{"id":"https://openalex.org/W3204529505","doi":"https://doi.org/10.7554/elife.72377","title":"The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation","display_name":"The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W3204529505","doi":"https://doi.org/10.7554/elife.72377","mag":"3204529505","pmid":"https://pubmed.ncbi.nlm.nih.gov/34591013","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8789314"},"language":"en","primary_location":{"id":"doi:10.7554/elife.72377","doi":"https://doi.org/10.7554/elife.72377","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.72377","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.72377","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041302923","display_name":"Laura Arribas\u2010Hern\u00e1ndez","orcid":"https://orcid.org/0000-0003-0605-0407","observed_orcids":["https://orcid.org/0000-0003-0605-0407"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Laura Arribas-Hern\u00e1ndez","raw_affiliation_strings":["University of Copenhagen, Copenhagen Plant Science Center, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","University of Copenhagen, Copenhagen Plant Science Center"],"raw_orcid":"https://orcid.org/0000-0003-0605-0407","affiliations":[{"raw_affiliation_string":"University of Copenhagen, Copenhagen Plant Science Center, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"University of Copenhagen, Copenhagen Plant Science Center","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065459007","display_name":"Sarah Rennie","orcid":"https://orcid.org/0000-0001-9731-6957","observed_orcids":["https://orcid.org/0000-0001-9731-6957"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sarah Rennie","raw_affiliation_strings":["University of Copenhagen, Department of Biology, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","University of Copenhagen, Department of Biology, Ole Maal\u00f8es Vej 5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Copenhagen, Department of Biology, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"University of Copenhagen, Department of Biology, Ole Maal\u00f8es Vej 5","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020852043","display_name":"Michael A. Schon","orcid":"https://orcid.org/0000-0002-4756-3906","observed_orcids":["https://orcid.org/0000-0002-4756-3906"]},"institutions":[{"id":"https://openalex.org/I137696358","display_name":"Gregor Mendel Institute of Molecular Plant Biology","ror":"https://ror.org/05twjp994","country_code":"AT","type":"facility","lineage":["https://openalex.org/I137696358","https://openalex.org/I138211613","https://openalex.org/I4210142901"]},{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210142901","display_name":"Vienna Biocenter","ror":"https://ror.org/04khwmr87","country_code":"AT","type":"other","lineage":["https://openalex.org/I4210142901"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Michael Schon","raw_affiliation_strings":["Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria","Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria","institution_ids":["https://openalex.org/I137696358","https://openalex.org/I138211613","https://openalex.org/I4210142901"]},{"raw_affiliation_string":"Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC)","institution_ids":["https://openalex.org/I137696358","https://openalex.org/I138211613","https://openalex.org/I4210142901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029344284","display_name":"Carlotta Porcelli","orcid":"https://orcid.org/0000-0003-4675-4898","observed_orcids":["https://orcid.org/0000-0003-4675-4898"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Carlotta Porcelli","raw_affiliation_strings":["University of Copenhagen, Copenhagen Plant Science Center, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","University of Copenhagen, Copenhagen Plant Science Center"],"raw_orcid":"https://orcid.org/0000-0003-4675-4898","affiliations":[{"raw_affiliation_string":"University of Copenhagen, Copenhagen Plant Science Center, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"University of Copenhagen, Copenhagen Plant Science Center","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015464841","display_name":"Balaji Enugutti","orcid":"https://orcid.org/0000-0002-0816-024X","observed_orcids":["https://orcid.org/0000-0002-0816-024X"]},"institutions":[{"id":"https://openalex.org/I137696358","display_name":"Gregor Mendel Institute of Molecular Plant Biology","ror":"https://ror.org/05twjp994","country_code":"AT","type":"facility","lineage":["https://openalex.org/I137696358","https://openalex.org/I138211613","https://openalex.org/I4210142901"]},{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210142901","display_name":"Vienna Biocenter","ror":"https://ror.org/04khwmr87","country_code":"AT","type":"other","lineage":["https://openalex.org/I4210142901"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Balaji Enugutti","raw_affiliation_strings":["Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria","Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC)"],"raw_orcid":"https://orcid.org/0000-0002-0816-024X","affiliations":[{"raw_affiliation_string":"Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria","institution_ids":["https://openalex.org/I137696358","https://openalex.org/I138211613","https://openalex.org/I4210142901"]},{"raw_affiliation_string":"Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC)","institution_ids":["https://openalex.org/I137696358","https://openalex.org/I138211613","https://openalex.org/I4210142901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087439948","display_name":"Robin Andersson","orcid":"https://orcid.org/0000-0003-1516-879X","observed_orcids":["https://orcid.org/0000-0003-1516-879X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Robin Andersson","raw_affiliation_strings":["University of Copenhagen, Department of Biology, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","University of Copenhagen, Department of Biology, Ole Maal\u00f8es Vej 5"],"raw_orcid":"https://orcid.org/0000-0003-1516-879X","affiliations":[{"raw_affiliation_string":"University of Copenhagen, Department of Biology, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"University of Copenhagen, Department of Biology, Ole Maal\u00f8es Vej 5","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041649675","display_name":"Michael D. Nodine","orcid":"https://orcid.org/0000-0002-6204-8857","observed_orcids":["https://orcid.org/0000-0002-6204-8857"]},"institutions":[{"id":"https://openalex.org/I137696358","display_name":"Gregor Mendel Institute of Molecular Plant Biology","ror":"https://ror.org/05twjp994","country_code":"AT","type":"facility","lineage":["https://openalex.org/I137696358","https://openalex.org/I138211613","https://openalex.org/I4210142901"]},{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210142901","display_name":"Vienna Biocenter","ror":"https://ror.org/04khwmr87","country_code":"AT","type":"other","lineage":["https://openalex.org/I4210142901"]},{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["AT","NL"],"is_corresponding":false,"raw_author_name":"Michael Nodine","raw_affiliation_strings":["Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria","Laboratory of Molecular Biology, Wageningen University, Wageningen, 6708 PB, the Netherlands","Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC)","Laboratory of Molecular Biology, Wageningen University"],"raw_orcid":"https://orcid.org/0000-0002-6204-8857","affiliations":[{"raw_affiliation_string":"Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria","institution_ids":["https://openalex.org/I137696358","https://openalex.org/I138211613","https://openalex.org/I4210142901"]},{"raw_affiliation_string":"Laboratory of Molecular Biology, Wageningen University, Wageningen, 6708 PB, the Netherlands","institution_ids":["https://openalex.org/I913481162"]},{"raw_affiliation_string":"Gregor Mendel Institute (GMI), Austrian Academy of Sciences, Vienna Biocenter (VBC)","institution_ids":["https://openalex.org/I137696358","https://openalex.org/I138211613","https://openalex.org/I4210142901"]},{"raw_affiliation_string":"Laboratory of Molecular Biology, Wageningen University","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057910690","display_name":"Peter Brodersen","orcid":"https://orcid.org/0000-0003-1083-1150","observed_orcids":["https://orcid.org/0000-0003-1083-1150"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Peter Brodersen","raw_affiliation_strings":["University of Copenhagen, Copenhagen Plant Science Center, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","University of Copenhagen, Copenhagen Plant Science Center"],"raw_orcid":"https://orcid.org/0000-0003-1083-1150","affiliations":[{"raw_affiliation_string":"University of Copenhagen, Copenhagen Plant Science Center, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen N","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"University of Copenhagen, Copenhagen Plant Science Center","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5041302923","https://openalex.org/A5057910690"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":4.3121,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.9665047,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"10","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.27000001072883606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.05849999934434891,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ect2","display_name":"ECT2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/n6-methyladenosine","display_name":"N6-methyladenosine","score":0.9039999842643738},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/yth-domain","display_name":"YTH domain","score":0.7519999742507935},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.5759999752044678},{"id":"https://openalex.org/keywords/alternative-polyadenylation","display_name":"alternative polyadenylation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.47099998593330383},{"id":"https://openalex.org/keywords/genetic-redundancy","display_name":"gene redundancy","score":0.722000002861023},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.5830000042915344},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8410000205039978},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.8244206309318542},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.718208909034729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6606965661048889},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5531326532363892},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5100381970405579},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.49297547340393066},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.44949716329574585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4308258593082428},{"id":"https://openalex.org/C102063271","wikidata":"https://www.wikidata.org/wiki/Q7243183","display_name":"Precursor mRNA","level":5,"score":0.42510801553726196},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4225555956363678},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41899290680885315},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3340749740600586},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.251552551984787}],"mesh":[{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.7554/elife.72377","doi":"https://doi.org/10.7554/elife.72377","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.72377","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/2021.08.01.454660","doi":"https://doi.org/10.1101/2021.08.01.454660","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.08.01.454660","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/08/03/2021.08.01.454660.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8789314","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8789314","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:34591013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34591013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/7d49c62e-a7d8-4862-8310-2a2b8dfe7832","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/7d49c62e-a7d8-4862-8310-2a2b8dfe7832","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arribas-Hern\u00e1ndez, L, Rennie, S, Schon, M, Porcelli, C, Enugutti, B, Andersson, R, Nodine, M D & Brodersen, P 2021, 'The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation', eLife, vol. 10, e72377. https://doi.org/10.7554/eLife.72377","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:library.wur.nl:wurpubs/588336","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/the-ythdf-proteins-ect2-and-ect3-bind-largely-overlapping-target-","pdf_url":"https://edepot.wur.nl/563832","source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 2050-084X","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:digital.csic.es:10261/378866","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/378866","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:b9847e04c0e8441cae1b125dcde7e00e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b9847e04c0e8441cae1b125dcde7e00e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 10 (2021)","raw_type":"article"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/588336","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/the-ythdf-proteins-ect2-and-ect3-bind-largely-overlapping-target-","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, 10","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.7554/elife.72377","doi":"https://doi.org/10.7554/elife.72377","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.72377","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G49635230","display_name":null,"funder_award_id":"9040-00409B","funder_id":"https://openalex.org/F4320322928","funder_display_name":"Danmarks Frie Forskningsfond"},{"id":"https://openalex.org/G5266328737","display_name":null,"funder_award_id":"6108-00038B","funder_id":"https://openalex.org/F4320322928","funder_display_name":"Danmarks Frie Forskningsfond"},{"id":"https://openalex.org/G5642957640","display_name":null,"funder_award_id":"PATHORISC ERC-2016-COG 726417","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G6599368735","display_name":null,"funder_award_id":"63788","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G8070669682","display_name":"In-cavity thermophotonic cooling","funder_award_id":"638173","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322928","display_name":"Danmarks Frie Forskningsfond","ror":"https://ror.org/02sptwz63"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1764846306","https://openalex.org/W1785302862","https://openalex.org/W1941339056","https://openalex.org/W1968225222","https://openalex.org/W1979764753","https://openalex.org/W1987981719","https://openalex.org/W1991807334","https://openalex.org/W1992672580","https://openalex.org/W1993026672","https://openalex.org/W1999833129","https://openalex.org/W2019552331","https://openalex.org/W2021341670","https://openalex.org/W2022770379","https://openalex.org/W2025727763","https://openalex.org/W2029439198","https://openalex.org/W2050791777","https://openalex.org/W2065847836","https://openalex.org/W2073311353","https://openalex.org/W2073324553","https://openalex.org/W2083196263","https://openalex.org/W2085222580","https://openalex.org/W2091931541","https://openalex.org/W2097584289","https://openalex.org/W2101636211","https://openalex.org/W2102619694","https://openalex.org/W2114532236","https://openalex.org/W2127087804","https://openalex.org/W2138207763","https://openalex.org/W2157220798","https://openalex.org/W2164852392","https://openalex.org/W2167279371","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2316850457","https://openalex.org/W2466739815","https://openalex.org/W2519012306","https://openalex.org/W2521016898","https://openalex.org/W2546967042","https://openalex.org/W2575691519","https://openalex.org/W2578506026","https://openalex.org/W2592811885","https://openalex.org/W2613267149","https://openalex.org/W2632544498","https://openalex.org/W2735092275","https://openalex.org/W2765639695","https://openalex.org/W2783502736","https://openalex.org/W2794480084","https://openalex.org/W2795649819","https://openalex.org/W2796894265","https://openalex.org/W2800770690","https://openalex.org/W2898202447","https://openalex.org/W2899065760","https://openalex.org/W2905560848","https://openalex.org/W2921275324","https://openalex.org/W2921763102","https://openalex.org/W2922995994","https://openalex.org/W2944545583","https://openalex.org/W2947725313","https://openalex.org/W2951686094","https://openalex.org/W2972933339","https://openalex.org/W2989644512","https://openalex.org/W2990002161","https://openalex.org/W2999689892","https://openalex.org/W3013539060","https://openalex.org/W3029046617","https://openalex.org/W3040615014","https://openalex.org/W3069335452","https://openalex.org/W3087500438","https://openalex.org/W3113710960","https://openalex.org/W3119069404","https://openalex.org/W3121517575","https://openalex.org/W3123434787","https://openalex.org/W3134861028","https://openalex.org/W3203512539","https://openalex.org/W3206879614","https://openalex.org/W6638054149"],"related_works":["https://openalex.org/W2795649819","https://openalex.org/W4401374247","https://openalex.org/W6986581663","https://openalex.org/W4387493067","https://openalex.org/W2796894265","https://openalex.org/W2800770690","https://openalex.org/W3040615014","https://openalex.org/W4399444096","https://openalex.org/W4404860145","https://openalex.org/W4367555465"],"abstract_inverted_index":{"Abstract":[0],"Gene":[1],"regulation":[2],"via":[3,19,172],"N6":[4],"-methyladenosine":[5],"(m":[6],"6":[7,17],"A)":[8],"in":[9,36,87,119,140,168,204],"mRNA":[10,157],"involves":[11],"RNA-binding":[12,59],"proteins":[13,29,60],"that":[14,66,108],"recognize":[15],"m":[16],"A":[18],"a":[20],"YT521-B":[21],"homology":[22],"(YTH)":[23],"domain.":[24],"The":[25],"plant":[26],"YTH":[27],"domain":[28],"ECT2":[30,68,115,125,184,191],"and":[31,69,97,128,158,190,192],"ECT3":[32,70,127,193],"act":[33,194],"genetically":[34],"redundantly":[35,196],"stimulating":[37],"cell":[38],"proliferation":[39],"during":[40],"organogenesis,":[41],"but":[42,144],"several":[43],"fundamental":[44],"questions":[45],"regarding":[46],"their":[47,129],"mode":[48],"of":[49,58,77,82,95,101,112,124,136,152,164,178,180],"action":[50],"remain":[51],"unclear.":[52],"Here,":[53],"we":[54],"use":[55],"HyperTRIBE":[56,86],"(targets":[57],"identified":[61],"by":[62,80,183,188],"editing)":[63],"to":[64,110,147,197],"show":[65,107,162],"most":[67],"targets":[71],"overlap,":[72],"with":[73],"only":[74],"few":[75],"examples":[76],"preferential":[78],"targeting":[79],"either":[81],"the":[83,102,120,205],"two":[84,103],"proteins.":[85,104],"different":[88],"mutant":[89],"backgrounds":[90],"also":[91,106],"provides":[92],"direct":[93],"views":[94],"redundant":[96],"specific":[98],"target":[99,142,153,199],"interactions":[100],"We":[105],"contrary":[109],"conclusions":[111],"previous":[113,176],"reports,":[114],"does":[116,132,145],"not":[117,133,186],"accumulate":[118],"nucleus.":[121],"Accordingly,":[122],"inactivation":[123],",":[126],"surrogate":[130],"ECT4":[131],"change":[134],"patterns":[135],"polyadenylation":[137,182],"site":[138],"choice":[139],"ECT2/3":[141],"mRNAs,":[143],"lead":[146],"lower":[148],"steady":[149],"state":[150],"accumulation":[151],"mRNAs.":[154],"In":[155],"addition,":[156],"microRNA":[159],"expression":[160],"profiles":[161],"indications":[163],"stress":[165],"response":[166],"activation":[167],"ect2/ect3/ect4":[169],"mutants,":[170],"likely":[171],"indirect":[173],"effects.":[174],"Thus,":[175],"suggestions":[177],"control":[179],"alternative":[181],"are":[185],"supported":[187],"evidence,":[189],"largely":[195],"regulate":[198],"mRNA,":[200],"including":[201],"its":[202],"abundance,":[203],"cytoplasm.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-11T00:00:00"}
