{"id":"https://openalex.org/W3203850845","doi":"https://doi.org/10.1016/j.ymben.2021.09.010","title":"Cycling between growth and production phases increases cyanobacteria bioproduction of lactate","display_name":"Cycling between growth and production phases increases cyanobacteria bioproduction of lactate","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3203850845","doi":"https://doi.org/10.1016/j.ymben.2021.09.010","mag":"3203850845","pmid":"https://pubmed.ncbi.nlm.nih.gov/34601120"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymben.2021.09.010","doi":"https://doi.org/10.1016/j.ymben.2021.09.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymben.2021.09.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1096717621001506/pdf","source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1096717621001506/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042107215","display_name":"Kiyan Shabestary","orcid":"https://orcid.org/0000-0002-4207-0547","observed_orcids":["https://orcid.org/0000-0002-4207-0547"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kiyan Shabestary","raw_affiliation_strings":["School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-4207-0547","affiliations":[{"raw_affiliation_string":"School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056452214","display_name":"Hugo Pineda Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hugo Pineda Hern\u00e1ndez","raw_affiliation_strings":["Molecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, the Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068026623","display_name":"Rui Miao","orcid":"https://orcid.org/0000-0003-2911-6886","observed_orcids":["https://orcid.org/0000-0003-2911-6886"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Rui Miao","raw_affiliation_strings":["School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-2911-6886","affiliations":[{"raw_affiliation_string":"School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013377655","display_name":"Emil Ljungqvist","orcid":"https://orcid.org/0000-0003-3920-7909","observed_orcids":["https://orcid.org/0000-0003-3920-7909"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Emil Ljungqvist","raw_affiliation_strings":["School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-3920-7909","affiliations":[{"raw_affiliation_string":"School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022131786","display_name":"Olivia Hallman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olivia Hallman","raw_affiliation_strings":["School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008803755","display_name":"Emil Sporre","orcid":"https://orcid.org/0000-0003-4105-7567","observed_orcids":["https://orcid.org/0000-0003-4105-7567"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Emil Sporre","raw_affiliation_strings":["School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4105-7567","affiliations":[{"raw_affiliation_string":"School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008471314","display_name":"Filipe Branco dos Santos","orcid":"https://orcid.org/0000-0002-4268-8080","observed_orcids":["https://orcid.org/0000-0002-4268-8080"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Filipe Branco dos Santos","raw_affiliation_strings":["Molecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, the Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027625454","display_name":"Elton Paul Hudson","orcid":"https://orcid.org/0000-0003-1899-7649","observed_orcids":["https://orcid.org/0000-0003-1899-7649"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Elton P. Hudson","raw_affiliation_strings":["School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden. Electronic address: paul.hudson@scilifelab.se","School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-1899-7649","affiliations":[{"raw_affiliation_string":"School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden. Electronic address: paul.hudson@scilifelab.se","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"]},{"raw_affiliation_string":"School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027625454"],"corresponding_institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"],"apc_list":{"value":4420,"currency":"USD","value_usd":4420},"apc_paid":{"value":4420,"currency":"USD","value_usd":4420},"fwci":1.9621,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.8854615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"68","issue":null,"first_page":"131","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyanobacteria","display_name":"cyanobacteria","score":0.7059999704360962},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.828000009059906},{"id":"https://openalex.org/keywords/synechocystis-sp-pcc-6803","display_name":"Synechocystis sp. PCC 6803","score":0.9919999837875366},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.6520000100135803},{"id":"https://openalex.org/keywords/crispr-interference","display_name":"CRISPR interference","score":0.8050000071525574},{"id":"https://openalex.org/keywords/carbon-allocation","display_name":"carbon allocation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cell-factories","display_name":"cell factories","score":0.5730000138282776},{"id":"https://openalex.org/keywords/co2-uptake","display_name":"CO2 uptake","score":0.7179999947547913},{"id":"https://openalex.org/keywords/atp-homeostasis","display_name":"ATP homeostasis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/adenylate-energy-charge","display_name":"energy charge","score":0.9049999713897705},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.628000020980835},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779227428","wikidata":"https://www.wikidata.org/wiki/Q4915219","display_name":"Bioproduction","level":2,"score":0.8064222931861877},{"id":"https://openalex.org/C2779669040","wikidata":"https://www.wikidata.org/wiki/Q93315","display_name":"Cyanobacteria","level":3,"score":0.5195403695106506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48094409704208374},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4443577826023102},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.43043723702430725},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.4202868342399597},{"id":"https://openalex.org/C3075310","wikidata":"https://www.wikidata.org/wiki/Q356718","display_name":"Energy charge","level":4,"score":0.41461828351020813},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3765331208705902},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37011998891830444},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3621387481689453},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16297656297683716},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.15593448281288147},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09921690821647644},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046939","descriptor_name":"Synechocystis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ymben.2021.09.010","doi":"https://doi.org/10.1016/j.ymben.2021.09.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymben.2021.09.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1096717621001506/pdf","source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},{"id":"pmid:34601120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34601120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic engineering","raw_type":"Journal Article"},{"id":"pmh:oai:dare.uva.nl:openaire/3721a30f-dd0b-47b3-858f-18bfcecec1b8","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11245.1/3721a30f-dd0b-47b3-858f-18bfcecec1b8","pdf_url":"https://pure.uva.nl/ws/files/195944499/Cycling_between_growth_and_production_phases_increases_cyanobacteria_bioproduction_of_lactate.pdf","source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Shabestary, K, Hern\u00e1ndez, H P, Miao, R, Ljungqvist, E, Hallman, O, Sporre, E, Branco Dos Santos, F & Hudson, E P 2021, 'Cycling between growth and production phases increases cyanobacteria bioproduction of lactate', Metabolic Engineering, vol. 68, pp. 131-141. https://doi.org/10.1016/j.ymben.2021.09.010","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ymben.2021.09.010","doi":"https://doi.org/10.1016/j.ymben.2021.09.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymben.2021.09.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1096717621001506/pdf","source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2688465049","display_name":null,"funder_award_id":"NNF20OC0064371","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G2867647430","display_name":null,"funder_award_id":"NNF20OC0061469","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G3858166691","display_name":"Engineered microbial factories for CO2 exploitation in an integrated waste treatment platform","funder_award_id":"760994","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4764852707","display_name":"High-throughput techniques for understanding and industrializing fast-growing cyanobacteria","funder_award_id":"2020-04329","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G5315350563","display_name":null,"funder_award_id":"NNF20OC0064371","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G7919593309","display_name":null,"funder_award_id":"760994","funder_id":"https://openalex.org/F4320314745","funder_display_name":"FP7 Coherent Development of Research Policies"}],"funders":[{"id":"https://openalex.org/F4320314745","display_name":"FP7 Coherent Development of Research Policies","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320322509","display_name":"Kungliga Tekniska H\u00f6gskolan","ror":"https://ror.org/026vcq606"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203850845.pdf","grobid_xml":"https://content.openalex.org/works/W3203850845.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1547106545","https://openalex.org/W1600883459","https://openalex.org/W1602046403","https://openalex.org/W1645305843","https://openalex.org/W1697966926","https://openalex.org/W1842464645","https://openalex.org/W1882036684","https://openalex.org/W1975356393","https://openalex.org/W1985708845","https://openalex.org/W1990397473","https://openalex.org/W1997433866","https://openalex.org/W2004791437","https://openalex.org/W2007597512","https://openalex.org/W2029836252","https://openalex.org/W2037135781","https://openalex.org/W2038922280","https://openalex.org/W2042315785","https://openalex.org/W2044977893","https://openalex.org/W2063670296","https://openalex.org/W2069820597","https://openalex.org/W2083878238","https://openalex.org/W2084964030","https://openalex.org/W2092219928","https://openalex.org/W2099255248","https://openalex.org/W2099925845","https://openalex.org/W2100814292","https://openalex.org/W2104722000","https://openalex.org/W2105248706","https://openalex.org/W2120761492","https://openalex.org/W2124524857","https://openalex.org/W2126540100","https://openalex.org/W2128287971","https://openalex.org/W2129386299","https://openalex.org/W2132124871","https://openalex.org/W2132405182","https://openalex.org/W2142111857","https://openalex.org/W2151245158","https://openalex.org/W2154715489","https://openalex.org/W2160273488","https://openalex.org/W2165905197","https://openalex.org/W2179438025","https://openalex.org/W2219786048","https://openalex.org/W2271308908","https://openalex.org/W2290932271","https://openalex.org/W2497615362","https://openalex.org/W2501269559","https://openalex.org/W2506766491","https://openalex.org/W2515050083","https://openalex.org/W2519404893","https://openalex.org/W2520289221","https://openalex.org/W2560641503","https://openalex.org/W2624919703","https://openalex.org/W2779403649","https://openalex.org/W2793252115","https://openalex.org/W2800698210","https://openalex.org/W2801974322","https://openalex.org/W2805865245","https://openalex.org/W2806256286","https://openalex.org/W2887444591","https://openalex.org/W2895831032","https://openalex.org/W2896654920","https://openalex.org/W2896764488","https://openalex.org/W2900820161","https://openalex.org/W2903074009","https://openalex.org/W2927966156","https://openalex.org/W2938666256","https://openalex.org/W2943791609","https://openalex.org/W2947763854","https://openalex.org/W2949111380","https://openalex.org/W2969967965","https://openalex.org/W3010630503","https://openalex.org/W3012191401","https://openalex.org/W3014677160","https://openalex.org/W3019323759","https://openalex.org/W3054056979","https://openalex.org/W3114104379","https://openalex.org/W3155264313","https://openalex.org/W3172807108"],"related_works":["https://openalex.org/W7130494877","https://openalex.org/W2806256286","https://openalex.org/W3111018219","https://openalex.org/W2560641503","https://openalex.org/W2805865245","https://openalex.org/W4224927253","https://openalex.org/W3014677160","https://openalex.org/W2172612097","https://openalex.org/W2079206636","https://openalex.org/W2982566998"],"abstract_inverted_index":{"Decoupling":[0],"growth":[1,46,74,83,98,139,207],"from":[2],"product":[3],"synthesis":[4],"is":[5],"a":[6,132,166,181],"promising":[7],"strategy":[8,135],"to":[9,44,55,70,111,117,150,180,198,221],"increase":[10],"carbon":[11,128],"partitioning":[12,54],"and":[13,26,87,123,141,185,215],"maximize":[14],"productivity":[15],"in":[16,21,29,47,57,92,160,165,216,227],"cell":[17],"factories.":[18],"However,":[19],"reduction":[20],"both":[22],"substrate":[23,113],"uptake":[24,65,71],"rate":[25],"metabolic":[27,121],"activity":[28,122],"the":[30,58,73,80,119,190,202],"production":[31,59,134],"phase":[32,60],"are":[33],"an":[34,103,147],"underlying":[35],"problem":[36],"for":[37,162,194,201,212],"upscaling.":[38],"Here,":[39],"we":[40,130,156],"used":[41],"CRISPR":[42],"interference":[43],"repress":[45],"lactate-producing":[48],"Synechocystis":[49,161],"sp.":[50],"PCC":[51],"6803.":[52],"Carbon":[53],"lactate":[56,158,172,193],"exceeded":[61],"90%,":[62],"but":[63],"CO2":[64],"was":[66,99],"severely":[67],"reduced":[68,112,120],"compared":[69,179,197],"during":[72,79],"phase.":[75],"We":[76],"characterized":[77],"strains":[78],"onset":[81],"of":[82,105,126,146],"arrest":[84,140,204,208],"using":[85],"transcriptomics":[86],"proteomics.":[88],"Multiple":[89],"genes":[90],"involved":[91,137],"ATP":[93],"homeostasis":[94],"were":[95,174],"regulated":[96],"once":[97],"inhibited,":[100],"which":[101],"suggests":[102],"alteration":[104],"energy":[106],"charge":[107],"that":[108,136,225],"may":[109],"lead":[110],"uptake.":[114],"In":[115],"order":[116],"overcome":[118],"take":[124],"advantage":[125],"increased":[127,176],"partitioning,":[129],"tested":[131],"novel":[133],"alternating":[138],"recovery":[142],"by":[143,177],"periodic":[144],"addition":[145],"inducer":[148],"molecule":[149],"activate":[151],"CRISPRi.":[152],"Using":[153],"this":[154],"strategy,":[155],"maintained":[157],"biosynthesis":[159],"30":[163,195],"days":[164,200],"constant":[167,182,228],"light":[168],"turbidostat":[169],"cultivation.":[170,205],"Cumulative":[171],"titers":[173],"also":[175],"100%":[178],"growth-arrest":[183],"regime,":[184],"reached":[186],"1":[187],"g/L.":[188],"Further,":[189],"cultivation":[191],"produced":[192],"days,":[196],"20":[199],"non-growth":[203],"Periodic":[206],"could":[209,218],"be":[210,219],"applicable":[211],"other":[213],"products,":[214],"cyanobacteria,":[217],"linked":[220],"internal":[222],"circadian":[223],"rhythms":[224],"persist":[226],"light.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-11T00:00:00"}