{"id":"https://openalex.org/W3205726985","doi":"https://doi.org/10.1016/j.joca.2021.09.014","title":"Post-traumatic osteoarthritis progression is diminished by early mechanical unloading and anti-inflammatory treatment in mice","display_name":"Post-traumatic osteoarthritis progression is diminished by early mechanical unloading and anti-inflammatory treatment in mice","publication_year":2021,"publication_date":"2021-10-14","ids":{"openalex":"https://openalex.org/W3205726985","doi":"https://doi.org/10.1016/j.joca.2021.09.014","mag":"3205726985","pmid":"https://pubmed.ncbi.nlm.nih.gov/34653605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8678362"},"language":"en","primary_location":{"id":"doi:10.1016/j.joca.2021.09.014","doi":"https://doi.org/10.1016/j.joca.2021.09.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2021.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.joca.2021.09.014","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023193279","display_name":"Allison W. Hsia","orcid":"https://orcid.org/0000-0002-4127-9680","observed_orcids":["https://orcid.org/0000-0002-4127-9680"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A.W. Hsia","raw_affiliation_strings":["University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: alwhsia@ucdavis.edu","University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA"],"raw_orcid":"https://orcid.org/0000-0002-4127-9680","affiliations":[{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: alwhsia@ucdavis.edu","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068963266","display_name":"Elias H. Jbeily","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E.H. Jbeily","raw_affiliation_strings":["University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: ehjbeily@ucdavis.edu","University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: ehjbeily@ucdavis.edu","institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017973943","display_name":"Melanie E. Mendez","orcid":"https://orcid.org/0000-0002-6233-5610","observed_orcids":["https://orcid.org/0000-0002-6233-5610"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M.E. Mendez","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Physical and Life Sciences Directorate, 7000 East Avenue, L-452, Livermore, CA 94550, USA. Electronic address: mendez20@llnl.gov","Lawrence Livermore National Laboratory, Physical and Life Sciences Directorate, 7000 East Avenue, L-452, Livermore, CA 94550, USA"],"raw_orcid":"https://orcid.org/0000-0002-6233-5610","affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Sciences Directorate, 7000 East Avenue, L-452, Livermore, CA 94550, USA. Electronic address: mendez20@llnl.gov","institution_ids":["https://openalex.org/I1282311441"]},{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Sciences Directorate, 7000 East Avenue, L-452, Livermore, CA 94550, USA","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000055182","display_name":"Hailey C. Cunningham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H.C. Cunningham","raw_affiliation_strings":["University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: hcunningham@ucdavis.edu","University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: hcunningham@ucdavis.edu","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038571095","display_name":"Kristin K. Biris","orcid":"https://orcid.org/0000-0001-6785-851X","observed_orcids":["https://orcid.org/0000-0001-6785-851X"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K.K. Biris","raw_affiliation_strings":["University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: kkbiris@ucdavis.edu","University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: kkbiris@ucdavis.edu","institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064350034","display_name":"Heejung Bang","orcid":"https://orcid.org/0000-0002-5755-9951","observed_orcids":["https://orcid.org/0000-0002-5755-9951"]},"institutions":[{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. Bang","raw_affiliation_strings":["University of California Davis Health, Department of Public Health Sciences, Sciences 1C, Suite 145, Davis, CA 95616, USA. Electronic address: hbang@ucdavis.edu","University of California Davis Health, Department of Public Health Sciences, Sciences 1C, Suite 145, Davis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0002-5755-9951","affiliations":[{"raw_affiliation_string":"University of California Davis Health, Department of Public Health Sciences, Sciences 1C, Suite 145, Davis, CA 95616, USA. Electronic address: hbang@ucdavis.edu","institution_ids":["https://openalex.org/I4210160856","https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California Davis Health, Department of Public Health Sciences, Sciences 1C, Suite 145, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022082036","display_name":"Cassandra Alda Lee","orcid":"https://orcid.org/0000-0003-2610-9584","observed_orcids":["https://orcid.org/0000-0003-2610-9584"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C.A. Lee","raw_affiliation_strings":["University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: casslee@ucdavis.edu","University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA"],"raw_orcid":"https://orcid.org/0000-0003-2610-9584","affiliations":[{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: casslee@ucdavis.edu","institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012395081","display_name":"Gabriela G. Loots","orcid":"https://orcid.org/0000-0001-9546-5561","observed_orcids":["https://orcid.org/0000-0001-9546-5561"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G.G. Loots","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Physical and Life Sciences Directorate, 7000 East Avenue, L-452, Livermore, CA 94550, USA. Electronic address: loots1@llnl.gov","Lawrence Livermore National Laboratory, Physical and Life Sciences Directorate, 7000 East Avenue, L-452, Livermore, CA 94550, USA"],"raw_orcid":"https://orcid.org/0000-0001-9546-5561","affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Sciences Directorate, 7000 East Avenue, L-452, Livermore, CA 94550, USA. Electronic address: loots1@llnl.gov","institution_ids":["https://openalex.org/I1282311441"]},{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Sciences Directorate, 7000 East Avenue, L-452, Livermore, CA 94550, USA","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109035472","display_name":"Bernd Christiansen","orcid":"https://orcid.org/0000-0002-0105-6458","observed_orcids":["https://orcid.org/0000-0002-0105-6458"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B.A. Christiansen","raw_affiliation_strings":["University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: bchristiansen@ucdavis.edu","University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA"],"raw_orcid":"https://orcid.org/0000-0002-0105-6458","affiliations":[{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA. Electronic address: bchristiansen@ucdavis.edu","institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California Davis Health, Department of Orthopaedic Surgery, Lawrence J. Ellison Musculoskeletal Research Center, 4635 2nd Ave, Suite 2000, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000055182","https://openalex.org/A5012395081","https://openalex.org/A5017973943","https://openalex.org/A5022082036","https://openalex.org/A5023193279","https://openalex.org/A5038571095","https://openalex.org/A5064350034","https://openalex.org/A5068963266","https://openalex.org/A5109035472"],"corresponding_institution_ids":["https://openalex.org/I1282311441","https://openalex.org/I2803209242","https://openalex.org/I4210160527","https://openalex.org/I4210160856","https://openalex.org/I84218800"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":null,"fwci":4.519,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.95881318,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"29","issue":"12","first_page":"1709","last_page":"1719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-traumatic-osteoarthritis","display_name":"post-traumatic osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mechanical-unloading","display_name":"mechanical unloading","score":0.8799999952316284},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anterior-cruciate-ligament-tear","display_name":"anterior cruciate ligament rupture","score":0.703000009059906},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.968999981880188},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.734000027179718},{"id":"https://openalex.org/keywords/osteophytes","display_name":"osteophytes","score":0.859000027179718},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.8149999976158142},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.9380000233650208},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8201563954353333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6660487055778503},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4588603973388672},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.4273245930671692},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2922365665435791},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17899805307388306},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.06840962171554565}],"mesh":[{"descriptor_ui":"D000068579","descriptor_name":"Celecoxib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068579","descriptor_name":"Celecoxib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068579","descriptor_name":"Celecoxib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068579","descriptor_name":"Celecoxib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000070598","descriptor_name":"Anterior Cruciate Ligament Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000070598","descriptor_name":"Anterior Cruciate Ligament Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000070598","descriptor_name":"Anterior Cruciate Ligament Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000070598","descriptor_name":"Anterior Cruciate Ligament Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013585","descriptor_name":"Synovitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013585","descriptor_name":"Synovitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013585","descriptor_name":"Synovitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013585","descriptor_name":"Synovitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019417","descriptor_name":"Hindlimb Suspension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019417","descriptor_name":"Hindlimb Suspension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019417","descriptor_name":"Hindlimb Suspension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019417","descriptor_name":"Hindlimb Suspension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054850","descriptor_name":"Osteophyte","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D054850","descriptor_name":"Osteophyte","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D054850","descriptor_name":"Osteophyte","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D054850","descriptor_name":"Osteophyte","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D055114","descriptor_name":"X-Ray Microtomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055114","descriptor_name":"X-Ray Microtomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055114","descriptor_name":"X-Ray Microtomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055114","descriptor_name":"X-Ray Microtomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.joca.2021.09.014","doi":"https://doi.org/10.1016/j.joca.2021.09.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2021.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},{"id":"pmid:34653605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34653605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and cartilage","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8678362","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8678362","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Osteoarthritis Cartilage","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt5t8105t4","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5t8105t4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Osteoarthritis and Cartilage, vol 29, iss 12","raw_type":"article"},{"id":"pmh:oai:osti.gov:1862584","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1862584","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1901458","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1901458","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.joca.2021.09.014","doi":"https://doi.org/10.1016/j.joca.2021.09.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2021.09.014","pdf_url":null,"source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1356433355","display_name":null,"funder_award_id":"DE\u2010AC5207NA27344","funder_id":"https://openalex.org/F4320338286","funder_display_name":"Lawrence Livermore National Laboratory"},{"id":"https://openalex.org/G4395775554","display_name":"Modification of Post-Traumatic Osteoarthritis Progression with Joint Unloading","funder_award_id":"R01AR075013","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320338286","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W40893476","https://openalex.org/W975543001","https://openalex.org/W1704299267","https://openalex.org/W1963541053","https://openalex.org/W1969564679","https://openalex.org/W1971136428","https://openalex.org/W1976846310","https://openalex.org/W1980248641","https://openalex.org/W1980550098","https://openalex.org/W1981828273","https://openalex.org/W1982167517","https://openalex.org/W1991493131","https://openalex.org/W1995234747","https://openalex.org/W2005240000","https://openalex.org/W2014105703","https://openalex.org/W2018647053","https://openalex.org/W2020032391","https://openalex.org/W2020423148","https://openalex.org/W2032782859","https://openalex.org/W2037523414","https://openalex.org/W2039829008","https://openalex.org/W2040655707","https://openalex.org/W2052351422","https://openalex.org/W2061179354","https://openalex.org/W2063391683","https://openalex.org/W2065742630","https://openalex.org/W2066749771","https://openalex.org/W2070470853","https://openalex.org/W2090179549","https://openalex.org/W2091921078","https://openalex.org/W2092746954","https://openalex.org/W2093670431","https://openalex.org/W2097178712","https://openalex.org/W2098095516","https://openalex.org/W2099842997","https://openalex.org/W2118963985","https://openalex.org/W2119618747","https://openalex.org/W2127174807","https://openalex.org/W2128995450","https://openalex.org/W2133915381","https://openalex.org/W2135543843","https://openalex.org/W2141579725","https://openalex.org/W2143461769","https://openalex.org/W2147585077","https://openalex.org/W2149935454","https://openalex.org/W2156027229","https://openalex.org/W2159867860","https://openalex.org/W2162299102","https://openalex.org/W2163144555","https://openalex.org/W2163263313","https://openalex.org/W2167037356","https://openalex.org/W2182431402","https://openalex.org/W2266314028","https://openalex.org/W2323018886","https://openalex.org/W2425593468","https://openalex.org/W2429523536","https://openalex.org/W2470079485","https://openalex.org/W2592858623","https://openalex.org/W2767017962","https://openalex.org/W2808020398","https://openalex.org/W2948889296","https://openalex.org/W2972428846","https://openalex.org/W2988816971","https://openalex.org/W3013200586","https://openalex.org/W4232900352"],"related_works":["https://openalex.org/W7125701307","https://openalex.org/W4206905772","https://openalex.org/W3174691691","https://openalex.org/W4410660567","https://openalex.org/W2780058781","https://openalex.org/W4396530292","https://openalex.org/W4200382866","https://openalex.org/W4394928145","https://openalex.org/W2619445376","https://openalex.org/W7142992893"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2021-10-25T00:00:00"}