{"id":"https://openalex.org/W3205000355","doi":"https://doi.org/10.3390/nu13103624","title":"Standardized Hydrangea serrata (Thunb.) Ser. Extract Ameliorates Obesity in db/db Mice","display_name":"Standardized Hydrangea serrata (Thunb.) Ser. Extract Ameliorates Obesity in db/db Mice","publication_year":2021,"publication_date":"2021-10-16","ids":{"openalex":"https://openalex.org/W3205000355","doi":"https://doi.org/10.3390/nu13103624","mag":"3205000355","pmid":"https://pubmed.ncbi.nlm.nih.gov/34684625","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8538090"},"language":"en","primary_location":{"id":"doi:10.3390/nu13103624","doi":"https://doi.org/10.3390/nu13103624","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu13103624","pdf_url":"https://www.mdpi.com/2072-6643/13/10/3624/pdf?version=1634710227","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3205000355"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/13/10/3624/pdf?version=1634710227","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015881907","display_name":"Hee-Soo Han","orcid":"https://orcid.org/0000-0002-2377-0847","observed_orcids":["https://orcid.org/0000-0002-2377-0847"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee-Soo Han","raw_affiliation_strings":["Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea","Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"],"raw_orcid":"https://orcid.org/0000-0002-2377-0847","affiliations":[{"raw_affiliation_string":"Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028958052","display_name":"Kyung\u2010Sook Chung","orcid":"https://orcid.org/0000-0002-0862-0779","observed_orcids":["https://orcid.org/0000-0002-0862-0779"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung-Sook Chung","raw_affiliation_strings":["Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004263329","display_name":"Yu\u2010Kyong Shin","orcid":"https://orcid.org/0000-0003-3545-2341","observed_orcids":["https://orcid.org/0000-0003-3545-2341"]},"institutions":[{"id":"https://openalex.org/I4405267993","display_name":"Cosmax Inc. (South Korea)","ror":"https://ror.org/05acby202","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405267993"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu-Kyoung Shin","raw_affiliation_strings":["Department of New Material Development, COSMAXBIO, Seongnam 13486, Korea"],"raw_orcid":"https://orcid.org/0000-0003-3545-2341","affiliations":[{"raw_affiliation_string":"Department of New Material Development, COSMAXBIO, Seongnam 13486, Korea","institution_ids":["https://openalex.org/I4405267993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734966","display_name":"Sun Hee Lee","orcid":"https://orcid.org/0000-0003-2908-5231","observed_orcids":["https://orcid.org/0000-0003-2908-5231"]},"institutions":[{"id":"https://openalex.org/I4405267993","display_name":"Cosmax Inc. (South Korea)","ror":"https://ror.org/05acby202","country_code":"KR","type":"company","lineage":["https://openalex.org/I4405267993"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun Hee Lee","raw_affiliation_strings":["Department of New Material Development, COSMAXBIO, Seongnam 13486, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of New Material Development, COSMAXBIO, Seongnam 13486, Korea","institution_ids":["https://openalex.org/I4405267993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073243425","display_name":"Kyung\u2010Tae Lee","orcid":"https://orcid.org/0000-0002-3141-3727","observed_orcids":["https://orcid.org/0000-0002-3141-3727"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyung-Tae Lee","raw_affiliation_strings":["Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea","Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea"],"raw_orcid":"https://orcid.org/0000-0002-3141-3727","affiliations":[{"raw_affiliation_string":"Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073243425"],"corresponding_institution_ids":["https://openalex.org/I35928602"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2592},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2592},"fwci":1.1985,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.7607861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"13","issue":"10","first_page":"3624","last_page":"3624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.35910001397132874,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.35910001397132874,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.3012999892234802,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.149399995803833,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrangea-serrata","display_name":"Hydrangea serrata","score":0.9950000047683716},{"id":"https://openalex.org/keywords/anti-obesity-effect","display_name":"anti-obesity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.6589999794960022},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.8289999961853027},{"id":"https://openalex.org/keywords/3t3-l1-preadipocytes","display_name":"3T3-L1 preadipocytes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/c-ebpalpha","display_name":"C/EBP\u03b1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":1.0},{"id":"https://openalex.org/keywords/srebp-1","display_name":"SREBP1","score":1.0},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.7730000019073486},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/adipocyte-hypertrophy","display_name":"adipocyte hypertrophy","score":0.902999997138977},{"id":"https://openalex.org/keywords/brown-adipose-tissue-thermogenesis","display_name":"brown adipose tissue thermogenesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8730000257492065},{"id":"https://openalex.org/keywords/high-fat-diet-induced-obesity","display_name":"high-fat diet-induced obesity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.770514190196991},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7602567672729492},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6153768301010132},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.6019788384437561},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.5613259077072144},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5206345915794373},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.5135155320167542},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.49115607142448425},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.4702260196208954},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.45616796612739563},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.4501662850379944},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.4178128242492676},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3167978525161743},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3050277829170227},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.27289700508117676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18042612075805664},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17985135316848755},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.13108891248703003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08993196487426758},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022763","descriptor_name":"CCAAT-Enhancer-Binding Protein-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022763","descriptor_name":"CCAAT-Enhancer-Binding Protein-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D031966","descriptor_name":"Hydrangea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/nu13103624","doi":"https://doi.org/10.3390/nu13103624","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu13103624","pdf_url":"https://www.mdpi.com/2072-6643/13/10/3624/pdf?version=1634710227","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmid:34684625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34684625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8538090","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8538090/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/nu13103624","doi":"https://doi.org/10.3390/nu13103624","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu13103624","pdf_url":"https://www.mdpi.com/2072-6643/13/10/3624/pdf?version=1634710227","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3466144619","display_name":null,"funder_award_id":"120047-2","funder_id":"https://openalex.org/F4320336122","funder_display_name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry"}],"funders":[{"id":"https://openalex.org/F4320336122","display_name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3205000355.pdf","grobid_xml":"https://content.openalex.org/works/W3205000355.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W119015983","https://openalex.org/W1483058314","https://openalex.org/W1502396947","https://openalex.org/W1542645650","https://openalex.org/W1591585742","https://openalex.org/W1989020172","https://openalex.org/W2000867519","https://openalex.org/W2012356144","https://openalex.org/W2016496971","https://openalex.org/W2022267544","https://openalex.org/W2031226404","https://openalex.org/W2035258932","https://openalex.org/W2036139926","https://openalex.org/W2043054174","https://openalex.org/W2059355019","https://openalex.org/W2074493657","https://openalex.org/W2077645437","https://openalex.org/W2110936821","https://openalex.org/W2112936536","https://openalex.org/W2121921343","https://openalex.org/W2143421197","https://openalex.org/W2143492243","https://openalex.org/W2157118250","https://openalex.org/W2160040908","https://openalex.org/W2164045012","https://openalex.org/W2200889199","https://openalex.org/W2284659436","https://openalex.org/W2326872755","https://openalex.org/W2383894930","https://openalex.org/W2437007381","https://openalex.org/W2443189794","https://openalex.org/W2543000715","https://openalex.org/W2592460195","https://openalex.org/W2619007540","https://openalex.org/W2707117275","https://openalex.org/W2729523416","https://openalex.org/W2757178317","https://openalex.org/W2765290991","https://openalex.org/W2892915798","https://openalex.org/W2902855242","https://openalex.org/W2904556508","https://openalex.org/W2915924151","https://openalex.org/W2921966151","https://openalex.org/W2924199431","https://openalex.org/W2946066575","https://openalex.org/W2961328380","https://openalex.org/W2987043898","https://openalex.org/W2991550491","https://openalex.org/W3023650184","https://openalex.org/W3088447862","https://openalex.org/W3120744005","https://openalex.org/W3134187763","https://openalex.org/W6756590333"],"related_works":["https://openalex.org/W3134187763","https://openalex.org/W4414382050","https://openalex.org/W4414166289","https://openalex.org/W4396951667","https://openalex.org/W4206624244","https://openalex.org/W3027198754","https://openalex.org/W2974005012","https://openalex.org/W2589103383","https://openalex.org/W4318054775","https://openalex.org/W2428062604"],"abstract_inverted_index":{"We":[0],"previously":[1],"reported":[2],"the":[3,8,32,54,79,141,162,188,192],"potential":[4],"anti-obesity":[5,35],"effects":[6,36],"of":[7,11,26,37,57,83,93,143,169],"water":[9],"extract":[10],"Hydrangea":[12],"serrata":[13],"(Thunb.)":[14],"Ser.":[15],"leaves":[16],"(WHS)":[17],"in":[18,44,103,128,154,185],"high-fat":[19],"diet-induced":[20],"obese":[21,49],"mice.":[22,51,171],"As":[23],"an":[24],"extension":[25],"our":[27,174],"previous":[28],"study,":[29],"we":[30],"investigated":[31],"anti-adipogenic":[33],"and":[34,39,47,69,99,109,121,124,134,152,187,190],"WHS":[38,52,77,94,115,117,137,160,178],"its":[40],"underlying":[41],"molecular":[42],"mechanisms":[43],"3T3-L1":[45],"preadipocytes":[46,84],"genetically":[48],"db/db":[50],"attenuated":[53],"gene":[55],"expression":[56,123,142],"adipogenic":[58],"transcription":[59],"factors,":[60],"CCAAT/enhancer":[61],"binding":[62,73],"protein":[63,74],"(C/EBP)\u03b1,":[64],"peroxisome":[65],"proliferator-activated":[66],"receptor":[67],"(PPAR)\u03b3,":[68],"sterol":[70],"regulatory":[71],"element":[72],"(SREBP)-1.":[75],"Moreover,":[76],"inhibited":[78],"mitotic":[80],"clonal":[81],"expansion":[82],"by":[85,114,182],"inducing":[86],"G1":[87],"cell":[88],"cycle":[89],"arrest.":[90],"Oral":[91],"administration":[92],"alleviated":[95],"body":[96,100],"weight":[97],"gain":[98],"fat":[101],"accumulation":[102],"vivo.":[104],"In":[105],"addition,":[106],"adipocyte":[107],"hypertrophy":[108],"liver":[110,135,189],"steatosis":[111],"were":[112],"ameliorated":[113],"treatment.":[116],"reduced":[118],"C/EBP\u03b1,":[119],"PPAR\u03b3,":[120],"SREBP-1":[122],"activated":[125],"AMPK\u03b1":[126],"phosphorylation":[127],"both":[129],"white":[130],"adipose":[131,156],"tissue":[132,157],"(WAT)":[133],"tissue.":[136],"also":[138],"mildly":[139],"upregulated":[140],"thermogenic":[144],"proteins,":[145],"including":[146],"uncoupling":[147],"protein-1,":[148],"PPARs,":[149],"PPAR\u03b3":[150],"coactivator-1\u03b1,":[151],"sirtuin-1,":[153],"brown":[155],"(BAT).":[158],"Furthermore,":[159],"altered":[161],"gut":[163,193],"microbiota":[164],"composition":[165],"to":[166],"resemble":[167],"that":[168,177],"wild-type":[170],"Taken":[172],"together,":[173],"findings":[175],"suggest":[176],"could":[179],"alleviate":[180],"adiposity":[181],"inhibiting":[183],"adipogenesis":[184],"WAT":[186],"modulating":[191],"microbiota.":[194]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-10-25T00:00:00"}