{"id":"https://openalex.org/W3204701792","doi":"https://doi.org/10.1093/qjmed/hcab117.002","title":"The Possible Protective Effect of Selenium on Liver Dysfunction in a Rat Model of Extrahepatic Cholestasis","display_name":"The Possible Protective Effect of Selenium on Liver Dysfunction in a Rat Model of Extrahepatic Cholestasis","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3204701792","doi":"https://doi.org/10.1093/qjmed/hcab117.002","mag":"3204701792"},"language":"en","primary_location":{"id":"doi:10.1093/qjmed/hcab117.002","doi":"https://doi.org/10.1093/qjmed/hcab117.002","is_oa":false,"landing_page_url":"https://doi.org/10.1093/qjmed/hcab117.002","pdf_url":null,"source":{"id":"https://openalex.org/S139075330","display_name":"QJM","issn_l":"0033-5622","issn":["0033-5622","1460-2393","1460-2725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"QJM: An International Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112250627","display_name":"Fatma Lebda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Fatma M Lebda","raw_affiliation_strings":["Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084652217","display_name":"Sahar Mohamed El Agaty","orcid":"https://orcid.org/0000-0002-1276-2147","observed_orcids":["https://orcid.org/0000-0002-1276-2147"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sahar M El Agaty","raw_affiliation_strings":["Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110147739","display_name":"Noha A. Nassef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Noha A Nassef","raw_affiliation_strings":["Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112693103","display_name":"Marina A Aziz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Marina A Aziz","raw_affiliation_strings":["Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I107720978"],"apc_list":{"value":2854,"currency":"GBP","value_usd":4280},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"114","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.7070000171661377},{"id":"https://openalex.org/keywords/sodium-selenite","display_name":"sodium selenite","score":0.9039999842643738},{"id":"https://openalex.org/keywords/extrahepatic-cholestasis","display_name":"extrahepatic cholestasis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.8399999737739563},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8450000286102295},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9829999804496765},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.6019999980926514},{"id":"https://openalex.org/keywords/serum-proteins","display_name":"serum proteins","score":0.4339999854564667},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.8622244000434875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7662567496299744},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.6837847828865051},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.645936906337738},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6306769251823425},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.5965630412101746},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5591419339179993},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5167185664176941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4844379723072052},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4514904022216797},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4420589804649353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30705928802490234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12285536527633667},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06424009799957275},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/qjmed/hcab117.002","doi":"https://doi.org/10.1093/qjmed/hcab117.002","is_oa":false,"landing_page_url":"https://doi.org/10.1093/qjmed/hcab117.002","pdf_url":null,"source":{"id":"https://openalex.org/S139075330","display_name":"QJM","issn_l":"0033-5622","issn":["0033-5622","1460-2393","1460-2725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"QJM: An International Journal of Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4221045648","https://openalex.org/W7214601415","https://openalex.org/W1998696352","https://openalex.org/W3023104572","https://openalex.org/W2997362963","https://openalex.org/W3108214600","https://openalex.org/W7202287712","https://openalex.org/W2376884483","https://openalex.org/W4382240286","https://openalex.org/W2103053343"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Oxidative":[2],"stress":[3],"and":[4,12,33,81,128,139,172,178,206,229,240],"inflammation":[5],"are":[6],"primarily":[7],"implicated":[8],"in":[9,53,93,115,150,185,188,210,217,233],"the":[10,46,106,203,211,246],"development":[11],"progression":[13],"of":[14,50,57,96,118,131,153,168,175,196,202,214],"liver":[15,129,173,197,227,231,247],"injury":[16,228],"during":[17],"cholestasis.":[18,59],"Selenium,":[19],"a":[20,30,54,94,112,147,182,199,207],"known":[21],"essential":[22],"antioxidant":[23,32,239],"trace":[24],"element,":[25],"was":[26,42,66,88],"found":[27],"to":[28,44,158],"provide":[29],"remarkable":[31],"anti-inflammatory":[34,241],"effects":[35],"on":[36,69],"various":[37],"diseases.":[38],"Aim":[39],"This":[40,64],"study":[41,65],"planned":[43],"evaluate":[45],"possible":[47],"protective":[48],"effect":[49],"selenium":[51],"supplementation":[52,163,225],"rat":[55],"model":[56],"chronic":[58],"Design":[60],"Experimental":[61],"study.":[62],"Methods":[63],"carried":[67],"out":[68],"adult":[70],"male":[71],"rats":[72],"allocated":[73],"randomly":[74],"into":[75],"sham,":[76],"bile":[77,251,256],"duct":[78,252,257],"ligated":[79,253],"(BDL),":[80],"BDL-selenium":[82],"treated":[83],"(BDL-Se)":[84],"groups.":[85],"Sodium":[86],"selenite":[87],"given":[89],"by":[90,237],"gavage":[91],"daily,":[92],"dose":[95],"100":[97],"\u00b5g/kg":[98],"for":[99],"6":[100],"weeks,":[101],"starting":[102],"2":[103],"weeks":[104],"before":[105],"BDL.":[107],"Results":[108],"BDL":[109,192,221],"group":[110,160,190,219],"presented":[111],"significant":[113,148,183,200,208],"increase":[114,184],"serum":[116,151,166,186],"levels":[117,130,152,167,174],"aspartate":[119,284],"aminotransferase":[120,123],"(AST),":[121],"alanine":[122,287],"(ALT),":[124],"alkaline":[125,290],"phosphatase":[126],"(ALP),":[127],"malondialdehyde":[132],"(MDA),":[133],"tumor":[134],"necrosis":[135,264],"factor":[136,142],"alpha":[137],"(TNF-\u03b1),":[138],"transforming":[140,267],"growth":[141,268],"beta":[143],"1(TGF-\u03b21),":[144],"associated":[145],"with":[146,181],"decrease":[149,209],"total":[154,293],"proteins":[155],"(TP)":[156],"compared":[157],"sham":[159],".":[161],"Selenium":[162,224],"significantly":[164],"lowered":[165],"AST,":[169],"ALT,":[170],"ALP,":[171],"MDA,":[176],"TNF-\u03b1,":[177],"TGF-\u03b21":[179],"along":[180],"TP":[187],"BDL-Se":[189,218],"versus":[191,220],"rats.":[193,222],"Histological":[194],"analysis":[195],"showed":[198],"attenuation":[201],"inflammatory":[204],"score":[205],"percentage":[212],"area":[213],"collagen":[215],"deposition":[216],"Conclusion":[223],"reduces":[226],"improves":[230],"functions":[232],"experimental":[234],"cholestasis":[235],"probably":[236],"its":[238],"activities,":[242],"which":[243],"further":[244],"alleviate":[245],"fibrosis.":[248],"Abbreviations":[249],"BDL:":[250],"group,":[254,259],"BDL-Se:":[255],"ligated-selenium":[258],"MDA:":[260],"malondialdehyde,":[261],"TNF-\u03b1:":[262],"tumour":[263],"factor-alpha,":[265],"TGF-\u03b21:":[266],"factor-":[269],"beta1,":[270],"ROS:":[271],"reactive":[272],"oxygen":[273],"species,":[274],"mRNA:":[275],"messenger":[276],"RNA,":[277],"IL-6:":[278],"interleukin-6,":[279],"BW:":[280],"body":[281],"weight,":[282],"AST:":[283],"aminotransferase,":[285,288],"ALT:":[286],"ALP:":[289],"phosphatase,":[291],"TP:":[292],"proteins,":[294],"CCl4:":[295],"carbon":[296],"tetrachloride,":[297],"GPx:":[298],"glutathione":[299],"peroxidase":[300],"enzyme,":[301],"SOD:":[302],"superoxide":[303],"dismutase,":[304],"IL-1:":[305],"interleukin-1.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-10-11T00:00:00"}
