{"id":"https://openalex.org/W3205757121","doi":null,"title":"Pretreatment with Naltrindole exhibits robust cardioprotection in an isolated rat heart model of ischemia-reperfusion injury","display_name":"Pretreatment with Naltrindole exhibits robust cardioprotection in an isolated rat heart model of ischemia-reperfusion injury","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3205757121","mag":"3205757121"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.pcom.edu:research_day-1561","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.pcom.edu/research_day/research_week_2021/research2021/16","pdf_url":null,"source":{"id":"https://openalex.org/S4377196547","display_name":"Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I106460735","host_organization_name":"Philadelphia College of Osteopathic Medicine","host_organization_lineage":["https://openalex.org/I106460735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Day","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089880071","display_name":"Alexis Verwoert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexis Verwoert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Arjun Nair","orcid":"https://orcid.org/0000-0001-9270-3771","observed_orcids":["https://orcid.org/0000-0001-9270-3771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arjun Nair","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9270-3771","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052489006","display_name":"Michael Abayomi Bamimore","orcid":"https://orcid.org/0000-0003-2235-0282","observed_orcids":["https://orcid.org/0000-0003-2235-0282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Bamimore","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2235-0282","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111056201","display_name":"Tameka Dean","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tameka Dean","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018977197","display_name":"Sunit G. Singh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunit Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032718927","display_name":"Melinda Beale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melinda Beale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010799333","display_name":"Kayla Harrell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kayla Harrell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007019851","display_name":"Cameron Stinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cameron Stinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Qian Chen","orcid":"https://orcid.org/0000-0002-1487-5479","observed_orcids":["https://orcid.org/0000-0002-1487-5479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qian Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1487-5479","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007579766","display_name":"Robert Barsotti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Barsotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088089771","display_name":"Lindon Howard Young","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lindon Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24427897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naltrindole","display_name":"naltrindole","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.847000002861023},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9509999752044678},{"id":"https://openalex.org/keywords/opioid-antagonists","display_name":"opioid antagonists","score":0.7710000276565552},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.8550000190734863},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.8389999866485596},{"id":"https://openalex.org/keywords/preconditioning","display_name":"preconditioning","score":0.6539999842643738},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.8230000138282776},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.8109999895095825},{"id":"https://openalex.org/keywords/global-myocardial-ischemia","display_name":"global myocardial ischemia","score":0.6819999814033508},{"id":"https://openalex.org/keywords/myocardial-stunning","display_name":"myocardial stunning","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.9281429052352905},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6767194271087646},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6520622968673706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.481089323759079},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.45307493209838867},{"id":"https://openalex.org/C2910935648","wikidata":"https://www.wikidata.org/wiki/Q5172187","display_name":"Cardiac ischemia","level":3,"score":0.43010807037353516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3674427270889282},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34191393852233887}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.pcom.edu:research_day-1561","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.pcom.edu/research_day/research_week_2021/research2021/16","pdf_url":null,"source":{"id":"https://openalex.org/S4377196547","display_name":"Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I106460735","host_organization_name":"Philadelphia College of Osteopathic Medicine","host_organization_lineage":["https://openalex.org/I106460735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Day","raw_type":"text"},{"id":"mag:3205757121","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.pcom.edu/cgi/viewcontent.cgi?article=1561&context=research_day","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3172860418","https://openalex.org/W4225381390","https://openalex.org/W3216786326","https://openalex.org/W2892721195","https://openalex.org/W6995938324","https://openalex.org/W4225372413","https://openalex.org/W4387615343","https://openalex.org/W4378649420","https://openalex.org/W7038536335","https://openalex.org/W2043525096"],"abstract_inverted_index":{"Previously,":[0],"a":[1,29,180,185,279],"novel":[2],"three-amino":[3],"acid":[4],"peptide":[5],"(tripeptide)":[6],"that":[7,367],"is":[8,421],"structurally":[9],"similar":[10,332],"to":[11,77,94,117,136,163,169,233,264,300,333,346,354,359,380,409],"other":[12,103,431],"amino":[13],"acid-based":[14],"delta":[15,425],"and":[16,35,64,102,124,171,215,278,292,311,324,350,375],"kappa-opioid":[17,67],"receptor":[18,23,68,74,426],"agonists":[19],"(the":[20],"predominant":[21],"opioid":[22,62,104],"subtypes":[24],"in":[25,32,43,109,179,275,395,398],"heart":[26,378,400],"tissue)":[27],"demonstrated":[28,294],"significant":[30,296],"reduction":[31],"infarct":[33,224,281,352],"size":[34,282,318,353],"improved":[36,340],"cardiac":[37],"function":[38,379],"when":[39],"administered":[40],"during":[41,172],"preconditioning":[42],"isolated":[44,128],"rat":[45],"hearts":[46,165,209,249,330],"using":[47,197,242],"the":[48,79,86,90,98,110,114,119,164,173,204,226,390,411],"Langendorf":[49,181],"model.":[50,112,402],"The":[51,364],"cardioprotective":[52,87,297,391],"effects":[53,80,88,99,120,298,392],"of":[54,81,89,100,121,177,188,206,228,258,269,283,306,393,413,415],"tripeptide":[55,95],"were":[56,92,106,134,161,195,210,240,331],"blocked":[57],"by":[58],"naloxone":[59],"(NX,":[60],"broad-spectrum":[61],"antagonist)":[63,75],"nor-binaltorphine":[65],"(BNI,":[66],"antagonist),":[69],"whereas":[70],"naltrindole":[71],"(NTI,":[72],"delta-opioid":[73],"seemed":[76],"augment":[78],"tripeptide.":[82],"To":[83,222],"determine":[84,223,410],"whether":[85,419],"combination":[91],"due":[93],"or":[96,155,428],"NTI,":[97,122],"NTI":[101,151,338,370,394,416],"antagonists":[105],"evaluated":[107,241],"individually":[108],"same":[111],"Therefore,":[113],"goal":[115],"was":[116,231],"evaluate":[118,389],"BNI,":[123],"NX":[125,143,291,320],"independently.":[126],"Hearts":[127],"from":[129],"male":[130],"Sprague-Dawley":[131],"rats":[132],"(~300g)":[133],"subjected":[135],"global":[137],"ischemia":[138,170],"(I,":[139],"30min)/reperfusion":[140],"(R,":[141],"50min).":[142],"(10":[144],"\u03bcM,":[145,149,153],"n=6),":[146],"BNI":[147,293,325],"(5":[148,152],"n=7),":[150],"n=8),":[154],"Krebs\u2019":[156],"buffer":[157],"control":[158,301,334],"(control":[159],"n=10)":[160],"given":[162],"5":[166,175,261],"min":[167,176,289],"prior":[168],"first":[174],"reperfusion":[178,207],"model,":[182],"perfused":[183],"at":[184,236,287],"constant":[186],"pressure":[187,200,256],"80mmHg.":[189],"Left":[190],"ventricular":[191],"(LV)":[192],"functional":[193],"indices":[194],"measured":[196],"an":[198,251,265,396],"indwelling":[199],"transducer-tipped":[201],"catheter.":[202],"At":[203],"end":[205],"(50min),":[208],"frozen,":[211],"sectioned":[212],"(2":[213],"mm),":[214],"stained":[216],"with":[217,302,369],"1%":[218],"triphenyltetrazolium":[219],"chloride":[220],"(TTC).":[221],"size,":[225],"weight":[227],"infarcted":[229],"tissue":[230,235],"compared":[232,263,299,358],"total":[234],"risk.":[237],"All":[238],"data":[239],"ANOVA":[243],"Student-Newman-Keuls":[244],"post-hoc":[245],"analysis.":[246],"Control":[247],"(untreated)":[248],"showed":[250],"elevated":[252],"final":[253,303,341],"LV":[254],"end-diastolic":[255],"(LVEDP)":[257],"60":[259],"\u00b1":[260,271,285,308,313,322,327,344,356],"mmHg":[262,273,310],"average":[266],"initial":[267],"baseline":[268,348],"8":[270,309],"1":[272],"(similar":[274],"all":[276,360],"groups)":[277],"mean":[280],"36":[284],"3%":[286],"50":[288],"post-reperfusion.":[290],"no":[295],"LVEDP":[304,342],"measures":[305],"64":[307],"61":[312],"2":[314],"mmHg,":[315],"respectively.":[316],"Infarct":[317],"for":[319],"(35":[321],"5%)":[323,328],"(36":[326],"treated":[329],"hearts.":[335],"By":[336],"contrast,":[337],"significantly":[339],"(17":[343],"3mmHg)":[345],"near":[347,381],"values":[349],"reduced":[351],"7":[355],"2%":[357],"groups":[361],"(p<":[362],"0.01).":[363],"results":[365],"indicate":[366],"pretreatment":[368],"can":[371],"prevent":[372],"I/R":[373,401],"injury":[374],"restore":[376],"post-reperfused":[377],"pre-ischemic":[382],"levels.":[383],"In":[384,403],"future":[385],"studies,":[386,405],"we":[387,406],"will":[388,407],"acute":[397],"vivo":[399],"separate":[404],"attempt":[408],"mechanism":[412],"action":[414],"preconditioning,":[417],"specifically":[418],"cardioprotection":[420],"indeed":[422],"mediated":[423],"via":[424,429],"antagonism":[427],"some":[430],"mechanism.":[432]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2021-10-25T00:00:00"}
