{"id":"https://openalex.org/W3204509329","doi":null,"title":"Review of Current and Potential Treatments for Chronic Hepatitis B Virus Infection.","display_name":"Review of Current and Potential Treatments for Chronic Hepatitis B Virus Infection.","publication_year":2021,"publication_date":"2021-08-01","ids":{"openalex":"https://openalex.org/W3204509329","mag":"3204509329","pmid":"https://pubmed.ncbi.nlm.nih.gov/34602899","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8475260"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:7377829","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8475260","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC8475260","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037655789","display_name":"Eugenia Tsai","orcid":"https://orcid.org/0000-0002-4619-6067","observed_orcids":["https://orcid.org/0000-0002-4619-6067"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210138836","display_name":"Texas Liver Institute","ror":"https://ror.org/03yk6x532","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210138836"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eugenia Tsai","raw_affiliation_strings":["Texas Liver Institute and UT Health San Antonio, San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Liver Institute and UT Health San Antonio, San Antonio, Texas","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4210138836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037655789"],"corresponding_institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4210138836"],"apc_list":null,"apc_paid":null,"fwci":3.8259,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.94415158,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"8","first_page":"367","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.828000009059906},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.8840000033378601},{"id":"https://openalex.org/keywords/nucleos-t-ide-analogues","display_name":"nucleos(t)ide analogues","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.796999990940094},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.8240000009536743},{"id":"https://openalex.org/keywords/viral-replication-inhibition","display_name":"viral replication inhibition","score":0.7540000081062317},{"id":"https://openalex.org/keywords/liver-cirrhosis-prevention","display_name":"cirrhosis prevention","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7879493236541748},{"id":"https://openalex.org/C3019392825","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic infection","level":3,"score":0.619263768196106},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6166349053382874},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5791858434677124},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5604398846626282},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5500244498252869},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4740588068962097},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47156116366386414},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.45004212856292725},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3867582678794861},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3449772596359253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1533854901790619}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:7377829","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8475260","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34602899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34602899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology & hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8475260","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8475260/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterol Hepatol (N Y)","raw_type":"Text"},{"id":"mag:3204509329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34602899/","pdf_url":null,"source":{"id":"https://openalex.org/S2501223270","display_name":"Gastroenterolog\u00eda y Hepatolog\u00eda","issn_l":"0210-5705","issn":["0210-5705","1578-9519"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Gastroenterolog\u00eda y Hepatolog\u00eda","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7377829","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8475260","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W1510860856","https://openalex.org/W1647175450","https://openalex.org/W1758726432","https://openalex.org/W1964509549","https://openalex.org/W1968106129","https://openalex.org/W1969878531","https://openalex.org/W1970704283","https://openalex.org/W1976097884","https://openalex.org/W1985860298","https://openalex.org/W1986388698","https://openalex.org/W2005657634","https://openalex.org/W2006774237","https://openalex.org/W2008517556","https://openalex.org/W2021553032","https://openalex.org/W2022770725","https://openalex.org/W2032152239","https://openalex.org/W2033726220","https://openalex.org/W2042565956","https://openalex.org/W2050385094","https://openalex.org/W2051976356","https://openalex.org/W2055339444","https://openalex.org/W2058376942","https://openalex.org/W2059560167","https://openalex.org/W2060321497","https://openalex.org/W2062680879","https://openalex.org/W2066970955","https://openalex.org/W2070905287","https://openalex.org/W2071833457","https://openalex.org/W2076571011","https://openalex.org/W2079096953","https://openalex.org/W2084177955","https://openalex.org/W2089108066","https://openalex.org/W2090738619","https://openalex.org/W2091191078","https://openalex.org/W2120426460","https://openalex.org/W2122749974","https://openalex.org/W2125065061","https://openalex.org/W2130575875","https://openalex.org/W2142064068","https://openalex.org/W2148987208","https://openalex.org/W2154097176","https://openalex.org/W2155000149","https://openalex.org/W2161280033","https://openalex.org/W2170397994","https://openalex.org/W2173007581","https://openalex.org/W2314223310","https://openalex.org/W2337332253","https://openalex.org/W2338794667","https://openalex.org/W2393327590","https://openalex.org/W2398313845","https://openalex.org/W2432543058","https://openalex.org/W2519375936","https://openalex.org/W2521726183","https://openalex.org/W2529757630","https://openalex.org/W2569712993","https://openalex.org/W2596506481","https://openalex.org/W2605389562","https://openalex.org/W2605785536","https://openalex.org/W2615622013","https://openalex.org/W2745921792","https://openalex.org/W2765217585","https://openalex.org/W2775305233","https://openalex.org/W2782856081","https://openalex.org/W2787915452","https://openalex.org/W2788473137","https://openalex.org/W2791839818","https://openalex.org/W2794200702","https://openalex.org/W2801666689","https://openalex.org/W2805832713","https://openalex.org/W2883340373","https://openalex.org/W2883358080","https://openalex.org/W2901066155","https://openalex.org/W2916919171","https://openalex.org/W2922025778","https://openalex.org/W2937689376","https://openalex.org/W2947410103","https://openalex.org/W2981927057","https://openalex.org/W2982130264","https://openalex.org/W2988788411","https://openalex.org/W2996247702","https://openalex.org/W3009378833","https://openalex.org/W3010530314","https://openalex.org/W3011632156","https://openalex.org/W3023868425","https://openalex.org/W3047035599","https://openalex.org/W3081809528","https://openalex.org/W3097327706","https://openalex.org/W3117081014","https://openalex.org/W3128309866","https://openalex.org/W3149727786","https://openalex.org/W3193978878","https://openalex.org/W4408240853"],"related_works":["https://openalex.org/W2092846101","https://openalex.org/W1986423407","https://openalex.org/W2395331476","https://openalex.org/W4322484495","https://openalex.org/W1977614873","https://openalex.org/W2154558894","https://openalex.org/W1877185991","https://openalex.org/W4366237417","https://openalex.org/W3032851942","https://openalex.org/W4400219710"],"abstract_inverted_index":{"Chronic":[0],"hepatitis":[1],"B":[2],"virus":[3],"(HBV)":[4],"infection":[5],"remains":[6],"a":[7,58,76],"major":[8],"global":[9],"health":[10],"burden.":[11],"Millions":[12],"of":[13,20,28,52,60,79,106],"people":[14],"are":[15],"at":[16,44],"risk":[17,51],"for":[18,37,65,83],"complications":[19],"chronic":[21,84,127],"HBV":[22,38,85,107,120],"infection,":[23,86],"despite":[24],"the":[25,50,63,103,111],"widespread":[26],"availability":[27],"an":[29],"effective":[30,43],"prophylactic":[31],"vaccine.":[32],"The":[33],"current":[34,104],"available":[35],"treatments":[36,56,108],"infection-interferon":[39],"and":[40,48,91,109],"nucleos(t)ide":[41],"analogues-are":[42],"suppressing":[45],"viral":[46],"replication":[47],"decreasing":[49],"cirrhosis.":[53],"However,":[54],"these":[55],"have":[57,74],"number":[59],"limitations,":[61],"creating":[62],"need":[64],"alternative":[66],"therapeutic":[67,81,114],"agents.":[68],"Recent":[69],"advances":[70],"in":[71,95],"drug":[72],"therapy":[73],"heralded":[75],"new":[77],"horizon":[78],"novel":[80],"approaches":[82],"with":[87],"several":[88],"promising":[89],"antiviral":[90],"immunomodulatory":[92],"agents":[93],"currently":[94],"preclinical":[96],"or":[97,121],"clinical":[98],"testing.":[99],"This":[100],"article":[101],"reviews":[102],"landscape":[105],"highlights":[110],"most":[112],"recent":[113],"strategies":[115],"designed":[116],"to":[117,122],"directly":[118],"target":[119],"improve":[123],"immune":[124],"response":[125],"during":[126],"infection.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}
