{"id":"https://openalex.org/W3204879978","doi":"https://doi.org/10.1177/13524585211049397","title":"Interpreting change on the Symbol Digit Modalities Test in people with relapsing multiple sclerosis using the reliable change methodology","display_name":"Interpreting change on the Symbol Digit Modalities Test in people with relapsing multiple sclerosis using the reliable change methodology","publication_year":2021,"publication_date":"2021-10-06","ids":{"openalex":"https://openalex.org/W3204879978","doi":"https://doi.org/10.1177/13524585211049397","mag":"3204879978","pmid":"https://pubmed.ncbi.nlm.nih.gov/34612114"},"language":"en","primary_location":{"id":"doi:10.1177/13524585211049397","doi":"https://doi.org/10.1177/13524585211049397","is_oa":false,"landing_page_url":"https://doi.org/10.1177/13524585211049397","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072681456","display_name":"Zachary L. Weinstock","orcid":"https://orcid.org/0000-0002-2929-8432","observed_orcids":["https://orcid.org/0000-0002-2929-8432"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Weinstock","raw_affiliation_strings":["Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-2929-8432","affiliations":[{"raw_affiliation_string":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037427363","display_name":"Sarah Anne Morrow","orcid":"https://orcid.org/0000-0001-7522-6440","observed_orcids":["https://orcid.org/0000-0001-7522-6440"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I2800925808","display_name":"London Health Sciences Centre","ror":"https://ror.org/037tz0e16","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sarah Morrow","raw_affiliation_strings":["Department of Clinical Neurological Sciences, Western University and London Health Sciences Center, London, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neurological Sciences, Western University and London Health Sciences Center, London, ON, Canada","institution_ids":["https://openalex.org/I125749732","https://openalex.org/I2800925808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090965713","display_name":"Devon S. Conway","orcid":"https://orcid.org/0000-0001-5359-6686","observed_orcids":["https://orcid.org/0000-0001-5359-6686"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devon Conway","raw_affiliation_strings":["Mellen Center for Multiple Sclerosis Treatment, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0001-5359-6686","affiliations":[{"raw_affiliation_string":"Mellen Center for Multiple Sclerosis Treatment, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058745536","display_name":"Tom A. Fuchs","orcid":"https://orcid.org/0000-0002-0219-3518","observed_orcids":["https://orcid.org/0000-0002-0219-3518"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Fuchs","raw_affiliation_strings":["Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-0219-3518","affiliations":[{"raw_affiliation_string":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059030751","display_name":"Curtis M. Wojcik","orcid":"https://orcid.org/0000-0003-2367-6102","observed_orcids":["https://orcid.org/0000-0003-2367-6102"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curtis Wojcik","raw_affiliation_strings":["Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034545768","display_name":"Mahmut \u00dcnverdi","orcid":"https://orcid.org/0000-0002-5526-3532","observed_orcids":["https://orcid.org/0000-0002-5526-3532"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmut Unverdi","raw_affiliation_strings":["Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-5526-3532","affiliations":[{"raw_affiliation_string":"Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079130521","display_name":"Robert Zivadinov","orcid":"https://orcid.org/0000-0002-7799-1485","observed_orcids":["https://orcid.org/0000-0002-7799-1485"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Zivadinov","raw_affiliation_strings":["Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-7799-1485","affiliations":[{"raw_affiliation_string":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075596287","display_name":"Bianca Weinstock\u2010Guttman","orcid":"https://orcid.org/0000-0001-6732-151X","observed_orcids":["https://orcid.org/0000-0001-6732-151X"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bianca Weinstock-Guttman","raw_affiliation_strings":["Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-6732-151X","affiliations":[{"raw_affiliation_string":"Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021760618","display_name":"Grant L. Iverson","orcid":"https://orcid.org/0000-0001-7348-9570","observed_orcids":["https://orcid.org/0000-0001-7348-9570"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405272316","display_name":"Schoen Adams Research Institute at Spaulding Rehabilitation","ror":"https://ror.org/03z41bq39","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405272316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grant L Iverson","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA/Spaulding Rehabilitation Hospital and Spaulding Research Institute, Charlestown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA/Spaulding Rehabilitation Hospital and Spaulding Research Institute, Charlestown, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799748957","https://openalex.org/I4405272316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041234325","display_name":"Michael G. Dwyer","orcid":"https://orcid.org/0000-0003-4684-4658","observed_orcids":["https://orcid.org/0000-0003-4684-4658"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Dwyer","raw_affiliation_strings":["Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA/Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033147621","display_name":"Ralph H. B. Benedict","orcid":"https://orcid.org/0000-0002-2080-3631","observed_orcids":["https://orcid.org/0000-0002-2080-3631"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ralph HB Benedict","raw_affiliation_strings":["Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5033147621"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":5.1776,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.96995556,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"28","issue":"7","first_page":"1101","last_page":"1111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10467","display_name":"Psychometric Methodologies and Testing","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12848","display_name":"Psychological Testing and Assessment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3202","display_name":"Applied Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/symbol-digit-modalities-test","display_name":"Symbol Digit Modalities Test","score":0.996999979019165},{"id":"https://openalex.org/keywords/relapsing-multiple-sclerosis","display_name":"relapsing multiple sclerosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/reliable-change-index","display_name":"reliable change index","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8840000033378601},{"id":"https://openalex.org/keywords/measurement-error","display_name":"measurement error","score":0.6439999938011169},{"id":"https://openalex.org/keywords/clinical-trial-outcome-measures","display_name":"clinical trial outcome measures","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5919029116630554},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5095067620277405},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.49475187063217163},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.484857439994812},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4487815499305725},{"id":"https://openalex.org/C173633133","wikidata":"https://www.wikidata.org/wiki/Q2110223","display_name":"Raw score","level":3,"score":0.4225088357925415},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.41690003871917725},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.41467756032943726},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.40980932116508484},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.40493088960647583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34572285413742065},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.33524906635284424},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.18590852618217468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15134698152542114},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.14888527989387512},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14293259382247925},{"id":"https://openalex.org/C132964779","wikidata":"https://www.wikidata.org/wiki/Q2110223","display_name":"Raw data","level":2,"score":0.1242169439792633},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08472329378128052},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.07047224044799805},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/13524585211049397","doi":"https://doi.org/10.1177/13524585211049397","is_oa":false,"landing_page_url":"https://doi.org/10.1177/13524585211049397","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},{"id":"pmid:34612114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34612114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple sclerosis (Houndmills, Basingstoke, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3675334582","display_name":null,"funder_award_id":"NMSS RG 5195A4/1","funder_id":"https://openalex.org/F4320306161","funder_display_name":"National Multiple Sclerosis Society"}],"funders":[{"id":"https://openalex.org/F4320306161","display_name":"National Multiple Sclerosis Society","ror":"https://ror.org/03019wv17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1410710015","https://openalex.org/W1973799754","https://openalex.org/W1975693163","https://openalex.org/W2000399989","https://openalex.org/W2021455346","https://openalex.org/W2055670101","https://openalex.org/W2084724611","https://openalex.org/W2098706009","https://openalex.org/W2099979865","https://openalex.org/W2106806414","https://openalex.org/W2112336497","https://openalex.org/W2114242035","https://openalex.org/W2119705413","https://openalex.org/W2123359871","https://openalex.org/W2132417892","https://openalex.org/W2132936146","https://openalex.org/W2139473423","https://openalex.org/W2157092569","https://openalex.org/W2412926684","https://openalex.org/W2588292672","https://openalex.org/W2804361965","https://openalex.org/W2895845951","https://openalex.org/W2896912757","https://openalex.org/W2901460138","https://openalex.org/W3001018322","https://openalex.org/W3107056180","https://openalex.org/W3111909225","https://openalex.org/W4239267740"],"related_works":["https://openalex.org/W3211610430","https://openalex.org/W4389448615","https://openalex.org/W4410919379","https://openalex.org/W3125862509","https://openalex.org/W2588292672","https://openalex.org/W2132417892","https://openalex.org/W1973597599","https://openalex.org/W4410431338","https://openalex.org/W3089623732","https://openalex.org/W4254886004"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,53],"Symbol":[2],"Digit":[3],"Modalities":[4],"Test":[5],"(SDMT)":[6],"is":[7,20],"increasingly":[8],"utilized":[9],"in":[10,197],"clinical":[11,202,205],"trials.":[12],"A":[13],"SDMT":[14,35,83,146],"score":[15,153],"change":[16,67,147,182,196],"of":[17,55,65,148,162,180],"4":[18],"points":[19,154],"considered":[21],"clinically":[22,124],"important,":[23],"based":[24],"on":[25,68],"association":[26],"with":[27,79],"employment":[28],"anchors.":[29],"Optimal":[30],"thresholds":[31,111,130],"for":[32,38,112,131,168,184,200],"statistically":[33,62,186],"reliable":[34,63,113,132,181],"changes,":[36],"accounting":[37],"test":[39],"reliability":[40],"and":[41,88,95,105,117,122,142,165,178,204],"measurement":[42],"error,":[43],"are":[44],"yet":[45],"to":[46,49,59,157,194],"be":[47,192],"applied":[48],"individual":[50,66,198],"cases.":[51],"OBJECTIVE:":[52],"aim":[54],"this":[56],"study":[57,75,174],"was":[58,155],"derive":[60],"a":[61,123],"marker":[64],"the":[69,102,135,159,176],"SDMT.":[70],"METHODS:":[71],"This":[72,173],"prospective,":[73],"case-control":[74],"enrolled":[76],"166":[77],"patients":[78],"multiple":[80],"sclerosis":[81],"(MS).":[82],"scores":[84],"at":[85,134],"baseline,":[86],"relapse,":[87],"3-month":[89],"follow-up":[90],"were":[91,115],"compared":[92],"between":[93,140],"relapsing":[94],"stable":[96,103],"patient":[97],"groups.":[98],"Using":[99],"data":[100],"from":[101],"group":[104],"three":[106],"previously":[107],"published":[108],"studies,":[109],"candidate":[110],"decline":[114,133,189],"calculated":[116],"validated":[118],"against":[119],"other":[120],"tests":[121],"meaningful":[125,187],"anchor-cognitive":[126],"relapse.":[127],"RESULTS:":[128],"Candidate":[129],"80%":[136],"confidence":[137],"level":[138],"varied":[139],"6":[141],"11":[143],"points.":[144],"An":[145],"8":[149],"or":[150],"more":[151],"raw":[152],"deemed":[156],"offer":[158],"best":[160],"balance":[161],"discriminatory":[163],"power":[164],"external":[166],"validity":[167],"estimating":[169],"cognitive":[170,188],"decline.":[171],"CONCLUSION:":[172],"illustrates":[175],"feasibility":[177],"usefulness":[179],"methodology":[183],"identifying":[185],"that":[190],"could":[191],"implemented":[193],"identify":[195],"patients,":[199],"both":[201],"management":[203],"trial":[206],"outcomes.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-10-11T00:00:00"}