{"id":"https://openalex.org/W3204975328","doi":null,"title":"PTEN and HER2 regulate self-renewal and invasion of human mammary stem cells.","display_name":"PTEN and HER2 regulate self-renewal and invasion of human mammary stem cells.","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W3204975328","mag":"3204975328"},"language":"en","primary_location":{"id":"mag:3204975328","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/67/9_Supplement/1287","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037279132","display_name":"Hasan K\u00f6rkaya","orcid":"https://orcid.org/0000-0002-0719-5862","observed_orcids":["https://orcid.org/0000-0002-0719-5862"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hasan K\u00f6rkaya","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":"https://orcid.org/0000-0002-0719-5862","affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053929208","display_name":"Flora Iovino","orcid":"https://orcid.org/0000-0002-6374-5582","observed_orcids":["https://orcid.org/0000-0002-6374-5582"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Flora Iovino","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":"https://orcid.org/0000-0002-6374-5582","affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059956218","display_name":"Max S. Wicha","orcid":"https://orcid.org/0000-0003-4180-7727","observed_orcids":["https://orcid.org/0000-0003-4180-7727"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max S. Wicha","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI;"],"raw_orcid":"https://orcid.org/0000-0003-4180-7727","affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI;","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.1791,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64382421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":null,"first_page":"1287","last_page":"1287"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9950000047683716},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9020000100135803},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/aldh1","display_name":"ALDH1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mammosphere-formation","display_name":"mammosphere formation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/pten-knockdown","display_name":"PTEN knockdown","score":0.7639999985694885},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.9290000200271606},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.5740000009536743},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7129999995231628},{"id":"https://openalex.org/keywords/nod-scid-xenograft","display_name":"NOD/SCID xenograft","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9233146905899048},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7232300639152527},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7087169885635376},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6529110074043274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6158146262168884},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5367148518562317},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.48855575919151306},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4873860478401184},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42186439037323},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31977343559265137},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.30360156297683716},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2700248956680298},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22925233840942383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2038116455078125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19410720467567444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05988660454750061},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3204975328","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/67/9_Supplement/1287","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098438925","https://openalex.org/W1976203623","https://openalex.org/W7043034252","https://openalex.org/W2321152376","https://openalex.org/W2009094422","https://openalex.org/W7132951235","https://openalex.org/W1974784117","https://openalex.org/W2143927620","https://openalex.org/W1573024086","https://openalex.org/W2564262167"],"abstract_inverted_index":{"1287":[0],"There":[2],"is":[3,16,33,48,79,89,100,110],"increasing":[4,375],"evidence":[5],"in":[6,50,70,81,102,173,183,198,236,306,319,325,358,406],"breast":[7,72,86,107,408],"cancers":[8,73],"as":[9,11,158,160,246,248],"well":[10,159,247],"other":[12],"malignancies":[13],"that":[14,22,401],"tumorigenesis":[15],"driven":[17],"by":[18,195,275],"a":[19,92,122,131,177],"cell":[20,25,46,64,238,254,272,290,321,395,421],"population":[21,291],"retains":[23],"stem":[24,31,45,63,237,253,271,289,320,394,420],"properties.":[26],"The":[27,96],"key":[28],"property":[29],"of":[30,41,55,84,105,125,145,147,170,209,251,258,262,267,281,332,353,361],"cells":[32,157,175,200,268,335,362,367,388],"their":[34,202,376],"ability":[35,331],"to":[36,141,189,220,226,293,314,336,350,355,379,383,424],"self-renew.":[37],"Thus,":[38],"the":[39,61,143,207,249,252,265,270,279,288,330,339,359,364,390,393],"elucidation":[40],"pathways":[42,149],"which":[43,58],"regulate":[44],"self-renewal":[47],"important":[49],"understanding":[51],"mammary":[52,155,163,309],"carcinogenesis":[53],"and":[54,76,88,109,116,127,212,260,284,372,410,417,427],"developing":[56],"agents":[57],"can":[59],"target":[60],"tumor":[62,181,326],"pool.":[65],"Two":[66],"genes":[67,302,303,403],"frequently":[68],"deregulated":[69,101,305,405],"human":[71,85,106,154,162,308],"are":[74],"HER2":[75,78,128,193,210,263,285,347,373,416],"PTEN.":[77],"amplified":[80],"approximately":[82,103],"20-25%":[83],"carcinomas":[87,108],"associated":[90,111,411],"with":[91,112,121,366,368,412],"poor":[93,117,413],"clinical":[94,118,414],"outcome.":[95,119,415],"lipid":[97],"phosphatase":[98],"PTEN":[99,126,171,213,259,282,344,370,418],"40%":[104],"increased":[113,180,201,215,264,425],"Akt":[114],"activation":[115],"Patients":[120],"combined":[123,369],"loss":[124],"amplification":[129],"have":[130],"worse":[132],"prognosis":[133],"than":[134],"either":[135],"molecular":[136],"defect":[137],"alone.":[138],"In":[139,224,312],"order":[140,225,313],"study":[142],"effect":[144],"deregulation":[146],"these":[148,199,229,301],"we":[150,240,328],"utilized":[151,241],"both":[152,242],"MCF7":[153,174,334,384],"carcinoma":[156],"normal":[161,307],"epithelium":[164],"isolated":[165],"from":[166,234],"reduction":[167],"mammoplasties.":[168],"Knockdown":[169],"expression":[172,250],"utilizing":[176,338],"lenti-viral":[178,196],"siRNA":[179],"formation":[182,244],"NOD-SCID":[184],"mice":[185],"4":[186],"fold":[187,205,218,277,357,381],"compared":[188,219,382],"GFP":[190,221,385],"transfected":[191,222,333],"cells.":[192,311,386],"overexpression":[194,211,261,286,348,374],"infection":[197],"tumorigenicity":[203,216,232],"6":[204],"whereas":[206,278],"combination":[208,280],"knockdown":[214,371],"10":[217,380],"controls.":[223],"determine":[227,315],"whether":[228,316],"effects":[230,297],"on":[231],"resulted":[233],"changes":[235,324],"populations,":[239],"mammosphere":[243],"assay":[245],"marker":[255,273,396],"ALDH1.":[256,397],"Deletion":[257],"proportion":[266],"expressing":[269],"ALDH1":[274],"2-4":[276,356],"deletion":[283,345],"placed":[287],"up":[292,354,378],"8":[294],"fold.":[295],"Similar":[296],"were":[298,304],"observed":[299],"when":[300],"epithelial":[310],"this":[317],"increase":[318,352],"populations":[322],"produced":[323],"characteristics":[327],"examined":[329],"invade":[337],"matrigell":[340],"Boyden":[341],"Chamber":[342],"assay.":[343],"or":[346],"led":[349],"an":[351],"number":[360],"invading":[363,389],"matrix,":[365],"invasion":[377,426],"Furthermore,":[387],"matrix":[391],"expressed":[392],"These":[398],"experiments":[399],"suggest":[400],"two":[402],"commonly":[404],"sporadic":[407],"cancer":[409],"modulate":[419],"function":[422],"leading":[423],"tumorigenicity.":[428]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2021-10-25T00:00:00"}
