{"id":"https://openalex.org/W3203973511","doi":"https://doi.org/10.12793/tcp.2021.29.e18","title":"The use of real-world data in drug repurposing","display_name":"The use of real-world data in drug repurposing","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3203973511","doi":"https://doi.org/10.12793/tcp.2021.29.e18","mag":"3203973511","pmid":"https://pubmed.ncbi.nlm.nih.gov/34621704","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8492393"},"language":"en","primary_location":{"id":"doi:10.12793/tcp.2021.29.e18","doi":"https://doi.org/10.12793/tcp.2021.29.e18","is_oa":true,"landing_page_url":"https://doi.org/10.12793/tcp.2021.29.e18","pdf_url":"http://tcpharm.org/Synapse/Data/PDFData/1179TCP/tcp-29-117.pdf","source":{"id":"https://openalex.org/S4210230709","display_name":"Translational and Clinical Pharmacology","issn_l":"2289-0882","issn":["2289-0882","2383-5427"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","kci-registered","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational and Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://tcpharm.org/Synapse/Data/PDFData/1179TCP/tcp-29-117.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073604371","display_name":"Kyungsoo Park","orcid":"https://orcid.org/0000-0002-6972-1143","observed_orcids":["https://orcid.org/0000-0002-6972-1143","https://orcid.org/0009-0009-5065-2799"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyungsoo Park","raw_affiliation_strings":["Department of Pharmacology, Yonsei University College of Medicine, Seoul 03722, Korea"],"raw_orcid":"https://orcid.org/0000-0002-6972-1143","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Yonsei University College of Medicine, Seoul 03722, Korea","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073604371"],"corresponding_institution_ids":["https://openalex.org/I193775966"],"apc_list":null,"apc_paid":null,"fwci":0.5581,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.58739596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"29","issue":"3","first_page":"117","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.4560999870300293,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.4560999870300293,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.1655000001192093,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.10679999738931656,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9950000047683716},{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.9580000042915344},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.7559999823570251},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.8999999761581421},{"id":"https://openalex.org/keywords/21st-century-cures-act","display_name":"21st Century Cures Act","score":0.9959999918937683},{"id":"https://openalex.org/keywords/regulatory-policy","display_name":"regulatory policy","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.8059943914413452},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6511597037315369},{"id":"https://openalex.org/C3020493868","wikidata":"https://www.wikidata.org/wiki/Q55631277","display_name":"Real world data","level":2,"score":0.5619072318077087},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4375761151313782},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36152124404907227},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.35693642497062683},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22740483283996582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20153731107711792},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12843018770217896},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.12793/tcp.2021.29.e18","doi":"https://doi.org/10.12793/tcp.2021.29.e18","is_oa":true,"landing_page_url":"https://doi.org/10.12793/tcp.2021.29.e18","pdf_url":"http://tcpharm.org/Synapse/Data/PDFData/1179TCP/tcp-29-117.pdf","source":{"id":"https://openalex.org/S4210230709","display_name":"Translational and Clinical Pharmacology","issn_l":"2289-0882","issn":["2289-0882","2383-5427"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","kci-registered","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational and Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7385843","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8492393","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34621704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34621704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational and clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8492393","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8492393/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Clin Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.12793/tcp.2021.29.e18","doi":"https://doi.org/10.12793/tcp.2021.29.e18","is_oa":true,"landing_page_url":"https://doi.org/10.12793/tcp.2021.29.e18","pdf_url":"http://tcpharm.org/Synapse/Data/PDFData/1179TCP/tcp-29-117.pdf","source":{"id":"https://openalex.org/S4210230709","display_name":"Translational and Clinical Pharmacology","issn_l":"2289-0882","issn":["2289-0882","2383-5427"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","kci-registered","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational and Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203973511.pdf","grobid_xml":"https://content.openalex.org/works/W3203973511.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1126991912","https://openalex.org/W1737223868","https://openalex.org/W1924182355","https://openalex.org/W1971463294","https://openalex.org/W2018960130","https://openalex.org/W2026967508","https://openalex.org/W2036906022","https://openalex.org/W2039299300","https://openalex.org/W2058725063","https://openalex.org/W2062941476","https://openalex.org/W2067577774","https://openalex.org/W2098167876","https://openalex.org/W2105050951","https://openalex.org/W2182748314","https://openalex.org/W2298338128","https://openalex.org/W2406299101","https://openalex.org/W2560688864","https://openalex.org/W2598265731","https://openalex.org/W2794249288","https://openalex.org/W2905487017","https://openalex.org/W2946951051","https://openalex.org/W2959798450","https://openalex.org/W3042558069","https://openalex.org/W3099918881","https://openalex.org/W3114294941","https://openalex.org/W3117435802","https://openalex.org/W3118755727","https://openalex.org/W3159965121"],"related_works":["https://openalex.org/W4412636617","https://openalex.org/W4308158649","https://openalex.org/W7216406299","https://openalex.org/W2960245070","https://openalex.org/W3042722497","https://openalex.org/W4238797266","https://openalex.org/W3120049458","https://openalex.org/W2777322952","https://openalex.org/W7129522929","https://openalex.org/W4384935541"],"abstract_inverted_index":{"Drug":[0],"repurposing,":[1,170],"or":[2,88],"repositioning,":[3],"is":[4],"to":[5,28,46,52,72],"identify":[6],"new":[7],"uses":[8],"for":[9,82],"existing":[10],"drugs.":[11],"Significantly":[12],"reducing":[13],"the":[14,34,67,94,97,104,136,148,155,174],"costs":[15],"and":[16,61,90,111,151,177,181],"time-to-market":[17],"of":[18,58,96,106,132,138,157,183],"a":[19],"medication,":[20],"drug":[21,30,48,59,109,139,160,169],"repurposing":[22,112,140,175],"has":[23,41],"been":[24,42],"an":[25,130],"alternative":[26],"tool":[27],"accelerate":[29],"development":[31,49,110],"process.":[32],"On":[33],"other":[35,77],"hand,":[36],"'real":[37],"world":[38],"data":[39,73],"(RWD)'":[40],"also":[43],"increasingly":[44],"used":[45,144],"support":[47],"process":[50],"owing":[51],"its":[53],"better":[54],"representing":[55],"actual":[56],"pattern":[57],"treatment":[60],"outcome":[62],"in":[63,84,108,118,135,154,159,168,173],"real":[64],"world.":[65],"In":[66,124],"healthcare":[68],"domain,":[69],"RWD":[70,107,119,142,158,167],"refers":[71],"collected":[74],"from":[75],"sources":[76],"than":[78],"traditional":[79],"clinical":[80],"trials;":[81],"example,":[83],"electronic":[85],"health":[86],"records":[87],"claims":[89],"billing":[91],"data.":[92],"With":[93],"enactment":[95],"21st":[98],"Century":[99],"Cures":[100],"Act,":[101],"which":[102],"encourages":[103],"use":[105,120,156],"as":[113],"well,":[114],"such":[115],"increasing":[116,149],"trend":[117,150],"will":[121],"be":[122],"expedited.":[123],"this":[125,127],"context,":[126],"review":[128],"provides":[129],"overview":[131],"recent":[133],"progresses":[134],"area":[137],"where":[141],"was":[143],"by":[145],"firstly":[146],"introducing":[147],"regulatory":[152],"change":[153],"development,":[161],"secondly":[162],"reviewing":[163],"published":[164],"works":[165],"using":[166],"classifying":[171],"them":[172],"strategy,":[176],"lastly":[178],"addressing":[179],"limitations":[180],"advantages":[182],"RWDs.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}