-0005-5648-8425","observed_orcids":["https://orcid.org/0009-0005-5648-8425"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quyen T. Nguyen","raw_affiliation_strings":["Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego  San Diego California U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego  San Diego California U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040666240","display_name":"Ryan K. Orosco","orcid":"https://orcid.org/0000-0002-7885-4327","observed_orcids":["https://orcid.org/0000-0002-7885-4327"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan K. Orosco","raw_affiliation_strings":["Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego  San Diego California U.S.A","Moores Cancer Center  La Jolla California U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-7885-4327","affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego  San Diego California U.S.A","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Moores Cancer Center  La Jolla California U.S.A","institution_ids":["https://openalex.org/I4390039236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":2.2402,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.88489759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"132","issue":"1","first_page":"36","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.12870000302791595,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-guided-surgery","display_name":"fluorescence-guided surgery","score":1.0},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.7049999833106995},{"id":"https://openalex.org/keywords/surgical-oncology","display_name":"surgical oncology","score":0.6499999761581421},{"id":"https://openalex.org/keywords/lymph-node-detection","display_name":"lymph node detection","score":0.7570000290870667},{"id":"https://openalex.org/keywords/fluorophores","display_name":"fluorophores","score":0.8149999976158142},{"id":"https://openalex.org/keywords/indocyanine-green","display_name":"indocyanine green","score":0.9929999709129333},{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fluorescein-derivatives","display_name":"fluorescein derivatives","score":0.9110000133514404},{"id":"https://openalex.org/keywords/thyroidectomy","display_name":"thyroidectomy","score":0.671999990940094},{"id":"https://openalex.org/keywords/parathyroid-function","display_name":"parathyroid function","score":0.8379999995231628},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9302494525909424},{"id":"https://openalex.org/C108516343","wikidata":"https://www.wikidata.org/wiki/Q189553","display_name":"Otorhinolaryngology","level":2,"score":0.8207725286483765},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5582860708236694},{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.5187604427337646},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4697364270687103},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4300515055656433},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.36242079734802246},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2354627549648285}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013517","descriptor_name":"Otorhinolaryngologic Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/lary.29891","doi":"https://doi.org/10.1002/lary.29891","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lary.29891","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},{"id":"pmid:34633092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34633092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1970845490","https://openalex.org/W1974100712","https://openalex.org/W1991429659","https://openalex.org/W1993873557","https://openalex.org/W2006664904","https://openalex.org/W2031871723","https://openalex.org/W2038391554","https://openalex.org/W2048563197","https://openalex.org/W2104810134","https://openalex.org/W2127153586","https://openalex.org/W2142222095","https://openalex.org/W2147561480","https://openalex.org/W2323205080","https://openalex.org/W2905223314","https://openalex.org/W2914381630","https://openalex.org/W2943292700","https://openalex.org/W2969027265","https://openalex.org/W3007679056","https://openalex.org/W3020160908","https://openalex.org/W3027111213","https://openalex.org/W3039087942","https://openalex.org/W3039900132","https://openalex.org/W3104624274","https://openalex.org/W4406965925"],"related_works":["https://openalex.org/W3007679056","https://openalex.org/W7221669870","https://openalex.org/W4414767438","https://openalex.org/W2563665409","https://openalex.org/W4231141045","https://openalex.org/W4410464458","https://openalex.org/W4401347846","https://openalex.org/W4221011461","https://openalex.org/W2554584625","https://openalex.org/W4235602721"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Fluorescence-guided":[1],"surgery":[2,96],"(FGS)":[3],"is":[4],"a":[5,22,55],"rapidly":[6],"developing":[7],"intraoperative":[8],"technology,":[9],"and":[10,48,74,94,115,125,157,179,183,192,198,208,220,222],"many":[11],"contrast":[12,173],"agents":[13,134,174,187],"are":[14,108,137,166,204],"currently":[15],"under":[16,135],"investigation.":[17],"We":[18],"sought":[19],"to":[20,40,76,88,139],"provide":[21],"review":[23],"of":[24,28,70],"the":[25,41,144,196],"current":[26],"state":[27],"FGS":[29,111,172,202],"clinical":[30,56,64],"trials":[31,65,169],"in":[32,143,181,195,214],"Otolaryngology,":[33],"emphasizing":[34],"its":[35],"oncologic":[36,113,215],"applications.":[37],"METHODS:":[38],"According":[39],"preferred":[42],"reporting":[43],"Items":[44],"for":[45,52,68,104,112,175],"systematic":[46],"reviews":[47],"meta-analyses":[49],"(PRISMA)":[50],"workflow":[51],"scoping":[53],"reviews,":[54],"trial":[57],"search":[58],"was":[59],"performed":[60],"across":[61],"multiple":[62],"international":[63],"registries,":[66],"searching":[67],"permutations":[69],"\"fluorescence,\"":[71],"\"tumor,\"":[72],"\"surgery,\"":[73],"\"nerve\"":[75],"identify":[77],"all":[78],"relevant":[79],"studies.":[80],"Studies":[81],"that":[82,141],"were":[83,97,102],"active,":[84],"enrolling,":[85],"or":[86],"soon":[87],"be":[89],"enrolling":[90],"patients":[91],"undergoing":[92],"head":[93],"neck":[95],"included.":[98],"RESULTS:":[99],"Nineteen":[100],"studies":[101,107,203],"eligible":[103],"inclusion.":[105],"Seventeen":[106],"focused":[109],"on":[110,189],"resection":[114],"lymph":[116,217],"node":[117,218],"detection.":[118],"One":[119],"study":[120],"assesses":[121],"peripheral":[122],"nerve":[123],"fluorescence,":[124],"one":[126],"evaluates":[127],"normal":[128],"parathyroid":[129],"function":[130],"after":[131],"thyroidectomy.":[132],"Contrast":[133],"development":[136],"conjugated":[138],"fluorophores":[140,191],"excite":[142],"800":[145],"nm":[146,150,154,159],"(indocyanine":[147],"green),":[148],"410":[149],"(5-aminolevulinic":[151],"acid),":[152],"700":[153],"(Cyanine":[155],"5.5),":[156],"525":[158],"ranges":[160,194],"(fluorescein":[161],"derivatives).":[162],"CONCLUSION:":[163],"Presently,":[164],"there":[165],"19":[167],"ongoing":[168],"investigating":[170],"novel":[171],"their":[176],"safety,":[177],"efficacy,":[178],"utility":[180],"Otolaryngology-Head":[182,207],"Neck":[184,209],"Surgery.":[185],"These":[186],"rely":[188],"unique":[190],"absorption":[193],"near-infrared":[197],"visible":[199],"light":[200],"spectra.":[201],"expanding":[205],"within":[206],"Surgery":[210],"with":[211],"profound":[212],"implications":[213],"surgery,":[216],"detection,":[219],"anatomic":[221],"functional":[223],"assessment.":[224],"Laryngoscope,":[225],"132:36-44,":[226],"2022.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}
