{"id":"https://openalex.org/W3205659697","doi":"https://doi.org/10.1590/1519-6984.251219","title":"Eugenol and its liposome-based nano carrier reduce anxiety by inhibiting glyoxylase-1 expression in mice","display_name":"Eugenol and its liposome-based nano carrier reduce anxiety by inhibiting glyoxylase-1 expression in mice","publication_year":2021,"publication_date":"2021-10-19","ids":{"openalex":"https://openalex.org/W3205659697","doi":"https://doi.org/10.1590/1519-6984.251219","mag":"3205659697","pmid":"https://pubmed.ncbi.nlm.nih.gov/34669914"},"language":"en","primary_location":{"id":"doi:10.1590/1519-6984.251219","doi":"https://doi.org/10.1590/1519-6984.251219","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1519-6984.251219","pdf_url":"https://www.scielo.br/j/bjb/a/W6TP6vgw8czXTkYjSrzczYx/?lang=en&format=pdf","source":{"id":"https://openalex.org/S90590500","display_name":"Brazilian Journal of Biology","issn_l":"1519-6984","issn":["1519-6984","1678-4375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310311986","host_organization_name":"Instituto Internacional de Ecologia (Brazil)","host_organization_lineage":["https://openalex.org/P4310311986"],"host_organization_lineage_names":["Instituto Internacional de Ecologia (Brazil)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.scielo.br/j/bjb/a/W6TP6vgw8czXTkYjSrzczYx/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049172785","display_name":"Fahad Jibran Siyal","orcid":"https://orcid.org/0000-0003-0318-6659","observed_orcids":["https://orcid.org/0000-0003-0318-6659"]},"institutions":[{"id":"https://openalex.org/I3131820683","display_name":"Shaheed Mohtarma Benazir Bhutto Medical University","ror":"https://ror.org/03nw0tx25","country_code":"PK","type":"education","lineage":["https://openalex.org/I3131820683"]},{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"F. J. Siyal","raw_affiliation_strings":["Ziauddin University,  Pakistan; Shaheed Mohtarma Benazir Bhutto Medical University,  Pakistan","Ziauddin University, Faculty of Pharmacy, Department of Pharmacology, Karachi, PakistanShaheed Mohtarma Benazir Bhutto Medical University, Institute of Pharmacy, Larkana, Pakistan"],"raw_orcid":"https://orcid.org/0000-0003-0318-6659","affiliations":[{"raw_affiliation_string":"Ziauddin University,  Pakistan; Shaheed Mohtarma Benazir Bhutto Medical University,  Pakistan","institution_ids":["https://openalex.org/I3131820683","https://openalex.org/I923305593"]},{"raw_affiliation_string":"Ziauddin University, Faculty of Pharmacy, Department of Pharmacology, Karachi, PakistanShaheed Mohtarma Benazir Bhutto Medical University, Institute of Pharmacy, Larkana, Pakistan","institution_ids":["https://openalex.org/I3131820683","https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102767053","display_name":"Rehan Ahmed Siddiqui","orcid":"https://orcid.org/0000-0003-0099-3156","observed_orcids":["https://orcid.org/0000-0003-0099-3156"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"R. A. Siddiqui","raw_affiliation_strings":["Ziauddin University,  Pakistan","Ziauddin University, Department of Research, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ziauddin University,  Pakistan","institution_ids":["https://openalex.org/I923305593"]},{"raw_affiliation_string":"Ziauddin University, Department of Research, Karachi, Pakistan","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080421336","display_name":"Z. Memon","orcid":"https://orcid.org/0009-0005-1878-2383","observed_orcids":["https://orcid.org/0009-0005-1878-2383"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Z. Memon","raw_affiliation_strings":["Ziauddin University,  Pakistan","Ziauddin University, Ziauddin Medical College, Department of Pharmacology, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ziauddin University,  Pakistan","institution_ids":["https://openalex.org/I923305593"]},{"raw_affiliation_string":"Ziauddin University, Ziauddin Medical College, Department of Pharmacology, Karachi, Pakistan","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059345136","display_name":"Zara Aslam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Z. Aslam","raw_affiliation_strings":["University of Karachi,  Pakistan","University of Karachi, International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Karachi,  Pakistan","institution_ids":["https://openalex.org/I193670377"]},{"raw_affiliation_string":"University of Karachi, International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, Karachi, Pakistan","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064465130","display_name":"Uzair Nisar","orcid":"https://orcid.org/0000-0001-5956-0828","observed_orcids":["https://orcid.org/0000-0001-5956-0828"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"U. Nisar","raw_affiliation_strings":["Ziauddin University,  Pakistan","Ziauddin University, Faculty of Pharmacy, Department of Pharmacology, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ziauddin University,  Pakistan","institution_ids":["https://openalex.org/I923305593"]},{"raw_affiliation_string":"Ziauddin University, Faculty of Pharmacy, Department of Pharmacology, Karachi, Pakistan","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031431793","display_name":"Rehan Imad","orcid":"https://orcid.org/0000-0003-0560-0171","observed_orcids":["https://orcid.org/0000-0003-0560-0171"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"R. Imad","raw_affiliation_strings":["Ziauddin University,  Pakistan","Ziauddin University, Department of Research, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ziauddin University,  Pakistan","institution_ids":["https://openalex.org/I923305593"]},{"raw_affiliation_string":"Ziauddin University, Department of Research, Karachi, Pakistan","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091775788","display_name":"Muhammad Raza Shah","orcid":"https://orcid.org/0000-0003-4978-3627","observed_orcids":["https://orcid.org/0000-0003-4978-3627"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"M. R. Shah","raw_affiliation_strings":["University of Karachi,  Pakistan","University of Karachi, International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Karachi,  Pakistan","institution_ids":["https://openalex.org/I193670377"]},{"raw_affiliation_string":"University of Karachi, International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, Karachi, Pakistan","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":680,"currency":"USD","value_usd":680},"apc_paid":{"value":680,"currency":"USD","value_usd":680},"fwci":0.8469,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71131197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"83","issue":null,"first_page":"e251219","last_page":"e251219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eugenol","display_name":"eugenol","score":1.0},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.8460000157356262},{"id":"https://openalex.org/keywords/glyoxalase-1","display_name":"glyoxalase I","score":0.9319999814033508},{"id":"https://openalex.org/keywords/methylglyoxal","display_name":"methylglyoxal","score":0.9670000076293945},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.7609999775886536},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.9449999928474426},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.49399998784065247},{"id":"https://openalex.org/keywords/anterior-cingulate-cortex","display_name":"anterior cingulate cortex","score":0.6880000233650208},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2778592357","wikidata":"https://www.wikidata.org/wiki/Q903881","display_name":"Methylglyoxal","level":3,"score":0.6853457689285278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.586144208908081},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.524401068687439},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.48585912585258484},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.4368038773536682},{"id":"https://openalex.org/C205044023","wikidata":"https://www.wikidata.org/wiki/Q4778117","display_name":"Anxiogenic","level":4,"score":0.4340442419052124},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34647393226623535},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.344083696603775},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.33562660217285156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3255789875984192},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1611369550228119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14603620767593384},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007791","descriptor_name":"Lactoylglutathione Lyase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1590/1519-6984.251219","doi":"https://doi.org/10.1590/1519-6984.251219","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1519-6984.251219","pdf_url":"https://www.scielo.br/j/bjb/a/W6TP6vgw8czXTkYjSrzczYx/?lang=en&format=pdf","source":{"id":"https://openalex.org/S90590500","display_name":"Brazilian Journal of Biology","issn_l":"1519-6984","issn":["1519-6984","1678-4375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310311986","host_organization_name":"Instituto Internacional de Ecologia (Brazil)","host_organization_lineage":["https://openalex.org/P4310311986"],"host_organization_lineage_names":["Instituto Internacional de Ecologia (Brazil)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Biology","raw_type":"journal-article"},{"id":"pmid:34669914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34669914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian journal of biology = Revista brasleira de biologia","raw_type":"Journal Article"},{"id":"pmh:oai:scielo:S1519-69842023000100290","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&amp;pid=S1519-69842023000100290","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Biology v.83 2023","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1d513aaf7238480f86125a311f70de56","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1d513aaf7238480f86125a311f70de56","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brazilian Journal of Biology, Vol 83 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/1519-6984.251219","doi":"https://doi.org/10.1590/1519-6984.251219","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1519-6984.251219","pdf_url":"https://www.scielo.br/j/bjb/a/W6TP6vgw8czXTkYjSrzczYx/?lang=en&format=pdf","source":{"id":"https://openalex.org/S90590500","display_name":"Brazilian Journal of Biology","issn_l":"1519-6984","issn":["1519-6984","1678-4375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310311986","host_organization_name":"Instituto Internacional de Ecologia (Brazil)","host_organization_lineage":["https://openalex.org/P4310311986"],"host_organization_lineage_names":["Instituto Internacional de Ecologia (Brazil)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205659697.pdf","grobid_xml":"https://content.openalex.org/works/W3205659697.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W54444533","https://openalex.org/W1547865271","https://openalex.org/W1948519169","https://openalex.org/W1961057880","https://openalex.org/W1973736177","https://openalex.org/W1977756664","https://openalex.org/W1981108953","https://openalex.org/W1987472752","https://openalex.org/W1994532676","https://openalex.org/W1997669849","https://openalex.org/W2004526768","https://openalex.org/W2006199723","https://openalex.org/W2007696393","https://openalex.org/W2010526028","https://openalex.org/W2019875250","https://openalex.org/W2034658058","https://openalex.org/W2034683060","https://openalex.org/W2049400932","https://openalex.org/W2050632824","https://openalex.org/W2050984832","https://openalex.org/W2059832613","https://openalex.org/W2080529335","https://openalex.org/W2088099653","https://openalex.org/W2135141310","https://openalex.org/W2522056295","https://openalex.org/W2558030236","https://openalex.org/W2559616332","https://openalex.org/W2803839085","https://openalex.org/W4235147263"],"related_works":["https://openalex.org/W3148056055","https://openalex.org/W4391389865","https://openalex.org/W2039322367","https://openalex.org/W2096066003","https://openalex.org/W2015092638","https://openalex.org/W2202213368","https://openalex.org/W2593461146","https://openalex.org/W2076664305","https://openalex.org/W2024313853","https://openalex.org/W2067182175"],"abstract_inverted_index":{"The":[0,105,139,168],"most":[1],"common":[2],"form":[3],"of":[4,24,55,113,116,142],"psycho-social":[5],"dysfunction":[6],"is":[7,38,49,65,225],"anxiety":[8,69,77,103,181],"with":[9,21,68,109,197,216],"depression":[10],"being":[11],"related":[12,67],"closely":[13],"without":[14],"any":[15],"age":[16],"bar.":[17],"They":[18],"are":[19],"present":[20,106],"combined":[22],"state":[23],"sadness,":[25],"confusion,":[26],"stress,":[27],"fear":[28],"etc.":[29],"Glyoxalase":[30],"system":[31],"contains":[32],"enzyme":[33],"named":[34],"glyoxalase":[35],"1":[36],"(GLO1).It":[37],"a":[39,204],"metabolic":[40],"pathway":[41],"which":[42],"detoxifies":[43],"alpha-oxo-aldehydes,":[44],"particularly":[45],"methylglyoxal":[46],"(MG).":[47],"Methylglyoxal":[48],"mainly":[50],"made":[51],"by":[52,79,146,158,237],"the":[53,56,87,110,151,185,189,194,209,221,228],"breakdown":[54],"glycolytic":[57],"intermediates,":[58],"glyceraldehyde-3-phosphates":[59],"and":[60,93,163,170,199,230],"dihydroxyacetone":[61],"phosphate.":[62],"Glyoxylase-1":[63],"expression":[64,85,101,141,154,241],"also":[66,156],"behavior.":[70,104],"A":[71,121],"casual":[72],"role":[73],"or":[74],"GLO-1":[75,99,143,152,239],"in":[76,86,160,178,193,203,213,242],"behavior":[78],"using":[80],"viral":[81],"vectors":[82],"for":[83],"over":[84,100],"anterior":[88],"cingulate":[89],"cortex":[90],"was":[91,95,125,144,155,166],"found":[92,96,174],"it":[94],"that":[97,227],"local":[98],"increased":[102,177],"study":[107,124],"deals":[108],"molecular":[111],"mechanism":[112],"protective":[114],"activity":[115,236],"eugenol":[117,198,229],"against":[118],"anxiolytic":[119,235],"disorder.":[120],"pre-clinical":[122],"animal":[123],"performed":[126],"on":[127],"42":[128],"BALB/c":[129],"mice.":[130,243],"Animals":[131],"were":[132,173,191,211],"given":[133,180],"stress":[134],"through":[135],"conventional":[136],"restrain":[137],"model.":[138],"mRNA":[140,169],"analyzed":[145],"real":[147],"time":[148],"RT-PCR.":[149],"Moreover,":[150],"protein":[153,171,240],"examined":[157],"immunohistochemistry":[159],"whole":[161],"brain":[162],"mean":[164],"density":[165],"calculated.":[167],"expressions":[172,190],"to":[175,184,220],"be":[176],"animals":[179,195,214],"as":[182,218],"compared":[183,219],"normal":[186],"control.":[187],"Whereas,":[188],"decreased":[192],"treated":[196,215],"its":[200,231],"liposome-based":[201,232],"nanocarriers":[202,217,233],"dose":[205],"dependent":[206],"manner.":[207],"However,":[208],"results":[210],"better":[212],"compound":[222],"alone.":[223],"It":[224],"concluded":[226],"exert":[234],"down-regulating":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-25T00:00:00"}
