{"id":"https://openalex.org/W3205364604","doi":"https://doi.org/10.1016/j.jad.2021.10.004","title":"Sex-specificities in anxiety and depressive symptoms across the lifespan and their links with multimodal neuroimaging","display_name":"Sex-specificities in anxiety and depressive symptoms across the lifespan and their links with multimodal neuroimaging","publication_year":2021,"publication_date":"2021-10-11","ids":{"openalex":"https://openalex.org/W3205364604","doi":"https://doi.org/10.1016/j.jad.2021.10.004","mag":"3205364604","pmid":"https://pubmed.ncbi.nlm.nih.gov/34637806"},"language":"en","primary_location":{"id":"doi:10.1016/j.jad.2021.10.004","doi":"https://doi.org/10.1016/j.jad.2021.10.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jad.2021.10.004","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0165032721010727/pdf","source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0165032721010727/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075926565","display_name":"In\u00e8s Moulinet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I4387153933","display_name":"Physiopathologie et imagerie des troubles neurologiques","ror":"https://ror.org/00vsvph51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4387153933","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"In\u00e8s Moulinet","raw_affiliation_strings":["Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038278091","display_name":"Brigitte Landeau","orcid":"https://orcid.org/0000-0002-0814-3714","observed_orcids":["https://orcid.org/0000-0002-0814-3714"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I4387153933","display_name":"Physiopathologie et imagerie des troubles neurologiques","ror":"https://ror.org/00vsvph51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4387153933","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Brigitte Landeau","raw_affiliation_strings":["Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037640626","display_name":"Edelweiss Touron","orcid":"https://orcid.org/0000-0001-7906-934X","observed_orcids":["https://orcid.org/0000-0001-7906-934X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I4387153933","display_name":"Physiopathologie et imagerie des troubles neurologiques","ror":"https://ror.org/00vsvph51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4387153933","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Edelweiss Touron","raw_affiliation_strings":["Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012752822","display_name":"Vincent de La Sayette","orcid":"https://orcid.org/0000-0003-0663-092X","observed_orcids":["https://orcid.org/0000-0003-0663-092X","https://orcid.org/0009-0001-4921-4507"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I159885104","display_name":"\u00c9cole Pratique des Hautes \u00c9tudes","ror":"https://ror.org/046b3cj80","country_code":"FR","type":"education","lineage":["https://openalex.org/I159885104","https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210114068","display_name":"Centre Hospitalier Universitaire de Caen Normandie","ror":"https://ror.org/027arzy69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210114068"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I4387155412","display_name":"Neuropsychologie et Imagerie de la M\u00e9moire Humaine","ror":"https://ror.org/04f6tkx67","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210105918","https://openalex.org/I4387155412","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent De La Sayette","raw_affiliation_strings":["Normandie Univ, UNICAEN, EPHE, INSERM, U1077, PSL Recherche Universit\u00e9s, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, GIP Cyceron, Caen 14000, France; Service de Neurologie, CHU de Caen, Caen, France","Normandie Univ, UNICAEN, EPHE, INSERM, U1077, PSL Recherche Universit\u00e9s, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, GIP Cyceron, Caen 14000, France","Service de Neurologie, CHU de Caen, Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Normandie Univ, UNICAEN, EPHE, INSERM, U1077, PSL Recherche Universit\u00e9s, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, GIP Cyceron, Caen 14000, France; Service de Neurologie, CHU de Caen, Caen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I4210114068","https://openalex.org/I4210154143","https://openalex.org/I4387155412","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Normandie Univ, UNICAEN, EPHE, INSERM, U1077, PSL Recherche Universit\u00e9s, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, GIP Cyceron, Caen 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I4210114068","https://openalex.org/I4387155412","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Service de Neurologie, CHU de Caen, Caen, France","institution_ids":["https://openalex.org/I4210114068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069352392","display_name":"B\u00e9atrice Desgranges","orcid":"https://orcid.org/0000-0002-3657-9996","observed_orcids":["https://orcid.org/0000-0002-3657-9996"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I159885104","display_name":"\u00c9cole Pratique des Hautes \u00c9tudes","ror":"https://ror.org/046b3cj80","country_code":"FR","type":"education","lineage":["https://openalex.org/I159885104","https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210114068","display_name":"Centre Hospitalier Universitaire de Caen Normandie","ror":"https://ror.org/027arzy69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210114068"]},{"id":"https://openalex.org/I4387155412","display_name":"Neuropsychologie et Imagerie de la M\u00e9moire Humaine","ror":"https://ror.org/04f6tkx67","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I2746051580","https://openalex.org/I4210105918","https://openalex.org/I4387155412","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B\u00e9atrice Desgranges","raw_affiliation_strings":["Normandie Univ, UNICAEN, EPHE, INSERM, U1077, PSL Recherche Universit\u00e9s, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, GIP Cyceron, Caen 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Normandie Univ, UNICAEN, EPHE, INSERM, U1077, PSL Recherche Universit\u00e9s, CHU de Caen, Neuropsychologie et Imagerie de la M\u00e9moire Humaine, GIP Cyceron, Caen 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I4210114068","https://openalex.org/I4387155412","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004749164","display_name":"Denis Vivien","orcid":"https://orcid.org/0000-0002-7636-2185","observed_orcids":["https://orcid.org/0000-0002-7636-2185"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210114068","display_name":"Centre Hospitalier Universitaire de Caen Normandie","ror":"https://ror.org/027arzy69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210114068"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I4387153933","display_name":"Physiopathologie et imagerie des troubles neurologiques","ror":"https://ror.org/00vsvph51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4387153933","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denis Vivien","raw_affiliation_strings":["Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France; Department of Clinical Research, Caen Normandy Hospital (CHU) de Caen, Caen 14000, France","Department of Clinical Research, Caen Normandy Hospital (CHU) de Caen, Caen 14000, France","Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France; Department of Clinical Research, Caen Normandy Hospital (CHU) de Caen, Caen 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Department of Clinical Research, Caen Normandy Hospital (CHU) de Caen, Caen 14000, France","institution_ids":["https://openalex.org/I4210114068"]},{"raw_affiliation_string":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013518357","display_name":"Natalie L. Marchant","orcid":"https://orcid.org/0000-0003-0669-6910","observed_orcids":["https://orcid.org/0000-0003-0669-6910"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natalie Marchant","raw_affiliation_strings":["Division of Psychiatry, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015213682","display_name":"G\u00e9raldine Poisnel","orcid":"https://orcid.org/0000-0001-7943-1281","observed_orcids":["https://orcid.org/0000-0001-7943-1281"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I4387153933","display_name":"Physiopathologie et imagerie des troubles neurologiques","ror":"https://ror.org/00vsvph51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4387153933","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G\u00e9raldine Poisnel","raw_affiliation_strings":["Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007086576","display_name":"Ga\u00ebl Ch\u00e9telat","orcid":"https://orcid.org/0000-0002-4889-7932","observed_orcids":["https://orcid.org/0000-0002-4889-7932"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105918","display_name":"Normandie Universit\u00e9","ror":"https://ror.org/01k40cz91","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I4387153933","display_name":"Physiopathologie et imagerie des troubles neurologiques","ror":"https://ror.org/00vsvph51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4387153933","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Ga\u00ebl Ch\u00e9telat","raw_affiliation_strings":["Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France. Electronic address: chetelat@cyceron.fr","Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France. Electronic address: chetelat@cyceron.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Normandie Univ, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, 4 Bvd Henri Becquerel, Caen 14000, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5007086576"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210105918","https://openalex.org/I4210154143","https://openalex.org/I4387153933","https://openalex.org/I98702875"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":{"value":2730,"currency":"EUR","value_usd":2944},"fwci":1.0899,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75130531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"296","issue":null,"first_page":"593","last_page":"602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anxiety-symptoms","display_name":"anxiety symptoms","score":0.9729999899864197},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":1.0},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9789999723434448},{"id":"https://openalex.org/keywords/lifespan-development","display_name":"lifespan development","score":0.6129999756813049},{"id":"https://openalex.org/keywords/alzheimer-s-disease-risk","display_name":"Alzheimer's disease risk","score":0.8870000243186951},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.7820000052452087},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8610000014305115},{"id":"https://openalex.org/keywords/amyloid-pet","display_name":"amyloid PET","score":0.8999999761581421},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.9549999833106995},{"id":"https://openalex.org/keywords/structural-mri","display_name":"structural MRI","score":0.7369999885559082},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.7480000257492065},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.8349811434745789},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.7350972890853882},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5564113259315491},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.5346742272377014},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5294023752212524},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.49859046936035156},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.35737234354019165},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33129721879959106},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.305172324180603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2573157846927643}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jad.2021.10.004","doi":"https://doi.org/10.1016/j.jad.2021.10.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jad.2021.10.004","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0165032721010727/pdf","source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},{"id":"pmid:34637806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34637806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of affective disorders","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05749371v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05749371","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Affective Disorders, 2022, 296, pp.593-602. ⟨10.1016/j.jad.2021.10.004⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.jad.2021.10.004","doi":"https://doi.org/10.1016/j.jad.2021.10.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jad.2021.10.004","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0165032721010727/pdf","source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5657553712","display_name":null,"funder_award_id":"AAP 2013","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G620848983","display_name":null,"funder_award_id":"LONGVIE 2007","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7432890126","display_name":"Investigating the impact of meditation training on mental health and wellbeing in the ageing population","funder_award_id":"667696","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322130","display_name":"Association France Alzheimer","ror":"https://ror.org/015yand93"},{"id":"https://openalex.org/F4320329010","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16"},{"id":"https://openalex.org/F4320329938","display_name":"R\u00e9gion Normandie","ror":"https://ror.org/03cq89j92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205364604.pdf","grobid_xml":"https://content.openalex.org/works/W3205364604.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W132371621","https://openalex.org/W609049029","https://openalex.org/W1551333599","https://openalex.org/W1607171655","https://openalex.org/W1792740614","https://openalex.org/W1847168837","https://openalex.org/W1968756080","https://openalex.org/W1969298821","https://openalex.org/W1969686278","https://openalex.org/W1970129540","https://openalex.org/W1974243531","https://openalex.org/W1980261142","https://openalex.org/W1982195105","https://openalex.org/W1982826699","https://openalex.org/W1983719968","https://openalex.org/W1984462107","https://openalex.org/W1988104043","https://openalex.org/W1999233676","https://openalex.org/W2007641266","https://openalex.org/W2007721897","https://openalex.org/W2015540524","https://openalex.org/W2019743404","https://openalex.org/W2025262281","https://openalex.org/W2034199982","https://openalex.org/W2043616512","https://openalex.org/W2049163404","https://openalex.org/W2049167320","https://openalex.org/W2049932209","https://openalex.org/W2050214509","https://openalex.org/W2053859325","https://openalex.org/W2064378998","https://openalex.org/W2076960269","https://openalex.org/W2081481111","https://openalex.org/W2101514363","https://openalex.org/W2104214286","https://openalex.org/W2105870669","https://openalex.org/W2106188323","https://openalex.org/W2106931873","https://openalex.org/W2107381357","https://openalex.org/W2121778399","https://openalex.org/W2127613563","https://openalex.org/W2129497119","https://openalex.org/W2129795806","https://openalex.org/W2131386294","https://openalex.org/W2131823335","https://openalex.org/W2134126124","https://openalex.org/W2134892170","https://openalex.org/W2139095467","https://openalex.org/W2146355700","https://openalex.org/W2149039050","https://openalex.org/W2159531352","https://openalex.org/W2159617025","https://openalex.org/W2173274334","https://openalex.org/W2231366022","https://openalex.org/W2337539519","https://openalex.org/W2462869437","https://openalex.org/W2510458273","https://openalex.org/W2595875607","https://openalex.org/W2616302329","https://openalex.org/W2619446912","https://openalex.org/W2737702854","https://openalex.org/W2775352283","https://openalex.org/W2780232561","https://openalex.org/W2782579702","https://openalex.org/W2797154203","https://openalex.org/W2798054687","https://openalex.org/W2885621583","https://openalex.org/W2914880683","https://openalex.org/W2952574438","https://openalex.org/W3128184085"],"related_works":["https://openalex.org/W2737702854","https://openalex.org/W2048494908","https://openalex.org/W4205410650","https://openalex.org/W4283205856","https://openalex.org/W4312087300","https://openalex.org/W4318542695","https://openalex.org/W2985953089","https://openalex.org/W4321013994","https://openalex.org/W4412657367","https://openalex.org/W3206252609"],"abstract_inverted_index":{"BACKGROUND:":[0],"Anxiety":[1],"and":[2,16,29,44,50,81,87,90,97,130,132,172],"depressive":[3,45,82,118,207],"symptoms":[4,46,83,119,150,156,163,198,235],"are":[5,17],"associated":[6,165],"with":[7,35,48,84,152,166,175,199],"impaired":[8],"well-being,":[9],"higher":[10],"risk":[11,18],"of":[12,79,100,143,178,204],"developing":[13],"psychoaffective":[14],"disorders":[15],"factors":[19],"for":[20,238],"Alzheimer's":[21],"disease":[22],"(AD).":[23],"To":[24],"further":[25],"understand":[26],"their":[27,33],"relevance":[28],"the":[30,57,85,113,140,212,216,230],"mechanisms":[31],"underlying":[32],"link":[34],"AD,":[36],"our":[37],"aims":[38],"were":[39,102,109,164],"to":[40,52,111,138,232],"assess":[41,112],"how":[42],"anxiety":[43,80,116,155,162,197,234],"changed":[47],"age":[49],"related":[51],"AD":[53],"neuroimaging":[54,91],"biomarkers":[55],"across":[56],"adult":[58],"lifespan,":[59],"while":[60,154],"also":[61],"exploring":[62],"sex":[63,144],"specificities.":[64],"METHODS:":[65],"210":[66],"cognitively":[67],"normal":[68],"participants":[69,205],"aged":[70],"19-86":[71],"years":[72],"(101":[73],"men,":[74],"109":[75],"women)":[76],"completed":[77],"assessments":[78,237],"STAI-A":[86],"MADRS":[88],"respectively,":[89],"measurements":[92],"including":[93],"structural":[94],"MRI,":[95],"FDG-PET":[96],"amyloid-PET.":[98],"167":[99],"those":[101],"followed-up":[103],"over":[104],"1.5-3":[105],"years.":[106],"Multiple":[107],"regressions":[108],"performed":[110],"links":[114],"between":[115],"or":[117,124],"versus":[120],"age,":[121,153],"global":[122],"cognition":[123],"each":[125],"imaging":[126],"modality,":[127],"both":[128],"cross-sectionally":[129],"longitudinally;":[131],"general":[133],"linear":[134],"models":[135],"we":[136],"used":[137],"test":[139],"interactive":[141],"effect":[142],"on":[145],"these":[146],"associations.":[147],"RESULTS:":[148],"Depressive":[149],"decreased":[151],"increased":[157],"only":[158,184,188],"among":[159],"women.":[160,186,243],"Higher":[161],"lower":[167],"grey":[168],"matter":[169],"(GM)":[170],"volume":[171,192],"glucose":[173],"metabolism,":[174],"an":[176,194],"interaction":[177],"sex,":[179],"this":[180],"relationship":[181],"being":[182],"significant":[183],"in":[185,196,215,236,242],"Longitudinally,":[187],"low":[189,213],"baseline":[190],"GM":[191],"predicted":[193],"increase":[195],"time.":[200],"LIMITATIONS:":[201],"Only":[202],"43%":[203],"reported":[206],"symptoms.":[208],"Despite":[209],"additional":[210],"analyses,":[211],"variability":[214],"measure":[217],"might":[218],"have":[219],"prevented":[220],"us":[221],"from":[222],"detecting":[223],"subtle":[224],"changes.":[225],"CONCLUSIONS:":[226],"This":[227],"study":[228],"emphasizes":[229],"need":[231],"consider":[233],"dementia":[239],"risk,":[240],"particularly":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-10-25T00:00:00"}