{"id":"https://openalex.org/W3205604385","doi":"https://doi.org/10.1056/nejmoa2024848","title":"Efficacy of a Cell-Culture\u2013Derived Quadrivalent Influenza Vaccine in Children","display_name":"Efficacy of a Cell-Culture\u2013Derived Quadrivalent Influenza Vaccine in Children","publication_year":2021,"publication_date":"2021-10-13","ids":{"openalex":"https://openalex.org/W3205604385","doi":"https://doi.org/10.1056/nejmoa2024848","mag":"3205604385","pmid":"https://pubmed.ncbi.nlm.nih.gov/34644472"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa2024848","doi":"https://doi.org/10.1056/nejmoa2024848","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa2024848","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa2024848?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa2024848?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Terence Nolan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH"],"is_corresponding":false,"raw_author_name":"Terence Nolan","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Murdoch Children's Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Murdoch Children's Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057066875","display_name":"Alexandre C. Fortanier","orcid":"https://orcid.org/0000-0001-9788-6458","observed_orcids":["https://orcid.org/0000-0001-9788-6458"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH"],"is_corresponding":false,"raw_author_name":"Alexandre C. Fortanier","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Seqirus Clinical Development, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Seqirus Clinical Development, Amsterdam","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064664004","display_name":"Brett A. Leav","orcid":"https://orcid.org/0000-0003-0907-0817","observed_orcids":["https://orcid.org/0000-0003-0907-0817"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210129217","display_name":"Seqirus (United States)","ror":"https://ror.org/03k879d12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129217"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH","US"],"is_corresponding":false,"raw_author_name":"Brett Leav","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Seqirus Clinical Development, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Seqirus Clinical Development, Cambridge, MA","institution_ids":["https://openalex.org/I4210129217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014198940","display_name":"Airi P\u00f5der","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2802241215","display_name":"Tartu University Hospital","ror":"https://ror.org/01dm91j21","country_code":"EE","type":"healthcare","lineage":["https://openalex.org/I2802241215"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","EE","PH"],"is_corresponding":false,"raw_author_name":"Airi P\u00f5der","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Clinical Research Center, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Clinical Research Center, Tartu, Estonia","institution_ids":["https://openalex.org/I2802241215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071955082","display_name":"Lulu C Bravo","orcid":"https://orcid.org/0009-0006-4052-7677","observed_orcids":["https://orcid.org/0009-0006-4052-7677"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH"],"is_corresponding":false,"raw_author_name":"Lulu C. Bravo","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","University of the Philippines, Manila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"University of the Philippines, Manila","institution_ids":["https://openalex.org/I5791819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030526501","display_name":"Henryk Szyma\u0144ski","orcid":"https://orcid.org/0000-0002-0589-7748","observed_orcids":["https://orcid.org/0000-0002-0589-7748"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I4405255666","display_name":"Szpital im \u015awi\u0119tej Jadwigi w Trzebnicy","ror":"https://ror.org/0396j7182","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4405255666"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH","PL"],"is_corresponding":false,"raw_author_name":"Henryk T. Szyma\u0144ski","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Hedwig of Silesia Hospital, Trzebnica, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Hedwig of Silesia Hospital, Trzebnica, Poland","institution_ids":["https://openalex.org/I4405255666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109228433","display_name":"Marten J. Heeringa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH"],"is_corresponding":false,"raw_author_name":"Marten Heeringa","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Seqirus Clinical Development, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Seqirus Clinical Development, Amsterdam","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wim Vermeulen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH"],"is_corresponding":false,"raw_author_name":"Wim Vermeulen","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Seqirus Clinical Development, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Seqirus Clinical Development, Amsterdam","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021591231","display_name":"Vince Matassa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH"],"is_corresponding":false,"raw_author_name":"Vince Matassa","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Seqirus Clinical Development, Parkville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Seqirus Clinical Development, Parkville","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078223339","display_name":"Igor V. Smolenov","orcid":"https://orcid.org/0000-0002-7075-9827","observed_orcids":["https://orcid.org/0000-0002-7075-9827"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210129217","display_name":"Seqirus (United States)","ror":"https://ror.org/03k879d12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129217"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH","US"],"is_corresponding":false,"raw_author_name":"Igor Smolenov","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Seqirus Clinical Development, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Seqirus Clinical Development, Cambridge, MA","institution_ids":["https://openalex.org/I4210129217"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110526818","display_name":"Jonathan M. Edelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I4210129217","display_name":"Seqirus (United States)","ror":"https://ror.org/03k879d12","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129217"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]},{"id":"https://openalex.org/I5791819","display_name":"University of the Philippines Manila","ror":"https://ror.org/01rrczv41","country_code":"PH","type":"education","lineage":["https://openalex.org/I103911934","https://openalex.org/I5791819"]}],"countries":["AU","PH","US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Edelman","raw_affiliation_strings":["From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","Seqirus Clinical Development, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Murdoch Children\u2019s Research Institute and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne (T.N.), and Seqirus Clinical Development, Parkville (V.M.) \u2014 both in VIC, Australia; Seqirus Clinical Development, Amsterdam (A.C.F., M.H., W.V.); Seqirus Clinical Development, Cambridge, MA (B.L., I.S., J.M.E.); the Clinical Research Center, Tartu, Estonia (A.P.); the University of the Philippines, Manila (L.C.B.); and Hedwig of Silesia Hospital, Trzebnica, Poland (H.T.S.)","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210150290","https://openalex.org/I5791819"]},{"raw_affiliation_string":"Seqirus Clinical Development, Cambridge, MA","institution_ids":["https://openalex.org/I4210129217"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3724,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.95651028,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"385","issue":"16","first_page":"1485","last_page":"1495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quadrivalent-inactivated-influenza-vaccine","display_name":"quadrivalent inactivated influenza vaccine","score":0.984000027179718},{"id":"https://openalex.org/keywords/mdck-cells","display_name":"MDCK cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.8629999756813049},{"id":"https://openalex.org/keywords/h1n1-influenza","display_name":"H1N1 influenza","score":0.8460000157356262},{"id":"https://openalex.org/keywords/h3n2","display_name":"H3N2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/influenza-b","display_name":"influenza B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.531000018119812},{"id":"https://openalex.org/keywords/influenza-like-illness","display_name":"influenza-like illness","score":0.5569999814033508},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.37299999594688416},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8008333444595337},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.5952214598655701},{"id":"https://openalex.org/C180915046","wikidata":"https://www.wikidata.org/wiki/Q575264","display_name":"Original antigenic sin","level":5,"score":0.5836881995201111},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5461481809616089},{"id":"https://openalex.org/C133239900","wikidata":"https://www.wikidata.org/wiki/Q2043512","display_name":"Live attenuated influenza vaccine","level":4,"score":0.5347589254379272},{"id":"https://openalex.org/C7842527","wikidata":"https://www.wikidata.org/wiki/Q575258","display_name":"Antigenic drift","level":4,"score":0.5160045623779297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4909262955188751},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4878551959991455},{"id":"https://openalex.org/C82988372","wikidata":"https://www.wikidata.org/wiki/Q5628866","display_name":"H5N1 genetic structure","level":5,"score":0.4682137966156006},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44183388352394104},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.4406575560569763},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43441373109817505},{"id":"https://openalex.org/C86282344","wikidata":"https://www.wikidata.org/wiki/Q575314","display_name":"Antigenic shift","level":5,"score":0.42546069622039795},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.35126543045043945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3251689076423645},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.1616804003715515},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12555447220802307},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06733021140098572},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.052758485078811646},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015164","descriptor_name":"Vaccines, Inactivated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022401","descriptor_name":"Meningococcal Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejmoa2024848","doi":"https://doi.org/10.1056/nejmoa2024848","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa2024848","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa2024848?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:34644472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34644472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":{"id":"doi:10.1056/nejmoa2024848","doi":"https://doi.org/10.1056/nejmoa2024848","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa2024848","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa2024848?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320329769","display_name":"Commonwealth Serum Laboratories","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3205604385.pdf"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2029220396","https://openalex.org/W2043798455","https://openalex.org/W2043925105","https://openalex.org/W2071657440","https://openalex.org/W2078495043","https://openalex.org/W2110607810","https://openalex.org/W2119950877","https://openalex.org/W2120718343","https://openalex.org/W2153564793","https://openalex.org/W2163738297","https://openalex.org/W2172283179","https://openalex.org/W2173609232","https://openalex.org/W2308892148","https://openalex.org/W2329310459","https://openalex.org/W2738648163","https://openalex.org/W2765398298","https://openalex.org/W2767495920","https://openalex.org/W2788685606","https://openalex.org/W2804447836","https://openalex.org/W2889891640","https://openalex.org/W2903749437","https://openalex.org/W2945500233","https://openalex.org/W2951360390","https://openalex.org/W2952048915","https://openalex.org/W2969322952","https://openalex.org/W2982405140","https://openalex.org/W3009029371","https://openalex.org/W4211222382"],"related_works":["https://openalex.org/W4205811861","https://openalex.org/W7151792041","https://openalex.org/W3211709384","https://openalex.org/W3014346874","https://openalex.org/W2963848810","https://openalex.org/W2552875577","https://openalex.org/W2120718343","https://openalex.org/W4303980604","https://openalex.org/W4284883884","https://openalex.org/W3036021947"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cell-culture-derived":[1],"influenza":[2,14,30,54,97,139,181,207,253,262,272,288,310,321],"vaccines":[3],"may":[4],"enable":[5],"a":[6,26,34,71,80,83,107,190],"closer":[7],"antigenic":[8],"match":[9],"to":[10,45,88,102,118,163,198,242,250,259,269,282],"circulating":[11],"strains":[12],"of":[13,25,50,82,93,138,167,175,192,211,222,233,292,319],"virus":[15,140],"by":[16,151,171,324],"avoiding":[17],"egg-adapted":[18],"mutations.":[19],"METHODS:":[20],"We":[21],"evaluated":[22],"the":[23,77,103,119,165,172,202,216,227,231,298,302],"efficacy":[24,133,166,232,278],"cell-culture-derived":[27],"quadrivalent":[28],"inactivated":[29],"vaccine":[31,73,277],"(IIV4c)":[32],"using":[33],"Madin-Darby":[35],"canine":[36],"kidney":[37],"cell":[38],"line":[39],"in":[40,62,141,209,215,220,226,279,297,311],"children":[41,313],"and":[42,134,154,188,219,230,264,286,301,314],"adolescents":[43,315],"2":[44,87],"less":[46,89],"than":[47,90],"18":[48],"years":[49,92],"age.":[51],"During":[52],"three":[53],"seasons,":[55,317],"participants":[56,78,145,194,213,224],"from":[57,144],"eight":[58],"countries":[59],"were":[60,100,116,125,195,295],"enrolled":[61],"an":[63],"observer-blinded,":[64],"randomized":[65],"clinical":[66],"trial":[67,84],"comparing":[68],"IIV4c":[69,104,168,200,217,234,274,299,306],"with":[70,146],"noninfluenza":[72],"(meningococcal":[74],"ACWY).":[75],"All":[76],"received":[79,106,122],"dose":[81,109],"vaccine.":[85,205],"Children":[86],"9":[91],"age":[94],"without":[95],"previous":[96,287,320],"vaccination":[98],"who":[99,115],"assigned":[101,117,197],"group":[105,121,218,300],"second":[108],"on":[110],"day":[111],"29;":[112],"their":[113],"counterparts":[114],"comparator":[120,228,303],"placebo.":[123],"Participants":[124],"followed":[126],"for":[127,132],"at":[128],"least":[129],"180":[130],"days":[131],"safety.":[135],"The":[136,290],"presence":[137],"nasopharyngeal":[142],"swabs":[143],"influenza-like":[147],"illness":[148],"was":[149,161,235,245],"confirmed":[150],"reverse-transcriptase-polymerase-chain-reaction":[152],"assay":[153],"viral":[155],"culture.":[156],"A":[157,178],"Cox":[158],"proportional-hazards":[159],"model":[160],"used":[162],"evaluate":[164],"as":[169],"measured":[170],"first":[173],"occurrence":[174],"laboratory-confirmed":[176],"type":[177],"or":[179,201],"B":[180],"(primary":[182],"end":[183],"point).":[184],"RESULTS:":[185],"Between":[186],"2017":[187],"2019,":[189],"total":[191],"4514":[193],"randomly":[196],"receive":[199],"meningococcal":[203],"ACWY":[204],"Laboratory-confirmed":[206],"occurred":[208],"175":[210],"2257":[212],"(7.8%)":[214],"364":[221],"2252":[223],"(16.2%)":[225],"group,":[229],"54.6%":[236],"(95%":[237,247,256,266],"confidence":[238],"interval":[239],"[CI],":[240],"45.7":[241],"62.1).":[243],"Efficacy":[244],"80.7%":[246],"CI,":[248,257,267],"69.2":[249],"87.9)":[251],"against":[252,261,271,309],"A/H1N1,":[254],"42.1%":[255],"20.3":[258],"57.9)":[260],"A/H3N2,":[263],"47.6%":[265],"31.4":[268],"60.0)":[270],"B.":[273],"showed":[275],"consistent":[276],"subgroups":[280],"according":[281],"age,":[283],"sex,":[284],"race,":[285],"vaccination.":[289,322],"incidences":[291],"adverse":[293],"events":[294],"similar":[296],"group.":[304],"CONCLUSIONS:":[305],"provided":[307],"protection":[308],"healthy":[312],"across":[316],"regardless":[318],"(Funded":[323],"Seqirus;":[325],"EudraCT":[326],"number,":[327,330],"2016-002883-15;":[328],"ClinicalTrials.gov":[329],"NCT03165617.).":[331]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-10-25T00:00:00"}