{"id":"https://openalex.org/W3204724932","doi":"https://doi.org/10.1016/j.annonc.2021.08.556","title":"273P Talazoparib (TALA) for patients with germline BRCA1/2 mutated (gBRCA1/2mut) advanced breast cancer (ABC): Characteristics of patients who experienced hematologic toxicity in the phase III EMBRACA trial","display_name":"273P Talazoparib (TALA) for patients with germline BRCA1/2 mutated (gBRCA1/2mut) advanced breast cancer (ABC): Characteristics of patients who experienced hematologic toxicity in the phase III EMBRACA trial","publication_year":2021,"publication_date":"2021-09-01","ids":{"openalex":"https://openalex.org/W3204724932","doi":"https://doi.org/10.1016/j.annonc.2021.08.556","mag":"3204724932"},"language":"en","primary_location":{"id":"doi:10.1016/j.annonc.2021.08.556","doi":"https://doi.org/10.1016/j.annonc.2021.08.556","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2021.08.556","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(21)02785-X/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.annalsofoncology.org/article/S0923-7534(21)02785-X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068059897","display_name":"Sara Alsterlind Hurvitz","orcid":"https://orcid.org/0000-0001-7808-7191","observed_orcids":["https://orcid.org/0000-0001-7808-7191"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.A. Hurvitz","raw_affiliation_strings":["Internal Medicine Hematology and Oncology, University of California, Los Angeles/Jonsson Comprehensive Cancer Center, Santa Monica, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Hematology and Oncology, University of California, Los Angeles/Jonsson Comprehensive Cancer Center, Santa Monica, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090188675","display_name":"Hope S. Rugo","orcid":"https://orcid.org/0000-0001-6710-4814","observed_orcids":["https://orcid.org/0000-0001-6710-4814"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.S. Rugo","raw_affiliation_strings":["Department of Medicine, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048706345","display_name":"Johannes Ettl","orcid":"https://orcid.org/0000-0003-4754-8447","observed_orcids":["https://orcid.org/0000-0003-4754-8447"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Ettl","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100671433","display_name":"Miguel Mart\u00edn","orcid":"https://orcid.org/0000-0001-9237-3231","observed_orcids":["https://orcid.org/0000-0001-9237-3231"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I4405268975","display_name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/02p8e3h61","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268975"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Martin","raw_affiliation_strings":["Departamento de Medicina, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERONC, Universidad Complutense, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Medicina, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERONC, Universidad Complutense, Madrid, Spain","institution_ids":["https://openalex.org/I121748325","https://openalex.org/I4210158561","https://openalex.org/I4405268975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052648400","display_name":"Henri Hubert Roche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128666","display_name":"Institut Claudius Regaud","ror":"https://ror.org/03pa87f90","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H. Roche","raw_affiliation_strings":["Oncology, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse, Toulouse, Haute-Garonne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse, Toulouse, Haute-Garonne, France","institution_ids":["https://openalex.org/I4210128666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076815825","display_name":"Kong Hwee Lee","orcid":"https://orcid.org/0000-0001-7098-367X","observed_orcids":["https://orcid.org/0000-0001-7098-367X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"K-H. Lee","raw_affiliation_strings":["Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015645119","display_name":"Annabel Goodwin","orcid":"https://orcid.org/0000-0002-8859-9980","observed_orcids":["https://orcid.org/0000-0002-8859-9980"]},"institutions":[{"id":"https://openalex.org/I2800249840","display_name":"Concord Repatriation General Hospital","ror":"https://ror.org/04b0n4406","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800249840"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A. Goodwin","raw_affiliation_strings":["Medical Oncology Department, Concord Repatriation General Hospital, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Concord Repatriation General Hospital, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I2800249840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053411791","display_name":"Tiziana Usari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142120","display_name":"Pfizer (Italy)","ror":"https://ror.org/03htt2d69","country_code":"IT","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210142120"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"T. Usari","raw_affiliation_strings":["Oncology, Pfizer, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Pfizer, Milan, Italy","institution_ids":["https://openalex.org/I4210142120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017925719","display_name":"Silvana Lanzalone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142120","display_name":"Pfizer (Italy)","ror":"https://ror.org/03htt2d69","country_code":"IT","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210142120"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Lanzalone","raw_affiliation_strings":["Oncology, Pfizer, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Pfizer, Milan, Italy","institution_ids":["https://openalex.org/I4210142120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016823873","display_name":"Carolin Guenzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100293","display_name":"Pfizer (Germany)","ror":"https://ror.org/00m8w3m39","country_code":"DE","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4210100293"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C.A. Guenzel","raw_affiliation_strings":["Oncology, Pfizer, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Pfizer, Berlin, Germany","institution_ids":["https://openalex.org/I4210100293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042123072","display_name":"Joanne Lorraine Blum","orcid":"https://orcid.org/0000-0002-7951-6645","observed_orcids":["https://orcid.org/0000-0002-7951-6645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Blum","raw_affiliation_strings":["Hematology and Medical Oncology, Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Medical Oncology, Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, TX, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014713051","display_name":"Jennifer Keating Litton","orcid":"https://orcid.org/0000-0001-8390-4985","observed_orcids":["https://orcid.org/0000-0001-8390-4985"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.K. Litton","raw_affiliation_strings":["Breast Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17530919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":null,"first_page":"S482","last_page":"S482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/talazoparib","display_name":"talazoparib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/germline-brca1-2-mutation","display_name":"germline BRCA1/2 mutation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8859999775886536},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8309999704360962},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7170000076293945},{"id":"https://openalex.org/keywords/chemotherapy-comparison","display_name":"chemotherapy comparison","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9212596416473389},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7986820936203003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6115546226501465},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5997218489646912},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4952508509159088},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41809701919555664},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40534576773643494},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36892732977867126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.annonc.2021.08.556","doi":"https://doi.org/10.1016/j.annonc.2021.08.556","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2021.08.556","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(21)02785-X/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.annonc.2021.08.556","doi":"https://doi.org/10.1016/j.annonc.2021.08.556","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2021.08.556","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(21)02785-X/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204724932.pdf","grobid_xml":"https://content.openalex.org/works/W3204724932.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3202115015","https://openalex.org/W2898158489","https://openalex.org/W2898606077","https://openalex.org/W2807659903","https://openalex.org/W2947996306","https://openalex.org/W3083341170","https://openalex.org/W2944637757","https://openalex.org/W2990201173","https://openalex.org/W2990079331","https://openalex.org/W3203458575"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-10-11T00:00:00"}