{"id":"https://openalex.org/W3204861367","doi":"https://doi.org/10.1016/j.intimp.2021.108213","title":"Schisandrin B promotes TH1 cell differentiation by targeting STAT1","display_name":"Schisandrin B promotes TH1 cell differentiation by targeting STAT1","publication_year":2021,"publication_date":"2021-10-06","ids":{"openalex":"https://openalex.org/W3204861367","doi":"https://doi.org/10.1016/j.intimp.2021.108213","mag":"3204861367","pmid":"https://pubmed.ncbi.nlm.nih.gov/34624651"},"language":"en","primary_location":{"id":"doi:10.1016/j.intimp.2021.108213","doi":"https://doi.org/10.1016/j.intimp.2021.108213","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2021.108213","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051435389","display_name":"Jufeng Guo","orcid":"https://orcid.org/0000-0001-5341-0271","observed_orcids":["https://orcid.org/0000-0001-5341-0271"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jufeng Guo","raw_affiliation_strings":["Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101637164","display_name":"Yingying Shen","orcid":"https://orcid.org/0009-0003-0552-687X","observed_orcids":["https://orcid.org/0009-0003-0552-687X"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Shen","raw_affiliation_strings":["Institute of Immunology, Zhejiang University School of Medicine, 310058 Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Zhejiang University School of Medicine, 310058 Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xia Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Lin","raw_affiliation_strings":["Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767640","display_name":"Honggang Chen","orcid":"https://orcid.org/0000-0001-7830-1936","observed_orcids":["https://orcid.org/0000-0001-7830-1936"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Honggang Chen","raw_affiliation_strings":["Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100414716","display_name":"Jian Liu","orcid":"https://orcid.org/0000-0003-0607-7917","observed_orcids":["https://orcid.org/0000-0003-0607-7917"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Liu","raw_affiliation_strings":["Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China. Electronic address: 529120238@qq.com","Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-0607-7917","affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China. Electronic address: 529120238@qq.com","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100414716"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":2580,"currency":"USD","value_usd":2580},"apc_paid":null,"fwci":0.2796,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.40888216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"101","issue":"Pt A","first_page":"108213","last_page":"108213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.34279999136924744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.34279999136924744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.20980000495910645,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.11509999632835388,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schisandrin-b","display_name":"schisandrin B","score":0.9079999923706055},{"id":"https://openalex.org/keywords/schisandra-chinensis","display_name":"Schisandra chinensis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/th1-cell-differentiation","display_name":"Th1 differentiation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/stat1-phosphorylation","display_name":"STAT1 phosphorylation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/t-bet","display_name":"T-bet","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/naive-t-cell-differentiation","display_name":"naive T cell differentiation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C2780876136","wikidata":"https://www.wikidata.org/wiki/Q900986","display_name":"Schisandra chinensis","level":4,"score":0.7305071353912354},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5796875953674316},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.5320360064506531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5231134295463562},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5084423422813416},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5036119818687439},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5003368854522705},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.47280946373939514},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4452383816242218},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35160648822784424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33592164516448975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15264329314231873},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15029630064964294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0958063006401062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09545925259590149},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.07851353287696838},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011083","descriptor_name":"Polycyclic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D034242","descriptor_name":"Cyclooctanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.intimp.2021.108213","doi":"https://doi.org/10.1016/j.intimp.2021.108213","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.intimp.2021.108213","pdf_url":null,"source":{"id":"https://openalex.org/S158377717","display_name":"International Immunopharmacology","issn_l":"1567-5769","issn":["1567-5769","1878-1705"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunopharmacology","raw_type":"journal-article"},{"id":"pmid:34624651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34624651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5672463646","display_name":null,"funder_award_id":"OO20191170","funder_id":"https://openalex.org/F4320322162","funder_display_name":"Hangzhou Science and Technology Bureau"},{"id":"https://openalex.org/G6388537847","display_name":null,"funder_award_id":"LQ20H160018","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G866691633","display_name":null,"funder_award_id":"LQ21H100002","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320322162","display_name":"Hangzhou Science and Technology Bureau","ror":"https://ror.org/04gvkax77"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1486722793","https://openalex.org/W1540824853","https://openalex.org/W1939125543","https://openalex.org/W1942668068","https://openalex.org/W1965734808","https://openalex.org/W1967261754","https://openalex.org/W1973548013","https://openalex.org/W1977701102","https://openalex.org/W2027699993","https://openalex.org/W2120010406","https://openalex.org/W2128475635","https://openalex.org/W2142017607","https://openalex.org/W2152014155","https://openalex.org/W2162819001","https://openalex.org/W2339194328","https://openalex.org/W2519292031","https://openalex.org/W2886978647","https://openalex.org/W2903617989","https://openalex.org/W2981725236","https://openalex.org/W3017312058","https://openalex.org/W3128813484","https://openalex.org/W4408239020"],"related_works":["https://openalex.org/W2339194328","https://openalex.org/W3128813484","https://openalex.org/W2905364732","https://openalex.org/W2075852433","https://openalex.org/W2470828798","https://openalex.org/W2092558345","https://openalex.org/W4400100526","https://openalex.org/W4404292034","https://openalex.org/W2038915116","https://openalex.org/W2358939379"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-10-11T00:00:00"}