{"id":"https://openalex.org/W3204096795","doi":"https://doi.org/10.3390/md19100546","title":"A Marine \u03bb-Oligocarrageenan Inhibits Migratory and Invasive Ability of MDA-MB-231 Human Breast Cancer Cells through Actions on Heparanase Metabolism and MMP-14/MMP-2 Axis","display_name":"A Marine \u03bb-Oligocarrageenan Inhibits Migratory and Invasive Ability of MDA-MB-231 Human Breast Cancer Cells through Actions on Heparanase Metabolism and MMP-14/MMP-2 Axis","publication_year":2021,"publication_date":"2021-09-28","ids":{"openalex":"https://openalex.org/W3204096795","doi":"https://doi.org/10.3390/md19100546","mag":"3204096795","pmid":"https://pubmed.ncbi.nlm.nih.gov/34677445","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8539239"},"language":"en","primary_location":{"id":"doi:10.3390/md19100546","doi":"https://doi.org/10.3390/md19100546","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md19100546","pdf_url":"https://www.mdpi.com/1660-3397/19/10/546/pdf?version=1633656703","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-3397/19/10/546/pdf?version=1633656703","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035911417","display_name":"R\u00e9mi Cousin","orcid":"https://orcid.org/0000-0003-3038-9988","observed_orcids":["https://orcid.org/0000-0003-3038-9988"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R\u00e9mi Cousin","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007168308","display_name":"Hugo Groult","orcid":"https://orcid.org/0000-0002-1571-9400","observed_orcids":["https://orcid.org/0000-0002-1571-9400"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hugo Groult","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":"https://orcid.org/0000-0002-1571-9400","affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048953798","display_name":"Chanez Manseur","orcid":"https://orcid.org/0009-0009-8499-0198","observed_orcids":["https://orcid.org/0009-0009-8499-0198"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chanez Manseur","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102993851","display_name":"Romain Ferru-Cl\u00e9ment","orcid":"https://orcid.org/0000-0001-5309-0861","observed_orcids":["https://orcid.org/0000-0001-5309-0861"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Romain Ferru-Cl\u00e9ment","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":"https://orcid.org/0000-0001-5309-0861","affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028103457","display_name":"Mario Gani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mario Gani","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012379902","display_name":"Rachel Havret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rachel Havret","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007828387","display_name":"Claire Toucheteau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Toucheteau","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053746552","display_name":"Gr\u00e9goire Prunier","orcid":"https://orcid.org/0000-0003-2560-513X","observed_orcids":["https://orcid.org/0000-0003-2560-513X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gr\u00e9goire Prunier","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070710360","display_name":"Beatrice Colin","orcid":"https://orcid.org/0000-0002-2499-3962","observed_orcids":["https://orcid.org/0000-0002-2499-3962"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B\u00e9atrice Colin","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045559923","display_name":"Franck Morel","orcid":"https://orcid.org/0000-0003-3812-9304","observed_orcids":["https://orcid.org/0000-0003-3812-9304"]},"institutions":[{"id":"https://openalex.org/I32881790","display_name":"Universit\u00e9 de Poitiers","ror":"https://ror.org/04xhy8q59","country_code":"FR","type":"education","lineage":["https://openalex.org/I32881790"]},{"id":"https://openalex.org/I4405268524","display_name":"Laboratoire Inflammation, Tissus \u00c9pith\u00e9liaux et Cytokines","ror":"https://ror.org/017t4tj27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I32881790","https://openalex.org/I4405268524"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Morel","raw_affiliation_strings":["Laboratoire Inflammation, Tissus Epith\u00e9liaux et Cytokines, Poitiers University, LITEC EA 4331, 86073 Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Inflammation, Tissus Epith\u00e9liaux et Cytokines, Poitiers University, LITEC EA 4331, 86073 Poitiers, France","institution_ids":["https://openalex.org/I32881790","https://openalex.org/I4405268524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051970214","display_name":"Jean\u2010Marie Piot","orcid":"https://orcid.org/0000-0003-4018-5380","observed_orcids":["https://orcid.org/0000-0003-4018-5380"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Marie Piot","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030760411","display_name":"Isabelle Lanneluc","orcid":"https://orcid.org/0000-0002-7268-3950","observed_orcids":["https://orcid.org/0000-0002-7268-3950"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Lanneluc","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":"https://orcid.org/0000-0002-7268-3950","affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040826567","display_name":"K\u00e9vin Baranger","orcid":"https://orcid.org/0000-0001-8206-8874","observed_orcids":["https://orcid.org/0000-0001-8206-8874"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210097886","display_name":"Institut de Neurophysiopathologie","ror":"https://ror.org/00w2q5j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210097886"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"K\u00e9vin Baranger","raw_affiliation_strings":["Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, 13385 Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, 13385 Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210097886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070531895","display_name":"Thierry Maugard","orcid":"https://orcid.org/0000-0002-9196-7780","observed_orcids":["https://orcid.org/0000-0002-9196-7780"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Maugard","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":"https://orcid.org/0000-0002-9196-7780","affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079282435","display_name":"Ingrid Fruitier\u2010Arnaudin","orcid":"https://orcid.org/0000-0001-8993-1095","observed_orcids":["https://orcid.org/0000-0001-8993-1095"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210098382","display_name":"LIttoral ENvironnement et Soci\u00e9t\u00e9s","ror":"https://ror.org/00r8amq78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]},{"id":"https://openalex.org/I78744979","display_name":"La Rochelle Universit\u00e9","ror":"https://ror.org/04mv1z119","country_code":"FR","type":"education","lineage":["https://openalex.org/I78744979"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Ingrid Fruitier-Arnaudin","raw_affiliation_strings":["BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCBS Group (Biotechnologies et Chimie des Bioressources pour la Sant\u00e9), Laboratoire Littoral Environnement et Soci\u00e9t\u00e9s, La Rochelle University, UMR CNRS 7266, 17000 La Rochelle, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5079282435"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210098382","https://openalex.org/I78744979"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2592},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2592},"fwci":0.374,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.4369832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"10","first_page":"546","last_page":"546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.034699998795986176,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparanase","display_name":"heparanase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mmp-14","display_name":"MMP-14","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer-cell-migration","display_name":"breast cancer cell migration","score":0.902999997138977},{"id":"https://openalex.org/keywords/breast-cancer-cell-invasion","display_name":"breast cancer cell invasion","score":0.8769999742507935},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.968999981880188},{"id":"https://openalex.org/keywords/marine-polysaccharides","display_name":"marine polysaccharides","score":0.8100000023841858},{"id":"https://openalex.org/keywords/antimetastatic-agents","display_name":"anti-metastatic agents","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2777478136","wikidata":"https://www.wikidata.org/wiki/Q909646","display_name":"Heparanase","level":4,"score":0.987066388130188},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.6005153059959412},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.5595664381980896},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5574449300765991},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5441668033599854},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.526858925819397},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5124847888946533},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5069692134857178},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4756065011024475},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.463897705078125},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4608582556247711},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43311911821365356},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.419027715921402},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.41136372089385986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40045419335365295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37222927808761597},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099175","descriptor_name":"Heparanase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000461","descriptor_name":"Rhodophyta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002351","descriptor_name":"Carrageenan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002351","descriptor_name":"Carrageenan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053511","descriptor_name":"Matrix Metalloproteinase 14","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059001","descriptor_name":"Aquatic Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/md19100546","doi":"https://doi.org/10.3390/md19100546","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md19100546","pdf_url":"https://www.mdpi.com/1660-3397/19/10/546/pdf?version=1633656703","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},{"id":"pmid:34677445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34677445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine drugs","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8539239","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8539239/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mar Drugs","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-03369118v1","doi":null,"is_oa":true,"landing_page_url":"https://univ-rochelle.hal.science/hal-03369118","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine drugs, 2021, 19 (10), pp.546. &#x27E8;10.3390/md19100546&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:0045017d096c4a4bab005a78baa18637","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0045017d096c4a4bab005a78baa18637","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine Drugs, Vol 19, Iss 10, p 546 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/md19100546","doi":"https://doi.org/10.3390/md19100546","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md19100546","pdf_url":"https://www.mdpi.com/1660-3397/19/10/546/pdf?version=1633656703","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204096795.pdf","grobid_xml":"https://content.openalex.org/works/W3204096795.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W190833853","https://openalex.org/W1476658428","https://openalex.org/W1491748226","https://openalex.org/W1574172480","https://openalex.org/W1883520857","https://openalex.org/W1964935114","https://openalex.org/W1968521818","https://openalex.org/W1970850028","https://openalex.org/W1980974289","https://openalex.org/W2011229547","https://openalex.org/W2022532273","https://openalex.org/W2033096051","https://openalex.org/W2049056185","https://openalex.org/W2050225501","https://openalex.org/W2053175158","https://openalex.org/W2054649531","https://openalex.org/W2056680779","https://openalex.org/W2100033465","https://openalex.org/W2104368170","https://openalex.org/W2112611468","https://openalex.org/W2117692326","https://openalex.org/W2118705802","https://openalex.org/W2121179180","https://openalex.org/W2123398651","https://openalex.org/W2163367650","https://openalex.org/W2167648889","https://openalex.org/W2267809411","https://openalex.org/W2273821763","https://openalex.org/W2276751188","https://openalex.org/W2489590314","https://openalex.org/W2539079898","https://openalex.org/W2555935710","https://openalex.org/W2588694183","https://openalex.org/W2612142971","https://openalex.org/W2614388893","https://openalex.org/W2760987893","https://openalex.org/W2810652866","https://openalex.org/W2897107489","https://openalex.org/W2900367378","https://openalex.org/W2913062750","https://openalex.org/W2917622945","https://openalex.org/W2942536939","https://openalex.org/W2943022158","https://openalex.org/W2966710588","https://openalex.org/W2977969423","https://openalex.org/W3006930853","https://openalex.org/W3015567900","https://openalex.org/W3034435925","https://openalex.org/W3035593737","https://openalex.org/W3113812720","https://openalex.org/W3115036692","https://openalex.org/W3126736432","https://openalex.org/W3197000993"],"related_works":["https://openalex.org/W7214248872","https://openalex.org/W7151103803","https://openalex.org/W2917622945","https://openalex.org/W1975993565","https://openalex.org/W3135283588","https://openalex.org/W2612142971","https://openalex.org/W91061769","https://openalex.org/W2058143304","https://openalex.org/W2438602659","https://openalex.org/W2101535860"],"abstract_inverted_index":{"Sugar-based":[0],"molecules":[1],"such":[2],"as":[3,167],"heparins":[4],"or":[5],"natural":[6],"heparan":[7],"sulfate":[8],"polysaccharides":[9],"have":[10,37],"been":[11,39],"developed":[12],"and":[13,87,94,119,137,142],"widely":[14],"studied":[15],"for":[16],"controlling":[17],"heparanase":[18],"(HPSE)":[19],"enzymatic":[20,56,178],"activity,":[21],"a":[22,144,154,168],"key":[23],"player":[24],"in":[25,41,106,143],"extracellular":[26],"matrix":[27],"remodelling":[28],"during":[29],"cancer":[30,99],"pathogenesis.":[31],"However,":[32],"non-enzymatic":[33,59],"functions":[34,185],"of":[35,69,83,96,103,110,123,173,180],"HPSE":[36,60,111,170,181,189],"also":[38,58,102,183],"described":[40],"tumour":[42],"mechanisms.":[43],"Given":[44],"their":[45],"versatile":[46],"properties,":[47],"we":[48,65,77],"hypothesized":[49],"that":[50,150],"sugar-based":[51],"inhibitors":[52],"may":[53],"interfere":[54],"with":[55,81,140],"but":[57,101,126,182],"activities.":[61],"In":[62],"this":[63,163],"work,":[64],"assessed":[66],"the":[67,108,130,177,184,188],"effects":[68,122],"an":[70],"original":[71],"marine":[72],"\u03bb-carrageenan":[73],"derived":[74],"oligosaccharide":[75],"(\u03bb-CO)":[76],"previously":[78],"described,":[79],"along":[80],"those":[82],"its":[84],"native":[85],"counterpart":[86],"heparins,":[88,141],"on":[89],"cell":[90,135],"viability,":[91],"proliferation,":[92],"migration,":[93],"invasion":[95,138],"MDA-MB-231":[97],"breast":[98],"cells":[100],"sh-MDA-MB-231":[104],"cells,":[105],"which":[107],"expression":[109],"was":[112,129],"selectively":[113],"downregulated.":[114],"We":[115,147],"observed":[116],"no":[117,120],"cytotoxic":[118],"anti-proliferative":[121],"our":[124],"compounds":[125],"surprisingly":[127],"\u03bb-CO":[128,151,166],"most":[131],"efficient":[132],"to":[133,158],"reduce":[134],"migration":[136],"compared":[139],"HPSE-dependent":[145],"manner.":[146],"provided":[148],"evidence":[149],"tightly":[152],"controlled":[153,186],"HPSE/MMP-14/MMP-2":[155],"axis,":[156],"leading":[157],"reduced":[159],"MMP-2":[160],"activity.":[161],"Altogether,":[162],"study":[164],"highlights":[165],"potent":[169],"\"modulator\"":[171],"capable":[172],"reducing":[174],"not":[175],"only":[176],"activity":[179],"by":[187],"levels.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-10-11T00:00:00"}
