{"id":"https://openalex.org/W3205771427","doi":"https://doi.org/10.1007/s00415-021-10841-x","title":"Phoenix from the ashes: dramatic improvement in severe late-onset methylenetetrahydrofolate reductase (MTHFR) deficiency with a complete loss of vision","display_name":"Phoenix from the ashes: dramatic improvement in severe late-onset methylenetetrahydrofolate reductase (MTHFR) deficiency with a complete loss of vision","publication_year":2021,"publication_date":"2021-10-17","ids":{"openalex":"https://openalex.org/W3205771427","doi":"https://doi.org/10.1007/s00415-021-10841-x","mag":"3205771427","pmid":"https://pubmed.ncbi.nlm.nih.gov/34657180","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8940754"},"language":"en","primary_location":{"id":"doi:10.1007/s00415-021-10841-x","doi":"https://doi.org/10.1007/s00415-021-10841-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-021-10841-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-021-10841-x.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00415-021-10841-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083342263","display_name":"Anne\u2010Sophie Biesalski","orcid":"https://orcid.org/0000-0002-1288-884X","observed_orcids":["https://orcid.org/0000-0002-1288-884X"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anne-Sophie Biesalski","raw_affiliation_strings":["Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany. abiesalski@yahoo.de","Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1288-884X","affiliations":[{"raw_affiliation_string":"Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany. abiesalski@yahoo.de","institution_ids":["https://openalex.org/I4210138993"]},{"raw_affiliation_string":"Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055426639","display_name":"Sabine Hoffjan","orcid":"https://orcid.org/0009-0009-6280-1931","observed_orcids":["https://orcid.org/0009-0009-6280-1931"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Hoffjan","raw_affiliation_strings":["Center for Rare Diseases Ruhr (CeSER), Bochum, Germany","Department of Human Genetics, Ruhr-University, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rare Diseases Ruhr (CeSER), Bochum, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Human Genetics, Ruhr-University, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051943352","display_name":"Ruth Schneider","orcid":"https://orcid.org/0000-0002-0997-2725","observed_orcids":["https://orcid.org/0000-0002-0997-2725"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ruth Schneider","raw_affiliation_strings":["Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051768163","display_name":"Huu Phuc Nguyen","orcid":"https://orcid.org/0000-0001-6139-788X","observed_orcids":["https://orcid.org/0000-0001-6139-788X"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Huu Phuc Nguyen","raw_affiliation_strings":["Center for Rare Diseases Ruhr (CeSER), Bochum, Germany","Department of Human Genetics, Ruhr-University, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rare Diseases Ruhr (CeSER), Bochum, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Human Genetics, Ruhr-University, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053425472","display_name":"Gabriele Dekomien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabriele Dekomien","raw_affiliation_strings":["Center for Rare Diseases Ruhr (CeSER), Bochum, Germany","Department of Human Genetics, Ruhr-University, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rare Diseases Ruhr (CeSER), Bochum, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Human Genetics, Ruhr-University, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111506197","display_name":"Thomas L\u00fccke","orcid":"https://orcid.org/0000-0001-6875-6582","observed_orcids":["https://orcid.org/0000-0001-6875-6582"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas L\u00fccke","raw_affiliation_strings":["Center for Rare Diseases Ruhr (CeSER), Bochum, Germany","University Children's Hospital, St. Josef Hospital, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Rare Diseases Ruhr (CeSER), Bochum, Germany","institution_ids":[]},{"raw_affiliation_string":"University Children's Hospital, St. Josef Hospital, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005790498","display_name":"Christiane Schneider\u2010Gold","orcid":"https://orcid.org/0000-0002-9232-201X","observed_orcids":["https://orcid.org/0000-0002-9232-201X"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Schneider-Gold","raw_affiliation_strings":["Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072573822","display_name":"Britta Krieger","orcid":"https://orcid.org/0000-0002-6364-2743","observed_orcids":["https://orcid.org/0000-0002-6364-2743"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Britta Matusche","raw_affiliation_strings":["Institute of Neuroradiology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroradiology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062220148","display_name":"Ralf Gold","orcid":"https://orcid.org/0000-0002-7223-3052","observed_orcids":["https://orcid.org/0000-0002-7223-3052"]},"institutions":[{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Gold","raw_affiliation_strings":["Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087811944","display_name":"Ilya Ayzenberg","orcid":"https://orcid.org/0000-0002-6009-792X","observed_orcids":["https://orcid.org/0000-0002-6009-792X"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]},{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]}],"countries":["DE","RU"],"is_corresponding":false,"raw_author_name":"Ilya Ayzenberg","raw_affiliation_strings":["Department of Neurology, Sechenov First Moscow State Medical University, Moscow, Russia","Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Sechenov First Moscow State Medical University, Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]},{"raw_affiliation_string":"Department of Neurology, St. Josef Hospital, Gudrunstra\u00dfe 56, 44791, Bochum, Germany","institution_ids":["https://openalex.org/I4210138993"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083342263"],"corresponding_institution_ids":["https://openalex.org/I4210138993"],"apc_list":{"value":3760,"currency":"USD","value_usd":3760},"apc_paid":{"value":3760,"currency":"USD","value_usd":3760},"fwci":0.6364,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.60671199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"269","issue":"4","first_page":"2206","last_page":"2209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mthfr-deficiency","display_name":"MTHFR deficiency","score":0.8429999947547913},{"id":"https://openalex.org/keywords/visual-recovery","display_name":"visual recovery","score":0.5210000276565552},{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":0.6259999871253967},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cancer-specific-survival","display_name":"cancer-specific survival","score":0.9369999766349792},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7440000176429749},{"id":"https://openalex.org/keywords/geographic-variation-in-incidence","display_name":"geographic variation in incidence","score":0.6190000176429749},{"id":"https://openalex.org/keywords/sex-differences-in-incidence","display_name":"sex differences in incidence","score":0.6119999885559082},{"id":"https://openalex.org/keywords/german-states","display_name":"German states","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.8803894519805908},{"id":"https://openalex.org/C2779167034","wikidata":"https://www.wikidata.org/wiki/Q27685","display_name":"Phoenix","level":3,"score":0.6516218185424805},{"id":"https://openalex.org/C2779889316","wikidata":"https://www.wikidata.org/wiki/Q642836","display_name":"Neuroradiology","level":3,"score":0.6439839601516724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5926347970962524},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.47457364201545715},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.41627538204193115},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.41004645824432373},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14917930960655212},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10697588324546814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09738284349441528},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09671711921691895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0962333083152771},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09065589308738708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0896158218383789},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08561977744102478},{"id":"https://openalex.org/C158739034","wikidata":"https://www.wikidata.org/wiki/Q1907114","display_name":"Metropolitan area","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001766","descriptor_name":"Blindness","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009128","descriptor_name":"Muscle Spasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00415-021-10841-x","doi":"https://doi.org/10.1007/s00415-021-10841-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-021-10841-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-021-10841-x.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},{"id":"pmid:34657180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34657180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:8940754","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8940754/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol","raw_type":"Text"},{"id":"pmh:oai:hss-opus.ub.ruhr-uni-bochum.de:10634","doi":null,"is_oa":true,"landing_page_url":"http://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/10634","pdf_url":"https://hss-opus.ub.ruhr-uni-bochum.de/opus4/files/10634/BiesalskiAnneSophie17102021.pdf","source":{"id":"https://openalex.org/S4306400167","display_name":"Dokumentenrepositorium der RUB (Ruhr University Bochum)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I904495901","host_organization_name":"Ruhr University Bochum","host_organization_lineage":["https://openalex.org/I904495901"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:frl.publisso.de:frl:6450206","doi":null,"is_oa":true,"landing_page_url":"https://repository.publisso.de/resource/frl:6450206","pdf_url":null,"source":{"id":"https://openalex.org/S4306402606","display_name":"Informationszentrum Lebenswissenschaften (ZB MED)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of neurology, 269(4):2206-2209","raw_type":"Zeitschriftenartikel"}],"best_oa_location":{"id":"doi:10.1007/s00415-021-10841-x","doi":"https://doi.org/10.1007/s00415-021-10841-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-021-10841-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-021-10841-x.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0},{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.4000000059604645}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323715","display_name":"Ruhr-Universit\u00e4t Bochum","ror":"https://ror.org/04tsk2644"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205771427.pdf","grobid_xml":"https://content.openalex.org/works/W3205771427.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W813325591","https://openalex.org/W1544987908","https://openalex.org/W2009694699","https://openalex.org/W2015312591","https://openalex.org/W2026663403","https://openalex.org/W2059404228","https://openalex.org/W2065631587","https://openalex.org/W2069963586","https://openalex.org/W2076656138","https://openalex.org/W2299189976","https://openalex.org/W2804084104","https://openalex.org/W2889893194"],"related_works":["https://openalex.org/W3204726417","https://openalex.org/W7161114565","https://openalex.org/W7162694073","https://openalex.org/W7038643640","https://openalex.org/W4414120919","https://openalex.org/W2103994632","https://openalex.org/W4410804565","https://openalex.org/W3125929057","https://openalex.org/W3007276053","https://openalex.org/W4206858616"],"abstract_inverted_index":{"Purpose!#!To":[0],"calculate":[1],"the":[2,22,31,38,45,65,85,123,149,162,181,212,223,234],"overall":[3,23,112,175,202],"incidence":[4,66,114,144,236],"of":[5,73,205,240],"uveal":[6,100,206],"melanoma":[7,59,207],"in":[8,14,127,148,158,171,197,208,217,229,237],"Germany":[9,209],"and":[10,24,35,55,107,194,219],"to":[11,63],"compare":[12],"incidences":[13],"different":[15],"German":[16,40,46],"states.":[17],"In":[18],"addition,":[19],"we":[20],"computed":[21],"cancer-specific":[25,182],"survival":[26,93,176,183],"rates":[27,145],"nationwide.!##!Methods!#!Incidence":[28],"data":[29],"for":[30,48,58,79,92],"period":[32],"between":[33],"2009":[34],"2015,":[36],"covering":[37],"entire":[39],"population,":[41],"was":[42,82,90,117,125],"collected":[43],"through":[44],"Center":[47],"Cancer":[49],"Registry.":[50],"ICD-O-3":[51],"topography":[52],"codes":[53,57],"C69.3-C69.4":[54],"histology":[56],"subtypes":[60],"were":[61,77,146],"used":[62,91],"collect":[64],"data.":[67],"Confidence":[68],"Intervals":[69],"with":[70,99,105,161,233],"a":[71],"level":[72],"95%":[74],"(95%":[75,132,137,155,168],"CI)":[76],"calculated":[78,83],"rates.":[80],"Survival":[81],"using":[84],"Kaplan-Meier.":[86],"The":[87,111,173],"log-rank":[88],"test":[89],"comparisons.!##!Results!#!This":[94],"study":[95],"comprised":[96],"3654":[97],"patients":[98,195],"melanomas,":[101],"including":[102],"467":[103],"(12.8%)":[104],"iridial":[106],"ciliary":[108],"body":[109],"tumors.":[110],"age-standardized":[113],"rate":[115],"(ASIR)":[116],"6.41":[118],"person":[119],"per":[120,140,153,166],"million.":[121],"Generally,":[122],"ASIR":[124,204],"higher":[126,201],"males":[128,218],"than":[129],"females":[130],"(6.67":[131],"CI":[133,138,156,169],"6.37-6.98)":[134],"vs.":[135],"6.16":[136],"5.88-6.45":[139],"million).":[141],"Higher":[142],"crude":[143],"noted":[147,228],"northeastern":[150],"states":[151,164],"(12.5":[152],"million":[154,167],"10.5-14.7)":[157],"Mecklenburg-Vorpommern)":[159],"compared":[160],"southwestern":[163],"(2.1":[165],"1.7-2.6)":[170],"Hessen).":[172],"5-year":[174],"stood":[177,184],"at":[178,185],"47%,":[179],"while":[180],"84%.":[186],"Multivariate":[187],"analysis":[188],"showed":[189],"that":[190,211,220],"women,":[191],"younger":[192],"patients,":[193],"living":[196],"Berlin":[198],"achieved":[199],"significantly":[200],"survival.!##!Conclusion!#!Overall":[203],"indicates":[210],"disease":[213],"is":[214],"more":[215],"common":[216],"it":[221],"follows":[222],"same":[224],"geographical":[225],"distribution":[226],"previously":[227],"central":[230],"European":[231],"countries,":[232],"highest":[235],"northern":[238],"parts":[239],"Germany.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-10-25T00:00:00"}
