{"id":"https://openalex.org/W3204501931","doi":"https://doi.org/10.3390/jcm10194444","title":"Neutrophil-to-Lymphocyte Ratio as a Factor Predicting Radiotherapy Induced Oral Mucositis in Head Neck Cancer Patients Treated with Radiotherapy","display_name":"Neutrophil-to-Lymphocyte Ratio as a Factor Predicting Radiotherapy Induced Oral Mucositis in Head Neck Cancer Patients Treated with Radiotherapy","publication_year":2021,"publication_date":"2021-09-27","ids":{"openalex":"https://openalex.org/W3204501931","doi":"https://doi.org/10.3390/jcm10194444","mag":"3204501931","pmid":"https://pubmed.ncbi.nlm.nih.gov/34640462","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8509431"},"language":"en","primary_location":{"id":"doi:10.3390/jcm10194444","doi":"https://doi.org/10.3390/jcm10194444","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm10194444","pdf_url":"https://www.mdpi.com/2077-0383/10/19/4444/pdf?version=1632886645","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/10/19/4444/pdf?version=1632886645","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053468054","display_name":"Iwona Homa\u2010Mlak","orcid":"https://orcid.org/0000-0003-1244-6803","observed_orcids":["https://orcid.org/0000-0003-1244-6803"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Iwona Homa-Mlak","raw_affiliation_strings":["Department of Human Physiology, Medical University of Lublin, Radziwi\u0142\u0142owska 11, 20-080 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Physiology, Medical University of Lublin, Radziwi\u0142\u0142owska 11, 20-080 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035695609","display_name":"Anna Brzozowska","orcid":"https://orcid.org/0000-0002-8883-5816","observed_orcids":["https://orcid.org/0000-0002-8883-5816"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Brzozowska","raw_affiliation_strings":["Department of Oncology, Medical University of Lublin, Jaczewskiego 7, 20-090 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Medical University of Lublin, Jaczewskiego 7, 20-090 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033466730","display_name":"Rados\u0142aw Mlak","orcid":"https://orcid.org/0000-0001-7399-8340","observed_orcids":["https://orcid.org/0000-0001-7399-8340"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rados\u0142aw Mlak","raw_affiliation_strings":["Department of Human Physiology, Medical University of Lublin, Radziwi\u0142\u0142owska 11, 20-080 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Physiology, Medical University of Lublin, Radziwi\u0142\u0142owska 11, 20-080 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078646616","display_name":"Aneta Szudy\u2010Szczyrek","orcid":"https://orcid.org/0000-0003-2352-394X","observed_orcids":["https://orcid.org/0000-0003-2352-394X"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aneta Szudy-Szczyrek","raw_affiliation_strings":["Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-081 Lublin, Poland"],"raw_orcid":"https://orcid.org/0000-0003-2352-394X","affiliations":[{"raw_affiliation_string":"Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-081 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081732469","display_name":"Teresa J Malecka-Massalska","orcid":"https://orcid.org/0000-0003-3384-0324","observed_orcids":["https://orcid.org/0000-0003-3384-0324"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Teresa Ma\u0142ecka-Massalska","raw_affiliation_strings":["Department of Human Physiology, Medical University of Lublin, Radziwi\u0142\u0142owska 11, 20-080 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Physiology, Medical University of Lublin, Radziwi\u0142\u0142owska 11, 20-080 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053468054"],"corresponding_institution_ids":["https://openalex.org/I121032520"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":1.7007,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.87930469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"10","issue":"19","first_page":"4444","last_page":"4444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.23240000009536743,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/radiotherapy-induced-oral-mucositis","display_name":"radiotherapy-induced oral mucositis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7559999823570251},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tnm-stage","display_name":"TNM stage","score":0.6420000195503235},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.625},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9831562042236328},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.9609535932540894},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.8589296340942383},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.7427887916564941},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5352310538291931},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4690571129322052},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.46885594725608826},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.4438631236553192},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4330842196941376},{"id":"https://openalex.org/C2778963024","wikidata":"https://www.wikidata.org/wiki/Q17132454","display_name":"Neutrophil to lymphocyte ratio","level":3,"score":0.4307398200035095},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2978675365447998}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jcm10194444","doi":"https://doi.org/10.3390/jcm10194444","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm10194444","pdf_url":"https://www.mdpi.com/2077-0383/10/19/4444/pdf?version=1632886645","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmid:34640462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34640462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8509431","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8509431/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7a3274d0141e48c5a58be7f2cd86e4e5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7a3274d0141e48c5a58be7f2cd86e4e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Medicine, Vol 10, Iss 4444, p 4444 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jcm10194444","doi":"https://doi.org/10.3390/jcm10194444","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm10194444","pdf_url":"https://www.mdpi.com/2077-0383/10/19/4444/pdf?version=1632886645","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204501931.pdf","grobid_xml":"https://content.openalex.org/works/W3204501931.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W157657351","https://openalex.org/W850103728","https://openalex.org/W1491651242","https://openalex.org/W1822373200","https://openalex.org/W1967208836","https://openalex.org/W1970902949","https://openalex.org/W1978454448","https://openalex.org/W1982906652","https://openalex.org/W1984063570","https://openalex.org/W2002002528","https://openalex.org/W2009537560","https://openalex.org/W2014229457","https://openalex.org/W2014365040","https://openalex.org/W2019924096","https://openalex.org/W2021530129","https://openalex.org/W2033658212","https://openalex.org/W2034314920","https://openalex.org/W2036005555","https://openalex.org/W2042814134","https://openalex.org/W2057321587","https://openalex.org/W2067239783","https://openalex.org/W2067429538","https://openalex.org/W2075524348","https://openalex.org/W2085138849","https://openalex.org/W2086568618","https://openalex.org/W2090018471","https://openalex.org/W2096560865","https://openalex.org/W2105150213","https://openalex.org/W2115597075","https://openalex.org/W2123105952","https://openalex.org/W2129191628","https://openalex.org/W2131440269","https://openalex.org/W2132229428","https://openalex.org/W2139887409","https://openalex.org/W2145063848","https://openalex.org/W2150743941","https://openalex.org/W2153598797","https://openalex.org/W2317471836","https://openalex.org/W2570618306","https://openalex.org/W2571423414","https://openalex.org/W2598584164","https://openalex.org/W2622937510","https://openalex.org/W2624784373","https://openalex.org/W2767769629","https://openalex.org/W2771342962","https://openalex.org/W2792974948","https://openalex.org/W2799321885","https://openalex.org/W2802256643","https://openalex.org/W2806536798","https://openalex.org/W2929486546","https://openalex.org/W2954293137","https://openalex.org/W2981524284","https://openalex.org/W3017023262","https://openalex.org/W3033915627","https://openalex.org/W3084143595","https://openalex.org/W3104254817","https://openalex.org/W3117301540","https://openalex.org/W3120669051","https://openalex.org/W3161934314","https://openalex.org/W4214512856","https://openalex.org/W4249281955","https://openalex.org/W4317527937"],"related_works":["https://openalex.org/W7161553710","https://openalex.org/W4399204958","https://openalex.org/W3201831695","https://openalex.org/W2902482819","https://openalex.org/W1552684697","https://openalex.org/W2899847886","https://openalex.org/W4320924060","https://openalex.org/W2995781831","https://openalex.org/W2761354075","https://openalex.org/W4388186152"],"abstract_inverted_index":{"Background:":[0],"The":[1,42,60],"objective":[2],"of":[3,17,27,51,83,103,121,123,178,181,192],"this":[4],"research":[5],"conducted":[6],"in":[7,47,118,175,194],"head":[8],"and":[9,24,94,150,169],"neck":[10],"cancer":[11],"(HNC)":[12],"patients":[13,46,195],"was":[14,55,63],"the":[15,18,25,66,72,98,119,176,179],"assessment":[16],"relationship":[19],"between":[20,91],"neutrophil-to-lymphocyte":[21],"ratio":[22],"(NLR)":[23],"incidence":[26],"severe":[28,125,183],"radiotherapy":[29],"(RT)":[30],"induced":[31],"oral":[32],"mucositis":[33],"(OM),":[34],"as":[35,37,65,185,187],"well":[36,186],"overall":[38],"survival":[39,137],"(OS).":[40],"Methods:":[41],"study":[43],"involved":[44],"207":[45],"advanced":[48],"stages":[49],"(III\u2013IV)":[50],"HNC.":[52,201],"RTOG/EORTC":[53],"scale":[54],"used":[56],"to":[57,80,100,115,197,200],"assess":[58],"OM.":[59],"pre-treatment":[61],"NLR":[62,92,106,152,165],"specified":[64],"absolute":[67,73],"neutrophil":[68],"count":[69],"divided":[70],"by":[71],"lymphocyte":[74],"count.":[75],"Results:":[76],"Starting":[77],"from":[78],"second":[79,99],"seventh":[81,101],"week":[82,102],"RT,":[84,104],"we":[85],"observed":[86],"a":[87,167],"significant,":[88],"positive":[89],"correlation":[90],"values":[93,107,153],"OM":[95,126],"grade.":[96],"From":[97],"higher":[105,141,151],"were":[108,160],"related":[109],"with":[110],"significant":[111],"increases":[112],"(from":[113],"2-":[114],"over":[116],"24-fold)":[117],"risk":[120,180],"occurrence":[122],"more":[124,182],"(multivariate":[127],"analysis":[128,135],"confirmed":[129],"its":[130],"independent":[131,161,189],"influence).":[132],"Moreover,":[133],"multivariate":[134],"for":[136],"revealed":[138],"that":[139,172],"both":[140],"TNM":[142],"stage":[143],"(HR":[144,154],"=":[145,148,155,158],"1.84;":[146],"p":[147,157],"0.0043)":[149],"1.48;":[156],"0.0395)":[159],"prognostic":[162,190],"factors.":[163],"Conclusion:":[164],"is":[166,173],"simple":[168],"accurate":[170],"parameter":[171],"useful":[174],"evaluation":[177],"OM,":[184],"an":[188],"factor":[191],"OS":[193],"subjected":[196],"RT":[198],"due":[199]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}