{"id":"https://openalex.org/W3204567638","doi":"https://doi.org/10.1016/j.isci.2021.103196","title":"Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2","display_name":"Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2","publication_year":2021,"publication_date":"2021-10-02","ids":{"openalex":"https://openalex.org/W3204567638","doi":"https://doi.org/10.1016/j.isci.2021.103196","mag":"3204567638","pmid":"https://pubmed.ncbi.nlm.nih.gov/34746691","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8554487"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2021.103196","doi":"https://doi.org/10.1016/j.isci.2021.103196","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2021.103196","pdf_url":"http://www.cell.com/article/S2589004221011640/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2589004221011640/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087622795","display_name":"Yanbo Fan","orcid":"https://orcid.org/0000-0002-3845-7562","observed_orcids":["https://orcid.org/0000-0002-3845-7562"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yanbo Fan","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","Department of Cancer Biology, University of Cincinnati College of Medicine, Vontz Center, 3125 Eden Avenue, Cincinnati, OH45267, USA"],"raw_orcid":"https://orcid.org/0000-0002-3845-7562","affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Cancer Biology, University of Cincinnati College of Medicine, Vontz Center, 3125 Eden Avenue, Cincinnati, OH45267, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091351708","display_name":"Brooke N. Wolford","orcid":"https://orcid.org/0000-0003-3153-1552","observed_orcids":["https://orcid.org/0000-0003-3153-1552"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke N. Wolford","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI48109, USA"],"raw_orcid":"https://orcid.org/0000-0003-3153-1552","affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071587889","display_name":"Haocheng Lu","orcid":"https://orcid.org/0000-0002-5740-8010","observed_orcids":["https://orcid.org/0000-0002-5740-8010"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haocheng Lu","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":"https://orcid.org/0000-0002-5740-8010","affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031129296","display_name":"Wenying Liang","orcid":"https://orcid.org/0000-0001-9985-6674","observed_orcids":["https://orcid.org/0000-0001-9985-6674"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenying Liang","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103942632","display_name":"Jinjian Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinjian Sun","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100766761","display_name":"Wei Zhou","orcid":"https://orcid.org/0000-0001-7719-0859","observed_orcids":["https://orcid.org/0000-0001-7719-0859","https://orcid.org/0000-0001-7534-3065","https://orcid.org/0000-0001-7815-9538"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhou","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038686753","display_name":"Oren Rom","orcid":"https://orcid.org/0000-0002-9272-086X","observed_orcids":["https://orcid.org/0000-0002-9272-086X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oren Rom","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA71103, USA"],"raw_orcid":"https://orcid.org/0000-0002-9272-086X","affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA71103, USA","institution_ids":["https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030469052","display_name":"Anubha Mahajan","orcid":"https://orcid.org/0000-0001-5585-3420","observed_orcids":["https://orcid.org/0000-0001-5585-3420"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anubha Mahajan","raw_affiliation_strings":["Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024138963","display_name":"Ida L. Surakka","orcid":"https://orcid.org/0000-0002-6669-5541","observed_orcids":["https://orcid.org/0000-0002-6669-5541"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ida Surakka","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043987277","display_name":"Sarah E. Graham","orcid":"https://orcid.org/0000-0003-1271-2489","observed_orcids":["https://orcid.org/0000-0003-1271-2489"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah E. Graham","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449762","display_name":"Zhipeng Liu","orcid":"https://orcid.org/0000-0001-7159-5038","observed_orcids":["https://orcid.org/0000-0001-7159-5038"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhipeng Liu","raw_affiliation_strings":["Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102759714","display_name":"Hyunbae Kim","orcid":"https://orcid.org/0000-0001-9015-8415","observed_orcids":["https://orcid.org/0000-0001-9015-8415","https://orcid.org/0000-0002-7209-4574"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyunbae Kim","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006408722","display_name":"Shweta Ramdas","orcid":"https://orcid.org/0000-0001-8888-4661","observed_orcids":["https://orcid.org/0000-0001-8888-4661"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shweta Ramdas","raw_affiliation_strings":["Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006257131","display_name":"Lars G. Fritsche","orcid":"https://orcid.org/0000-0002-2110-1690","observed_orcids":["https://orcid.org/0000-0002-2110-1690"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lars G. Fritsche","raw_affiliation_strings":["Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090431422","display_name":"Jonas Bille Nielsen","orcid":"https://orcid.org/0000-0002-6654-2852","observed_orcids":["https://orcid.org/0000-0002-6654-2852"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonas B. Nielsen","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002117619","display_name":"Maiken Elvestad Gabrielsen","orcid":"https://orcid.org/0000-0002-7132-5633","observed_orcids":["https://orcid.org/0000-0002-7132-5633"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Maiken Elvestad Gabrielsen","raw_affiliation_strings":["K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033780024","display_name":"Kristian Hveem","orcid":"https://orcid.org/0000-0001-8157-9744","observed_orcids":["https://orcid.org/0000-0001-8157-9744"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kristian Hveem","raw_affiliation_strings":["K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007667712","display_name":"Dongshan Yang","orcid":"https://orcid.org/0000-0003-2449-8651","observed_orcids":["https://orcid.org/0000-0003-2449-8651"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongshan Yang","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067527032","display_name":"Jun Whi Song","orcid":"https://orcid.org/0000-0002-6128-6378","observed_orcids":["https://orcid.org/0000-0002-6128-6378"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Song","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":"https://orcid.org/0000-0002-6128-6378","affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040445213","display_name":"Minerva T. Garcia-Barrio","orcid":"https://orcid.org/0000-0002-3381-3847","observed_orcids":["https://orcid.org/0000-0002-3381-3847"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minerva T. Garcia-Barrio","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784039","display_name":"Jifeng Zhang","orcid":"https://orcid.org/0000-0001-5161-4705","observed_orcids":["https://orcid.org/0000-0001-5161-4705"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jifeng Zhang","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":"https://orcid.org/0000-0001-5161-4705","affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048206421","display_name":"Wanqing Liu","orcid":"https://orcid.org/0009-0001-7836-6489","observed_orcids":["https://orcid.org/0009-0001-7836-6489","https://orcid.org/0000-0001-8636-6596"]},"institutions":[{"id":"https://openalex.org/I12311892","display_name":"Eugene Applebaum College of Pharmacy and Health Sciences","ror":"https://ror.org/0222p1e69","country_code":"US","type":"education","lineage":["https://openalex.org/I12311892"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanqing Liu","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I12311892","https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011891226","display_name":"Kezhong Zhang","orcid":"https://orcid.org/0000-0002-6062-235X","observed_orcids":["https://orcid.org/0000-0002-6062-235X"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kezhong Zhang","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI48201, USA"],"raw_orcid":"https://orcid.org/0000-0002-6062-235X","affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064287149","display_name":"Cristen J. Willer","orcid":"https://orcid.org/0000-0001-5645-4966","observed_orcids":["https://orcid.org/0000-0001-5645-4966"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cristen J. Willer","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI48109, USA","Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007976180","display_name":"Y. Eugene Chen","orcid":"https://orcid.org/0000-0003-2357-7825","observed_orcids":["https://orcid.org/0000-0003-2357-7825"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Y. Eugene Chen","raw_affiliation_strings":["Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, NCRC Bldg 26, Rm 361S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5007976180","https://openalex.org/A5064287149","https://openalex.org/A5087622795"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445","https://openalex.org/I63135867"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.9772,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.86788188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"24","issue":"11","first_page":"103196","last_page":"103196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.1581999957561493,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tm6sf2","display_name":"TM6SF2","score":0.8989999890327454},{"id":"https://openalex.org/keywords/rs58542926","display_name":"rs58542926","score":0.9810000061988831},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9700000286102295},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8859999775886536},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.6790000200271606},{"id":"https://openalex.org/keywords/ire1alpha-signaling","display_name":"IRE1\u03b1 signaling","score":0.8289999961853027},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8700000047683716},{"id":"https://openalex.org/keywords/knockin-mouse-model","display_name":"knockin mouse model","score":0.7080000042915344},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.8370000123977661},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6861667633056641},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5222712159156799},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5065137147903442},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49858522415161133},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.4699409604072571},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.466019868850708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42019155621528625},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3339328169822693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3286908268928528},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.311836838722229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20244291424751282}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.isci.2021.103196","doi":"https://doi.org/10.1016/j.isci.2021.103196","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2021.103196","pdf_url":"http://www.cell.com/article/S2589004221011640/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7458800","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8554487","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8554487","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8554487","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:34746691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34746691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:123d0eb5291545f598be4e64a51063ec","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/123d0eb5291545f598be4e64a51063ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 24, Iss 11, Pp 103196- (2021)","raw_type":"article"},{"id":"pmh:oai:ntnuopen.ntnu.no:11250/3042895","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11250/3042895","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"0","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2021.103196","doi":"https://doi.org/10.1016/j.isci.2021.103196","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2021.103196","pdf_url":"http://www.cell.com/article/S2589004221011640/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1233095484","display_name":"Using genetic variation to study biology of blood lipids & coronary heart disease","funder_award_id":"R01HL127564","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2348938734","display_name":"KLF14 and Cardiovascular Disease","funder_award_id":"R01HL134569","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2485593709","display_name":"Mechanisms of glycine-based therapy for atherosclerosis","funder_award_id":"R00HL150233","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2642026176","display_name":"A novel CREBH-derived hepatokine regulates triglyceride metabolism","funder_award_id":"5r01dk090313-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4810641599","display_name":"Fatty Acid Desaturase 1 (FADS1) Variants and Non-alcoholic Fatty Liver Disease","funder_award_id":"R01DK106540","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5194495836","display_name":"Using Genetics to Inform Mechanism of Cardiovascular Disease","funder_award_id":"R35HL135824","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6219713290","display_name":null,"funder_award_id":"DGE 1256260","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G643570424","display_name":null,"funder_award_id":"R01-DK-090313","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7108381864","display_name":"Kruppel-like factor 11 (KLF11) and atherosclerosis","funder_award_id":"R01HL138139","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G745026636","display_name":"Transcription Factor-EB and Postischemic Angiogenesis","funder_award_id":"R01HL138094","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8209275764","display_name":"The Role of TM6SF2 in Cardiovascular Disease","funder_award_id":"R01HL137214","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8257453039","display_name":null,"funder_award_id":"R01HL135824","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8604391010","display_name":null,"funder_award_id":"R01DK090313","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000864114","display_name":"University of Michigan Training Program in Genomic Science","funder_award_id":"T32HG000040","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000865330","display_name":"Michigan Diabetes Research Center (MDRC)","funder_award_id":"P30DK020572","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000909214","display_name":"Using genetics to discover mechanisms of abdominal aortic aneurysm","funder_award_id":"R01HL109946","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G928306717","display_name":"The role of TFEB in aortic aneurysms","funder_award_id":"R01HL145176","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320332682","display_name":"Medical School, University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3204567638.pdf"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1511417959","https://openalex.org/W1783727169","https://openalex.org/W1826389973","https://openalex.org/W1966157599","https://openalex.org/W1966549856","https://openalex.org/W1986219467","https://openalex.org/W2011004630","https://openalex.org/W2025471227","https://openalex.org/W2030379010","https://openalex.org/W2038831349","https://openalex.org/W2048209604","https://openalex.org/W2054311777","https://openalex.org/W2058979870","https://openalex.org/W2066018879","https://openalex.org/W2070332131","https://openalex.org/W2075418587","https://openalex.org/W2099540722","https://openalex.org/W2109796699","https://openalex.org/W2133520037","https://openalex.org/W2143203517","https://openalex.org/W2159400209","https://openalex.org/W2159422401","https://openalex.org/W2159581380","https://openalex.org/W2236161220","https://openalex.org/W2271597607","https://openalex.org/W2303094910","https://openalex.org/W2345328813","https://openalex.org/W2414852181","https://openalex.org/W2427573956","https://openalex.org/W2461498196","https://openalex.org/W2566842452","https://openalex.org/W2594223161","https://openalex.org/W2606513998","https://openalex.org/W2613169846","https://openalex.org/W2619692554","https://openalex.org/W2728065598","https://openalex.org/W2740317623","https://openalex.org/W2765317155","https://openalex.org/W2767038995","https://openalex.org/W2786330760","https://openalex.org/W2796811655","https://openalex.org/W2803942685","https://openalex.org/W2810423511","https://openalex.org/W2886996205","https://openalex.org/W2894662039","https://openalex.org/W2895486342","https://openalex.org/W2914978609","https://openalex.org/W2916906274","https://openalex.org/W2944123026","https://openalex.org/W2950099124","https://openalex.org/W2952686929","https://openalex.org/W2995395884","https://openalex.org/W3009606898","https://openalex.org/W3030834164","https://openalex.org/W3110600404","https://openalex.org/W6638766374"],"related_works":["https://openalex.org/W2950798519","https://openalex.org/W2948212676","https://openalex.org/W4381377626","https://openalex.org/W4379928181","https://openalex.org/W4367674456","https://openalex.org/W2386450076","https://openalex.org/W4401506551","https://openalex.org/W2066504840","https://openalex.org/W7099263084","https://openalex.org/W2085807294"],"abstract_inverted_index":{"The":[0,64,117],"rs58542926C":[1,56],">T":[2,57],"(E167K)":[3],"variant":[4,39,58,66,133],"of":[5,35,51,134],"the":[6,33,36,52,55,88,127,131],"transmembrane":[7],"6":[8],"superfamily":[9],"member":[10],"2":[11,29],"gene":[12],"(":[13],"TM6SF2":[14,37,101,135],")":[15],"is":[16,43,136],"associated":[17,69,137],"with":[18,70,106,138],"increased":[19],"risks":[20],"for":[21],"nonalcoholic":[22],"fatty":[23],"liver":[24],"disease":[25],"(NAFLD)":[26],"and":[27,59,147],"type":[28],"diabetes":[30],"(T2D).":[31],"Nevertheless,":[32],"role":[34],"rs58542926":[38],"in":[40,61,73,126,142,145],"glucose":[41,94,139],"metabolism":[42],"poorly":[44],"understood.":[45],"We":[46],"performed":[47],"a":[48,112],"sex-stratified":[49],"analysis":[50],"association":[53],"between":[54],"T2D":[60],"multiple":[62],"cohorts.":[63],"E167K":[65,77,132],"was":[67,102],"significantly":[68],"T2D,":[71],"especially":[72],"males.":[74],"Using":[75],"an":[76,97],"knockin":[78],"(KI)":[79],"mouse":[80],"model,":[81],"we":[82],"found":[83,103],"that":[84],"male":[85,118],"but":[86],"not":[87],"female":[89],"KI":[90,120],"mice":[91,121],"exhibited":[92,122],"impaired":[93,123],"tolerance.":[95],"As":[96],"ER":[98,114],"membrane":[99],"protein,":[100],"to":[104],"interact":[105],"inositol-requiring":[107],"enzyme":[108],"1":[109],"\u03b1":[110],"(IRE1\u03b1),":[111],"primary":[113],"stress":[115],"sensor.":[116],"Tm6sf2":[119],"IRE1\u03b1":[124],"signaling":[125],"liver.":[128],"In":[129],"conclusion,":[130],"intolerance":[140],"primarily":[141],"males,":[143],"both":[144],"humans":[146],"mice.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-10-11T00:00:00"}
