{"id":"https://openalex.org/W3204829583","doi":"https://doi.org/10.3389/fimmu.2021.732667","title":"Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans","display_name":"Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W3204829583","doi":"https://doi.org/10.3389/fimmu.2021.732667","mag":"3204829583","pmid":"https://pubmed.ncbi.nlm.nih.gov/34659219","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8515144"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2021.732667","doi":"https://doi.org/10.3389/fimmu.2021.732667","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.732667","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.732667/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.732667/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008675413","display_name":"Marija Zaric","orcid":"https://orcid.org/0000-0002-0569-6049","observed_orcids":["https://orcid.org/0000-0002-0569-6049"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marija Zaric","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039852163","display_name":"Arianna Marini","orcid":"https://orcid.org/0000-0003-3416-7362","observed_orcids":["https://orcid.org/0000-0003-3416-7362"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arianna Marini","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013585344","display_name":"Carolyn M. Nielsen","orcid":"https://orcid.org/0000-0002-9033-1318","observed_orcids":["https://orcid.org/0000-0002-9033-1318"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carolyn M. Nielsen","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690498","display_name":"Gaurav Gupta","orcid":"https://orcid.org/0000-0001-7941-0229","observed_orcids":["https://orcid.org/0000-0001-7941-0229"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gaurav Gupta","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008870138","display_name":"David Mekhaiel","orcid":"https://orcid.org/0000-0001-9338-811X","observed_orcids":["https://orcid.org/0000-0001-9338-811X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Mekhaiel","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101864785","display_name":"Thao Pham","orcid":"https://orcid.org/0000-0002-1283-557X","observed_orcids":["https://orcid.org/0000-0002-1283-557X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thao P. Pham","raw_affiliation_strings":["Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007799369","display_name":"Sean C. Elias","orcid":"https://orcid.org/0000-0002-6053-8238","observed_orcids":["https://orcid.org/0000-0002-6053-8238"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sean C. Elias","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065406333","display_name":"Iona Jennifer Taylor","orcid":"https://orcid.org/0000-0002-2287-9488","observed_orcids":["https://orcid.org/0000-0002-2287-9488"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Iona J. Taylor","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044329711","display_name":"Hans de Graaf","orcid":"https://orcid.org/0000-0001-8055-8749","observed_orcids":["https://orcid.org/0000-0001-8055-8749"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hans de Graaf","raw_affiliation_strings":["NIHR Clinical Research Facility, University Hospital Southampton NHS Foundation Trust and Faculty of Medicine, University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Clinical Research Facility, University Hospital Southampton NHS Foundation Trust and Faculty of Medicine, University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083590098","display_name":"Ruth Payne","orcid":"https://orcid.org/0000-0002-8490-671X","observed_orcids":["https://orcid.org/0000-0002-8490-671X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth O. Payne","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101573445","display_name":"Yuanyuan Li","orcid":"https://orcid.org/0000-0002-9143-8029","observed_orcids":["https://orcid.org/0000-0002-9143-8029","https://orcid.org/0000-0002-2877-9568"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yuanyuan Li","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063777614","display_name":"Sarah E. Silk","orcid":"https://orcid.org/0000-0003-0563-4814","observed_orcids":["https://orcid.org/0000-0003-0563-4814"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah E. Silk","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008215906","display_name":"Chris Williams","orcid":"https://orcid.org/0000-0003-2236-5644","observed_orcids":["https://orcid.org/0000-0003-2236-5644"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Williams","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037138357","display_name":"Adrian V. S. Hill","orcid":"https://orcid.org/0000-0003-0900-9629","observed_orcids":["https://orcid.org/0000-0003-0900-9629"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adrian V. S. Hill","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028156362","display_name":"Carole A. Long","orcid":"https://orcid.org/0000-0002-3835-5443","observed_orcids":["https://orcid.org/0000-0002-3835-5443"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carole A. Long","raw_affiliation_strings":["Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089823757","display_name":"Kazutoyo Miura","orcid":"https://orcid.org/0000-0003-4455-2432","observed_orcids":["https://orcid.org/0000-0003-4455-2432"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazutoyo Miura","raw_affiliation_strings":["Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052936033","display_name":"Sumi Biswas","orcid":"https://orcid.org/0000-0001-8507-7282","observed_orcids":["https://orcid.org/0000-0001-8507-7282"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sumi Biswas","raw_affiliation_strings":["Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5052936033"],"corresponding_institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.8491,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.83601025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":null,"first_page":"732667","last_page":"732667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pfs25","display_name":"Pfs25","score":0.9290000200271606},{"id":"https://openalex.org/keywords/transmission-blocking-vaccine","display_name":"transmission-blocking vaccine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/malaria-vaccine","display_name":"malaria vaccine","score":0.44600000977516174},{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/b-cell-response","display_name":"B cell response","score":0.7540000081062317},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cxcl13","display_name":"CXCL13","score":0.9039999842643738},{"id":"https://openalex.org/keywords/peptide-epitopes","display_name":"peptide epitopes","score":0.6389999985694885},{"id":"https://openalex.org/keywords/mva","display_name":"MVA","score":0.8939999938011169},{"id":"https://openalex.org/keywords/heterologous-prime-boost-vaccination","display_name":"heterologous prime-boost","score":0.8830000162124634},{"id":"https://openalex.org/keywords/malaria-transmission","display_name":"malaria transmission","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.7162439823150635},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6475337743759155},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6247785687446594},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6172186136245728},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4693910479545593},{"id":"https://openalex.org/C2781356689","wikidata":"https://www.wikidata.org/wiki/Q1986297","display_name":"Vaccinia","level":4,"score":0.45910313725471497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43723487854003906},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.43331533670425415},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4283086061477661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36301708221435547},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.11167225241661072},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000913","descriptor_name":"Antibodies, Protozoan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.3389/fimmu.2021.732667","doi":"https://doi.org/10.3389/fimmu.2021.732667","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.732667","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.732667/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:34659219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34659219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:pubmedcentral.nih.gov:8515144","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8515144/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:eprints.whiterose.ac.uk:179959","doi":null,"is_oa":false,"landing_page_url":"https://eprints.whiterose.ac.uk/179959/1/Poor%20CD4%2B%20T%20Cell%20Immunogenicity%20Limits%20Humoral%20Immunity%20to%20P.%C2%A0falciparum%20Transmission-Blocking%20Candidate%20Pfs25%20in%20Humans.%20.pdf","pdf_url":"https://eprints.whiterose.ac.uk/179959/1/Poor%20CD4%2B%20T%20Cell%20Immunogenicity%20Limits%20Humoral%20Immunity%20to%20P.%C2%A0falciparum%20Transmission-Blocking%20Candidate%20Pfs25%20in%20Humans.%20.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.soton.ac.uk:453259","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.3389/fimmu.2021.732667>).","pdf_url":"https://eprints.soton.ac.uk/453259/1/fimmu_12_732667.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:f21e9455de774a698a42b7af607f559b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f21e9455de774a698a42b7af607f559b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 12 (2021)","raw_type":"article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/331192","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/331192","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.78639","doi":"https://doi.org/10.17863/cam.78639","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.78639","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2021.732667","doi":"https://doi.org/10.3389/fimmu.2021.732667","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2021.732667","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.732667/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G118949","display_name":"A Multi-Stage Malaria Vaccine","funder_award_id":"305282","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G119964413","display_name":null,"funder_award_id":"FP7/2007\u20132013","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1405180835","display_name":null,"funder_award_id":"209200/Z/17/Z","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G2114474074","display_name":"The impact of vaccine platform on the cellular drivers of humoral immunity","funder_award_id":"209200","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2473961061","display_name":null,"funder_award_id":"FP7/2007\u20132013","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G2973790809","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G339059223","display_name":null,"funder_award_id":"Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4437677446","display_name":null,"funder_award_id":"209200/Z/17/Z","funder_id":"https://openalex.org/F4320336045","funder_display_name":"NIHR Oxford Biomedical Research Centre"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8560241033","display_name":null,"funder_award_id":"209200/Z/17/Z","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320336045","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204829583.pdf","grobid_xml":"https://content.openalex.org/works/W3204829583.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1242484266","https://openalex.org/W1841805549","https://openalex.org/W1969256234","https://openalex.org/W1971747284","https://openalex.org/W1981732254","https://openalex.org/W1986169276","https://openalex.org/W1998562159","https://openalex.org/W2016844693","https://openalex.org/W2017219476","https://openalex.org/W2020651720","https://openalex.org/W2020808295","https://openalex.org/W2027088291","https://openalex.org/W2027963539","https://openalex.org/W2030388818","https://openalex.org/W2034728213","https://openalex.org/W2035829098","https://openalex.org/W2038990150","https://openalex.org/W2041647537","https://openalex.org/W2043157968","https://openalex.org/W2045812733","https://openalex.org/W2067447412","https://openalex.org/W2071380288","https://openalex.org/W2072765827","https://openalex.org/W2074096962","https://openalex.org/W2074905094","https://openalex.org/W2086970585","https://openalex.org/W2096080350","https://openalex.org/W2098123605","https://openalex.org/W2113395588","https://openalex.org/W2120255678","https://openalex.org/W2137268127","https://openalex.org/W2137780548","https://openalex.org/W2139132743","https://openalex.org/W2139565733","https://openalex.org/W2146604395","https://openalex.org/W2147450297","https://openalex.org/W2159017032","https://openalex.org/W2160654020","https://openalex.org/W2161738112","https://openalex.org/W2167010530","https://openalex.org/W2181213627","https://openalex.org/W2194222044","https://openalex.org/W2286883753","https://openalex.org/W2306615822","https://openalex.org/W2411305194","https://openalex.org/W2413417242","https://openalex.org/W2440721038","https://openalex.org/W2460575784","https://openalex.org/W2464400647","https://openalex.org/W2474050077","https://openalex.org/W2495406093","https://openalex.org/W2536285012","https://openalex.org/W2578705601","https://openalex.org/W2582269309","https://openalex.org/W2588930849","https://openalex.org/W2601086746","https://openalex.org/W2625837026","https://openalex.org/W2626760342","https://openalex.org/W2626760732","https://openalex.org/W2765584638","https://openalex.org/W2773736921","https://openalex.org/W2783203982","https://openalex.org/W2801474028","https://openalex.org/W2802973938","https://openalex.org/W2803463081","https://openalex.org/W2829383402","https://openalex.org/W2885422062","https://openalex.org/W2886058877","https://openalex.org/W2891224336","https://openalex.org/W2894881231","https://openalex.org/W2902472115","https://openalex.org/W2903491984","https://openalex.org/W2938100698","https://openalex.org/W2950187344","https://openalex.org/W2950340990","https://openalex.org/W2962479809","https://openalex.org/W2991159931","https://openalex.org/W3177637593","https://openalex.org/W4244457796"],"related_works":["https://openalex.org/W2975047170","https://openalex.org/W7203962507","https://openalex.org/W2626760732","https://openalex.org/W66820731","https://openalex.org/W3110330792","https://openalex.org/W2767717559","https://openalex.org/W2954428213","https://openalex.org/W1425651523","https://openalex.org/W4320730822","https://openalex.org/W2096403964"],"abstract_inverted_index":{"Plasmodium":[0],"falciparum":[1],"transmission-blocking":[2,84],"vaccines":[3,233],"(TBVs)":[4],"targeting":[5],"the":[6,15,54,115,125,137,164,168,176,195,207,228],"Pfs25":[7],"antigen":[8],"have":[9,25],"shown":[10],"promise":[11],"in":[12,22,37,80,98,124,142,147,173],"mice":[13,99,146],"but":[14],"same":[16],"efficacy":[17],"has":[18,72],"never":[19],"been":[20],"achieved":[21],"humans.":[23],"We":[24,86,132,161],"previously":[26],"published":[27],"pre-clinical":[28],"data":[29],"related":[30],"to":[31,47,68,74,82,145],"a":[32],"TBV":[33],"candidate":[34],"Pfs25-IMX313":[35,105,138,184],"encoded":[36,106],"viral":[38],"vectors":[39],"which":[40],"was":[41,139,175],"very":[42,61],"promising":[43],"and":[44,91,100,114,153,157,206,236],"hence":[45],"progressed":[46],"human":[48],"clinical":[49,55],"trials.":[50],"The":[51],"results":[52],"from":[53],"trial":[56],"of":[57,149,178,183,197,210,230,239],"this":[58,70],"vaccine":[59,71],"were":[60],"modest.":[62],"Here":[63],"we":[64],"unravel":[65],"why,":[66],"contrary":[67],"mice,":[69],"failed":[73],"induce":[75],"robust":[76,235],"antibody":[77],"(Ab)":[78],"titres":[79],"humans":[81,101,143,174],"elicit":[83],"activity.":[85],"examined":[87],"Pfs25-specific":[88,212],"B":[89,214],"cell":[90,96,159,181],"T":[92,180,201],"follicular":[93],"helper":[94],"(Tfh)":[95],"responses":[97],"after":[102,135],"vaccination":[103],"with":[104],"by":[107,191],"replication-deficient":[108],"chimpanzee":[109],"adenovirus":[110],"serotype":[111],"63":[112],"(ChAd63)":[113],"attenuated":[116],"orthopoxvirus":[117],"modified":[118],"vaccinia":[119],"virus":[120],"Ankara":[121],"(MVA)":[122],"delivered":[123],"heterologous":[126],"prime-boost":[127],"regimen":[128],"via":[129],"intramuscular":[130],"route.":[131],"found":[133],"that":[134,163,216],"vaccination,":[136],"immunologically":[140],"suboptimal":[141],"compared":[144],"terms":[148],"serum":[150],"Ab":[151,171],"production":[152],"antigen-specific":[154,199,220],"B,":[155],"CD4+":[156,179],"Tfh":[158],"responses.":[160],"identified":[162],"key":[165],"determinant":[166],"for":[167,234],"poor":[169],"anti-Pfs25":[170],"formation":[172],"lack":[177],"recognition":[182],"derived":[185],"peptide":[186],"epitopes.":[187],"This":[188],"is":[189],"supported":[190],"correlations":[192,225],"established":[193],"between":[194],"ratio":[196],"proliferated":[198],"CD4+/Tfh-like":[200],"cells,":[202,215],"CXCL13":[203],"sera":[204,222],"levels,":[205],"corresponding":[208],"numbers":[209],"circulating":[211],"memory":[213],"consequently":[217],"reflected":[218],"on":[219],"IgG":[221],"levels.":[223],"These":[224],"can":[226],"inform":[227],"design":[229],"next-generation":[231],"Pfs25-based":[232],"durable":[237],"blocking":[238],"malaria":[240],"transmission.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-10-11T00:00:00"}