{"id":"https://openalex.org/W3205089247","doi":"https://doi.org/10.1590/fst.77021","title":"Evaluation on a supersaturatable self-microemulsifying (s-smdds) formulation of biphenyl dimethyl dicarboxylate (BDD) in Vitro and in Vivo","display_name":"Evaluation on a supersaturatable self-microemulsifying (s-smdds) formulation of biphenyl dimethyl dicarboxylate (BDD) in Vitro and in Vivo","publication_year":2021,"publication_date":"2021-10-11","ids":{"openalex":"https://openalex.org/W3205089247","doi":"https://doi.org/10.1590/fst.77021","mag":"3205089247"},"language":"en","primary_location":{"id":"doi:10.1590/fst.77021","doi":"https://doi.org/10.1590/fst.77021","is_oa":true,"landing_page_url":"https://doi.org/10.1590/fst.77021","pdf_url":"https://www.scielo.br/j/cta/a/3gQkLcdgzR9dxChYbDnKZ8C/?lang=en&format=pdf","source":{"id":"https://openalex.org/S4210223135","display_name":"Food Science and Technology","issn_l":"0101-2061","issn":["0101-2061","1678-457X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310312337","host_organization_name":"Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos","host_organization_lineage":["https://openalex.org/P4310312337"],"host_organization_lineage_names":["Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.scielo.br/j/cta/a/3gQkLcdgzR9dxChYbDnKZ8C/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075150548","display_name":"Qingwei Jiang","orcid":"https://orcid.org/0000-0001-8693-4231","observed_orcids":["https://orcid.org/0000-0001-8693-4231"]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingwei JIANG","raw_affiliation_strings":["Yanbian University College of Pharmacy,  China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yanbian University College of Pharmacy,  China","institution_ids":["https://openalex.org/I1793135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045113959","display_name":"Tao Wang","orcid":"https://orcid.org/0000-0003-1118-9876","observed_orcids":["https://orcid.org/0000-0003-1118-9876"]},"institutions":[{"id":"https://openalex.org/I4210155088","display_name":"Institute of Chemistry","ror":"https://ror.org/048y1rc66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210155088"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao WANG","raw_affiliation_strings":["Institute of Chemistry,  China"],"raw_orcid":"https://orcid.org/0000-0003-1118-9876","affiliations":[{"raw_affiliation_string":"Institute of Chemistry,  China","institution_ids":["https://openalex.org/I4210155088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103117458","display_name":"Li Gao","orcid":"https://orcid.org/0000-0003-1652-6851","observed_orcids":["https://orcid.org/0000-0003-1652-6851"]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gao LI","raw_affiliation_strings":["Yanbian University College of Pharmacy,  China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yanbian University College of Pharmacy,  China","institution_ids":["https://openalex.org/I1793135"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045113959","https://openalex.org/A5103117458"],"corresponding_institution_ids":["https://openalex.org/I1793135","https://openalex.org/I4210155088"],"apc_list":{"value":750,"currency":"USD","value_usd":750},"apc_paid":{"value":750,"currency":"USD","value_usd":750},"fwci":0.2025,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.35189229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"42","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9139999747276306},{"id":"https://openalex.org/keywords/dissolution-enhancement","display_name":"dissolution enhancement","score":0.6710000038146973},{"id":"https://openalex.org/keywords/polyvinylpyrrolidone","display_name":"polyvinylpyrrolidone","score":0.8820000290870667},{"id":"https://openalex.org/keywords/ternary-phase-diagram","display_name":"ternary phase diagram","score":0.8450000286102295},{"id":"https://openalex.org/keywords/microemulsification","display_name":"microemulsification","score":0.6370000243186951},{"id":"https://openalex.org/keywords/transcutol-hp","display_name":"Transcutol HP","score":0.9710000157356262},{"id":"https://openalex.org/keywords/medium-chain-triglycerides","display_name":"medium-chain triglycerides","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7239999771118164},{"id":"https://openalex.org/keywords/physical-stability","display_name":"physical stability","score":0.6010000109672546},{"id":"https://openalex.org/keywords/droplet-size","display_name":"droplet size","score":0.5799999833106995},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.775300145149231},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.7481995820999146},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6101291179656982},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5791914463043213},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5622152090072632},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.522517204284668},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4988555908203125},{"id":"https://openalex.org/C14029885","wikidata":"https://www.wikidata.org/wiki/Q5282807","display_name":"Dissolution testing","level":4,"score":0.4857357144355774},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4545005261898041},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.4450386166572571},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.43810027837753296},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.35358643531799316},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13649404048919678},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.09593319892883301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08506542444229126},{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.07919347286224365},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.06895393133163452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1590/fst.77021","doi":"https://doi.org/10.1590/fst.77021","is_oa":true,"landing_page_url":"https://doi.org/10.1590/fst.77021","pdf_url":"https://www.scielo.br/j/cta/a/3gQkLcdgzR9dxChYbDnKZ8C/?lang=en&format=pdf","source":{"id":"https://openalex.org/S4210223135","display_name":"Food Science and Technology","issn_l":"0101-2061","issn":["0101-2061","1678-457X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310312337","host_organization_name":"Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos","host_organization_lineage":["https://openalex.org/P4310312337"],"host_organization_lineage_names":["Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Technology","raw_type":"journal-article"},{"id":"pmh:oai:scielo:S0101-20612022000100793","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100793","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:SBCTA","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e663cff24ad643e69574d119a753e748","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e663cff24ad643e69574d119a753e748","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Food Science and Technology (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/fst.77021","doi":"https://doi.org/10.1590/fst.77021","is_oa":true,"landing_page_url":"https://doi.org/10.1590/fst.77021","pdf_url":"https://www.scielo.br/j/cta/a/3gQkLcdgzR9dxChYbDnKZ8C/?lang=en&format=pdf","source":{"id":"https://openalex.org/S4210223135","display_name":"Food Science and Technology","issn_l":"0101-2061","issn":["0101-2061","1678-457X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310312337","host_organization_name":"Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos","host_organization_lineage":["https://openalex.org/P4310312337"],"host_organization_lineage_names":["Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205089247.pdf","grobid_xml":"https://content.openalex.org/works/W3205089247.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1993563764","https://openalex.org/W1997341902","https://openalex.org/W1997384329","https://openalex.org/W2004497503","https://openalex.org/W2015279891","https://openalex.org/W2020282466","https://openalex.org/W2036208975","https://openalex.org/W2044475288","https://openalex.org/W2076269997","https://openalex.org/W2079574505","https://openalex.org/W2095480328","https://openalex.org/W2351693583","https://openalex.org/W2353066527","https://openalex.org/W2359156306","https://openalex.org/W2373811878"],"related_works":["https://openalex.org/W2375222184","https://openalex.org/W2012573360","https://openalex.org/W2023537271","https://openalex.org/W2059110208","https://openalex.org/W2043810138","https://openalex.org/W3087489767","https://openalex.org/W2792479669","https://openalex.org/W3092119129","https://openalex.org/W1966163938","https://openalex.org/W2166609445"],"abstract_inverted_index":{"To":[0],"enhance":[1],"the":[2,14,33,49,58,62,78,83,132,146,151],"dissolution":[3],"and":[4,35,66,82,104,119,124,148],"oral":[5,166,171],"bioavailability":[6,172],"of":[7,32,61,92,108,173],"poorly":[8],"water-soluble":[9,26],"biphenyl":[10],"dimethyl":[11],"dicarboxylate":[12],"(BDD),":[13],"supersaturatable":[15],"self-microemulsifying":[16],"drug":[17,34,121],"delivery":[18],"system":[19],"(S-SMEDDS)":[20],"was":[21,75],"developed":[22],"by":[23,56],"adding":[24],"a":[25,37],"polymer":[27],"PVP":[28,133],"to":[29,47],"prevent":[30],"precipitation":[31],"maintain":[36],"supersaturate":[38],"state":[39],"in":[40,72,128,137],"vivo.":[41],"Ternary":[42],"phase":[43],"diagrams":[44],"were":[45,54],"drawn":[46],"evaluate":[48],"microemulsification":[50],"domain.":[51],"The":[52,69,87,136,159],"formulations":[53],"characterized":[55],"testing":[57],"physical":[59,126],"stability":[60,127],"drug,":[63],"particle":[64],"size":[65,115],"zeta":[67],"potential.":[68],"pharmacokinetic":[70],"study":[71],"beagle":[73],"dogs":[74],"performed":[76],"for":[77,169],"S-SMEDDS,":[79],"SMEDDS":[80],"formulation":[81,90,161],"market":[84],"drop":[85],"pills.":[86],"optimized":[88],"S-SMEDDS":[89,142,160],"consist":[91],"35%":[93],"(w/w)":[94,98,102,106],"Cremphor":[95],"EL35,":[96],"33%":[97],"Transcutol":[99],"HP,":[100],"30%":[101],"MCT":[103],"2%":[105],"PVPK30":[107],"each":[109],"excipient":[110],"showed":[111,140],"minimum":[112],"mean":[113],"droplet":[114],"(37.71":[116],"\u00b1":[117],"0.87nm)":[118],"optimal":[120],"release":[122],"profile":[123],"better":[125],"water":[129],"compared":[130],"with":[131],"absent":[134],"SMEDDS.":[135],"vivo":[138],"studies":[139],"that":[141],"had":[143],"significantly":[144],"increased":[145],"Cmax":[147],"area":[149],"under":[150],"plasma":[152],"concentration-time":[153],"curve":[154],"(AUC)":[155],"(P":[156],"<":[157],"0.01).":[158],"should":[162],"be":[163],"an":[164],"effective":[165],"dosage":[167],"form":[168],"improving":[170],"water-insoluble":[174],"BDD.":[175]},"counts_by_year":[{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-10-25T00:00:00"}
