{"id":"https://openalex.org/W3204550481","doi":"https://doi.org/10.1021/acsmedchemlett.1c00456","title":"Small Peptides for Inhibiting Serum Amyloid A Aggregation","display_name":"Small Peptides for Inhibiting Serum Amyloid A Aggregation","publication_year":2021,"publication_date":"2021-10-05","ids":{"openalex":"https://openalex.org/W3204550481","doi":"https://doi.org/10.1021/acsmedchemlett.1c00456","mag":"3204550481","pmid":"https://pubmed.ncbi.nlm.nih.gov/34676044","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8521652"},"language":"en","primary_location":{"id":"doi:10.1021/acsmedchemlett.1c00456","doi":"https://doi.org/10.1021/acsmedchemlett.1c00456","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.1c00456","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.26434/chemrxiv-2021-m9c8j","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062192545","display_name":"Asis K. Jana","orcid":"https://orcid.org/0000-0002-8959-4583","observed_orcids":["https://orcid.org/0000-0002-8959-4583"]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asis K. Jana","raw_affiliation_strings":["Department of Chemistry & Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056523097","display_name":"Augustus B. Greenwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Augustus B. Greenwood","raw_affiliation_strings":["Department of Chemistry & Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005661488","display_name":"Ulrich H. E. Hansmann","orcid":"https://orcid.org/0000-0002-0700-4835","observed_orcids":["https://orcid.org/0000-0002-0700-4835"]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ulrich H. E. Hansmann","raw_affiliation_strings":["Department of Chemistry & Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States","institution_ids":["https://openalex.org/I8692664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005661488"],"corresponding_institution_ids":["https://openalex.org/I8692664"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9042,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.66122617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"12","issue":"10","first_page":"1613","last_page":"1621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.14659999310970306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":0.9210000038146973},{"id":"https://openalex.org/keywords/amyloid-fibril-aggregation","display_name":"amyloid fibril aggregation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/peptide-inhibitors","display_name":"peptide inhibitors","score":0.625},{"id":"https://openalex.org/keywords/d-peptides","display_name":"D-peptides","score":0.7549999952316284},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"amyloidosis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/fibril-destabilization","display_name":"fibril destabilization","score":0.8550000190734863},{"id":"https://openalex.org/keywords/peptide-drug-design","display_name":"peptide drug design","score":0.40299999713897705},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.796342134475708},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.7305433750152588},{"id":"https://openalex.org/C55359608","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum amyloid A","level":3,"score":0.693472146987915},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6455221772193909},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6021018028259277},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.5697238445281982},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5547950863838196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4844229519367218},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4748040735721588},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45644882321357727},{"id":"https://openalex.org/C2910060150","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum Amyloid A Protein","level":4,"score":0.4422643184661865},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4395720958709717},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4230012893676758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4148324131965637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.411067932844162},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28663042187690735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21238577365875244},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13722482323646545},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13594138622283936},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.09386539459228516},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08787649869918823}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsmedchemlett.1c00456","doi":"https://doi.org/10.1021/acsmedchemlett.1c00456","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.1c00456","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv-2021-m9c8j","doi":"https://doi.org/10.26434/chemrxiv-2021-m9c8j","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2021-m9c8j","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:34676044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34676044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS medicinal chemistry letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8521652","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8521652/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Med Chem Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv-2021-m9c8j","doi":"https://doi.org/10.26434/chemrxiv-2021-m9c8j","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2021-m9c8j","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2220315292","display_name":"Structural Transitions in Proteins and Protein Assemblies","funder_award_id":"R01GM120634","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G580195664","display_name":null,"funder_award_id":"MCB20016","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8447927469","display_name":null,"funder_award_id":"MCB160005","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310179","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1967838681","https://openalex.org/W1969046853","https://openalex.org/W1973060079","https://openalex.org/W1976499671","https://openalex.org/W1978314140","https://openalex.org/W2001900513","https://openalex.org/W2004400100","https://openalex.org/W2035687084","https://openalex.org/W2055533240","https://openalex.org/W2056993402","https://openalex.org/W2057477511","https://openalex.org/W2079932486","https://openalex.org/W2080512444","https://openalex.org/W2081693079","https://openalex.org/W2103318075","https://openalex.org/W2103402325","https://openalex.org/W2103945336","https://openalex.org/W2132629607","https://openalex.org/W2134967712","https://openalex.org/W2136739754","https://openalex.org/W2145864424","https://openalex.org/W2147400963","https://openalex.org/W2161598216","https://openalex.org/W2238872287","https://openalex.org/W2274134681","https://openalex.org/W2314146263","https://openalex.org/W2346499202","https://openalex.org/W2561366344","https://openalex.org/W2902861774","https://openalex.org/W2919170549","https://openalex.org/W2952380252","https://openalex.org/W3000656447","https://openalex.org/W3001963480","https://openalex.org/W3015410891","https://openalex.org/W3042433061","https://openalex.org/W3046182162","https://openalex.org/W3081195961","https://openalex.org/W3106515327","https://openalex.org/W3190065470","https://openalex.org/W4251951115"],"related_works":["https://openalex.org/W7164154848","https://openalex.org/W2090022092","https://openalex.org/W4403941971","https://openalex.org/W2952380252","https://openalex.org/W1982324476","https://openalex.org/W2965370871","https://openalex.org/W3000656447","https://openalex.org/W2238872287","https://openalex.org/W2156032277","https://openalex.org/W2137501083"],"abstract_inverted_index":{"Deposition":[0],"of":[1,24,67,96,122,128],"human":[2],"serum":[3],"amyloid":[4],"A":[5],"(SAA)":[6],"amyloids":[7],"in":[8],"blood":[9],"vessels,":[10],"causing":[11],"inflammation,":[12],"thrombosis,":[13],"and":[14,27,30,78,141],"eventually":[15],"organ":[16],"damage,":[17],"is":[18],"commonly":[19],"seen":[20],"as":[21],"a":[22,34,89,145],"consequence":[23],"certain":[25],"cancers":[26],"inflammatory":[28],"diseases":[29],"may":[31,143],"also":[32,113],"be":[33,100,144],"risk":[35],"after":[36],"SARS-COV-2":[37],"infections.":[38],"Several":[39],"attempts":[40],"have":[41,112],"been":[42],"made":[43],"to":[44,64,74,79,137],"develop":[45],"peptide-based":[46],"drugs":[47,98,149],"that":[48,119],"inhibit":[49],"or":[50],"at":[51],"least":[52],"slow":[53],"down":[54],"SAA":[55,76,151],"amyloidosis.":[56,152],"We":[57,117],"use":[58],"extensive":[59],"all-atom":[60],"molecular":[61],"dynamic":[62],"simulations":[63],"compare":[65],"three":[66],"these":[68],"drug":[69],"candidates":[70],"for":[71,81,91,148],"their":[72,107],"ability":[73],"destabilize":[75],"fibrils":[77],"propose":[80],"the":[82,85,94,126,129,138],"best":[83],"candidate,":[84],"N-terminal":[86],"sequence":[87,127],"SAA1-5,":[88],"mechanism":[90],"inhibition.":[92],"As":[93],"lifetime":[95],"peptide":[97,130],"can":[99],"increased":[101],"by":[102],"replacing":[103],"l-amino":[104],"acids":[105,124],"with":[106,125],"mirror":[108],"d-amino":[109,123],"acids,":[110],"we":[111],"studied":[114],"corresponding":[115],"d-peptides.":[116],"find":[118],"DRI-SAA1-5,":[120],"formed":[121],"reversed,":[131],"has":[132],"similar":[133],"inhibitory":[134],"properties":[135],"compared":[136],"original":[139],"l-peptide":[140],"therefore":[142],"promising":[146],"candidate":[147],"targeting":[150]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}