{"id":"https://openalex.org/W3204886854","doi":"https://doi.org/10.1016/j.jep.2021.114657","title":"Daphnes Cortex and its licorice-processed products suppress inflammation via the TLR4/NF-\u03baB/NLRP3 signaling pathway and regulation of the metabolic profile in the treatment of rheumatoid arthritis","display_name":"Daphnes Cortex and its licorice-processed products suppress inflammation via the TLR4/NF-\u03baB/NLRP3 signaling pathway and regulation of the metabolic profile in the treatment of rheumatoid arthritis","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W3204886854","doi":"https://doi.org/10.1016/j.jep.2021.114657","mag":"3204886854","pmid":"https://pubmed.ncbi.nlm.nih.gov/34600080"},"language":"en","primary_location":{"id":"doi:10.1016/j.jep.2021.114657","doi":"https://doi.org/10.1016/j.jep.2021.114657","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jep.2021.114657","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jep.2021.114657","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054449046","display_name":"Xianglong Meng","orcid":"https://orcid.org/0000-0001-8934-128X","observed_orcids":["https://orcid.org/0000-0001-8934-128X"]},"institutions":[{"id":"https://openalex.org/I4210142037","display_name":"Shanxi University of Traditional Chinese Medicine","ror":"https://ror.org/0522dg826","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianglong Meng","raw_affiliation_strings":["College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: sszywzh@126.com","College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: sszywzh@126.com","institution_ids":["https://openalex.org/I4210142037"]},{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China","institution_ids":["https://openalex.org/I4210142037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352069","display_name":"Xiaoyan Zhang","orcid":"https://orcid.org/0000-0002-3193-1401","observed_orcids":["https://orcid.org/0000-0002-3193-1401"]},"institutions":[{"id":"https://openalex.org/I4210142037","display_name":"Shanxi University of Traditional Chinese Medicine","ror":"https://ror.org/0522dg826","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Zhang","raw_affiliation_strings":["College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: zhangxiaoyan0522@163.com","College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: zhangxiaoyan0522@163.com","institution_ids":["https://openalex.org/I4210142037"]},{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China","institution_ids":["https://openalex.org/I4210142037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033915750","display_name":"Xiaojuan Su","orcid":"https://orcid.org/0000-0001-5544-554X","observed_orcids":["https://orcid.org/0000-0001-5544-554X","https://orcid.org/0000-0002-5527-678X"]},"institutions":[{"id":"https://openalex.org/I4210142037","display_name":"Shanxi University of Traditional Chinese Medicine","ror":"https://ror.org/0522dg826","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojuan Su","raw_affiliation_strings":["College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: 15735649397@163.com","College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: 15735649397@163.com","institution_ids":["https://openalex.org/I4210142037"]},{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China","institution_ids":["https://openalex.org/I4210142037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100705103","display_name":"Xiaoqin Liu","orcid":"https://orcid.org/0000-0002-3646-4427","observed_orcids":["https://orcid.org/0000-0002-3646-4427"]},"institutions":[{"id":"https://openalex.org/I4210142037","display_name":"Shanxi University of Traditional Chinese Medicine","ror":"https://ror.org/0522dg826","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqin Liu","raw_affiliation_strings":["College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: xiaoqinl0124@163.com","College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: xiaoqinl0124@163.com","institution_ids":["https://openalex.org/I4210142037"]},{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China","institution_ids":["https://openalex.org/I4210142037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009438631","display_name":"Kele Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142037","display_name":"Shanxi University of Traditional Chinese Medicine","ror":"https://ror.org/0522dg826","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kele Ren","raw_affiliation_strings":["College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: 1165341281@qq.com","College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: 1165341281@qq.com","institution_ids":["https://openalex.org/I4210142037"]},{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China","institution_ids":["https://openalex.org/I4210142037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023901114","display_name":"Chen-Xu Ning","orcid":"https://orcid.org/0000-0003-3951-2962","observed_orcids":["https://orcid.org/0000-0003-3951-2962"]},"institutions":[{"id":"https://openalex.org/I4210142037","display_name":"Shanxi University of Traditional Chinese Medicine","ror":"https://ror.org/0522dg826","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenxu Ning","raw_affiliation_strings":["College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: sunshine213112@163.com","College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: sunshine213112@163.com","institution_ids":["https://openalex.org/I4210142037"]},{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China","institution_ids":["https://openalex.org/I4210142037"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I4210142037","display_name":"Shanxi University of Traditional Chinese Medicine","ror":"https://ror.org/0522dg826","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China; College of Pharmacy, Shenyang Pharmaceutical University, Benxi, China. Electronic address: dkzhangqi@126.com","College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China","College of Pharmacy, Shenyang Pharmaceutical University, Benxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China; College of Pharmacy, Shenyang Pharmaceutical University, Benxi, China. Electronic address: dkzhangqi@126.com","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China","institution_ids":["https://openalex.org/I4210142037"]},{"raw_affiliation_string":"College of Pharmacy, Shenyang Pharmaceutical University, Benxi, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103093671","display_name":"Shuosheng Zhang","orcid":"https://orcid.org/0000-0002-0825-8116","observed_orcids":["https://orcid.org/0000-0002-0825-8116"]},"institutions":[{"id":"https://openalex.org/I4210142037","display_name":"Shanxi University of Traditional Chinese Medicine","ror":"https://ror.org/0522dg826","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210142037"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"ShuoSheng Zhang","raw_affiliation_strings":["College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: zhangshuosheng@aliyun.com","College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China. Electronic address: zhangshuosheng@aliyun.com","institution_ids":["https://openalex.org/I4210142037"]},{"raw_affiliation_string":"College of Chinese Materia Medica and food engineering, Shanxi University of Chinese Medicine, Jinzhong, China","institution_ids":["https://openalex.org/I4210142037"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103093671"],"corresponding_institution_ids":["https://openalex.org/I4210142037"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":9.04,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.98653014,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"283","issue":null,"first_page":"114657","last_page":"114657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.972000002861023},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.7480000257492065},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.6679999828338623},{"id":"https://openalex.org/keywords/macrophage-inflammatory-response","display_name":"macrophage inflammation","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6848655343055725},{"id":"https://openalex.org/C2779655422","wikidata":"https://www.wikidata.org/wiki/Q1196166","display_name":"Glycyrrhiza uralensis","level":3,"score":0.6110426783561707},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5806820392608643},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5794903039932251},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4734613299369812},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42133229970932007},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2779276967048645},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08706769347190857},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006035","descriptor_name":"Glycyrrhiza","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032364","descriptor_name":"Daphne","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jep.2021.114657","doi":"https://doi.org/10.1016/j.jep.2021.114657","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jep.2021.114657","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},{"id":"pmid:34600080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34600080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ethnopharmacology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/j.jep.2021.114657","doi":"https://doi.org/10.1016/j.jep.2021.114657","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jep.2021.114657","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2339349141","display_name":null,"funder_award_id":"2018TD-006","funder_id":"https://openalex.org/F4320329789","funder_display_name":"Shaanxi University of Chinese Medicine"},{"id":"https://openalex.org/G3252754810","display_name":null,"funder_award_id":"81673601","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329789","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132"},{"id":"https://openalex.org/F4320336035","display_name":"Shanxi Provincial Key Research and Development Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1970082345","https://openalex.org/W1980545875","https://openalex.org/W2004508336","https://openalex.org/W2005233485","https://openalex.org/W2040375528","https://openalex.org/W2092708089","https://openalex.org/W2107190751","https://openalex.org/W2111621675","https://openalex.org/W2144181811","https://openalex.org/W2150465569","https://openalex.org/W2226985646","https://openalex.org/W2255082228","https://openalex.org/W2353978315","https://openalex.org/W2571021552","https://openalex.org/W2584615010","https://openalex.org/W2604594511","https://openalex.org/W2623617647","https://openalex.org/W2784035341","https://openalex.org/W2789708933","https://openalex.org/W2792509381","https://openalex.org/W2804745430","https://openalex.org/W2883737013","https://openalex.org/W2884150642","https://openalex.org/W2905182489","https://openalex.org/W2920893744","https://openalex.org/W2946438596","https://openalex.org/W2966888496","https://openalex.org/W2978627145","https://openalex.org/W2989545598","https://openalex.org/W2998495371","https://openalex.org/W2999085069","https://openalex.org/W3014146563","https://openalex.org/W3016234837","https://openalex.org/W3024065145","https://openalex.org/W3024179740","https://openalex.org/W3029836818","https://openalex.org/W3039259714","https://openalex.org/W3045774404","https://openalex.org/W3082105577","https://openalex.org/W3085790969","https://openalex.org/W3087331232","https://openalex.org/W3088218385","https://openalex.org/W3094068139","https://openalex.org/W3094578730","https://openalex.org/W3095462916","https://openalex.org/W3109074619","https://openalex.org/W3109863244","https://openalex.org/W3110285492","https://openalex.org/W3118244505","https://openalex.org/W3178725380","https://openalex.org/W3179809924","https://openalex.org/W3184084653","https://openalex.org/W6753124511","https://openalex.org/W7161494996"],"related_works":["https://openalex.org/W6989249710","https://openalex.org/W2001681439","https://openalex.org/W2092801963","https://openalex.org/W4416345397","https://openalex.org/W26874760","https://openalex.org/W4365395723","https://openalex.org/W2072760508","https://openalex.org/W3011151108","https://openalex.org/W7096843371","https://openalex.org/W4399992194"],"abstract_inverted_index":{"ETHNOPHARMACOLOGICAL":[0],"RELEVANCE:":[1],"Daphnes":[2],"Cortex":[3],"(Daphne":[4],"Giraldii":[5],"Nitsche,":[6],"DGN)":[7],"is":[8],"a":[9],"popular":[10],"traditional":[11],"Chinese":[12],"herbal":[13],"medicine":[14],"for":[15,116],"traumatic":[16],"injuries":[17],"and":[18,25,51,57,75,81,86,104,111,146,159,176,199,207,232,240,267,289,293],"rheumatoid":[19],"arthritis":[20],"(RA)":[21],"in":[22,45,62,79,82,91,129,187,204,229,257,299],"the":[23,49,73,77,121,139,205,282,296],"Shaanxi":[24],"Gansu":[26],"provinces":[27],"of":[28,53,109,138,163,248,295],"China.":[29],"Due":[30],"to":[31,119,169],"skin":[32],"irritation":[33],"caused":[34],"by":[35,134],"raw":[36],"DGN":[37,40,56,60,89,114,145,149,174,181,191,211,243,259,275],"(RDGN),":[38],"licorice-processed":[39,59,88,113,148,242,258],"products":[41,61,90,115,150,182,192,212,244,276],"are":[42],"usually":[43],"used":[44,168],"clinical":[46],"practice.":[47],"However,":[48],"efficacy":[50,74],"mechanisms":[52,78],"action":[54],"between":[55,84,144,173,238,262],"its":[58,87,112,147,177,241],"treating":[63,92,300],"RA":[64,99,185],"have":[65],"not":[66],"been":[67],"compared.":[68],"AIMS:":[69],"This":[70],"study":[71],"compared":[72],"elucidated":[76],"vitro":[80],"vivo":[83],"RDGN":[85,110,239],"RA.":[93,301],"MATERIALS":[94],"AND":[95],"METHODS:":[96],"A":[97],"collagen-induced":[98],"rat":[100,164],"model":[101],"was":[102],"established,":[103],"treated":[105],"with":[106,264],"different":[107],"doses":[108],"4":[117],"weeks":[118],"explore":[120,171],"therapeutic":[122],"effects.":[123],"The":[124,236],"anti-inflammatory":[125,279],"effects":[126,280],"were":[127,167,245,250,271],"assessed":[128],"RAW":[130],"264.7":[131],"macrophages":[132],"stimulated":[133],"lipopolysaccharide":[135],"(LPS).":[136],"Analyses":[137],"differential":[140,265,268],"quality":[141],"markers":[142],"(DQMs)":[143],"using":[151],"ultra-high":[152],"performance":[153],"liquid":[154],"chromatography-quadrupole":[155],"time-of-flight":[156],"mass":[157],"spectrometry,":[158],"non-targeted":[160],"metabolomics":[161],"analyses":[162],"synovial":[165],"tissues":[166],"systematically":[170],"correlations":[172],"processing":[175],"efficacy.":[178],"RESULTS:":[179],"Licorice-processed":[180,190,210,274],"significantly":[183,213],"ameliorated":[184],"symptoms":[186],"CIA":[188,230,287],"rats.":[189],"also":[193],"regulated":[194],"inflammatory":[195],"cytokines,":[196],"matrix":[197],"metalloproteinases,":[198],"vascular":[200],"endothelial":[201],"growth":[202],"factor":[203,218],"serum":[206],"cell":[208],"supernatants.":[209],"inhibited":[214],"Toll-like":[215],"receptor":[216,221],"4/nuclear":[217],"kappa":[219],"B/NOD-like":[220],"family,":[222],"pyrin":[223],"domain":[224],"containing":[225],"3":[226],"(TLR4/NF-\u03baB/NLRP3)":[227],"signaling":[228,284],"rats":[231,288],"LPS-induced":[233,290],"RAW264.7":[234,291],"cells.":[235],"DQMs":[237,263],"identified,":[246],"most":[247],"which":[249],"amino":[251],"acids":[252],"or":[253],"energy-related":[254],"metabolites":[255,266],"present":[256],"products.":[260],"Correlations":[261],"metabolic":[269,297],"pathways":[270],"established.":[272],"CONCLUSIONS:":[273],"displayed":[277],"better":[278],"via":[281],"TLR4/NF-\u03baB/NLRP3":[283],"pathway":[285],"on":[286],"cells,":[292],"regulation":[294],"profile":[298]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-10-11T00:00:00"}