{"id":"https://openalex.org/W3203900967","doi":"https://doi.org/10.17533/udea.vitae.v28n3a346531","title":"Gliptins vs. Milk-derived Dipeptidyl-Peptidase IV Inhibiting Biopeptides: Physicochemical Characterization and Pharmacokinetic Profiling","display_name":"Gliptins vs. Milk-derived Dipeptidyl-Peptidase IV Inhibiting Biopeptides: Physicochemical Characterization and Pharmacokinetic Profiling","publication_year":2021,"publication_date":"2021-10-04","ids":{"openalex":"https://openalex.org/W3203900967","doi":"https://doi.org/10.17533/udea.vitae.v28n3a346531","mag":"3203900967"},"language":"en","primary_location":{"id":"doi:10.17533/udea.vitae.v28n3a346531","doi":"https://doi.org/10.17533/udea.vitae.v28n3a346531","is_oa":true,"landing_page_url":"https://doi.org/10.17533/udea.vitae.v28n3a346531","pdf_url":"https://revistas.udea.edu.co/index.php/vitae/article/download/346531/20806467","source":{"id":"https://openalex.org/S111148215","display_name":"Revista Vitae","issn_l":"0121-4004","issn":["0121-4004","2145-2660"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","publindex-b","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318837","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/P4310318837"],"host_organization_lineage_names":["Universidad de Antioquia"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vitae","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://revistas.udea.edu.co/index.php/vitae/article/download/346531/20806467","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087101796","display_name":"Jorge A. Barrero","orcid":"https://orcid.org/0000-0003-2958-5551","observed_orcids":["https://orcid.org/0000-0003-2958-5551"]},"institutions":[{"id":"https://openalex.org/I36243813","display_name":"Universidad Nacional de Colombia","ror":"https://ror.org/059yx9a68","country_code":"CO","type":"education","lineage":["https://openalex.org/I36243813"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Jorge Andr\u00e9s Barrero","raw_affiliation_strings":["Universidad Nacional de Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional de Colombia","institution_ids":["https://openalex.org/I36243813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061589531","display_name":"Fabio Cabrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabio Cabrera","raw_affiliation_strings":["Department of Science & Technology Studies, Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science & Technology Studies, Cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":null,"display_name":"Claudia Marcela Cruz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Marcela Cruz","raw_affiliation_strings":["Gimnasio Vermont, Head of the Natural Science Department, IB Chemistry Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gimnasio Vermont, Head of the Natural Science Department, IB Chemistry Division","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":100,"currency":"USD","value_usd":100},"apc_paid":{"value":100,"currency":"USD","value_usd":100},"fwci":0.2477,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.51747832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"28","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0640999972820282,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dpp-4-inhibition","display_name":"DPP-4 inhibition","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6589999794960022},{"id":"https://openalex.org/keywords/physicochemical-properties","display_name":"physicochemical properties","score":0.7689999938011169},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.8980000019073486},{"id":"https://openalex.org/keywords/gastrointestinal-absorption","display_name":"gastrointestinal absorption","score":0.7519999742507935},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6340000033378601},{"id":"https://openalex.org/keywords/synthetic-accessibility","display_name":"synthetic accessibility","score":0.6729999780654907},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.9700000286102295},{"id":"https://openalex.org/keywords/adme-prediction","display_name":"ADME prediction","score":0.6380000114440918},{"id":"https://openalex.org/keywords/peptide-solubility","display_name":"peptide solubility","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.626754879951477},{"id":"https://openalex.org/C2781469919","wikidata":"https://www.wikidata.org/wiki/Q5279728","display_name":"Dipeptidyl peptidase","level":3,"score":0.5792137384414673},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5703224539756775},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5543667674064636},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.515509843826294},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.4936014413833618},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43918025493621826},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4047234058380127},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1946110725402832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.17533/udea.vitae.v28n3a346531","doi":"https://doi.org/10.17533/udea.vitae.v28n3a346531","is_oa":true,"landing_page_url":"https://doi.org/10.17533/udea.vitae.v28n3a346531","pdf_url":"https://revistas.udea.edu.co/index.php/vitae/article/download/346531/20806467","source":{"id":"https://openalex.org/S111148215","display_name":"Revista Vitae","issn_l":"0121-4004","issn":["0121-4004","2145-2660"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","publindex-b","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318837","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/P4310318837"],"host_organization_lineage_names":["Universidad de Antioquia"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vitae","raw_type":"journal-article"},{"id":"pmh:oai:ojs.pkp.sfu.ca:article/346531","doi":null,"is_oa":true,"landing_page_url":"https://revistas.udea.edu.co/index.php/vitae/article/view/346531","pdf_url":null,"source":{"id":"https://openalex.org/S4306401799","display_name":"Vitae (Universidad de Antioquia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35961687","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/I35961687"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vitae; Vol 28 No 3 (2021)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:b54a861ec7f74571ad98ecd6286ca34c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b54a861ec7f74571ad98ecd6286ca34c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vitae, Vol 28, Iss 3 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.17533/udea.vitae.v28n3a346531","doi":"https://doi.org/10.17533/udea.vitae.v28n3a346531","is_oa":true,"landing_page_url":"https://doi.org/10.17533/udea.vitae.v28n3a346531","pdf_url":"https://revistas.udea.edu.co/index.php/vitae/article/download/346531/20806467","source":{"id":"https://openalex.org/S111148215","display_name":"Revista Vitae","issn_l":"0121-4004","issn":["0121-4004","2145-2660"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","publindex-b","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318837","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/P4310318837"],"host_organization_lineage_names":["Universidad de Antioquia"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vitae","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203900967.pdf","grobid_xml":"https://content.openalex.org/works/W3203900967.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W149769536","https://openalex.org/W1574994167","https://openalex.org/W1611092567","https://openalex.org/W1962425360","https://openalex.org/W1977304530","https://openalex.org/W1981737096","https://openalex.org/W1985628945","https://openalex.org/W1985740632","https://openalex.org/W1985933988","https://openalex.org/W1987612487","https://openalex.org/W2003076573","https://openalex.org/W2011505858","https://openalex.org/W2024829861","https://openalex.org/W2037428083","https://openalex.org/W2042338355","https://openalex.org/W2050564499","https://openalex.org/W2052907531","https://openalex.org/W2063255933","https://openalex.org/W2065494411","https://openalex.org/W2069506489","https://openalex.org/W2070099122","https://openalex.org/W2070685035","https://openalex.org/W2077483199","https://openalex.org/W2105649494","https://openalex.org/W2160592148","https://openalex.org/W2191306565","https://openalex.org/W2195203261","https://openalex.org/W2326124692","https://openalex.org/W2396930286","https://openalex.org/W2508390964","https://openalex.org/W2525611773","https://openalex.org/W2536610379","https://openalex.org/W2556857110","https://openalex.org/W2593436234","https://openalex.org/W2767714545","https://openalex.org/W2767891136","https://openalex.org/W2783666262","https://openalex.org/W2793729526","https://openalex.org/W2800530372","https://openalex.org/W2810023675","https://openalex.org/W2891800472","https://openalex.org/W2906506692","https://openalex.org/W2908281806","https://openalex.org/W2909984636","https://openalex.org/W2913173637","https://openalex.org/W2945792041","https://openalex.org/W2946412700","https://openalex.org/W2979759717","https://openalex.org/W2985636042","https://openalex.org/W2989775272","https://openalex.org/W3001449207","https://openalex.org/W3003470647","https://openalex.org/W3003617438","https://openalex.org/W3005226159","https://openalex.org/W3011199786","https://openalex.org/W3017382529","https://openalex.org/W3020298715","https://openalex.org/W3024085885","https://openalex.org/W3044390354","https://openalex.org/W3044859337","https://openalex.org/W3101492567","https://openalex.org/W3105705503","https://openalex.org/W3109453709","https://openalex.org/W3112770431","https://openalex.org/W3123280459","https://openalex.org/W3132877651","https://openalex.org/W4213065361"],"related_works":["https://openalex.org/W7202242986","https://openalex.org/W4295421029","https://openalex.org/W7213619751","https://openalex.org/W7104009652","https://openalex.org/W4320916245","https://openalex.org/W2562408238","https://openalex.org/W2282542030","https://openalex.org/W2057599473","https://openalex.org/W3196847841","https://openalex.org/W4402992426"],"abstract_inverted_index":{"Background:":[0],"Milk-derived":[1],"biopeptides":[2,84,105,143,154,189,258,290],"have":[3],"reported":[4,190,203,244,276],"in":[5,15,54,66,89,145,161],"vitro":[6],"dipeptidyl-peptidase":[7],"IV":[8],"(DPP-IV)":[9],"inhibition,":[10],"suggesting":[11],"a":[12,129,169,216,225,245,285],"glycemic-regulatory":[13],"effect":[14],"Type":[16],"2":[17],"Diabetes":[18],"Mellitus":[19],"(T2DM).":[20],"Nonetheless,":[21],"the":[22,31,47],"therapeutic":[23,304],"application":[24],"of":[25,33,49,92,148,186,288],"these":[26],"nutraceuticals":[27],"is":[28],"limited":[29],"by":[30,224],"scarcity":[32],"knowledge":[34],"regarding":[35],"their":[36,303],"pharmacokinetic":[37],"profile.":[38],"Objective:":[39],"This":[40],"study":[41],"aimed":[42],"to":[43,62,210,249,255,308],"characterize":[44],"and":[45,68,83,97,120,142,182,206,251,266,274,282,295],"assess":[46],"pharmacokinetics":[48],"milk-derived":[50,289],"biopeptides.":[51,238],"Through":[52],"an":[53,277],"silico":[55,90],"comparative":[56],"analysis":[57,124],"with":[58,159,176],"gliptins,":[59,256],"we":[60],"expected":[61],"identify":[63],"enhanced":[64,179],"properties":[65,262],"food-hydrolysates":[67],"suitable":[69,292],"DPP-IV":[70,250,281],"inhibiting":[71],"peptides":[72,177,243],"as":[73,108],"candidates":[74,297],"for":[75,103,237,280,298],"T2DM":[76,299],"therapy.":[77],"Methods:":[78],"A":[79],"comparison":[80],"between":[81,140,173],"gliptins":[82,141,160,221],"was":[85,112,125],"conducted":[86],"based":[87],"on":[88,114],"evaluation":[91,167],"drug-likeness,":[93],"physicochemical":[94,166,261],"properties,":[95],"pharmacokinetics,":[96],"synthetic":[98,230,235,272],"accessibility.":[99],"Suitable":[100],"target":[101],"proteins":[102],"gastrointestinal-absorbable":[104,153,193,257],"were":[106,208],"determined":[107,209],"well.":[109],"Data":[110],"collection":[111],"performed":[113],"SwissADME,":[115],"ADMETlab,":[116],"DrugBank,":[117],"SwissTargetPrediction,":[118],"ChemDes,":[119],"BIOPEP-UWM":[121],"platforms.":[122],"Statistical":[123],"carried":[126],"out":[127,147,185],"using":[128],"one-way":[130],"ANOVA":[131],"test.":[132],"Results:":[133],"Drug-likeness":[134],"compliance":[135],"showed":[136,215],"no":[137,156],"significant":[138,157,170],"difference":[139,158,171],"(p>0.05)":[144],"three":[146],"nine":[149],"assessed":[150,188],"rules,":[151],"though":[152],"exhibited":[155],"five":[162],"drug-likeness":[163],"guidelines.":[164],"The":[165],"revealed":[168],"(p<0.05)":[172],"both":[174],"groups,":[175],"exhibiting":[178],"solubility,":[180,264],"flexibility,":[181,265],"polarity.":[183],"Nine":[184],"thirty-six":[187],"being":[191],"likely":[192],"molecules,":[194],"from":[195],"which":[196],"six":[197],"displayed":[198],"\u226530%":[199],"predicted":[200],"bioavailability,":[201],"two":[202],"CYP450":[204,269],"interactions,":[205,270],"all":[207],"be":[211],"blood":[212],"confined.":[213],"Biopeptides":[214],"slightly":[217],"lower":[218,227],"clearance":[219],"than":[220],"yet":[222],"counteracted":[223],"significantly":[226],"half-life.":[228],"Moreover,":[229],"accessibility":[231],"scores":[232],"indicated":[233],"higher":[234,271],"ease":[236],"In":[239],"addition,":[240],"absorbable":[241],"bioactive":[242],"considerable":[246],"binding":[247],"affinity":[248,279],"Calpain-I.":[252,283],"Conclusions:":[253],"Compared":[254],"exhibit":[259],"superior":[260],"(higher":[263],"polarity),":[267],"lesser":[268],"ease,":[273],"some":[275],"important":[278],"Only":[284],"small":[286],"fraction":[287],"are":[291],"drug-like":[293],"compounds":[294],"feasible":[296],"therapy;":[300],"yet,":[301],"testing":[302],"potency":[305],"remains":[306],"subject":[307],"further":[309],"studies.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-11T00:00:00"}