{"id":"https://openalex.org/W3204892845","doi":"https://doi.org/10.21203/rs.3.rs-929998/v1","title":"UCHL1 inhibited by A1 astrocytes facilitates aggregates clearance to promote neural stem cells activation after spinal cord injury","display_name":"UCHL1 inhibited by A1 astrocytes facilitates aggregates clearance to promote neural stem cells activation after spinal cord injury","publication_year":2021,"publication_date":"2021-10-20","ids":{"openalex":"https://openalex.org/W3204892845","doi":"https://doi.org/10.21203/rs.3.rs-929998/v1","mag":"3204892845"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-929998/v1","doi":"https://doi.org/10.21203/rs.3.rs-929998/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-929998/v1","pdf_url":"https://www.researchsquare.com/article/rs-929998/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-929998/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032421319","display_name":"Lu Ding","orcid":"https://orcid.org/0000-0001-7547-2844","observed_orcids":["https://orcid.org/0000-0001-7547-2844"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Ding","raw_affiliation_strings":["Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University","Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]},{"raw_affiliation_string":"Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049593540","display_name":"Weiwei Chu","orcid":"https://orcid.org/0000-0002-9050-8136","observed_orcids":["https://orcid.org/0000-0002-9050-8136","https://orcid.org/0009-0002-0376-2337","https://orcid.org/0009-0006-0544-5393"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiwei Chu","raw_affiliation_strings":["Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062534695","display_name":"Yu Xia","orcid":"https://orcid.org/0000-0001-8694-9900","observed_orcids":["https://orcid.org/0000-0001-8694-9900"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Xia","raw_affiliation_strings":["Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University","Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]},{"raw_affiliation_string":"Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345568","display_name":"Tian Li","orcid":"https://orcid.org/0000-0002-1996-9001","observed_orcids":["https://orcid.org/0000-0002-1996-9001"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Li","raw_affiliation_strings":["The Seventh Affiliated Hospital, Sun Yat-sen University","Obstetrics and Gynecology Department, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Seventh Affiliated Hospital, Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]},{"raw_affiliation_string":"Obstetrics and Gynecology Department, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002981031","display_name":"Shi Ming","orcid":"https://orcid.org/0009-0008-8444-7569","observed_orcids":["https://orcid.org/0009-0008-8444-7569"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Shi","raw_affiliation_strings":["584647570@qq.com","Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"584647570@qq.com","institution_ids":[]},{"raw_affiliation_string":"Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054214253","display_name":"Feng\u2010Quan Zhou","orcid":"https://orcid.org/0000-0002-1525-9969","observed_orcids":["https://orcid.org/0000-0002-1525-9969"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feng-Quan Zhou","raw_affiliation_strings":["Johns Hopkins University","Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA"],"raw_orcid":"https://orcid.org/0000-0002-1525-9969","affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100526066","display_name":"Yubin Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yubin Deng","raw_affiliation_strings":["Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University","Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]},{"raw_affiliation_string":"Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054214253"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.08609999716281891,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9160000085830688},{"id":"https://openalex.org/keywords/uchl1","display_name":"UCHL1","score":0.921999990940094},{"id":"https://openalex.org/keywords/deubiquitinase","display_name":"deubiquitinase","score":0.8809999823570251},{"id":"https://openalex.org/keywords/protein-aggregates","display_name":"protein aggregates","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/motor-recovery","display_name":"motor recovery","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.7739173173904419},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.7213845252990723},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6307617425918579},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6165128946304321},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5231205821037292},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5192061066627502},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42148345708847046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36574554443359375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3219240605831146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26624512672424316},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2310624122619629}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-929998/v1","doi":"https://doi.org/10.21203/rs.3.rs-929998/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-929998/v1","pdf_url":"https://www.researchsquare.com/article/rs-929998/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-929998/v1","doi":"https://doi.org/10.21203/rs.3.rs-929998/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-929998/v1","pdf_url":"https://www.researchsquare.com/article/rs-929998/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7099999785423279,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1088468014","display_name":null,"funder_award_id":"JCYJ20190809165201646","funder_id":"https://openalex.org/F4320326705","funder_display_name":"Science, Technology and Innovation Commission of Shenzhen Municipality"},{"id":"https://openalex.org/G5143598910","display_name":null,"funder_award_id":"82071362","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326705","display_name":"Science, Technology and Innovation Commission of Shenzhen Municipality","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204892845.pdf","grobid_xml":"https://content.openalex.org/works/W3204892845.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1877278762","https://openalex.org/W1943422254","https://openalex.org/W1970161481","https://openalex.org/W1974432822","https://openalex.org/W1978451090","https://openalex.org/W1989811807","https://openalex.org/W2026607364","https://openalex.org/W2039758887","https://openalex.org/W2046704592","https://openalex.org/W2047661701","https://openalex.org/W2061558355","https://openalex.org/W2065802840","https://openalex.org/W2082232396","https://openalex.org/W2086871526","https://openalex.org/W2089234060","https://openalex.org/W2093588436","https://openalex.org/W2096125390","https://openalex.org/W2101362932","https://openalex.org/W2115654652","https://openalex.org/W2128475302","https://openalex.org/W2131041787","https://openalex.org/W2139344466","https://openalex.org/W2155569675","https://openalex.org/W2280963565","https://openalex.org/W2314634699","https://openalex.org/W2408581686","https://openalex.org/W2512418227","https://openalex.org/W2572710398","https://openalex.org/W2608611322","https://openalex.org/W2618135007","https://openalex.org/W2645537330","https://openalex.org/W2742940528","https://openalex.org/W2781484159","https://openalex.org/W2792158423","https://openalex.org/W2806723635","https://openalex.org/W2807256450","https://openalex.org/W2889283495","https://openalex.org/W2913677653","https://openalex.org/W2942948351","https://openalex.org/W2969396388","https://openalex.org/W2974865755","https://openalex.org/W2981196568","https://openalex.org/W2998520357","https://openalex.org/W3007679838","https://openalex.org/W3017950292","https://openalex.org/W3116630073","https://openalex.org/W3132240972","https://openalex.org/W3133536873","https://openalex.org/W3164097903","https://openalex.org/W3174591919","https://openalex.org/W3194004635","https://openalex.org/W4205904338","https://openalex.org/W4211246989"],"related_works":["https://openalex.org/W4247433414","https://openalex.org/W4311701113","https://openalex.org/W4385349361","https://openalex.org/W4414788836","https://openalex.org/W4392744767","https://openalex.org/W4214514505","https://openalex.org/W2944005016","https://openalex.org/W2621316263","https://openalex.org/W2806600269","https://openalex.org/W2069273217"],"abstract_inverted_index":{"Abstract":[0],"Spinal":[1],"cord":[2,46,99],"injury":[3],"(SCI)":[4],"is":[5,39],"a":[6,74,179],"devastating":[7],"central":[8],"nervous":[9],"system":[10],"(CNS)":[11],"disease":[12],"with":[13,103],"no":[14],"satisfying":[15],"therapies":[16],"available.":[17],"Mobilizing":[18],"endogenous":[19,37],"neural":[20,196],"stem":[21],"cells":[22],"(NSCs)":[23],"to":[24,56,78,114,136,163],"trigger":[25],"intrinsic":[26],"regeneration":[27],"exhibits":[28],"promising":[29],"potentials":[30],"for":[31,195],"SCI":[32,106,160],"repair.":[33],"However,":[34],"neurogenesis":[35,83,139,167,184],"from":[36],"NSCs":[38,59,80,100,109,138,164],"extremely":[40],"restricted":[41],"in":[42,92,97,185],"the":[43,62,148,186],"non-neurogenic":[44],"spinal":[45,98,187],"after":[47,159,199],"SCI.":[48,200],"Accumulation":[49],"of":[50,95,101,124,153],"protein":[51,86,121,144],"aggregates":[52,145],"has":[53],"been":[54],"shown":[55],"impede":[57],"quiescent":[58],"activation":[60,81],"and":[61,82,111,168],"subsequent":[63],"neurogenesis.":[64],"Here,":[65],"we":[66],"found":[67],"that":[68,131],"ubiquitin":[69],"c-terminal":[70],"hydrolase":[71],"l-1":[72],"(UCHL1),":[73],"deubiquitinating":[75],"enzyme,":[76],"functioned":[77],"regulate":[79],"by":[84,140],"reducing":[85],"aggregations":[87],"through":[88],"ubiquitin-proteasome":[89],"pathway":[90],"(UPP)":[91],"vitro.":[93],"Upregulation":[94],"UCHL1":[96],"rats":[102],"complete":[104],"transection":[105],"efficiently":[107],"enhanced":[108,170],"proliferation":[110],"neurogenesis,":[112],"leading":[113],"significantly":[115],"improved":[116],"functional":[117],"outcomes.":[118],"Based":[119],"on":[120],"microarray":[122],"analysis":[123],"cerebrospinal":[125],"fluid":[126],"(CSF),":[127],"our":[128],"results":[129],"revealed":[130,178],"A1":[132,154],"reactive":[133],"astrocytes":[134,155],"acted":[135],"restrict":[137],"negatively":[141],"regulating":[142,182],"UCHL1-depentdent":[143],"removal":[146],"via":[147],"C3/Nrf2":[149],"signaling.":[150],"Indeed,":[151],"blockade":[152],"using":[156],"neutralizing":[157],"antibodies":[158],"also":[161,190],"led":[162],"activation,":[165],"increased":[166],"remarkably":[169],"motor":[171],"function":[172],"recovery.":[173],"This":[174],"study":[175],"not":[176],"only":[177],"novel":[180],"mechanism":[181],"NSCs-medicated":[183],"cord,":[188],"but":[189],"provided":[191],"new":[192],"molecular":[193],"targets":[194],"repair":[197],"strategies":[198]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-11T00:00:00"}
