{"id":"https://openalex.org/W3205048858","doi":"https://doi.org/10.1080/13813455.2021.1985144","title":"lncRNA MALAT1 promotes diabetic retinopathy by upregulating PDE6G via miR-378a-3p","display_name":"lncRNA MALAT1 promotes diabetic retinopathy by upregulating PDE6G via miR-378a-3p","publication_year":2021,"publication_date":"2021-10-21","ids":{"openalex":"https://openalex.org/W3205048858","doi":"https://doi.org/10.1080/13813455.2021.1985144","mag":"3205048858","pmid":"https://pubmed.ncbi.nlm.nih.gov/34674599"},"language":"en","primary_location":{"id":"doi:10.1080/13813455.2021.1985144","doi":"https://doi.org/10.1080/13813455.2021.1985144","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13813455.2021.1985144","pdf_url":null,"source":{"id":"https://openalex.org/S19783875","display_name":"Archives of Physiology and Biochemistry","issn_l":"0778-3124","issn":["0778-3124","1381-3455","1744-4160"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100348756","display_name":"Xiaoxia Li","orcid":"https://orcid.org/0000-0002-4872-9525","observed_orcids":["https://orcid.org/0000-0002-4872-9525"]},"institutions":[{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoxia Li","raw_affiliation_strings":["Department of Ophthalmology, Wuhan Third Hospital, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Wuhan Third Hospital, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210138122"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100348756"],"corresponding_institution_ids":["https://openalex.org/I4210138122"],"apc_list":null,"apc_paid":null,"fwci":3.1357,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.91962441,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"130","issue":"2","first_page":"119","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.28760001063346863,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/malat1","display_name":"MALAT1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.828000009059906},{"id":"https://openalex.org/keywords/mir-378a-3p","display_name":"miR-378a-3p","score":0.996999979019165},{"id":"https://openalex.org/keywords/retinal-microvascular-endothelial-cells","display_name":"retinal microvascular endothelial cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.6100000143051147},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.984000027179718},{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"competing endogenous RNA","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mirna-sponge","display_name":"microRNA sponge","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2779134362","wikidata":"https://www.wikidata.org/wiki/Q18056223","display_name":"MALAT1","level":5,"score":0.9492125511169434},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.755249559879303},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.631972074508667},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.4691411852836609},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4529615044593811},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4373292326927185},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.43207111954689026},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40074044466018677},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.39954873919487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35294413566589355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34185129404067993},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33895182609558105},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2692239284515381},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.2609257996082306},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.25399380922317505},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17903798818588257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15484803915023804}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/13813455.2021.1985144","doi":"https://doi.org/10.1080/13813455.2021.1985144","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13813455.2021.1985144","pdf_url":null,"source":{"id":"https://openalex.org/S19783875","display_name":"Archives of Physiology and Biochemistry","issn_l":"0778-3124","issn":["0778-3124","1381-3455","1744-4160"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:34674599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34674599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of physiology and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W600207206","https://openalex.org/W1968469250","https://openalex.org/W1978809540","https://openalex.org/W1997065647","https://openalex.org/W2041857857","https://openalex.org/W2060969093","https://openalex.org/W2138480916","https://openalex.org/W2146584636","https://openalex.org/W2205469249","https://openalex.org/W2594076864","https://openalex.org/W2752133246","https://openalex.org/W2758616471","https://openalex.org/W2765457786","https://openalex.org/W2807740012","https://openalex.org/W2884910822","https://openalex.org/W2903181500","https://openalex.org/W2939525480","https://openalex.org/W2944423078","https://openalex.org/W2945734925","https://openalex.org/W2969879575","https://openalex.org/W2985585531","https://openalex.org/W3000204277","https://openalex.org/W3022279113","https://openalex.org/W3028117670","https://openalex.org/W3088313291","https://openalex.org/W3119124420","https://openalex.org/W3121031931","https://openalex.org/W3125233521"],"related_works":["https://openalex.org/W4380290910","https://openalex.org/W2939525480","https://openalex.org/W4213220153","https://openalex.org/W2985585531","https://openalex.org/W4327892341","https://openalex.org/W4412110386","https://openalex.org/W3129864321","https://openalex.org/W3001217445","https://openalex.org/W2076873046","https://openalex.org/W3154494316"],"abstract_inverted_index":{"Diabetic":[0],"retinopathy":[1],"(DR)":[2],"is":[3],"the":[4,22,94,102,110,134,146],"main":[5],"cause":[6],"of":[7,27,62,74,96,104,107,112,136,148],"adult":[8],"insomnia,":[9],"which":[10,124],"causes":[11],"certain":[12],"social":[13],"and":[14,24,30,44,52,58,68,77,88,98,100,114],"economic":[15],"pressure.":[16],"This":[17,140],"research":[18],"was":[19],"to":[20,144],"investigate":[21],"role":[23],"regulatory":[25],"mechanisms":[26],"MALAT1,":[28,42,75],"miR-378a-3p":[29,76],"PDE6g":[31],"in":[32],"retinal":[33],"microvascular":[34],"endothelial":[35],"cells":[36],"(RMECs)":[37],"under":[38,117,138],"high":[39],"glucose":[40],"(HG).":[41],"Mir-378a-3p":[43],"PDE6G":[45,78],"expressions":[46],"level":[47],"were":[48,64,79],"detected":[49,65],"by":[50,66,81],"qRT-PCR":[51],"Western":[53],"blot.":[54,70],"The":[55,71],"proliferation,":[56],"Bax":[57],"Bcl-2":[59],"protein":[60],"expression":[61,95,103],"RMECs":[63,113,137],"CCK-8":[67],"western":[69],"target":[72],"relationships":[73],"determined":[80],"bioinformatics":[82],"analysis,":[83],"dual-luciferase":[84],"reporter":[85],"gene,":[86],"RIP":[87],"RNA":[89],"pull-down":[90],"assay.":[91],"HG":[92,118],"enhanced":[93],"MALAT1":[97,108,120],"PDE6G,":[99],"inhibited":[101],"miR-378a-3p.":[105],"Overexpression":[106],"promotes":[109],"proliferation":[111],"inhibits":[115],"apoptosis":[116,135],"condition.":[119],"competitively":[121],"adsorbed":[122],"miR-378a-3p,":[123],"targeted":[125],"PDE6G.":[126],"Data":[127],"reveal":[128],"that":[129],"MALAT1/miR-378a-3p/PDE6G":[130],"signal":[131],"axis":[132],"restrain":[133],"HG.":[139],"finding":[141],"may":[142],"help":[143],"delay":[145],"development":[147],"DR.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}
