{"id":"https://openalex.org/W3204367481","doi":"https://doi.org/10.1101/2021.10.04.463043","title":"Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of \u03b1-synuclein","display_name":"Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of \u03b1-synuclein","publication_year":2021,"publication_date":"2021-10-05","ids":{"openalex":"https://openalex.org/W3204367481","doi":"https://doi.org/10.1101/2021.10.04.463043","mag":"3204367481"},"language":"en","primary_location":{"id":"doi:10.1101/2021.10.04.463043","doi":"https://doi.org/10.1101/2021.10.04.463043","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.04.463043","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/05/2021.10.04.463043.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/05/2021.10.04.463043.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078608675","display_name":"Charlotte F. Brzozowski","orcid":"https://orcid.org/0000-0002-8871-2453","observed_orcids":["https://orcid.org/0000-0002-8871-2453"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Charlotte F. Brzozowski","raw_affiliation_strings":["Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA","Interfaculty Institute for Biochemistry, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany","Interfaculty Institute for Biochemistry, University of T\u00fcbingen, 7076 T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Interfaculty Institute for Biochemistry, University of T\u00fcbingen, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Interfaculty Institute for Biochemistry, University of T\u00fcbingen, 7076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036381410","display_name":"Baraa A. Hijaz","orcid":"https://orcid.org/0000-0002-1192-1812","observed_orcids":["https://orcid.org/0000-0002-1192-1812"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baraa A. Hijaz","raw_affiliation_strings":["Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vijay Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Singh","raw_affiliation_strings":["Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055115140","display_name":"Nolwazi Z. Gcwensa","orcid":"https://orcid.org/0000-0001-9708-6119","observed_orcids":["https://orcid.org/0000-0001-9708-6119"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nolwazi Z. Gcwensa","raw_affiliation_strings":["Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090488994","display_name":"Kaela Kelly","orcid":"https://orcid.org/0000-0002-3313-9768","observed_orcids":["https://orcid.org/0000-0002-3313-9768"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaela Kelly","raw_affiliation_strings":["Duke Center for Neurodegeneration Research, Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Center for Neurodegeneration Research, Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109593948","display_name":"Edward S. Boyden","orcid":"https://orcid.org/0000-0002-0419-3351","observed_orcids":["https://orcid.org/0000-0002-0419-3351"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I144112489","display_name":"McGovern Institute for Brain Research","ror":"https://ror.org/05ymca674","country_code":"US","type":"facility","lineage":["https://openalex.org/I144112489","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward S. Boyden","raw_affiliation_strings":["McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA"],"raw_orcid":"https://orcid.org/0000-0002-0419-3351","affiliations":[{"raw_affiliation_string":"McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I144112489","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I63966007"]},{"raw_affiliation_string":"McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I144112489","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071278272","display_name":"Andrew B. West","orcid":"https://orcid.org/0000-0002-3034-4061","observed_orcids":["https://orcid.org/0000-0002-3034-4061"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew B. West","raw_affiliation_strings":["Duke Center for Neurodegeneration Research, Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0002-3034-4061","affiliations":[{"raw_affiliation_string":"Duke Center for Neurodegeneration Research, Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047237761","display_name":"Deblina Sarkar","orcid":"https://orcid.org/0000-0002-9662-1666","observed_orcids":["https://orcid.org/0000-0002-9662-1666"]},"institutions":[{"id":"https://openalex.org/I4405268810","display_name":"MIT Media Lab","ror":"https://ror.org/0253jyq40","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268810"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deblina Sarkar","raw_affiliation_strings":["MIT Media Lab, Departments of Biological Engineering and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIT Media Lab, Departments of Biological Engineering and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 USA","institution_ids":["https://openalex.org/I4405268810","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049620072","display_name":"Laura A. Volpicelli\u2010Daley","orcid":"https://orcid.org/0000-0001-8934-4018","observed_orcids":["https://orcid.org/0000-0001-8934-4018"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laura A. Volpicelli-Daley","raw_affiliation_strings":["Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA"],"raw_orcid":"https://orcid.org/0000-0001-8934-4018","affiliations":[{"raw_affiliation_string":"Department of Neurology, Center for Neurodegeneration and Experimental therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294 USA","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5049620072"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.8640000224113464},{"id":"https://openalex.org/keywords/lrrk2-kinase-inhibition","display_name":"LRRK2 kinase inhibition","score":0.8100000023841858},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9580000042915344},{"id":"https://openalex.org/keywords/anterograde-axonal-transport","display_name":"anterograde axonal transport","score":0.9950000047683716},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lewy-body-pathology","display_name":"Lewy body pathology","score":0.8949999809265137},{"id":"https://openalex.org/keywords/g2019s-mutation","display_name":"G2019S mutation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mli-2","display_name":"MLi-2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/non-motor-symptoms","display_name":"non-motor symptoms","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.9332621097564697},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6107137799263},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.6007596254348755},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5369247198104858},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.5163165926933289},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5062245726585388},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4743936061859131},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.42702147364616394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3278637230396271},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27281808853149414},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2306942641735077},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11850568652153015},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.1020427942276001},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0853014886379242},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1101/2021.10.04.463043","doi":"https://doi.org/10.1101/2021.10.04.463043","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.04.463043","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/05/2021.10.04.463043.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:dspace.mit.edu:1721.1/138128","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/138128","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Central","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1101/2021.10.04.463043","doi":"https://doi.org/10.1101/2021.10.04.463043","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.04.463043","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/05/2021.10.04.463043.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5139619469","display_name":"Role of presynaptic targeting of alpha-synuclein in the pathogenesis of Parkinson's Disease and Dementia with Lewy Bodies","funder_award_id":"R01NS102257","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7118082807","display_name":null,"funder_award_id":"MJFF-004413","funder_id":"https://openalex.org/F4320306136","funder_display_name":"Michael J. Fox Foundation for Parkinson's Research"},{"id":"https://openalex.org/G7345536802","display_name":"Alpha-synuclein aggregate induced synapse loss is a pathological event contributing to Lewy body dementias","funder_award_id":"R56NS117465","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320315389","display_name":"Open Philanthropy Project","ror":"https://ror.org/004d1k391"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204367481.pdf","grobid_xml":"https://content.openalex.org/works/W3204367481.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W1495464662","https://openalex.org/W1527671059","https://openalex.org/W1841354354","https://openalex.org/W1886318170","https://openalex.org/W1910661134","https://openalex.org/W1965901737","https://openalex.org/W1967900265","https://openalex.org/W1987155530","https://openalex.org/W1989732798","https://openalex.org/W1989913002","https://openalex.org/W1990473626","https://openalex.org/W1992187783","https://openalex.org/W1992483894","https://openalex.org/W1992632425","https://openalex.org/W1994141638","https://openalex.org/W2004536040","https://openalex.org/W2012553386","https://openalex.org/W2017453788","https://openalex.org/W2024201618","https://openalex.org/W2025416265","https://openalex.org/W2027422916","https://openalex.org/W2039073478","https://openalex.org/W2039919932","https://openalex.org/W2040814741","https://openalex.org/W2043835731","https://openalex.org/W2044141286","https://openalex.org/W2044428616","https://openalex.org/W2062065799","https://openalex.org/W2063127941","https://openalex.org/W2078697067","https://openalex.org/W2081284091","https://openalex.org/W2082907050","https://openalex.org/W2090946801","https://openalex.org/W2100300726","https://openalex.org/W2106117608","https://openalex.org/W2121937669","https://openalex.org/W2126238482","https://openalex.org/W2130444809","https://openalex.org/W2130696471","https://openalex.org/W2140826149","https://openalex.org/W2144433399","https://openalex.org/W2144502720","https://openalex.org/W2161334375","https://openalex.org/W2163012098","https://openalex.org/W2253950023","https://openalex.org/W2272666074","https://openalex.org/W2325022883","https://openalex.org/W2406725268","https://openalex.org/W2413508469","https://openalex.org/W2471911977","https://openalex.org/W2472421578","https://openalex.org/W2545117990","https://openalex.org/W2557658586","https://openalex.org/W2559765167","https://openalex.org/W2570972408","https://openalex.org/W2606949627","https://openalex.org/W2743091325","https://openalex.org/W2755670910","https://openalex.org/W2767998367","https://openalex.org/W2768016303","https://openalex.org/W2771146782","https://openalex.org/W2781844066","https://openalex.org/W2802832869","https://openalex.org/W2806953769","https://openalex.org/W2883053634","https://openalex.org/W2884363644","https://openalex.org/W2888203729","https://openalex.org/W2889715260","https://openalex.org/W2893109289","https://openalex.org/W2898437587","https://openalex.org/W2902875229","https://openalex.org/W2903283657","https://openalex.org/W2905086723","https://openalex.org/W2908623828","https://openalex.org/W2910779362","https://openalex.org/W2945045846","https://openalex.org/W2945440919","https://openalex.org/W2945702369","https://openalex.org/W2947129787","https://openalex.org/W2948025690","https://openalex.org/W2978112145","https://openalex.org/W2994242284","https://openalex.org/W3068292362","https://openalex.org/W3080503232","https://openalex.org/W3082225631","https://openalex.org/W3090100713","https://openalex.org/W3090404065","https://openalex.org/W3105563048","https://openalex.org/W3135528648","https://openalex.org/W3136908976","https://openalex.org/W3163641486","https://openalex.org/W3171786035","https://openalex.org/W4232515155"],"related_works":["https://openalex.org/W2917033274","https://openalex.org/W2806830813","https://openalex.org/W4388006712","https://openalex.org/W7123040079","https://openalex.org/W7154938912","https://openalex.org/W1992483894","https://openalex.org/W2472421578","https://openalex.org/W7100466385","https://openalex.org/W2908623828","https://openalex.org/W2535698088"],"abstract_inverted_index":{"Abstract":[0],"Pathologic":[1],"inclusions":[2],"composed":[3],"of":[4,11,31,40,82,89,95,101,165,173,198,202,205,213,243,279,290],"\u03b1-synuclein":[5,74,133,144,218,230,252,291],"called":[6],"Lewy":[7,33,50],"pathology":[8,34,51,295],"are":[9,25],"hallmarks":[10],"Parkinson\u2019s":[12],"Disease":[13],"(PD).":[14],"Dominant":[15],"inherited":[16],"mutations":[17],"in":[18,37,52,123,178,186,235,273,296],"leucine":[19],"rich":[20],"repeat":[21],"kinase":[22,141,155,168,215,227,268],"2":[23],"(LRRK2)":[24],"the":[26,38,47,69,80,116,147,152,163,183,195,211,222],"most":[27],"common":[28],"genetic":[29],"cause":[30,294],"PD.":[32,301],"is":[35,108],"found":[36],"majority":[39],"individuals":[41],"with":[42,46,55,232,254],"LRRK2-PD,":[43,298],"particularly":[44,104],"those":[45],"G2019S-LRRK2":[48],"mutation.":[49],"LRRK2-PD":[53],"associates":[54],"increased":[56],"non-motor":[57,83],"symptoms":[58],"such":[59],"as":[60],"cognitive":[61],"deficits,":[62],"anxiety,":[63],"and":[64,73,98,111,129,158,182,238,258,276,299],"orthostatic":[65],"hypotension.":[66],"Thus,":[67],"understanding":[68],"relationship":[70],"between":[71],"LRRK2":[72,91,112,119,140,154,167,214,226,249,267],"could":[75,293],"be":[76],"important":[77],"for":[78],"determining":[79],"mechanisms":[81,285],"symptoms.":[84],"In":[85,246],"PD":[86],"models,":[87],"expression":[88],"mutant":[90],"reduces":[92],"membrane":[93,124],"localization":[94,172,197,292],"\u03b1-":[96,244],"synuclein,":[97],"enhances":[99],"formation":[100],"pathologic":[102],"\u03b1-synuclein,":[103],"when":[105],"synaptic":[106,134],"activity":[107,142,169,228,269],"increased.":[109],"\u03b1-Synuclein":[110],"both":[113,297],"localize":[114],"to":[115,146,161,191,209],"presynaptic":[117,148,171,196,223,233,261,277],"terminal.":[118,149,224],"plays":[120,270],"a":[121,271],"role":[122,272],"traffic,":[125],"including":[126],"axonal":[127,203,219,241,274],"transport,":[128,275],"therefore":[130],"may":[131],"influence":[132],"localization.":[135],"This":[136],"study":[137],"shows":[138],"that":[139,266],"influences":[143],"targeting":[145,278],"We":[150],"used":[151,190,208],"selective":[153],"inhibitors,":[156],"MLi-2":[157],"PF-06685360":[159],"(PF-360)":[160],"determine":[162],"impact":[164,212],"reduced":[166],"on":[170,217],"\u03b1-synuclein.":[174,199,280],"Expansion":[175],"microscopy":[176],"(ExM)":[177],"primary":[179,236],"hippocampal":[180],"cultures":[181],"mouse":[184],"striatum,":[185],"vivo":[187,247],",":[188,248],"was":[189,207],"more":[192],"precisely":[193],"resolve":[194],"Live":[200],"imaging":[201],"transport":[204,220,242],"\u03b1-synuclein-GFP":[206],"investigate":[210],"inhibition":[216,250],"towards":[221],"Reduced":[225],"increases":[229,239,251],"overlap":[231,253],"markers":[234],"neurons,":[237],"anterograde":[240],"synuclein-GFP.":[245],"glutamatergic,":[255],"cortico-striatal":[256],"terminals,":[257],"dopaminergic":[259],"nigral-striatal":[260],"terminals.":[262],"The":[263],"findings":[264],"suggest":[265],"These":[281],"data":[282],"provide":[283],"potential":[284],"by":[286],"which":[287],"LRRK2-mediated":[288],"perturbations":[289],"idiopathic":[300]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-10-11T00:00:00"}