{"id":"https://openalex.org/W3205496974","doi":null,"title":"Engineering inducible cell lines for recombinant Adeno-Associated Virus production","display_name":"Engineering inducible cell lines for recombinant Adeno-Associated Virus production","publication_year":2021,"publication_date":"2021-08-01","ids":{"openalex":"https://openalex.org/W3205496974","mag":"3205496974"},"language":"en","primary_location":{"id":"pmh:oai:conservancy.umn.edu:11299/225020","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11299/225020","pdf_url":"https://hdl.handle.net/11299/225020","source":{"id":"https://openalex.org/S4306402521","display_name":"University of Minnesota Digital Conservancy (University of Minnesota)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130238516","host_organization_name":"University of Minnesota","host_organization_lineage":["https://openalex.org/I130238516"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11299/225020","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088646150","display_name":"Zion Lee","orcid":"https://orcid.org/0000-0002-6869-4198","observed_orcids":["https://orcid.org/0000-0002-6869-4198"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zion Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6869-4198","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088646150"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.46880000829696655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.8999999761581421},{"id":"https://openalex.org/keywords/recombinant-aav-production","display_name":"recombinant AAV production","score":0.9259999990463257},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.7039999961853027},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.4819999933242798},{"id":"https://openalex.org/keywords/viral-vector-production","display_name":"viral vector production","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.8911501169204712},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6885295510292053},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5701219439506531},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4539797008037567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4288506805896759},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.27097582817077637},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22084271907806396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1381990909576416}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:conservancy.umn.edu:11299/225020","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11299/225020","pdf_url":"https://hdl.handle.net/11299/225020","source":{"id":"https://openalex.org/S4306402521","display_name":"University of Minnesota Digital Conservancy (University of Minnesota)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130238516","host_organization_name":"University of Minnesota","host_organization_lineage":["https://openalex.org/I130238516"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"mag:3205496974","doi":null,"is_oa":false,"landing_page_url":"https://conservancy.umn.edu/handle/11299/225020","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:conservancy.umn.edu:11299/225020","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11299/225020","pdf_url":"https://hdl.handle.net/11299/225020","source":{"id":"https://openalex.org/S4306402521","display_name":"University of Minnesota Digital Conservancy (University of Minnesota)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130238516","host_organization_name":"University of Minnesota","host_organization_lineage":["https://openalex.org/I130238516"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205496974.pdf","grobid_xml":"https://content.openalex.org/works/W3205496974.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W1489777963","https://openalex.org/W1523117612","https://openalex.org/W1604836384","https://openalex.org/W1619719840","https://openalex.org/W1810920534","https://openalex.org/W1831834373","https://openalex.org/W1971578941","https://openalex.org/W1972148441","https://openalex.org/W1976329054","https://openalex.org/W1979659851","https://openalex.org/W1982076968","https://openalex.org/W1982609556","https://openalex.org/W1989069389","https://openalex.org/W1994064996","https://openalex.org/W2000853857","https://openalex.org/W2001859776","https://openalex.org/W2006588585","https://openalex.org/W2010666698","https://openalex.org/W2018420071","https://openalex.org/W2019814860","https://openalex.org/W2026505509","https://openalex.org/W2026854040","https://openalex.org/W2027852704","https://openalex.org/W2032516674","https://openalex.org/W2035671670","https://openalex.org/W2042131554","https://openalex.org/W2048941695","https://openalex.org/W2049974202","https://openalex.org/W2051072233","https://openalex.org/W2051159468","https://openalex.org/W2056597498","https://openalex.org/W2060873330","https://openalex.org/W2062622002","https://openalex.org/W2066750991","https://openalex.org/W2068065419","https://openalex.org/W2076356087","https://openalex.org/W2077122170","https://openalex.org/W2079090019","https://openalex.org/W2086844465","https://openalex.org/W2087396336","https://openalex.org/W2090856790","https://openalex.org/W2092390808","https://openalex.org/W2093343938","https://openalex.org/W2096289466","https://openalex.org/W2113875073","https://openalex.org/W2114865184","https://openalex.org/W2115124797","https://openalex.org/W2117514532","https://openalex.org/W2118812883","https://openalex.org/W2119280607","https://openalex.org/W2119497317","https://openalex.org/W2124833370","https://openalex.org/W2126770839","https://openalex.org/W2130005269","https://openalex.org/W2131134586","https://openalex.org/W2131871590","https://openalex.org/W2135993011","https://openalex.org/W2140423552","https://openalex.org/W2144328273","https://openalex.org/W2147193337","https://openalex.org/W2148223197","https://openalex.org/W2149522560","https://openalex.org/W2149765709","https://openalex.org/W2161535481","https://openalex.org/W2163278605","https://openalex.org/W2165065847","https://openalex.org/W2165815741","https://openalex.org/W2169232403","https://openalex.org/W2171960436","https://openalex.org/W2172134808","https://openalex.org/W2174590326","https://openalex.org/W2190715683","https://openalex.org/W2235247229","https://openalex.org/W2265552569","https://openalex.org/W2269026928","https://openalex.org/W2394621867","https://openalex.org/W2418367670","https://openalex.org/W2428196399","https://openalex.org/W2474885948","https://openalex.org/W2559723230","https://openalex.org/W2561718265","https://openalex.org/W2586988241","https://openalex.org/W2606339183","https://openalex.org/W2606923561","https://openalex.org/W2607237411","https://openalex.org/W2607363971","https://openalex.org/W2786631874","https://openalex.org/W2883052546","https://openalex.org/W2883800592","https://openalex.org/W2888734161","https://openalex.org/W2892397277","https://openalex.org/W2899451645","https://openalex.org/W2921841818","https://openalex.org/W2928521482","https://openalex.org/W2962334628","https://openalex.org/W2965286186","https://openalex.org/W2969800101","https://openalex.org/W3000778706","https://openalex.org/W3004898466","https://openalex.org/W3026609212","https://openalex.org/W3034570116","https://openalex.org/W3088224260","https://openalex.org/W3120585537","https://openalex.org/W3126836997","https://openalex.org/W3130546939","https://openalex.org/W3140228115","https://openalex.org/W3152028382","https://openalex.org/W4233229998","https://openalex.org/W4239629847"],"related_works":["https://openalex.org/W7198016381","https://openalex.org/W3197740673","https://openalex.org/W7043802314","https://openalex.org/W4245648919","https://openalex.org/W2334342961","https://openalex.org/W7097702388","https://openalex.org/W121665557","https://openalex.org/W2210904745","https://openalex.org/W6986587863","https://openalex.org/W4253351667"],"abstract_inverted_index":{"University":[0],"of":[1],"Minnesota":[2],"Ph.D.":[3],"dissertation.":[4],"2021.":[5],"Major:":[6],"Chemical":[7],"Engineering.":[8],"Advisor:":[9],"Wei-Shou":[10],"Hu.":[11],"1":[12],"computer":[13],"file":[14],"(PDF);":[15],"ix,":[16],"74":[17],"pages.":[18]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-10-25T00:00:00"}