{"id":"https://openalex.org/W3205523901","doi":"https://doi.org/10.3892/mco.2021.2416","title":"Capecitabine\u2011induced hand\u2011foot syndrome does not emerge in the complex regional pain syndrome\u2011affected limb: A case report","display_name":"Capecitabine\u2011induced hand\u2011foot syndrome does not emerge in the complex regional pain syndrome\u2011affected limb: A case report","publication_year":2021,"publication_date":"2021-10-08","ids":{"openalex":"https://openalex.org/W3205523901","doi":"https://doi.org/10.3892/mco.2021.2416","mag":"3205523901","pmid":"https://pubmed.ncbi.nlm.nih.gov/34671472","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8521386"},"language":"en","primary_location":{"id":"doi:10.3892/mco.2021.2416","doi":"https://doi.org/10.3892/mco.2021.2416","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mco.2021.2416","pdf_url":"https://www.spandidos-publications.com/10.3892/mco.2021.2416/download","source":{"id":"https://openalex.org/S2754683124","display_name":"Molecular and Clinical Oncology","issn_l":"2049-9450","issn":["2049-9450","2049-9469"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.spandidos-publications.com/10.3892/mco.2021.2416/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101037476","display_name":"Reo Inoue","orcid":"https://orcid.org/0000-0001-5093-4379","observed_orcids":["https://orcid.org/0000-0001-5093-4379"]},"institutions":[{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reo Inoue","raw_affiliation_strings":["Anesthesiology and Pain Relief Centre, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology and Pain Relief Centre, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan","institution_ids":["https://openalex.org/I4210109338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076705668","display_name":"Hiroaki Abe","orcid":"https://orcid.org/0000-0002-2493-302X","observed_orcids":["https://orcid.org/0000-0002-2493-302X"]},"institutions":[{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Abe","raw_affiliation_strings":["Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan","institution_ids":["https://openalex.org/I4210109338"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mitsuru Konishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuru Konishi","raw_affiliation_strings":["Department of Pain and Palliative Medical Sciences, Faculty of Medicine, The University of Tokyo, Hongo, Tokyo 113\u20110033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pain and Palliative Medical Sciences, Faculty of Medicine, The University of Tokyo, Hongo, Tokyo 113\u20110033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005474653","display_name":"Rikuhei Tsuchida","orcid":"https://orcid.org/0000-0003-2274-7917","observed_orcids":["https://orcid.org/0000-0003-2274-7917"]},"institutions":[{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rikuhei Tsuchida","raw_affiliation_strings":["Anesthesiology and Pain Relief Centre, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology and Pain Relief Centre, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan","institution_ids":["https://openalex.org/I4210109338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071578522","display_name":"Tatsuma Edamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuma Edamura","raw_affiliation_strings":["Anesthesiology and Pain Relief Centre, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology and Pain Relief Centre, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan","institution_ids":["https://openalex.org/I4210109338"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013210055","display_name":"Masahiko Sumitani","orcid":"https://orcid.org/0000-0002-3662-8217","observed_orcids":["https://orcid.org/0000-0002-3662-8217"]},"institutions":[{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Sumitani","raw_affiliation_strings":["Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Hongo, Tokyo 113\u20110033, Japan","institution_ids":["https://openalex.org/I4210109338"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8889,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.73749776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"6","first_page":"254","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capecitabine","display_name":"capecitabine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hand-foot-syndrome","display_name":"hand-foot syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/complex-regional-pain-syndrome","display_name":"complex regional pain syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anhidrosis","display_name":"anhidrosis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7649999856948853},{"id":"https://openalex.org/keywords/drug-induced-skin-toxicity","display_name":"drug-induced skin toxicity","score":0.5460000038146973},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5370000004768372},{"id":"https://openalex.org/keywords/sweat-glands","display_name":"sweat glands","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.928805947303772},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7954168915748596},{"id":"https://openalex.org/C2780226346","wikidata":"https://www.wikidata.org/wiki/Q1066311","display_name":"Complex regional pain syndrome","level":2,"score":0.7614349126815796},{"id":"https://openalex.org/C2779203496","wikidata":"https://www.wikidata.org/wiki/Q545408","display_name":"Anhidrosis","level":2,"score":0.5533021092414856},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4585215449333191},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37702423334121704},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3747614622116089},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29458722472190857},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2835541069507599},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.1779758632183075}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/mco.2021.2416","doi":"https://doi.org/10.3892/mco.2021.2416","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mco.2021.2416","pdf_url":"https://www.spandidos-publications.com/10.3892/mco.2021.2416/download","source":{"id":"https://openalex.org/S2754683124","display_name":"Molecular and Clinical Oncology","issn_l":"2049-9450","issn":["2049-9450","2049-9469"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8521386","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8521386","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Clin Oncol","raw_type":"Text"},{"id":"pmid:34671472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34671472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and clinical oncology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.3892/mco.2021.2416","doi":"https://doi.org/10.3892/mco.2021.2416","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mco.2021.2416","pdf_url":"https://www.spandidos-publications.com/10.3892/mco.2021.2416/download","source":{"id":"https://openalex.org/S2754683124","display_name":"Molecular and Clinical Oncology","issn_l":"2049-9450","issn":["2049-9450","2049-9469"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205523901.pdf","grobid_xml":"https://content.openalex.org/works/W3205523901.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W59036416","https://openalex.org/W140910456","https://openalex.org/W1934171250","https://openalex.org/W1980663083","https://openalex.org/W2011552722","https://openalex.org/W2035418725","https://openalex.org/W2038232468","https://openalex.org/W2053622367","https://openalex.org/W2062611780","https://openalex.org/W2078797595","https://openalex.org/W2089709511","https://openalex.org/W2122525453","https://openalex.org/W2135498562","https://openalex.org/W2146161922","https://openalex.org/W2156017996","https://openalex.org/W2198934477","https://openalex.org/W2343038120","https://openalex.org/W2560029428","https://openalex.org/W2735958658"],"related_works":["https://openalex.org/W7098364169","https://openalex.org/W4404649458","https://openalex.org/W1980663083","https://openalex.org/W7217756945","https://openalex.org/W162399469","https://openalex.org/W2154594654","https://openalex.org/W2799652199","https://openalex.org/W2153625933","https://openalex.org/W3081699945","https://openalex.org/W4285491759"],"abstract_inverted_index":{"Hand-foot":[0],"syndrome":[1,90],"(HFS)":[2],"is":[3],"a":[4,43,144],"frequent":[5],"adverse":[6],"effect":[7],"of":[8,22,61,111,128,136,147],"various":[9],"anti-tumour":[10],"drugs,":[11],"such":[12],"as":[13],"capecitabine,":[14,95],"that":[15],"affects":[16],"their":[17,96],"dose-limiting":[18],"toxicity.":[19],"The":[20,39,80,102,119],"mechanism":[21,146],"HFS":[23,129,148],"remains":[24],"unknown":[25],"and":[26,68,76,105],"there":[27],"are":[28],"currently":[29],"no":[30],"effective":[31],"strategies":[32],"to":[33,55,116],"treat":[34],"HFS,":[35,112],"except":[36],"for":[37,86],"cessation.":[38,118],"current":[40],"study":[41],"presented":[42],"female":[44],"case":[45],"where":[46],"one":[47],"hand,":[48],"affected":[49],"by":[50],"brachial":[51],"plexus":[52],"infiltration":[53],"due":[54],"the":[56,83,125,133],"subclavian":[57],"lymph":[58],"node":[59],"metastasis":[60],"breast":[62],"cancer,":[63],"exhibited":[64],"not":[65],"only":[66],"pain":[67,89],"partial":[69],"motor":[70],"paralysis":[71],"but":[72],"also":[73],"anhidrosis,":[74,132],"oedema":[75],"skin":[77],"colour":[78],"changes.":[79],"patient":[81],"met":[82],"diagnostic":[84],"criteria":[85],"complex":[87],"regional":[88],"(CRPS).":[91],"After":[92],"treatment":[93],"with":[94,131],"anhidrosis":[97],"hand":[98,104,121],"completely":[99],"prevented":[100],"HFS.":[101],"other":[103],"both":[106],"feet":[107],"demonstrated":[108],"typical":[109],"symptoms":[110],"which":[113],"improved":[114],"consequent":[115],"capecitabine":[117,138],"CRPS-affected":[120],"remained":[122],"normal.":[123],"Considering":[124],"limited":[126],"presentation":[127],"concomitant":[130],"exocrine":[134],"release":[135],"condensed":[137],"through":[139],"sweat":[140],"glands":[141],"might":[142],"be":[143],"promising":[145],"induction.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-10-25T00:00:00"}
