{"id":"https://openalex.org/W3205610326","doi":"https://doi.org/10.1093/jas/skab235.873","title":"PSIX-21 Assessment of barrier function and cell junctional expression on differentiated intestinal porcine epithelial cells in response to Salmonella LPS challenge and treatment with Yeast cell wall products","display_name":"PSIX-21 Assessment of barrier function and cell junctional expression on differentiated intestinal porcine epithelial cells in response to Salmonella LPS challenge and treatment with Yeast cell wall products","publication_year":2021,"publication_date":"2021-10-08","ids":{"openalex":"https://openalex.org/W3205610326","doi":"https://doi.org/10.1093/jas/skab235.873","mag":"3205610326","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8506331"},"language":"en","primary_location":{"id":"doi:10.1093/jas/skab235.873","doi":"https://doi.org/10.1093/jas/skab235.873","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jas/skab235.873","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8506331/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046120876","display_name":"Niall Browne","orcid":"https://orcid.org/0000-0001-8016-028X","observed_orcids":["https://orcid.org/0000-0001-8016-028X"]},"institutions":[{"id":"https://openalex.org/I2970213756","display_name":"Alltech (United States)","ror":"https://ror.org/01gh6ja41","country_code":"US","type":"company","lineage":["https://openalex.org/I2970213756"]},{"id":"https://openalex.org/I4210128269","display_name":"Alltech (Ireland)","ror":"https://ror.org/03jnm8t41","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210128269"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"Niall Browne","raw_affiliation_strings":["Alltech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alltech","institution_ids":["https://openalex.org/I2970213756","https://openalex.org/I4210128269"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel Daly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2970213756","display_name":"Alltech (United States)","ror":"https://ror.org/01gh6ja41","country_code":"US","type":"company","lineage":["https://openalex.org/I2970213756"]},{"id":"https://openalex.org/I4210128269","display_name":"Alltech (Ireland)","ror":"https://ror.org/03jnm8t41","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210128269"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"Daniel Daly","raw_affiliation_strings":["Alltech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alltech","institution_ids":["https://openalex.org/I2970213756","https://openalex.org/I4210128269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064895872","display_name":"Karina A. Horgan","orcid":"https://orcid.org/0000-0002-2251-8391","observed_orcids":["https://orcid.org/0000-0002-2251-8391"]},"institutions":[{"id":"https://openalex.org/I2970213756","display_name":"Alltech (United States)","ror":"https://ror.org/01gh6ja41","country_code":"US","type":"company","lineage":["https://openalex.org/I2970213756"]},{"id":"https://openalex.org/I4210128269","display_name":"Alltech (Ireland)","ror":"https://ror.org/03jnm8t41","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210128269"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"Karina Horgan","raw_affiliation_strings":["Alltech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alltech","institution_ids":["https://openalex.org/I2970213756","https://openalex.org/I4210128269"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"99","issue":"Supplement_3","first_page":"496","last_page":"496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-barrier-function","display_name":"intestinal barrier function","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ipec-1-cells","display_name":"IPEC-1 cells","score":0.7720000147819519},{"id":"https://openalex.org/keywords/tight-junction-gene-expression","display_name":"tight junction gene expression","score":0.8769999742507935},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tjp1","display_name":"TJP1","score":0.925000011920929},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.765999972820282},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.4880000054836273},{"id":"https://openalex.org/keywords/piglets","display_name":"piglets","score":0.5220000147819519},{"id":"https://openalex.org/keywords/leaky-gut","display_name":"leaky gut","score":0.5619999766349792},{"id":"https://openalex.org/keywords/bacterial-infection-prevention","display_name":"bacterial infection prevention","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.8813806772232056},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7440029382705688},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.6666156649589539},{"id":"https://openalex.org/C2779719659","wikidata":"https://www.wikidata.org/wiki/Q24577942","display_name":"Mannan","level":3,"score":0.5860377550125122},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5820581912994385},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.5221664905548096},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5034055113792419},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5018911361694336},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.47389617562294006},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.47083330154418945},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43488946557044983},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4304816722869873},{"id":"https://openalex.org/C125235067","wikidata":"https://www.wikidata.org/wiki/Q128700","display_name":"Cell wall","level":2,"score":0.42820677161216736},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.4266259968280792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4062665104866028},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4049198627471924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3797941207885742},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28973230719566345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27560660243034363},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.27267885208129883},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.2651549279689789},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.21544760465621948},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20933374762535095},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10267245769500732}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/jas/skab235.873","doi":"https://doi.org/10.1093/jas/skab235.873","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jas/skab235.873","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8506331","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8506331/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anim Sci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8506331","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8506331/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anim Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4366223231","https://openalex.org/W2797212697","https://openalex.org/W3107303945","https://openalex.org/W2903966526","https://openalex.org/W2905007265","https://openalex.org/W2801687557","https://openalex.org/W2296191975","https://openalex.org/W2552918273","https://openalex.org/W2303911856","https://openalex.org/W2001913850"],"abstract_inverted_index":{"Abstract":[0],"Mannan":[1],"rich":[2],"fractions":[3],"were":[4,50,75,92,105,120,139,186],"previously":[5],"demonstrated":[6,176],"to":[7,41,52,69,107,180,261,308],"improve":[8],"junctional":[9,295],"gene":[10,191,247],"expression":[11,192,220,248,296],"which":[12],"can":[13],"reduce":[14],"leaky":[15],"intestinal":[16,36],"tracts":[17],"that":[18,306],"facilitate":[19],"bacterial":[20,42],"infection":[21],"in":[22,39,94,224,251,272,318],"piglets.":[23],"The":[24,313],"work":[25],"here":[26],"assessed":[27,121],"MRF":[28,80,152,183,225,253,275,293],"and":[29,77,86,97,115,173,201,213,239,281,300],"other":[30],"yeast":[31,82,324],"mannan":[32],"products\u2019":[33],"effects":[34],"on":[35],"barrier":[37,155],"function":[38,156],"response":[40],"challenge":[43],"from":[44],"Salmonella":[45],"LPS.":[46],"Differentiated":[47],"IPEC":[48],"cells":[49,74,91,185,227,255],"grown":[51],"14":[53],"days":[54],"until":[55],"a":[56,321],"trans-epithelial":[57],"electrical":[58],"resistance":[59],"reading":[60],"(TEER)":[61],"of":[62,320,323],"~":[63],"4500":[64],"Ohms/cm2":[65],"was":[66,131,221,249,269],"reached.":[67],"Prior":[68],"lipopolysaccharide":[70],"(LPS)":[71],"(1\u00b5g/mL)":[72],"challenge,":[73],"pre-treated":[76],"post-treated":[78],"with":[79,141],"or":[81],"products":[83],"A,":[84],"B,":[85],"C":[87,174,214,283],"(16mg/mL).":[88],"Post":[89],"treated":[90,184,226,254,276],"lysed":[93],"RLT":[95],"buffer":[96],"RNA":[98],"isolated":[99],"(RNeasy).":[100],"RIN":[101],"values":[102],"above":[103],"7":[104],"used":[106],"synthesise":[108],"cDNA":[109],"(SuperScript\u00ae-III).":[110],"Junctional":[111],"genes":[112],"Occludin,":[113],"Claudin3":[114,190],"Tight":[116],"junction":[117],"protein1":[118],"(TJP1)":[119],"by":[122,133],"qPCR":[123],"(Applied":[124],"Biosystems":[125],"7500":[126],"Fast).":[127],"TNF\u03b1":[128,265],"proinflammatory":[129,310],"secretion":[130,268],"measured":[132],"ELISA.":[134],"Three":[135],"independent":[136],"biological":[137],"replicates":[138],"performed,":[140],"One-way":[142],"ANOVA":[143],"carried":[144],"out":[145],"unless":[146],"stated":[147],"otherwise.":[148],"TEER":[149,298],"results":[150],"showed":[151],"significantly":[153,187,222,270],"recovered":[154],"(5090.3\u00b1187.0,":[157],"P":[158,194,205,210,216,229,236,243,278,286],"\u2264":[159,195,206,211,217,230,237,244,279,287],"0.05)":[160,196,212,231,238,280,288],"over":[161,197,232,289],"the":[162,181,198,233,252,262,274,290],"positive":[163],"control":[164,199],"(PC)":[165],"(3754.2\u00b1605.8)":[166],"while":[167],"product":[168],"A":[169,203],"(3502.5\u00b1182.7749),":[170],"B":[171,208,241],"(3414.289\u00b1733.8854)":[172],"(3938.4\u00b1491.4)":[175],"no":[177],"significant":[178],"improvement":[179],"PC.":[182],"higher":[188,223],"for":[189],"(1.33\u00b10.18,":[193],"(0.671661\u00b10.277)":[200],"treatments":[202],"(0.53\u00b10.16,":[204],"0.05),":[207],"(0.91\u00b10.18,":[209],"(0.69\u00b10.25,":[215],"0.05).":[218,245],"Occludin":[219],"(1.09\u00b10.01,":[228],"PC":[234,263,291],"(0.89\u00b10.09,":[235],"treatment":[240,282],"(0.88\u00b10.04,":[242],"TJP-1":[246],"highest":[250],"(1.30\u00b10.41)":[256],"but":[257],"not":[258],"significantly,":[259],"compared":[260],"(1.00\u00b10.14).":[264],"(pg/mL)":[266],"protein":[267,311],"lower":[271,309],"both":[273],"(0.0809\u00b10.86x10-3,":[277],"0.081\u00b10.18":[284],"x10-3,":[285],"(0.0813\u00b10.22x10-3).":[292],"augmented":[294],"improving":[297],"readings":[299],"potentially":[301],"lessened":[302],"LPS":[303],"intracellular":[304],"leakage":[305],"led":[307],"secretion.":[312],"present":[314],"study":[315],"highlights":[316],"differences":[317],"efficacy":[319],"variety":[322],"cell":[325],"wall":[326],"products.":[327]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-10-25T00:00:00"}