{"id":"https://openalex.org/W3205553589","doi":"https://doi.org/10.3390/cells10102765","title":"Integrative Analysis to Identify Genes Associated with Stemness and Immune Infiltration in Glioblastoma","display_name":"Integrative Analysis to Identify Genes Associated with Stemness and Immune Infiltration in Glioblastoma","publication_year":2021,"publication_date":"2021-10-15","ids":{"openalex":"https://openalex.org/W3205553589","doi":"https://doi.org/10.3390/cells10102765","mag":"3205553589","pmid":"https://pubmed.ncbi.nlm.nih.gov/34685742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8534801"},"language":"en","primary_location":{"id":"doi:10.3390/cells10102765","doi":"https://doi.org/10.3390/cells10102765","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells10102765","pdf_url":"https://www.mdpi.com/2073-4409/10/10/2765/pdf?version=1634616066","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/10/10/2765/pdf?version=1634616066","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037931489","display_name":"Neerada Meenakshi Warrier","orcid":"https://orcid.org/0000-0001-9321-2923","observed_orcids":["https://orcid.org/0000-0001-9321-2923"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neerada Meenakshi Warrier","raw_affiliation_strings":["Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0001-9321-2923","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067957722","display_name":"Prasoon Agarwal","orcid":"https://orcid.org/0000-0003-1813-7606","observed_orcids":["https://orcid.org/0000-0003-1813-7606"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Prasoon Agarwal","raw_affiliation_strings":["KTH Royal Institute of Technology, School of Electrical Engineering and Computer Science, 10044 Stockholm, Sweden","Science for Life Laboratory, 17121 Solna, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-1813-7606","affiliations":[{"raw_affiliation_string":"KTH Royal Institute of Technology, School of Electrical Engineering and Computer Science, 10044 Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Science for Life Laboratory, 17121 Solna, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088935363","display_name":"Praveen Kumar","orcid":"https://orcid.org/0000-0002-6330-7355","observed_orcids":["https://orcid.org/0000-0002-6330-7355"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Praveen Kumar","raw_affiliation_strings":["Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0002-6330-7355","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India","institution_ids":["https://openalex.org/I164861460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067957722","https://openalex.org/A5088935363"],"corresponding_institution_ids":["https://openalex.org/I164861460","https://openalex.org/I2800139495","https://openalex.org/I86987016"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":1.3005,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.83433408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"10","issue":"10","first_page":"2765","last_page":"2765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.847000002861023},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":1.0},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/eomes","display_name":"Eomes","score":0.8870000243186951},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":1.0},{"id":"https://openalex.org/keywords/hla-a","display_name":"HLA-A","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.9990000128746033},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.695432186126709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6533148288726807},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.62610924243927},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6145636439323425},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5069008469581604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26895684003829956},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.10272184014320374}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/cells10102765","doi":"https://doi.org/10.3390/cells10102765","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells10102765","pdf_url":"https://www.mdpi.com/2073-4409/10/10/2765/pdf?version=1634616066","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8534801","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8534801","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmid:34685742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34685742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:116f864f169b4d2da87fa29c11e30e59","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/116f864f169b4d2da87fa29c11e30e59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 10, Iss 10, p 2765 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells10102765","doi":"https://doi.org/10.3390/cells10102765","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells10102765","pdf_url":"https://www.mdpi.com/2073-4409/10/10/2765/pdf?version=1634616066","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205553589.pdf","grobid_xml":"https://content.openalex.org/works/W3205553589.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1146414419","https://openalex.org/W1568117622","https://openalex.org/W1969299292","https://openalex.org/W1977918192","https://openalex.org/W2070050178","https://openalex.org/W2075060412","https://openalex.org/W2088911689","https://openalex.org/W2091739868","https://openalex.org/W2127755727","https://openalex.org/W2156534427","https://openalex.org/W2159675211","https://openalex.org/W2167414381","https://openalex.org/W2224717864","https://openalex.org/W2317982666","https://openalex.org/W2345356016","https://openalex.org/W2509954024","https://openalex.org/W2517311614","https://openalex.org/W2551086590","https://openalex.org/W2559943555","https://openalex.org/W2605248400","https://openalex.org/W2730787475","https://openalex.org/W2736730167","https://openalex.org/W2738946651","https://openalex.org/W2763667496","https://openalex.org/W2765224588","https://openalex.org/W2800469107","https://openalex.org/W2801303736","https://openalex.org/W2801689575","https://openalex.org/W2892382428","https://openalex.org/W2906075703","https://openalex.org/W2925395230","https://openalex.org/W2928665623","https://openalex.org/W2930054187","https://openalex.org/W2943704915","https://openalex.org/W2974702474","https://openalex.org/W2989091284","https://openalex.org/W3003357115","https://openalex.org/W3012050933","https://openalex.org/W3026620415","https://openalex.org/W3027286012","https://openalex.org/W3027530932","https://openalex.org/W3043042054","https://openalex.org/W3048251357","https://openalex.org/W3094814831","https://openalex.org/W3108954587","https://openalex.org/W3114996910","https://openalex.org/W3123250777","https://openalex.org/W3123831642","https://openalex.org/W3132558808","https://openalex.org/W3133596036","https://openalex.org/W3135035839","https://openalex.org/W3137340042","https://openalex.org/W3137429091","https://openalex.org/W3137670646","https://openalex.org/W3145969289","https://openalex.org/W6751186468"],"related_works":["https://openalex.org/W3046866310","https://openalex.org/W7161770597","https://openalex.org/W4246313414","https://openalex.org/W2054745835","https://openalex.org/W3093193313","https://openalex.org/W3111821779","https://openalex.org/W1992187384","https://openalex.org/W2508102725","https://openalex.org/W4411520007","https://openalex.org/W4226153444"],"abstract_inverted_index":{"It":[0],"is":[1],"imperative":[2],"to":[3,10,99,118,132,144],"identify":[4],"the":[5,11,25,31,38,46,52,67],"mechanisms":[6],"that":[7,95],"confer":[8],"stemness":[9,28,124],"cancer":[12,60],"cells":[13],"for":[14],"more":[15],"effective":[16],"targeting.":[17],"Moreover,":[18],"there":[19],"are":[20],"not":[21,77],"many":[22],"studies":[23],"on":[24],"link":[26],"between":[27],"characteristics":[29],"and":[30,59,62,69,106,112,125,127],"immune":[32],"response":[33],"in":[34,37,57,66,90,123,139],"tumours.":[35],"Therefore,":[36],"current":[39],"study":[40,47],"involving":[41],"GBM,":[42],"we":[43,115],"started":[44],"with":[45,110],"of":[48,51,71,85],"BIRC5":[49,111],"(one":[50],"rare":[53],"genes":[54,75,97],"differentially":[55],"expressed":[56],"normal":[58],"cells)":[61],"CXCR4":[63],"(gene":[64],"involved":[65,109,122],"survival":[68],"proliferation":[70],"CSCs).":[72],"Together,":[73],"these":[74,100],"have":[76],"been":[78],"systematically":[79],"explored.":[80],"We":[81],"used":[82],"a":[83],"set":[84],"27":[86],"promoter":[87],"methylated":[88],"regions":[89],"GBM.":[91],"Our":[92],"analysis":[93],"showed":[94],"four":[96],"corresponding":[98],"regions,":[101],"namely":[102],"EOMES,":[103],"BDNF,":[104,135],"HLA-A,":[105],"PECAM1,":[107],"were":[108],"CXCR4.":[113,133],"Interestingly,":[114],"found":[116],"EOMES":[117],"be":[119],"very":[120],"significantly":[121],"immunology":[126],"it":[128],"was":[129,137,141],"positively":[130],"correlated":[131,143],"Additionally,":[134],"which":[136],"significant":[138],"methylation,":[140],"negatively":[142],"BIRC5.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-25T00:00:00"}