{"id":"https://openalex.org/W3203891014","doi":"https://doi.org/10.1016/j.biocel.2021.106093","title":"IFN\u03b3 induces JAK1/STAT1/p65 NF\u03baB-dependent interleukin-8 expression in ovarian cancer cells, resulting in their increased migration","display_name":"IFN\u03b3 induces JAK1/STAT1/p65 NF\u03baB-dependent interleukin-8 expression in ovarian cancer cells, resulting in their increased migration","publication_year":2021,"publication_date":"2021-10-07","ids":{"openalex":"https://openalex.org/W3203891014","doi":"https://doi.org/10.1016/j.biocel.2021.106093","mag":"3203891014","pmid":"https://pubmed.ncbi.nlm.nih.gov/34626802","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8639749"},"language":"en","primary_location":{"id":"doi:10.1016/j.biocel.2021.106093","doi":"https://doi.org/10.1016/j.biocel.2021.106093","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2021.106093","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry & Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8639749/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086887694","display_name":"Sveta Padmanabhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142823887","display_name":"St. John's University","ror":"https://ror.org/00bgtad15","country_code":"US","type":"education","lineage":["https://openalex.org/I142823887"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sveta Padmanabhan","raw_affiliation_strings":["Department of Biological Sciences, St. John's University, NY 11439, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, St. John's University, NY 11439, USA","institution_ids":["https://openalex.org/I142823887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077900878","display_name":"Bijaya Gaire","orcid":"https://orcid.org/0000-0002-1600-4757","observed_orcids":["https://orcid.org/0000-0002-1600-4757"]},"institutions":[{"id":"https://openalex.org/I142823887","display_name":"St. John's University","ror":"https://ror.org/00bgtad15","country_code":"US","type":"education","lineage":["https://openalex.org/I142823887"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bijaya Gaire","raw_affiliation_strings":["Department of Biological Sciences, St. John's University, NY 11439, USA"],"raw_orcid":"https://orcid.org/0000-0002-1600-4757","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, St. John's University, NY 11439, USA","institution_ids":["https://openalex.org/I142823887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102754574","display_name":"Yue Zou","orcid":"https://orcid.org/0000-0002-6999-8329","observed_orcids":["https://orcid.org/0000-0002-6999-8329"]},"institutions":[{"id":"https://openalex.org/I142823887","display_name":"St. John's University","ror":"https://ror.org/00bgtad15","country_code":"US","type":"education","lineage":["https://openalex.org/I142823887"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Zou","raw_affiliation_strings":["Department of Biological Sciences, St. John's University, NY 11439, USA"],"raw_orcid":"https://orcid.org/0000-0002-6999-8329","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, St. John's University, NY 11439, USA","institution_ids":["https://openalex.org/I142823887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102508071","display_name":"Mohammad M. Uddin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142823887","display_name":"St. John's University","ror":"https://ror.org/00bgtad15","country_code":"US","type":"education","lineage":["https://openalex.org/I142823887"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad M. Uddin","raw_affiliation_strings":["Department of Biological Sciences, St. John's University, NY 11439, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, St. John's University, NY 11439, USA","institution_ids":["https://openalex.org/I142823887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024636157","display_name":"Daniel DeLeon","orcid":"https://orcid.org/0000-0003-3243-8114","observed_orcids":["https://orcid.org/0000-0003-3243-8114"]},"institutions":[{"id":"https://openalex.org/I142823887","display_name":"St. John's University","ror":"https://ror.org/00bgtad15","country_code":"US","type":"education","lineage":["https://openalex.org/I142823887"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel DeLeon","raw_affiliation_strings":["Department of Biological Sciences, St. John's University, NY 11439, USA"],"raw_orcid":"https://orcid.org/0000-0003-3243-8114","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, St. John's University, NY 11439, USA","institution_ids":["https://openalex.org/I142823887"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054346929","display_name":"Ivana Vancurova","orcid":"https://orcid.org/0000-0002-7508-7396","observed_orcids":["https://orcid.org/0000-0002-7508-7396"]},"institutions":[{"id":"https://openalex.org/I142823887","display_name":"St. John's University","ror":"https://ror.org/00bgtad15","country_code":"US","type":"education","lineage":["https://openalex.org/I142823887"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ivana Vancurova","raw_affiliation_strings":["Department of Biological Sciences, St. John's University, NY 11439, USA. Electronic address: vancuroi@stjohns.edu","Department of Biological Sciences, St. John's University, NY 11439, USA"],"raw_orcid":"https://orcid.org/0000-0002-7508-7396","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, St. John's University, NY 11439, USA. Electronic address: vancuroi@stjohns.edu","institution_ids":["https://openalex.org/I142823887"]},{"raw_affiliation_string":"Department of Biological Sciences, St. John's University, NY 11439, USA","institution_ids":["https://openalex.org/I142823887"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054346929"],"corresponding_institution_ids":["https://openalex.org/I142823887"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":1.0909,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.72886388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"141","issue":null,"first_page":"106093","last_page":"106093"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.10320000350475311,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/jak1","display_name":"JAK1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chemokine-expression","display_name":"chemokine expression","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8809999823570251},{"id":"https://openalex.org/keywords/il-8-promoter","display_name":"IL-8 promoter","score":0.6389999985694885},{"id":"https://openalex.org/keywords/nf-kappab-acetylation","display_name":"NF-\u03baB acetylation","score":0.75},{"id":"https://openalex.org/keywords/stat1-phosphorylation","display_name":"STAT1 phosphorylation","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.6793590784072876},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6458730101585388},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6138045787811279},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5617304444313049},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.48944059014320374},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44453299045562744},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.4276737868785858},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.4241408407688141},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.41889190673828125},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.40809592604637146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40129685401916504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3832602798938751},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3293062150478363},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.309331476688385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2519610524177551},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2173292636871338},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1396426260471344},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.11818736791610718},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06756457686424255},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053613","descriptor_name":"Janus Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053613","descriptor_name":"Janus Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biocel.2021.106093","doi":"https://doi.org/10.1016/j.biocel.2021.106093","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2021.106093","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry & Cell Biology","raw_type":"journal-article"},{"id":"pmid:34626802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34626802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of biochemistry & cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8639749","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8639749/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Biochem Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8639749","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8639749/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Biochem Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8669926858","display_name":"Targeting IKK and HDAC Mediated IL-8 Expression in Ovarian and Prostate Cancer","funder_award_id":"R15CA202775","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W83138054","https://openalex.org/W1510735640","https://openalex.org/W1535274954","https://openalex.org/W1825540737","https://openalex.org/W1839872679","https://openalex.org/W1973454407","https://openalex.org/W1974417303","https://openalex.org/W1981528932","https://openalex.org/W1993403939","https://openalex.org/W2004335766","https://openalex.org/W2037299986","https://openalex.org/W2045057001","https://openalex.org/W2051033989","https://openalex.org/W2051784121","https://openalex.org/W2056635301","https://openalex.org/W2080889594","https://openalex.org/W2083741449","https://openalex.org/W2086159554","https://openalex.org/W2092921437","https://openalex.org/W2103629277","https://openalex.org/W2110567472","https://openalex.org/W2112601576","https://openalex.org/W2116158418","https://openalex.org/W2123105952","https://openalex.org/W2131322950","https://openalex.org/W2138049320","https://openalex.org/W2143172913","https://openalex.org/W2307487014","https://openalex.org/W2326425416","https://openalex.org/W2413595579","https://openalex.org/W2468308090","https://openalex.org/W2512931560","https://openalex.org/W2558219863","https://openalex.org/W2586167592","https://openalex.org/W2623388110","https://openalex.org/W2752182706","https://openalex.org/W2781052937","https://openalex.org/W2782476390","https://openalex.org/W2790935413","https://openalex.org/W2799849968","https://openalex.org/W2802731336","https://openalex.org/W2808825101","https://openalex.org/W2888766935","https://openalex.org/W2899408092","https://openalex.org/W2901824420","https://openalex.org/W2948288366","https://openalex.org/W2966495342","https://openalex.org/W2968188498","https://openalex.org/W2972293235","https://openalex.org/W2999067930","https://openalex.org/W2999256851","https://openalex.org/W2999310141","https://openalex.org/W2999630922","https://openalex.org/W3020886383","https://openalex.org/W3021646013","https://openalex.org/W3022826062","https://openalex.org/W6767098335"],"related_works":["https://openalex.org/W4375855629","https://openalex.org/W4401077870","https://openalex.org/W3016286862","https://openalex.org/W4225374253","https://openalex.org/W4284967154","https://openalex.org/W3185131317","https://openalex.org/W4225380023","https://openalex.org/W2741099630","https://openalex.org/W2999630922","https://openalex.org/W4389000620"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-10-11T00:00:00"}