{"id":"https://openalex.org/W3205547140","doi":"https://doi.org/10.1101/2021.10.13.461047","title":"Evolutionarily conserved clusters of colon with lung cancer susceptibility loci, linked with most DUSP phosphatase genes, may help to dissect mechanisms of cancer susceptibility","display_name":"Evolutionarily conserved clusters of colon with lung cancer susceptibility loci, linked with most DUSP phosphatase genes, may help to dissect mechanisms of cancer susceptibility","publication_year":2021,"publication_date":"2021-10-14","ids":{"openalex":"https://openalex.org/W3205547140","doi":"https://doi.org/10.1101/2021.10.13.461047","mag":"3205547140"},"language":"en","primary_location":{"id":"doi:10.1101/2021.10.13.461047","doi":"https://doi.org/10.1101/2021.10.13.461047","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.13.461047","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/14/2021.10.13.461047.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W3205547140"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/14/2021.10.13.461047.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042842051","display_name":"Lei Quan","orcid":"https://orcid.org/0000-0001-5559-7690","observed_orcids":["https://orcid.org/0000-0001-5559-7690"]},"institutions":[{"id":"https://openalex.org/I147139432","display_name":"Tianjin University of Sport","ror":"https://ror.org/007eyd925","country_code":"CN","type":"education","lineage":["https://openalex.org/I147139432"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Quan","raw_affiliation_strings":["Tianjin Key Laboratory of Exercise Physiology and Sport Medicine, Research Center for Exercise and Health Science, Tianjin University of Sport, Tianjin 310617, China","Tianjin Key Laboratory of Exercise Physiology and Sport Medicine, Research Center for Exercise and Health Science, Tianjin University of Sport, Tianjin 3067, China"],"raw_orcid":"https://orcid.org/0000-0001-5559-7690","affiliations":[{"raw_affiliation_string":"Tianjin Key Laboratory of Exercise Physiology and Sport Medicine, Research Center for Exercise and Health Science, Tianjin University of Sport, Tianjin 310617, China","institution_ids":["https://openalex.org/I147139432"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Exercise Physiology and Sport Medicine, Research Center for Exercise and Health Science, Tianjin University of Sport, Tianjin 3067, China","institution_ids":["https://openalex.org/I147139432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025397230","display_name":"Miranda L. Lynch","orcid":"https://orcid.org/0000-0001-8604-4431","observed_orcids":["https://orcid.org/0000-0001-8604-4431","https://orcid.org/0000-0003-4421-6527"]},"institutions":[{"id":"https://openalex.org/I1287610024","display_name":"Hauptman-Woodward Medical Research Institute","ror":"https://ror.org/02e1cpg76","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1287610024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miranda L. Lynch","raw_affiliation_strings":["Hauptman-Woodward Medical Research Institute, Buffalo, New York, U.S.A"],"raw_orcid":"https://orcid.org/0000-0001-8604-4431","affiliations":[{"raw_affiliation_string":"Hauptman-Woodward Medical Research Institute, Buffalo, New York, U.S.A","institution_ids":["https://openalex.org/I1287610024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045193381","display_name":"Peter D\u00e9mant","orcid":"https://orcid.org/0000-0002-1172-670X","observed_orcids":["https://orcid.org/0000-0002-1172-670X"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter Demant","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center, Buffalo, New York, U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-1172-670X","affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center, Buffalo, New York, U.S.A","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045193381"],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer-susceptibility","display_name":"lung cancer susceptibility","score":1.0},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.7049999833106995},{"id":"https://openalex.org/keywords/qtl-clusters","display_name":"QTL clusters","score":0.5339999794960022},{"id":"https://openalex.org/keywords/evolutionary-conservation","display_name":"evolutionary conservation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/cancer-susceptibility-loci","display_name":"cancer susceptibility loci","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8174603581428528},{"id":"https://openalex.org/C84951073","wikidata":"https://www.wikidata.org/wiki/Q2379153","display_name":"Congenic","level":3,"score":0.7747623920440674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6513864994049072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6421436667442322},{"id":"https://openalex.org/C2779372377","wikidata":"https://www.wikidata.org/wiki/Q17147792","display_name":"Lung cancer susceptibility","level":5,"score":0.5374695658683777},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5178337693214417},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.43374091386795044},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4299442172050476},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.41218259930610657},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.21970823407173157},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.15727469325065613},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.061832308769226074},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05886435508728027}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2021.10.13.461047","doi":"https://doi.org/10.1101/2021.10.13.461047","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.13.461047","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/14/2021.10.13.461047.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2021.10.13.461047","doi":"https://doi.org/10.1101/2021.10.13.461047","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.13.461047","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/14/2021.10.13.461047.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3330469080","display_name":null,"funder_award_id":"R01 CA","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306497","display_name":"Roswell Park Cancer Institute","ror":"https://ror.org/0499dwk57"},{"id":"https://openalex.org/F4320336656","display_name":"Thousand Young Talents Program of China","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205547140.pdf","grobid_xml":"https://content.openalex.org/works/W3205547140.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1964244253","https://openalex.org/W1967989711","https://openalex.org/W1973813521","https://openalex.org/W2006935241","https://openalex.org/W2008574867","https://openalex.org/W2040056194","https://openalex.org/W2052806541","https://openalex.org/W2063414913","https://openalex.org/W2099296937","https://openalex.org/W2153307836","https://openalex.org/W2154340576","https://openalex.org/W2163183874","https://openalex.org/W2168892933","https://openalex.org/W2324138891","https://openalex.org/W2559028527","https://openalex.org/W2612427157","https://openalex.org/W2762272043","https://openalex.org/W2763322182","https://openalex.org/W2766674094","https://openalex.org/W2795842108","https://openalex.org/W2802784998","https://openalex.org/W2808363286","https://openalex.org/W2883616472","https://openalex.org/W2888522927","https://openalex.org/W2898585601","https://openalex.org/W2903533144","https://openalex.org/W2944046200","https://openalex.org/W2998395427","https://openalex.org/W3040338113","https://openalex.org/W3043855777","https://openalex.org/W3131268785"],"related_works":["https://openalex.org/W2099296937","https://openalex.org/W2955394559","https://openalex.org/W4388582916","https://openalex.org/W2766674094","https://openalex.org/W17180322","https://openalex.org/W2025123483","https://openalex.org/W2765719474","https://openalex.org/W1965033845","https://openalex.org/W7097339364","https://openalex.org/W1480398946"],"abstract_inverted_index":{"We":[0],"show":[1],"evolutionarily":[2,91],"conserved":[3,92],"pairwise":[4],"genetic":[5],"linkage":[6],"and":[7,13,21,40,53,82,90],"clustering":[8],"of":[9,11,25,49,58,80],"majority":[10],"colon":[12,81],"lung":[14,83],"cancer":[15,84],"susceptibility":[16,26,43,85],"QTLs":[17],"in":[18,33,47],"mice,":[19],"rats":[20],"humans.":[22],"The":[23],"patterns":[24],"or":[27],"resistance":[28],"to":[29,70],"these":[30,71],"two":[31,60],"cancers":[32],"recombinant":[34],"congenic":[35],"mouse":[36],"strains":[37],"were":[38],"concordant":[39],"the":[41,59],"responsible":[42],"loci":[44],"closely":[45],"linked,":[46],"spite":[48],"completely":[50],"different":[51],"carcinogens":[52],"protocols":[54],"used":[55],"for":[56],"induction":[57],"tumors.":[61],"Most":[62],"DUSP":[63],"(Dual":[64],"specificity":[65],"phosphatase)":[66],"genes":[67],"are":[68],"linked":[69],"clusters.":[72],"These":[73],"data":[74],"suggest":[75],"that":[76],"an":[77],"important":[78],"part":[79],"is":[86],"controlled":[87],"by":[88],"related":[89],"processes.":[93]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-10-25T00:00:00"}
