{"id":"https://openalex.org/W3205089872","doi":"https://doi.org/10.1172/jci136329","title":"The key role of NLRP3 and STING in APOL1-associated podocytopathy","display_name":"The key role of NLRP3 and STING in APOL1-associated podocytopathy","publication_year":2021,"publication_date":"2021-10-14","ids":{"openalex":"https://openalex.org/W3205089872","doi":"https://doi.org/10.1172/jci136329","mag":"3205089872","pmid":"https://pubmed.ncbi.nlm.nih.gov/34651582","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8516463"},"language":"en","primary_location":{"id":"doi:10.1172/jci136329","doi":"https://doi.org/10.1172/jci136329","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci136329","pdf_url":"http://www.jci.org/articles/view/136329/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/136329/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065510367","display_name":"Junnan Wu","orcid":"https://orcid.org/0000-0002-0624-2057","observed_orcids":["https://orcid.org/0000-0002-0624-2057"]},"institutions":[{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Junnan Wu","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-0624-2057","affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046348410","display_name":"Archana Raman","orcid":"https://orcid.org/0000-0003-2819-4962","observed_orcids":["https://orcid.org/0000-0003-2819-4962"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Archana Raman","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0003-2819-4962","affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021663047","display_name":"Nathan J. Coffey","orcid":"https://orcid.org/0000-0002-9413-5533","observed_orcids":["https://orcid.org/0000-0002-9413-5533"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan J. Coffey","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-9413-5533","affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035659936","display_name":"Xin Sheng","orcid":"https://orcid.org/0000-0002-3620-3577","observed_orcids":["https://orcid.org/0000-0002-3620-3577"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Sheng","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-3620-3577","affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079633596","display_name":"Joseph Wahba","orcid":"https://orcid.org/0009-0001-9724-6052","observed_orcids":["https://orcid.org/0009-0001-9724-6052"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Wahba","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004406848","display_name":"Matthew J. Seasock","orcid":"https://orcid.org/0000-0002-5940-5913","observed_orcids":["https://orcid.org/0000-0002-5940-5913"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Seasock","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-5940-5913","affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028346981","display_name":"Ziyuan Ma","orcid":"https://orcid.org/0000-0002-1512-8993","observed_orcids":["https://orcid.org/0000-0002-1512-8993","https://orcid.org/0009-0009-6136-5875"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziyuan Ma","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-1512-8993","affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067159616","display_name":"Pazit Beckerman","orcid":"https://orcid.org/0000-0003-3061-6757","observed_orcids":["https://orcid.org/0000-0003-3061-6757"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pazit Beckerman","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048881030","display_name":"Dorottya I. Laczko","orcid":"https://orcid.org/0000-0002-6598-7411","observed_orcids":["https://orcid.org/0000-0002-6598-7411"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorottya Laczk\u00f3","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111734699","display_name":"Matthew B. Palmer","orcid":"https://orcid.org/0000-0002-9052-3694","observed_orcids":["https://orcid.org/0000-0002-9052-3694"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew B. Palmer","raw_affiliation_strings":["Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044494633","display_name":"Jeffrey B. Kopp","orcid":"https://orcid.org/0000-0001-9052-186X","observed_orcids":["https://orcid.org/0000-0001-9052-186X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey B. Kopp","raw_affiliation_strings":["Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0001-9052-186X","affiliations":[{"raw_affiliation_string":"Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026798465","display_name":"Jay J. Kuo","orcid":"https://orcid.org/0000-0001-8741-2638","observed_orcids":["https://orcid.org/0000-0001-8741-2638"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay J. Kuo","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA"],"raw_orcid":"https://orcid.org/0000-0001-8741-2638","affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034648951","display_name":"Steven S. Pullen","orcid":"https://orcid.org/0009-0007-5520-4771","observed_orcids":["https://orcid.org/0009-0007-5520-4771"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven S. Pullen","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069463387","display_name":"Carine Boustany","orcid":"https://orcid.org/0000-0003-1333-2242","observed_orcids":["https://orcid.org/0000-0003-1333-2242"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carine M. Boustany-Kari","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA"],"raw_orcid":"https://orcid.org/0000-0003-1333-2242","affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025159973","display_name":"Andreas Linkermann","orcid":"https://orcid.org/0000-0001-6287-9725","observed_orcids":["https://orcid.org/0000-0001-6287-9725"]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Linkermann","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6287-9725","affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057297665","display_name":"Katalin Suszt\u00e1k","orcid":"https://orcid.org/0000-0002-1005-3726","observed_orcids":["https://orcid.org/0000-0002-1005-3726"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katalin Susztak","raw_affiliation_strings":["Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-1005-3726","affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal-Electrolyte and Hypertension Division, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5057297665"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":15.7242,"has_fulltext":true,"cited_by_count":142,"citation_normalized_percentile":{"value":0.99619491,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"131","issue":"20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apol1","display_name":"APOL1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/podocytopathy","display_name":"podocytopathy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.8309999704360962},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/podocytes","display_name":"podocytes","score":0.6069999933242798},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.6110000014305115},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.906000018119812},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nlrp3-knockout-mice","display_name":"NLRP3 knockout mice","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mcc950","display_name":"MCC950","score":0.8399999737739563},{"id":"https://openalex.org/keywords/disulfiram","display_name":"disulfiram","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nlrp3-inhibitors","display_name":"NLRP3 inhibitors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/sting-inhibitors","display_name":"STING inhibitors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.775081992149353},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.6900571584701538},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.6355481147766113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6273764371871948},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5061964392662048},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4463132619857788},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.41985630989074707},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35802990198135376},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34443438053131104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32120171189308167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22984382510185242},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22410935163497925},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14743995666503906},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.11284273862838745},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.07604467868804932},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000075944","descriptor_name":"Apolipoprotein L1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000075944","descriptor_name":"Apolipoprotein L1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000099197","descriptor_name":"STING Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci136329","doi":"https://doi.org/10.1172/jci136329","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci136329","pdf_url":"http://www.jci.org/articles/view/136329/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8516463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8516463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:34651582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34651582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci136329","doi":"https://doi.org/10.1172/jci136329","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci136329","pdf_url":"http://www.jci.org/articles/view/136329/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2377913162","display_name":"Epigenetics of Chronic Kidney Disease","funder_award_id":"R01DK087635","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5264579213","display_name":"APOL1 associated disease spectrum","funder_award_id":"R01DK105821","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8879200380","display_name":"Focal Segmental Glomerulosclerosis: Genetics & Mechanisms","funder_award_id":"Z01DK043308","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000864591","display_name":"The role of cytosolic nucleotide sensors in inflammatory fibrosis","funder_award_id":"R01DK132630","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868773","display_name":"Adaptive and maladaptive repair after kidney injury","funder_award_id":"R01DK076077","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205089872.pdf","grobid_xml":"https://content.openalex.org/works/W3205089872.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1531295370","https://openalex.org/W1647605954","https://openalex.org/W1765667024","https://openalex.org/W1865072112","https://openalex.org/W1969979138","https://openalex.org/W1981426400","https://openalex.org/W1999574084","https://openalex.org/W2018509996","https://openalex.org/W2037600884","https://openalex.org/W2042134721","https://openalex.org/W2071178601","https://openalex.org/W2077388406","https://openalex.org/W2092001580","https://openalex.org/W2095763846","https://openalex.org/W2096465161","https://openalex.org/W2105057119","https://openalex.org/W2111994713","https://openalex.org/W2113589707","https://openalex.org/W2113634538","https://openalex.org/W2114104545","https://openalex.org/W2122838035","https://openalex.org/W2124164796","https://openalex.org/W2124641083","https://openalex.org/W2133557129","https://openalex.org/W2140637559","https://openalex.org/W2148745148","https://openalex.org/W2149588710","https://openalex.org/W2149616337","https://openalex.org/W2154949696","https://openalex.org/W2163113207","https://openalex.org/W2167157452","https://openalex.org/W2169456326","https://openalex.org/W2193787683","https://openalex.org/W2204928992","https://openalex.org/W2213899646","https://openalex.org/W2286146897","https://openalex.org/W2325672695","https://openalex.org/W2355660319","https://openalex.org/W2508156341","https://openalex.org/W2557180216","https://openalex.org/W2560745863","https://openalex.org/W2589644968","https://openalex.org/W2619266542","https://openalex.org/W2667009176","https://openalex.org/W2748400555","https://openalex.org/W2754997503","https://openalex.org/W2755045796","https://openalex.org/W2769072953","https://openalex.org/W2788752816","https://openalex.org/W2806405834","https://openalex.org/W2806866359","https://openalex.org/W2898984886","https://openalex.org/W2912692514","https://openalex.org/W2934093192","https://openalex.org/W2949622654","https://openalex.org/W2971339280","https://openalex.org/W2977052708","https://openalex.org/W2989263689","https://openalex.org/W3006214332","https://openalex.org/W3026603425","https://openalex.org/W3081619779","https://openalex.org/W3152090481","https://openalex.org/W3188625407","https://openalex.org/W6799107240"],"related_works":["https://openalex.org/W3081619779","https://openalex.org/W4313366082","https://openalex.org/W7223024381","https://openalex.org/W3017553066","https://openalex.org/W7140110204","https://openalex.org/W2982530128","https://openalex.org/W2092001580","https://openalex.org/W4396994502","https://openalex.org/W3139004505","https://openalex.org/W3010798713"],"abstract_inverted_index":{"Coding":[0],"variants":[1],"in":[2,17,39,75,103,136],"apolipoprotein":[3],"L1":[4],"(APOL1),":[5],"termed":[6],"G1":[7],"and":[8,60,70,83,90,101,117,127,139,155,163,166,172,181,186],"G2,":[9],"can":[10],"explain":[11],"most":[12],"excess":[13],"kidney":[14,26,105,140,188],"disease":[15],"risk":[16,115],"African":[18],"Americans;":[19],"however,":[20],"the":[21,40,51,61,97,112,148,197],"molecular":[22],"pathways":[23],"of":[24,36,42,50,56,85,99,120,151,169,199],"APOL1-induced":[25],"dysfunction":[27],"remain":[28],"poorly":[29],"understood.":[30],"Here,":[31],"we":[32,107,157],"report":[33],"that":[34],"expression":[35,72,84],"G2":[37,113],"APOL1":[38,81,86,114],"podocytes":[41,76],"Nphs1rtTA/TRE-G2APOL1":[43],"(G2APOL1)":[44],"mice":[45,110,132,159,176],"leads":[46],"to":[47],"early":[48],"activation":[49],"cytosolic":[52],"nucleotide":[53],"sensor,":[54],"stimulator":[55],"interferon":[57],"genes":[58],"(STING),":[59],"NLR":[62],"family":[63],"pyrin":[64],"domain-containing":[65],"3":[66],"(NLRP3)":[67],"inflammasome.":[68],"STING":[69,102,128],"NLRP3":[71,100],"was":[73,194],"increased":[74],"from":[77],"patients":[78],"with":[79,88,111,143,160,178],"high-risk":[80],"genotypes,":[82],"correlated":[87],"caspase-1":[89],"gasdermin":[91],"D":[92],"(GSDMD)":[93],"levels.":[94],"To":[95,146],"demonstrate":[96],"role":[98],"APOL1-associated":[104],"disease,":[106],"generated":[108],"transgenic":[109],"variant":[116],"genetic":[118],"deletion":[119],"Nlrp3":[121],"(G2APOL1/Nlrp3":[122],"KO),":[123,126],"Gsdmd":[124],"(G2APOL1/Gsdmd":[125],"(G2APOL1/STING":[129],"KO).":[130],"Knockout":[131],"displayed":[133],"marked":[134],"reduction":[135],"albuminuria,":[137],"azotemia,":[138],"fibrosis":[141],"compared":[142],"G2APOL1":[144,175],"mice.":[145],"evaluate":[147],"therapeutic":[149],"potential":[150],"targeting":[152],"NLRP3,":[153,170],"GSDMD,":[154,171],"STING,":[156,173],"treated":[158,177],"MCC950,":[161,179],"disulfiram,":[162,180],"C176,":[164],"potent":[165],"selective":[167],"inhibitors":[168],"respectively.":[174],"C176":[182],"showed":[183],"lower":[184],"albuminuria":[185],"improved":[187],"function":[189],"even":[190],"when":[191],"inhibitor":[192],"treatment":[193],"initiated":[195],"after":[196],"development":[198],"albuminuria.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":23}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}
