{"id":"https://openalex.org/W3205207270","doi":null,"title":"Retrospective Study of Safety and Effectiveness of Levodopa in Patients with Parkinsonandrsquo;s Disease","display_name":"Retrospective Study of Safety and Effectiveness of Levodopa in Patients with Parkinsonandrsquo;s Disease","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3205207270","mag":"3205207270"},"language":"en","primary_location":{"id":"mag:3205207270","doi":null,"is_oa":false,"landing_page_url":"https://www.longdom.org/open-access/retrospective-study-of-safety-and-effectiveness-of-levodopa-in-patients-with-parkinsons-disease.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037012760","display_name":"Linghui Wang","orcid":"https://orcid.org/0000-0003-2492-7364","observed_orcids":["https://orcid.org/0000-0003-2492-7364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linghui Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2492-7364","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061654403","display_name":"Lei Xu","orcid":"https://orcid.org/0000-0002-4095-6539","observed_orcids":["https://orcid.org/0000-0002-4095-6539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4095-6539","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"9","issue":"7","first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levodopa","display_name":"levodopa","score":0.9909999966621399},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8619999885559082},{"id":"https://openalex.org/keywords/wearing-off-phenomenon","display_name":"wearing-off phenomenon","score":0.7459999918937683},{"id":"https://openalex.org/keywords/dyskinesia","display_name":"dyskinesia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.722000002861023},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.5220000147819519},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.46700000762939453},{"id":"https://openalex.org/keywords/china","display_name":"China","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.9450839161872864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7193870544433594},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6646614670753479},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.6401957273483276},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.5280379056930542},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5113727450370789},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49237048625946045},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44377368688583374},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.42835739254951477},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.37486645579338074},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.36128509044647217},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16156992316246033},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3205207270","doi":null,"is_oa":false,"landing_page_url":"https://www.longdom.org/open-access/retrospective-study-of-safety-and-effectiveness-of-levodopa-in-patients-with-parkinsons-disease.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1533056363","https://openalex.org/W1980495418","https://openalex.org/W2000216201","https://openalex.org/W2009706073","https://openalex.org/W2010206955","https://openalex.org/W2035890213","https://openalex.org/W2052644551","https://openalex.org/W2118315022","https://openalex.org/W2139691646","https://openalex.org/W2149102126","https://openalex.org/W2626406141","https://openalex.org/W2953280198","https://openalex.org/W2965325483","https://openalex.org/W3005872741"],"related_works":["https://openalex.org/W2025685829","https://openalex.org/W6967644722","https://openalex.org/W4312686736","https://openalex.org/W2953280198","https://openalex.org/W2068153776","https://openalex.org/W21751063","https://openalex.org/W2587779319","https://openalex.org/W2802749084","https://openalex.org/W2171241738","https://openalex.org/W1991538916"],"abstract_inverted_index":{"Levodopa":[0],"has":[1],"been":[2],"widely":[3],"used":[4,117],"to":[5,46,118,237],"treat":[6],"symptoms":[7],"of":[8,27,37,52,65,73,84,101,125,136,147,164,244],"Parkinson\u2019s":[9,105],"Disease":[10,106],"(PD);":[11],"it":[12],"is":[13,42],"regarded":[14],"as":[15,149],"the":[16,25,32,48,61,78,90,120,152,158,190,225,240],"most":[17],"effective":[18],"therapy":[19],"for":[20,221],"PD":[21,38,66,222],"at":[22,97],"present.":[23],"Although":[24],"usage":[26],"levodopa":[28,53,69,102,129,137,215,245],"rapidly":[29],"increased":[30],"with":[31,93,231],"number":[33],"and":[34,50,63,110,123,173,185,207,242],"health":[35],"burden":[36],"in":[39,54,70,89,145,157,202,224,247],"China,":[40],"there":[41],"no":[43,199],"systematic":[44],"review":[45],"evaluate":[47,119],"efficiency":[49,62],"safety":[51,64,243],"China":[55],"mainland.":[56],"Here,":[57],"we":[58],"retrospectively":[59],"analyzed":[60],"treatment":[67,138,216,246],"using":[68],"Affiliated":[71],"Hospital":[72],"Shandong":[74,226],"Medical":[75],"College":[76],"during":[77],"last":[79],"decade":[80],"(2010-2020).":[81],"A":[82,162],"total":[83,163],"432":[85,169],"patients":[86,95,223],"were":[87,116,139,189,198],"included":[88],"present":[91],"study,":[92],"all":[94],"completed":[96],"least":[98],"24":[99],"weeks":[100],"treatment.":[103],"Unified":[104],"Rating":[107,113],"Scale":[108,114],"(UPDRS)":[109],"Hamilton":[111],"Depression":[112],"(HAMD)":[115],"drug":[121],"efficacy":[122,241],"management":[124],"affective":[126],"disorder":[127],"after":[128],"treatment,":[130],"respectively,":[131],"while":[132],"any":[133],"adverse":[134,203],"effects":[135],"recorded.":[140],"Patients":[141],"experienced":[142],"significant":[143,200],"improvements":[144],"quality":[146],"life,":[148],"recorded":[150],"by":[151,195],"mean":[153],"change":[154],"from":[155],"baseline":[156],"UPDRS":[159],"index":[160],"(p<0.001).":[161],"Adverse":[165],"Events":[166],"(AE)":[167],"was":[168],"cases,":[170],"2":[171],"deaths":[172],"3":[174],"serious":[175],"AE":[176,193],"occurred.":[177],"Wearing":[178],"off":[179],"(n=221,":[180],"51.15%),":[181],"dyskinesia":[182],"(n=174,":[183],"40.28%)":[184],"constipation":[186],"(n=131,":[187],"30.32%)":[188],"top":[191],"three":[192],"caused":[194],"levodopa.":[196],"There":[197],"differences":[201],"events":[204],"between":[205],"male":[206],"female.":[208],"In":[209],"conclusion,":[210],"our":[211],"results":[212],"demonstrated":[213],"that":[214],"offers":[217],"a":[218,232],"promising":[219],"option":[220],"area.":[227],"However,":[228],"more":[229],"studies":[230],"larger":[233],"sample":[234],"are":[235],"needed":[236],"further":[238],"confirm":[239],"China.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-25T00:00:00"}
