{"id":"https://openalex.org/W32047732","doi":null,"title":"History of the development of oral rehydration therapy.","display_name":"History of the development of oral rehydration therapy.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W32047732","mag":"32047732","pmid":"https://pubmed.ncbi.nlm.nih.gov/2187608"},"language":"en","primary_location":{"id":"pmid:2187608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2187608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical therapeutics","raw_type":"Historical Article"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040007726","display_name":"R.M.C. da Cunha Ferreira","orcid":"https://orcid.org/0009-0008-2135-8219","observed_orcids":["https://orcid.org/0009-0008-2135-8219"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4210149283","display_name":"Hospital de Santa Maria","ror":"https://ror.org/05bz1tw26","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210149283"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"R M da Cunha Ferreira","raw_affiliation_strings":["Department of Pediatrics, Hospital de Santa Maria, University of Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hospital de Santa Maria, University of Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210149283"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112009474","display_name":"Richard A. Cash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Cash","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12 Suppl A","issue":null,"first_page":"2","last_page":"11; discussion 11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.16089999675750732,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10596","display_name":"Child Nutrition and Water Access","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-rehydration-therapy","display_name":"oral rehydration therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oral-rehydration-solution","display_name":"oral rehydration solution","score":0.8119999766349792},{"id":"https://openalex.org/keywords/history-of-medicine","display_name":"history of medicine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cholera","display_name":"cholera","score":0.6890000104904175},{"id":"https://openalex.org/keywords/acute-diarrhea","display_name":"acute diarrhea","score":0.8539999723434448},{"id":"https://openalex.org/keywords/sodium-glucose-cotransport","display_name":"sodium-glucose cotransport","score":0.9039999842643738},{"id":"https://openalex.org/keywords/intestinal-electrolyte-transport","display_name":"intestinal electrolyte transport","score":0.6620000004768372},{"id":"https://openalex.org/keywords/childhood-diarrhea","display_name":"childhood diarrhea","score":0.6460000276565552},{"id":"https://openalex.org/keywords/intravenous-fluid-therapy","display_name":"intravenous fluid therapy","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.909128725528717},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.7598193883895874},{"id":"https://openalex.org/C2780722889","wikidata":"https://www.wikidata.org/wiki/Q12090","display_name":"Cholera","level":2,"score":0.7521741986274719},{"id":"https://openalex.org/C3019834005","wikidata":"https://www.wikidata.org/wiki/Q156103","display_name":"Acute diarrhea","level":3,"score":0.6917511820793152},{"id":"https://openalex.org/C2777717012","wikidata":"https://www.wikidata.org/wiki/Q1381652","display_name":"Oral rehydration therapy","level":4,"score":0.6862632632255554},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4696718156337738},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3800075650215149},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29100388288497925},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.16940626502037048},{"id":"https://openalex.org/C2986740045","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health services","level":3,"score":0.16708561778068542},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.12318310141563416},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08775901794433594}],"mesh":[{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2187608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2187608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical therapeutics","raw_type":"Historical Article"},{"id":"mag:32047732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2187608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2592677865","https://openalex.org/W2002307032","https://openalex.org/W2080286423","https://openalex.org/W2885156708","https://openalex.org/W2551751194","https://openalex.org/W2974782666","https://openalex.org/W2886676544","https://openalex.org/W2399526067","https://openalex.org/W2140884566","https://openalex.org/W2071627530","https://openalex.org/W2546400256","https://openalex.org/W1857587085","https://openalex.org/W2072062902","https://openalex.org/W2008284074","https://openalex.org/W1847168837","https://openalex.org/W2064466826","https://openalex.org/W2515803102","https://openalex.org/W2122146305","https://openalex.org/W2908750541"],"related_works":["https://openalex.org/W829823152","https://openalex.org/W7166851390","https://openalex.org/W2168122178","https://openalex.org/W2260276634","https://openalex.org/W7208019623","https://openalex.org/W63570798","https://openalex.org/W2043069067","https://openalex.org/W2322603770","https://openalex.org/W3196254838","https://openalex.org/W4402429756"],"abstract_inverted_index":{"Humans":[0],"have":[1,304],"often":[2],"used":[3,60],"oral":[4,49,77,162,185,206],"fluids":[5,30],"to":[6,258,306],"replace":[7],"perceived":[8],"losses":[9],"of":[10,22,41,48,76,99,121,150,184,194,215,219,226,231,266,278,282,289,301,313],"water,":[11],"either":[12],"instinctively":[13],"or":[14],"with":[15,27,43,70],"a":[16,253,275,283,290],"therapeutic":[17],"orientation":[18],"in":[19,34,56,66,84,92,108,130,141,157,170,177,217,264,310],"the":[20,35,39,57,73,85,93,96,109,114,133,148,182,205,211,244,287,299,311],"form":[21],"folk":[23],"remedies.":[24],"Replacement":[25],"therapy":[26,51,65,79],"intravenous":[28],"(IV)":[29],"was":[31,52,127],"formally":[32],"introduced":[33],"last":[36,86],"century":[37],"for":[38,117,260],"treatment":[40],"patients":[42,159,201,218],"cholera.":[44],"The":[45,119,229,280],"modern":[46],"implementation":[47],"replacement":[50],"begun":[53],"by":[54,135,204],"pediatricians":[55],"1940s":[58],"who":[59],"electrolyte":[61],"solutions":[62,163,187],"as":[63],"maintenance":[64],"mildly":[67],"purging":[68],"children":[69],"diarrhea.":[71],"However,":[72],"scientific":[74,115,125,285],"development":[75,312],"rehydration":[78,186],"(ORT)":[80],"has":[81,233],"occurred":[82],"only":[83],"30":[87],"years.":[88],"Basic":[89],"physiologic":[90],"research":[91],"1950s":[94],"demonstrated":[95,146,210],"cotransport":[97,154],"mechanism":[98,149],"sodium":[100,151],"and":[101,105,137,143,152,160,167,179,189,213,237,249,270,295,298],"organic":[102],"solutes":[103],"(sugars":[104],"amino":[106],"acids)":[107],"intestinal":[110],"cells,":[111],"thereby":[112],"establishing":[113],"basis":[116],"ORT.":[118,314],"use":[120,230,281,300],"ORT":[122,216,232,251],"based":[123],"on":[124,252],"observations":[126],"first":[128],"reported":[129],"1964":[131],"from":[132,223,239],"Philippines":[134],"Phillips":[136],"coworkers.":[138],"Research":[139],"laboratories":[140],"Dhaka":[142,178],"Calcutta":[144,180],"subsequently":[145],"that":[147,161,191],"glucose":[153],"remains":[155],"intact":[156],"cholera":[158],"can":[164],"successfully":[165],"rehydrate":[166],"maintain":[168],"hydration":[169],"these":[171],"patients.":[172],"Clinical":[173],"studies":[174,209,303],"carried":[175],"out":[176],"confirmed":[181],"efficacy":[183,214],"(ORS)":[188],"showed":[190],"nearly":[192],"80%":[193],"IV":[195],"fluid":[196],"could":[197],"be":[198,307],"saved":[199],"if":[200],"were":[202],"hydrated":[203],"route.":[207],"Further":[208],"safety":[212],"all":[220],"ages":[221],"suffering":[222],"acute":[224,240],"diarrhea":[225],"any":[227],"cause.":[228],"substantially":[234],"reduced":[235],"morbidity":[236],"mortality":[238],"diarrhea,":[241],"particularly":[242],"after":[243],"World":[245],"Health":[246],"Organization":[247],"adopted":[248],"promoted":[250],"worldwide":[254],"scale.":[255],"Researchers":[256],"continue":[257],"search":[259],"better":[261],"ORS":[262,273],"formulations":[263],"terms":[265],"safety,":[267],"efficacy,":[268],"availability,":[269],"cost.":[271],"Food-based":[272],"are":[274],"promising":[276],"area":[277],"research.":[279],"sound":[284],"method,":[286],"establishment":[288],"close":[291],"link":[292],"between":[293],"basic":[294],"clinical":[296],"science,":[297],"field":[302],"proved":[305],"major":[308],"assets":[309]},"counts_by_year":[{"year":2019,"cited_by_count":13},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}