{"id":"https://openalex.org/W3204033124","doi":"https://doi.org/10.3390/ijms221910599","title":"Integrin \u03b21 Promotes Pancreatic Tumor Growth by Upregulating Kindlin-2 and TGF-\u03b2 Receptor-2","display_name":"Integrin \u03b21 Promotes Pancreatic Tumor Growth by Upregulating Kindlin-2 and TGF-\u03b2 Receptor-2","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W3204033124","doi":"https://doi.org/10.3390/ijms221910599","mag":"3204033124","pmid":"https://pubmed.ncbi.nlm.nih.gov/34638957","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8508632"},"language":"en","primary_location":{"id":"doi:10.3390/ijms221910599","doi":"https://doi.org/10.3390/ijms221910599","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms221910599","pdf_url":"https://www.mdpi.com/1422-0067/22/19/10599/pdf?version=1633003717","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/19/10599/pdf?version=1633003717","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058056044","display_name":"Md Saimon Mia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57328836","display_name":"North Dakota State University","ror":"https://ror.org/05h1bnb22","country_code":"US","type":"education","lineage":["https://openalex.org/I57328836"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md Saimon Mia","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, Fargo, ND 58108-6050, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, Fargo, ND 58108-6050, USA","institution_ids":["https://openalex.org/I57328836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037915418","display_name":"Yagna P. R. Jarajapu","orcid":"https://orcid.org/0000-0002-7186-3693","observed_orcids":["https://orcid.org/0000-0002-7186-3693"]},"institutions":[{"id":"https://openalex.org/I57328836","display_name":"North Dakota State University","ror":"https://ror.org/05h1bnb22","country_code":"US","type":"education","lineage":["https://openalex.org/I57328836"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yagna Jarajapu","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, Fargo, ND 58108-6050, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, Fargo, ND 58108-6050, USA","institution_ids":["https://openalex.org/I57328836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102824684","display_name":"Reena Rao","orcid":"https://orcid.org/0000-0003-0739-9344","observed_orcids":["https://orcid.org/0000-0003-0739-9344"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reena Rao","raw_affiliation_strings":["Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":null,"display_name":"Sijo Mathew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57328836","display_name":"North Dakota State University","ror":"https://ror.org/05h1bnb22","country_code":"US","type":"education","lineage":["https://openalex.org/I57328836"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sijo Mathew","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, Fargo, ND 58108-6050, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, Fargo, ND 58108-6050, USA","institution_ids":["https://openalex.org/I57328836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I57328836"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":2.9953,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.91130037,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"22","issue":"19","first_page":"10599","last_page":"10599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8289999961853027},{"id":"https://openalex.org/keywords/kindlin-2","display_name":"Kindlin-2","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/smad2-3-phosphorylation","display_name":"Smad2/3 phosphorylation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.777999997138977},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.925000011920929},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.7390000224113464},{"id":"https://openalex.org/keywords/integrin-alpha5","display_name":"integrin alpha5","score":0.968999981880188},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.8242669105529785},{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.818433403968811},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.7700524926185608},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6465593576431274},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6084533929824829},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.5332571864128113},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5190180540084839},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47107210755348206},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.4681919515132904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45590701699256897},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4510941505432129},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4490078091621399},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.43938177824020386},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4094310998916626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37732869386672974},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3623500168323517},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22892960906028748},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1328892707824707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08329391479492188},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.05618879199028015},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019012","descriptor_name":"Integrin beta1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019012","descriptor_name":"Integrin beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms221910599","doi":"https://doi.org/10.3390/ijms221910599","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms221910599","pdf_url":"https://www.mdpi.com/1422-0067/22/19/10599/pdf?version=1633003717","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8508632","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8508632","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:34638957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34638957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:304b4419efeb426491be852d98532d91","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/304b4419efeb426491be852d98532d91","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 10599, p 10599 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms221910599","doi":"https://doi.org/10.3390/ijms221910599","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms221910599","pdf_url":"https://www.mdpi.com/1422-0067/22/19/10599/pdf?version=1633003717","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2547153460","display_name":null,"funder_award_id":"R01 DK-083525","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2830692597","display_name":"CTGF Induced Tubulointerstitial Crosstalk Regulates Fibrosis in PKD","funder_award_id":"5r01dk083525-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3979990166","display_name":"Dakota Cancer Collaborative on Translational Activity","funder_award_id":"U54GM128729","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5382135401","display_name":null,"funder_award_id":"1P20GM109024, U54GM128729","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000915703","display_name":"Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer","funder_award_id":"P20GM109024","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204033124.pdf","grobid_xml":"https://content.openalex.org/works/W3204033124.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W771030118","https://openalex.org/W1986689328","https://openalex.org/W1999614450","https://openalex.org/W2032030670","https://openalex.org/W2040095760","https://openalex.org/W2054302145","https://openalex.org/W2064977142","https://openalex.org/W2066291924","https://openalex.org/W2074446921","https://openalex.org/W2091065959","https://openalex.org/W2101451537","https://openalex.org/W2106091291","https://openalex.org/W2112061784","https://openalex.org/W2113581466","https://openalex.org/W2140256258","https://openalex.org/W2142508063","https://openalex.org/W2148954263","https://openalex.org/W2277501221","https://openalex.org/W2409321676","https://openalex.org/W2524907165","https://openalex.org/W2574485237","https://openalex.org/W2588121804","https://openalex.org/W2606595919","https://openalex.org/W2726346047","https://openalex.org/W2745440458","https://openalex.org/W2753960063","https://openalex.org/W2890452532","https://openalex.org/W2894197700","https://openalex.org/W3038616181","https://openalex.org/W3086939937","https://openalex.org/W3092873259","https://openalex.org/W3129148826"],"related_works":["https://openalex.org/W4225413450","https://openalex.org/W4393167881","https://openalex.org/W1994194265","https://openalex.org/W2135197020","https://openalex.org/W4241452360","https://openalex.org/W2327452172","https://openalex.org/W2162721477","https://openalex.org/W1986689328","https://openalex.org/W2092516523","https://openalex.org/W2043796673"],"abstract_inverted_index":{"The":[0,130],"tumor":[1,31,62,157],"microenvironment":[2],"plays":[3],"a":[4,85,94,150],"critical":[5],"role":[6],"in":[7,84,105,110,156],"defining":[8],"the":[9,30,45,54,71,78,90,123,135,141,161],"growth":[10,158],"and":[11,24,39,88,114,118,165],"malignancy":[12],"of":[13,29,73,80,100,122,132,137,143,153,163],"solid":[14],"tumors.":[15],"Extracellular":[16],"matrix":[17,87],"(ECM)":[18],"proteins":[19,41],"such":[20],"as":[21],"collagen,":[22],"vitronectin,":[23],"fibronectin":[25],"are":[26],"major":[27],"components":[28],"microenvironment.":[32],"Tumor":[33],"growth-promoting":[34],"reciprocal":[35],"interaction":[36],"between":[37],"ECM":[38],"cytoplasmic":[40],"is":[42],"regulated":[43],"by":[44,56,139,159],"cell":[46,69,112],"surface":[47],"receptors":[48],"called":[49],"integrins.":[50],"This":[51],"study":[52],"investigated":[53],"mechanism":[55,152],"which":[57,108],"integrin":[58,74,101,154],"\u03b21":[59,75,155],"promotes":[60],"pancreatic":[61,67],"growth.":[63],"In":[64],"MIA":[65],"PaCa-2":[66],"cancer":[68],"line,":[70],"loss":[72],"protein":[76],"reduced":[77],"ability":[79,91],"cells":[81],"to":[82,92],"proliferate":[83],"3D":[86],"compromised":[89],"form":[93],"focal":[95],"adhesion":[96,115],"complex.":[97],"Decreased":[98],"expression":[99,121,142,162],"\u03b15":[102],"was":[103,127],"observed":[104],"KO":[106],"cells,":[107],"resulted":[109],"impaired":[111],"spreading":[113],"on":[116],"vitronectin":[117],"fibronectin.":[119],"Reduced":[120],"integrin-associated":[124],"protein,":[125],"kindlin-2":[126,133,164],"also":[128],"recorded.":[129],"downregulation":[131],"decreased":[134],"phosphorylation":[136],"Smad2/3":[138],"reducing":[140],"TGF-\u03b2":[144,166],"receptor":[145,167],"2.":[146],"These":[147],"results":[148],"unravel":[149],"new":[151],"modifying":[160],"2":[168],"signaling.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-11T00:00:00"}