{"id":"https://openalex.org/W3205598152","doi":"https://doi.org/10.1186/s11689-021-09393-y","title":"Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda","display_name":"Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda","publication_year":2021,"publication_date":"2021-10-15","ids":{"openalex":"https://openalex.org/W3205598152","doi":"https://doi.org/10.1186/s11689-021-09393-y","mag":"3205598152","pmid":"https://pubmed.ncbi.nlm.nih.gov/34654371","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8520312"},"language":"en","primary_location":{"id":"doi:10.1186/s11689-021-09393-y","doi":"https://doi.org/10.1186/s11689-021-09393-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s11689-021-09393-y","pdf_url":null,"source":{"id":"https://openalex.org/S206192428","display_name":"Journal of Neurodevelopmental Disorders","issn_l":"1866-1947","issn":["1866-1947","1866-1955"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurodevelopmental Disorders","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s11689-021-09393-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030028999","display_name":"Rebecca Grzadzinski","orcid":"https://orcid.org/0000-0001-7764-6166","observed_orcids":["https://orcid.org/0000-0001-7764-6166"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca Grzadzinski","raw_affiliation_strings":["Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA. Rebecca_grzadzinski@med.unc.edu","Program for Early Autism Research Leadership and Service (PEARLS), University of North Carolina, Chapel Hill, NC, USA. Rebecca_grzadzinski@med.unc.edu","Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA","Program for Early Autism Research Leadership and Service (PEARLS), University of North Carolina, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0001-7764-6166","affiliations":[{"raw_affiliation_string":"Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA. Rebecca_grzadzinski@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Program for Early Autism Research Leadership and Service (PEARLS), University of North Carolina, Chapel Hill, NC, USA. Rebecca_grzadzinski@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Program for Early Autism Research Leadership and Service (PEARLS), University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046734415","display_name":"Dima Amso","orcid":"https://orcid.org/0000-0001-6798-4698","observed_orcids":["https://orcid.org/0000-0001-6798-4698"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dima Amso","raw_affiliation_strings":["Department of Psychology, Columbia University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071409063","display_name":"Rebecca J. Landa","orcid":"https://orcid.org/0000-0001-8894-8995","observed_orcids":["https://orcid.org/0000-0001-8894-8995"]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Landa","raw_affiliation_strings":["Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, MD, USA","Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1298154867"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041671694","display_name":"Linda R. Watson","orcid":"https://orcid.org/0000-0001-7722-406X","observed_orcids":["https://orcid.org/0000-0001-7722-406X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Watson","raw_affiliation_strings":["Division of Speech and Hearing Sciences, University of North Carolina, Chapel Hill, NC, USA","Program for Early Autism Research Leadership and Service (PEARLS), University of North Carolina, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Speech and Hearing Sciences, University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Program for Early Autism Research Leadership and Service (PEARLS), University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036007662","display_name":"Michael J. Guralnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Guralnick","raw_affiliation_strings":["Center on Human Development and Disability, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Human Development and Disability, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033141114","display_name":"Lonnie Zwaigenbaum","orcid":"https://orcid.org/0000-0001-9607-0799","observed_orcids":["https://orcid.org/0000-0001-9607-0799"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lonnie Zwaigenbaum","raw_affiliation_strings":["Department of Pediatrics, University of Alberta, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001354564","display_name":"Gedeon O. De\u00e1k","orcid":"https://orcid.org/0000-0001-8656-8796","observed_orcids":["https://orcid.org/0000-0001-8656-8796"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gedeon De\u00e1k","raw_affiliation_strings":["Department of Cognitive Science, University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cognitive Science, University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066366817","display_name":"Annette Mercer Estes","orcid":"https://orcid.org/0000-0003-2687-4155","observed_orcids":["https://orcid.org/0000-0003-2687-4155"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annette Estes","raw_affiliation_strings":["Department of Speech and Hearing Sciences, University of Washington Autism Center, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Speech and Hearing Sciences, University of Washington Autism Center, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029482914","display_name":"Jessica A. Brian","orcid":"https://orcid.org/0000-0001-8181-4353","observed_orcids":["https://orcid.org/0000-0001-8181-4353"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801420703","display_name":"Holland Bloorview Kids Rehabilitation Hospital","ror":"https://ror.org/03qea8398","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801420703"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jessica Brian","raw_affiliation_strings":["Department of Paediatrics, University of Toronto, Toronto, Canada","Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada","institution_ids":["https://openalex.org/I2801420703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044692135","display_name":"Kevin G. Bath","orcid":"https://orcid.org/0000-0003-2229-177X","observed_orcids":["https://orcid.org/0000-0003-2229-177X"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Bath","raw_affiliation_strings":["Department of Neuroscience, Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008296740","display_name":"Jed T. Elison","orcid":"https://orcid.org/0000-0002-6246-1000","observed_orcids":["https://orcid.org/0000-0002-6246-1000","https://orcid.org/0000-0001-9585-1382"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jed Elison","raw_affiliation_strings":["Institute of Child Development, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Child Development, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015814711","display_name":"Leonard Abbeduto","orcid":"https://orcid.org/0000-0002-2311-7194","observed_orcids":["https://orcid.org/0000-0002-2311-7194"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Abbeduto","raw_affiliation_strings":["University of California, Davis, MIND Institute, University of California, Davis, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Davis, MIND Institute, University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036803120","display_name":"Jason J. Wolff","orcid":"https://orcid.org/0000-0003-4300-8195","observed_orcids":["https://orcid.org/0000-0003-4300-8195"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Wolff","raw_affiliation_strings":["Department of Educational Psychology, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Educational Psychology, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052438867","display_name":"Joseph Piven","orcid":"https://orcid.org/0000-0003-0255-9003","observed_orcids":["https://orcid.org/0000-0003-0255-9003"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Piven","raw_affiliation_strings":["Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5030028999"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":1.7498,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.86018237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"49","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13393","display_name":"Child Nutrition and Feeding Issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":1.0},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.7139999866485596},{"id":"https://openalex.org/keywords/behavioral-interventions","display_name":"behavioral interventions","score":0.6869999766349792},{"id":"https://openalex.org/keywords/preclinical-trials","display_name":"preclinical trials","score":0.6000000238418579},{"id":"https://openalex.org/keywords/developmental-outcomes","display_name":"developmental outcomes","score":0.6119999885559082},{"id":"https://openalex.org/keywords/research-agenda","display_name":"research agenda","score":0.6759999990463257},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.8286668062210083},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.7707743048667908},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6711462736129761},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.5018417835235596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47045862674713135},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.4674184322357178},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4568853974342346},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.43993133306503296},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43893128633499146},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3668479919433594},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.19287052750587463},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001521","descriptor_name":"Behavior Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012919","descriptor_name":"Social Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/s11689-021-09393-y","doi":"https://doi.org/10.1186/s11689-021-09393-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s11689-021-09393-y","pdf_url":null,"source":{"id":"https://openalex.org/S206192428","display_name":"Journal of Neurodevelopmental Disorders","issn_l":"1866-1947","issn":["1866-1947","1866-1955"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurodevelopmental Disorders","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8520312","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8520312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurodev Disord","raw_type":"Text"},{"id":"pmid:34654371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34654371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurodevelopmental disorders","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt87g4p1kp","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/87g4p1kp","pdf_url":"https://escholarship.org/content/qt87g4p1kp/qt87g4p1kp.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neurodevelopmental Disorders, vol 13, iss 1","raw_type":"article"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/107737","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/107737","pdf_url":"https://utoronto.scholaris.ca/bitstreams/d5b7e820-18d2-4cd0-b8da-c23723804cb5/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:7c06d6c2a93242228f833f83a0edcf3d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c06d6c2a93242228f833f83a0edcf3d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neurodevelopmental Disorders, Vol 13, Iss 1, Pp 1-23 (2021)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt87g4p1kp","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/87g4p1kp","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of neurodevelopmental disorders, vol 13, iss 1","raw_type":"article"},{"id":"doi:10.7916/cfgm-9r80","doi":"https://doi.org/10.7916/cfgm-9r80","is_oa":true,"landing_page_url":"https://doi.org/10.7916/cfgm-9r80","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s11689-021-09393-y","doi":"https://doi.org/10.1186/s11689-021-09393-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s11689-021-09393-y","pdf_url":null,"source":{"id":"https://openalex.org/S206192428","display_name":"Journal of Neurodevelopmental Disorders","issn_l":"1866-1947","issn":["1866-1947","1866-1955"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurodevelopmental Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G190946354","display_name":null,"funder_award_id":"R01HD05574","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2800932290","display_name":null,"funder_award_id":"AC-90DDUC0017","funder_id":"https://openalex.org/F4320332398","funder_display_name":"Administration for Community Living"},{"id":"https://openalex.org/G3728671366","display_name":"Development and neural mechanisms of repetitive behavior and sensory responsivity in autism","funder_award_id":"R01MH116961","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4884579060","display_name":null,"funder_award_id":"R01HD05574","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5902904102","display_name":"Intellectual and Developmental Disabilities Research Center","funder_award_id":"P50HD103524","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6317168728","display_name":"Clinical Translational Research Center for Neurodevelopmental Disorders","funder_award_id":"P50HD103573","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6593207837","display_name":"MIND Institute Intellectual and Developmental Disabilities Research Center","funder_award_id":"P50HD103526","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G671347764","display_name":"North Carolina Translational and Clinical Science Institute (NC TraCS) KL2","funder_award_id":"KL2TR002490","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8936954841","display_name":"MRI Based Presymptomatic Prediction of ASD","funder_award_id":"R01MH118362","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000883416","display_name":"Postdoctoral Research in Neurodevelopmental Disorders","funder_award_id":"T32HD040127","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332398","display_name":"Administration for Community Living","ror":"https://ror.org/00vf4jm23"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205598152.pdf","grobid_xml":"https://content.openalex.org/works/W3205598152.grobid-xml"},"referenced_works_count":211,"referenced_works":["https://openalex.org/W233953933","https://openalex.org/W859030279","https://openalex.org/W1492870567","https://openalex.org/W1512091277","https://openalex.org/W1568828319","https://openalex.org/W1581378799","https://openalex.org/W1608979225","https://openalex.org/W1783747734","https://openalex.org/W1968044148","https://openalex.org/W1972139731","https://openalex.org/W1973765746","https://openalex.org/W1975893854","https://openalex.org/W1976748406","https://openalex.org/W1980741010","https://openalex.org/W1981760840","https://openalex.org/W1982840008","https://openalex.org/W1993127962","https://openalex.org/W1993793414","https://openalex.org/W1994915124","https://openalex.org/W1995792946","https://openalex.org/W2001911865","https://openalex.org/W2003154969","https://openalex.org/W2010638123","https://openalex.org/W2013235955","https://openalex.org/W2014051515","https://openalex.org/W2017777591","https://openalex.org/W2022285931","https://openalex.org/W2022662741","https://openalex.org/W2023125723","https://openalex.org/W2024274726","https://openalex.org/W2026210233","https://openalex.org/W2029347299","https://openalex.org/W2030155507","https://openalex.org/W2031771498","https://openalex.org/W2034556675","https://openalex.org/W2037070165","https://openalex.org/W2039424378","https://openalex.org/W2041807010","https://openalex.org/W2041923848","https://openalex.org/W2049773264","https://openalex.org/W2052809296","https://openalex.org/W2055504599","https://openalex.org/W2056364323","https://openalex.org/W2059507293","https://openalex.org/W2061873731","https://openalex.org/W2064974707","https://openalex.org/W2069698478","https://openalex.org/W2071465932","https://openalex.org/W2072808263","https://openalex.org/W2078678039","https://openalex.org/W2081932201","https://openalex.org/W2085193926","https://openalex.org/W2089015364","https://openalex.org/W2090237611","https://openalex.org/W2091341174","https://openalex.org/W2092462980","https://openalex.org/W2094692098","https://openalex.org/W2096701191","https://openalex.org/W2098941430","https://openalex.org/W2099484012","https://openalex.org/W2099756187","https://openalex.org/W2101504362","https://openalex.org/W2104759328","https://openalex.org/W2106155621","https://openalex.org/W2106462800","https://openalex.org/W2107159232","https://openalex.org/W2112121435","https://openalex.org/W2112991204","https://openalex.org/W2113001227","https://openalex.org/W2116697664","https://openalex.org/W2118780982","https://openalex.org/W2120006086","https://openalex.org/W2127870165","https://openalex.org/W2130534871","https://openalex.org/W2133015692","https://openalex.org/W2139013981","https://openalex.org/W2140050273","https://openalex.org/W2141023130","https://openalex.org/W2142367912","https://openalex.org/W2142418447","https://openalex.org/W2144236040","https://openalex.org/W2145053483","https://openalex.org/W2145857651","https://openalex.org/W2148044536","https://openalex.org/W2149107263","https://openalex.org/W2149479092","https://openalex.org/W2150060517","https://openalex.org/W2152570982","https://openalex.org/W2152806460","https://openalex.org/W2153913929","https://openalex.org/W2155427676","https://openalex.org/W2155582329","https://openalex.org/W2157183647","https://openalex.org/W2157875253","https://openalex.org/W2158409168","https://openalex.org/W2159810961","https://openalex.org/W2161362259","https://openalex.org/W2165770244","https://openalex.org/W2165845288","https://openalex.org/W2171099789","https://openalex.org/W2171373562","https://openalex.org/W2174932877","https://openalex.org/W2227824320","https://openalex.org/W2281421992","https://openalex.org/W2281803229","https://openalex.org/W2292012480","https://openalex.org/W2321381382","https://openalex.org/W2324499091","https://openalex.org/W2327375986","https://openalex.org/W2329167842","https://openalex.org/W2330594182","https://openalex.org/W2341449055","https://openalex.org/W2344493661","https://openalex.org/W2416495904","https://openalex.org/W2476896385","https://openalex.org/W2489557975","https://openalex.org/W2506744484","https://openalex.org/W2528909307","https://openalex.org/W2529872379","https://openalex.org/W2537346844","https://openalex.org/W2542198094","https://openalex.org/W2572116539","https://openalex.org/W2572837832","https://openalex.org/W2583642249","https://openalex.org/W2588003167","https://openalex.org/W2590967948","https://openalex.org/W2593972102","https://openalex.org/W2605716357","https://openalex.org/W2605961707","https://openalex.org/W2614349964","https://openalex.org/W2617537891","https://openalex.org/W2621066334","https://openalex.org/W2621301104","https://openalex.org/W2623800443","https://openalex.org/W2737078085","https://openalex.org/W2740920123","https://openalex.org/W2746652217","https://openalex.org/W2751095293","https://openalex.org/W2782820715","https://openalex.org/W2786745651","https://openalex.org/W2789967495","https://openalex.org/W2792921834","https://openalex.org/W2795176860","https://openalex.org/W2795455408","https://openalex.org/W2801674652","https://openalex.org/W2803791898","https://openalex.org/W2804098263","https://openalex.org/W2896782635","https://openalex.org/W2898002252","https://openalex.org/W2899543523","https://openalex.org/W2902918886","https://openalex.org/W2905374613","https://openalex.org/W2906253013","https://openalex.org/W2908892351","https://openalex.org/W2913192595","https://openalex.org/W2942924515","https://openalex.org/W2943932874","https://openalex.org/W2947120104","https://openalex.org/W2947325756","https://openalex.org/W2949295827","https://openalex.org/W2950605906","https://openalex.org/W2961169576","https://openalex.org/W2961826431","https://openalex.org/W2972227563","https://openalex.org/W2972846088","https://openalex.org/W2974976896","https://openalex.org/W2977708246","https://openalex.org/W2990306783","https://openalex.org/W2999424438","https://openalex.org/W3002320921","https://openalex.org/W3006559038","https://openalex.org/W3007068963","https://openalex.org/W3012502394","https://openalex.org/W3013358449","https://openalex.org/W3033242681","https://openalex.org/W3035372005","https://openalex.org/W3036995464","https://openalex.org/W3042607725","https://openalex.org/W3044271813","https://openalex.org/W3046234877","https://openalex.org/W3047544314","https://openalex.org/W3056244285","https://openalex.org/W3063847556","https://openalex.org/W3080200451","https://openalex.org/W3080547514","https://openalex.org/W3083347663","https://openalex.org/W3084747096","https://openalex.org/W3087507630","https://openalex.org/W3091924201","https://openalex.org/W3092976222","https://openalex.org/W3094331871","https://openalex.org/W3111968481","https://openalex.org/W3121491562","https://openalex.org/W3122724040","https://openalex.org/W3123275178","https://openalex.org/W3126514878","https://openalex.org/W3129117087","https://openalex.org/W3133627260","https://openalex.org/W3136797206","https://openalex.org/W3139087651","https://openalex.org/W3152958580","https://openalex.org/W3156635340","https://openalex.org/W3156915299","https://openalex.org/W3176566720","https://openalex.org/W3195740915","https://openalex.org/W3199581472","https://openalex.org/W4237054073","https://openalex.org/W4247031727","https://openalex.org/W4247665917","https://openalex.org/W4298328661","https://openalex.org/W4300986741"],"related_works":["https://openalex.org/W4367845136","https://openalex.org/W2961169576","https://openalex.org/W6966615406","https://openalex.org/W3207469355","https://openalex.org/W2130157722","https://openalex.org/W2980006933","https://openalex.org/W3043730916","https://openalex.org/W3199581472","https://openalex.org/W3156635340","https://openalex.org/W2990420363"],"abstract_inverted_index":{"Autism":[0],"spectrum":[1],"disorder":[2],"(ASD)":[3],"impacts":[4],"an":[5],"individual's":[6],"ability":[7],"to":[8,65,100,113,135,158],"socialize,":[9],"communicate,":[10],"and":[11,14,42,55,77,145],"interact":[12],"with,":[13],"adapt":[15],"to,":[16],"the":[17,20,39,66,82,87,89,109,114,137,153,159,162],"environment.":[18],"Over":[19],"last":[21],"two":[22],"decades,":[23],"research":[24],"has":[25],"focused":[26],"on":[27],"early":[28,40],"identification":[29,54],"of":[30,68,98,116,131,139,161,165],"ASD":[31,69,126],"with":[32],"significant":[33],"progress":[34],"being":[35],"made":[36],"in":[37,120],"understanding":[38],"behavioral":[41,106],"biological":[43],"markers":[44],"that":[45,62,81],"precede":[46],"a":[47,50,95,102],"diagnosis,":[48,119],"providing":[49],"catalyst":[51],"for":[52,105,124],"pre-symptomatic":[53,110,154],"intervention.":[56],"Evidence":[57],"from":[58],"preclinical":[59],"trials":[60],"suggest":[61,80],"intervention":[63,84,141],"prior":[64,112,157],"onset":[67],"symptoms":[70,117],"may":[71],"yield":[72],"more":[73],"improved":[74],"developmental":[75],"outcomes,":[76],"clinical":[78],"studies":[79],"earlier":[83],"is":[85],"administered,":[86],"better":[88],"outcomes.":[90],"This":[91],"article":[92],"brings":[93],"together":[94],"multidisciplinary":[96],"group":[97],"experts":[99],"develop":[101],"conceptual":[103],"framework":[104],"intervention,":[107],"during":[108,152],"period":[111,155],"consolidation":[115,160],"into":[118],"infants":[121,151],"at":[122,149],"very-high-likelihood":[123],"developing":[125],"(VHL-ASD).":[127],"The":[128],"overarching":[129],"goals":[130],"this":[132],"paper":[133],"are":[134],"promote":[136],"development":[138],"new":[140],"approaches,":[142],"empirical":[143],"research,":[144],"policy":[146],"efforts":[147],"aimed":[148],"VHL-ASD":[150],"(i.e.,":[156],"defining":[163],"features":[164],"ASD).":[166]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-25T00:00:00"}