{"id":"https://openalex.org/W3204433959","doi":"https://doi.org/10.4103/2221-1691.326098","title":"Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis","display_name":"Gracilaria fisheri oligosaccharides ameliorate inflammation and colonic epithelial barrier dysfunction in mice with acetic acid-induced colitis","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3204433959","doi":"https://doi.org/10.4103/2221-1691.326098","mag":"3204433959"},"language":"en","primary_location":{"id":"doi:10.4103/2221-1691.326098","doi":"https://doi.org/10.4103/2221-1691.326098","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2221-1691.326098","pdf_url":null,"source":{"id":"https://openalex.org/S2765002354","display_name":"Asian Pacific Journal of Tropical Biomedicine","issn_l":"2221-1691","issn":["2221-1691","2588-9222"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/2221-1691.326098","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036338767","display_name":"Brenda Siringoringo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brenda Siringoringo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070026159","display_name":"Nawiya Huipao","orcid":"https://orcid.org/0000-0002-0222-8581","observed_orcids":["https://orcid.org/0000-0002-0222-8581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nawiya Huipao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037072205","display_name":"Chittipong Tipbunjong","orcid":"https://orcid.org/0000-0002-9930-8763","observed_orcids":["https://orcid.org/0000-0002-9930-8763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chittipong Tipbunjong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060777737","display_name":"Jongdee Nopparat","orcid":"https://orcid.org/0000-0003-3532-1405","observed_orcids":["https://orcid.org/0000-0003-3532-1405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jongdee Nopparat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071313857","display_name":"Santad Wichienchot","orcid":"https://orcid.org/0000-0001-8352-7921","observed_orcids":["https://orcid.org/0000-0001-8352-7921","https://orcid.org/0009-0004-5693-9727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santad Wichienchot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048972792","display_name":"Albert Manggading Hutapea","orcid":"https://orcid.org/0000-0003-4775-6107","observed_orcids":["https://orcid.org/0000-0003-4775-6107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Albert M. Hutapea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050588798","display_name":"Pissared Khuituan","orcid":"https://orcid.org/0000-0003-1376-3253","observed_orcids":["https://orcid.org/0000-0003-1376-3253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pissared Khuituan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0571,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.74276319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"10","first_page":"440","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.03869999945163727,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gracilaria-fisheri","display_name":"Gracilaria fisheri","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oligosaccharides","display_name":"oligosaccharides","score":0.9110000133514404},{"id":"https://openalex.org/keywords/acetic-acid-induced-colitis","display_name":"acetic acid-induced colitis","score":0.906000018119812},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.968999981880188},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/claudin-2","display_name":"claudin-2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8410000205039978},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9739999771118164},{"id":"https://openalex.org/keywords/colonic-permeability","display_name":"colonic permeability","score":0.8109999895095825},{"id":"https://openalex.org/keywords/5-aminosalicylic-acid","display_name":"5-aminosalicylic acid","score":0.7279999852180481},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.6413324475288391},{"id":"https://openalex.org/C2776673659","wikidata":"https://www.wikidata.org/wiki/Q47512","display_name":"Acetic acid","level":2,"score":0.6410809755325317},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6159985065460205},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4250560402870178},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40353357791900635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36286842823028564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3519861698150635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32359427213668823},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32049745321273804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2217041552066803}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4103/2221-1691.326098","doi":"https://doi.org/10.4103/2221-1691.326098","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2221-1691.326098","pdf_url":null,"source":{"id":"https://openalex.org/S2765002354","display_name":"Asian Pacific Journal of Tropical Biomedicine","issn_l":"2221-1691","issn":["2221-1691","2588-9222"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ac3106b2faaf488ab33c2f41132d8039","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ac3106b2faaf488ab33c2f41132d8039","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine, Vol 11, Iss 10, Pp 440-449 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/2221-1691.326098","doi":"https://doi.org/10.4103/2221-1691.326098","is_oa":true,"landing_page_url":"https://doi.org/10.4103/2221-1691.326098","pdf_url":null,"source":{"id":"https://openalex.org/S2765002354","display_name":"Asian Pacific Journal of Tropical Biomedicine","issn_l":"2221-1691","issn":["2221-1691","2588-9222"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1618627661","https://openalex.org/W1685618362","https://openalex.org/W1778260808","https://openalex.org/W1928112806","https://openalex.org/W1996865440","https://openalex.org/W1997981215","https://openalex.org/W1998734250","https://openalex.org/W2002113350","https://openalex.org/W2013819796","https://openalex.org/W2026679422","https://openalex.org/W2033535624","https://openalex.org/W2040206306","https://openalex.org/W2043221183","https://openalex.org/W2045716003","https://openalex.org/W2047947935","https://openalex.org/W2079183971","https://openalex.org/W2108635800","https://openalex.org/W2113855055","https://openalex.org/W2122039020","https://openalex.org/W2122292170","https://openalex.org/W2133768599","https://openalex.org/W2154241784","https://openalex.org/W2157757382","https://openalex.org/W2281390906","https://openalex.org/W2345626787","https://openalex.org/W2414969435","https://openalex.org/W2486949243","https://openalex.org/W2620344213","https://openalex.org/W2740541362","https://openalex.org/W2744018445","https://openalex.org/W2792662981","https://openalex.org/W2796433952","https://openalex.org/W2920881623","https://openalex.org/W2921966151","https://openalex.org/W2942840957","https://openalex.org/W3031259087"],"related_works":["https://openalex.org/W4318777778","https://openalex.org/W3035010197","https://openalex.org/W2080372464","https://openalex.org/W3125542745","https://openalex.org/W3045601650","https://openalex.org/W4200540017","https://openalex.org/W2512894655","https://openalex.org/W4360955699","https://openalex.org/W2984025247","https://openalex.org/W2149014115"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"investigate":[2],"the":[3,175],"effect":[4],"of":[5,177],"Gracilaria":[6],"fisheri":[7],"oligosaccharides":[8],"(GFO)":[9],"on":[10],"inflammation":[11],"and":[12,65,73,81,104,123,142,148,159],"colonic":[13,63,162,186],"epithelial":[14,163],"barrier":[15,164,187],"dysfunction":[16,165],"in":[17,91,117,151,166,185],"colitis":[18,55,92,98,118,130,152,169],"mice.":[19,99,153,170],"Methods:":[20],"The":[21],"animals":[22],"were":[23,69],"treated":[24,46,120],"by":[25,71],"oral":[26],"gavage":[27],"with":[28,47,101,121],"distilled":[29],"water,":[30],"1":[31,38,105,124],"000":[32,39,106,125],"mg/kg":[33,40,49,107],"inulin,":[34],"100,":[35,102],"500,":[36,103],"or":[37,45],"GFO":[41,87,108,132,155,172],"for":[42,51],"14":[43],"d,":[44],"50":[48],"mesalamine":[50],"5":[52],"d":[53],"after":[54],"induction":[56],"(on":[57],"day":[58],"10).":[59],"Histopathology,":[60],"inflammatory":[61],"cytokines,":[62],"permeability,":[64],"tight":[66,144,178],"junction":[67,145,179],"proteins":[68,146,180],"investigated":[70],"hematoxylin":[72],"eosin":[74],"staining,":[75,77],"immunohistochemical":[76],"Ussing":[78],"chamber":[79],"technique,":[80],"Western":[82],"blotting":[83],"assays,":[84],"respectively.":[85],"Results:":[86],"ameliorated":[88],"histological":[89],"damage":[90],"mice":[93,119],"when":[94],"compared":[95],"to":[96,128],"untreated":[97,129],"Treatments":[100],"reduced":[109,116,137],"TNF-\u03b1":[110],"expression,":[111],"while":[112],"IL-1\u03b2":[113],"was":[114],"significantly":[115],"500":[122],"mg/kg.":[126],"Compared":[127],"mice,":[131],"increased":[133],"transepithelial":[134],"electrical":[135],"resistance,":[136],"fluorescein":[138],"isothiocyanate-dextran":[139],"paracellular":[140],"flux,":[141],"modulated":[143],"(occludin":[147],"claudin":[149],"2)":[150],"Conclusions:":[154],"has":[156],"anti-inflammatory":[157],"activity":[158],"could":[160,173],"modulate":[161,174],"acetic":[167],"acid-induced":[168],"Furthermore,":[171],"expression":[176],"that":[181],"play":[182],"important":[183],"roles":[184],"function.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-10-11T00:00:00"}
