{"id":"https://openalex.org/W3203844580","doi":"https://doi.org/10.3390/biom11101419","title":"Structural and Functional Insights into \u03b1-Synuclein Fibril Polymorphism","display_name":"Structural and Functional Insights into \u03b1-Synuclein Fibril Polymorphism","publication_year":2021,"publication_date":"2021-09-28","ids":{"openalex":"https://openalex.org/W3203844580","doi":"https://doi.org/10.3390/biom11101419","mag":"3203844580","pmid":"https://pubmed.ncbi.nlm.nih.gov/34680054","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8533119"},"language":"en","primary_location":{"id":"doi:10.3390/biom11101419","doi":"https://doi.org/10.3390/biom11101419","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom11101419","pdf_url":"https://www.mdpi.com/2218-273X/11/10/1419/pdf?version=1632831934","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-273X/11/10/1419/pdf?version=1632831934","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086114257","display_name":"Surabhi Mehra","orcid":"https://orcid.org/0000-0003-1777-673X","observed_orcids":["https://orcid.org/0000-0003-1777-673X"]},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Surabhi Mehra","raw_affiliation_strings":["Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India"],"raw_orcid":"https://orcid.org/0000-0003-1777-673X","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India","institution_ids":["https://openalex.org/I162827531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000183173","display_name":"Laxmikant G. Gadhe","orcid":"https://orcid.org/0000-0002-3157-2998","observed_orcids":["https://orcid.org/0000-0002-3157-2998"]},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Laxmikant Gadhe","raw_affiliation_strings":["Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India"],"raw_orcid":"https://orcid.org/0000-0002-3157-2998","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India","institution_ids":["https://openalex.org/I162827531"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Riya Bera","orcid":"https://orcid.org/0000-0002-1651-1097","observed_orcids":["https://orcid.org/0000-0002-1651-1097"]},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Riya Bera","raw_affiliation_strings":["Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India"],"raw_orcid":"https://orcid.org/0000-0002-1651-1097","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India","institution_ids":["https://openalex.org/I162827531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026957631","display_name":"Ajay Singh Sawner","orcid":"https://orcid.org/0000-0001-8270-1094","observed_orcids":["https://orcid.org/0000-0001-8270-1094"]},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ajay Singh Sawner","raw_affiliation_strings":["Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India","institution_ids":["https://openalex.org/I162827531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057817913","display_name":"Samir Kumar Maji","orcid":"https://orcid.org/0000-0002-9110-1565","observed_orcids":["https://orcid.org/0000-0002-9110-1565"]},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Samir K. Maji","raw_affiliation_strings":["Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India"],"raw_orcid":"https://orcid.org/0000-0002-9110-1565","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India","institution_ids":["https://openalex.org/I162827531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057817913","https://openalex.org/A5086114257"],"corresponding_institution_ids":["https://openalex.org/I162827531"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":2.002,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.9113365,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"11","issue":"10","first_page":"1419","last_page":"1419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9419999718666077},{"id":"https://openalex.org/keywords/fibril-polymorphism","display_name":"fibril polymorphism","score":0.9629999995231628},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.9660000205039978},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8759999871253967},{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":0.9779999852180481},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.6830000281333923},{"id":"https://openalex.org/keywords/clinical-heterogeneity","display_name":"clinical heterogeneity","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.9741109013557434},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.8729007840156555},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.816340446472168},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6087809801101685},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.5663902759552002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5179476141929626},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.49794816970825195},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.486987441778183},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4826684296131134},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46902787685394287},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.46107152104377747},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4458848237991333},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.43900761008262634},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.43595242500305176},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3669441342353821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23051726818084717},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2257426679134369},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09101444482803345}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017096","descriptor_name":"Prion Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017096","descriptor_name":"Prion Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019578","descriptor_name":"Multiple System Atrophy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019578","descriptor_name":"Multiple System Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D066329","descriptor_name":"Protein Aggregates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/biom11101419","doi":"https://doi.org/10.3390/biom11101419","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom11101419","pdf_url":"https://www.mdpi.com/2218-273X/11/10/1419/pdf?version=1632831934","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8533119","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8533119","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmid:34680054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34680054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:447d3d2097784b9482bf2f277c306c21","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/447d3d2097784b9482bf2f277c306c21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 11, Iss 10, p 1419 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom11101419","doi":"https://doi.org/10.3390/biom11101419","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom11101419","pdf_url":"https://www.mdpi.com/2218-273X/11/10/1419/pdf?version=1632831934","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203844580.pdf","grobid_xml":"https://content.openalex.org/works/W3203844580.grobid-xml"},"referenced_works_count":336,"referenced_works":["https://openalex.org/W36139474","https://openalex.org/W48484370","https://openalex.org/W1479935944","https://openalex.org/W1485683953","https://openalex.org/W1489708565","https://openalex.org/W1500851319","https://openalex.org/W1504584187","https://openalex.org/W1512139613","https://openalex.org/W1516672767","https://openalex.org/W1519095619","https://openalex.org/W1521032053","https://openalex.org/W1527671059","https://openalex.org/W1531667149","https://openalex.org/W1560372750","https://openalex.org/W1561445208","https://openalex.org/W1565049419","https://openalex.org/W1572679174","https://openalex.org/W1587476559","https://openalex.org/W1588296570","https://openalex.org/W1814284566","https://openalex.org/W1815242288","https://openalex.org/W1853679464","https://openalex.org/W1947901277","https://openalex.org/W1952608303","https://openalex.org/W1965095016","https://openalex.org/W1965132458","https://openalex.org/W1965229261","https://openalex.org/W1965778124","https://openalex.org/W1966130903","https://openalex.org/W1969541118","https://openalex.org/W1970577444","https://openalex.org/W1972646996","https://openalex.org/W1973166472","https://openalex.org/W1973652068","https://openalex.org/W1974433124","https://openalex.org/W1976749972","https://openalex.org/W1977044612","https://openalex.org/W1977682751","https://openalex.org/W1978959047","https://openalex.org/W1980110509","https://openalex.org/W1980610450","https://openalex.org/W1981738652","https://openalex.org/W1984122954","https://openalex.org/W1984766678","https://openalex.org/W1985716072","https://openalex.org/W1986625112","https://openalex.org/W1987356462","https://openalex.org/W1987686455","https://openalex.org/W1988094412","https://openalex.org/W1989150559","https://openalex.org/W1989780699","https://openalex.org/W1990473626","https://openalex.org/W1991347541","https://openalex.org/W1993608820","https://openalex.org/W1994345812","https://openalex.org/W1995191747","https://openalex.org/W1995248194","https://openalex.org/W1995281235","https://openalex.org/W1995496955","https://openalex.org/W1997167527","https://openalex.org/W1997417422","https://openalex.org/W1999883522","https://openalex.org/W2001407922","https://openalex.org/W2003511766","https://openalex.org/W2004098528","https://openalex.org/W2004185979","https://openalex.org/W2009556855","https://openalex.org/W2010648364","https://openalex.org/W2011881593","https://openalex.org/W2013313629","https://openalex.org/W2013679718","https://openalex.org/W2014485936","https://openalex.org/W2016464395","https://openalex.org/W2016473759","https://openalex.org/W2016875890","https://openalex.org/W2018429667","https://openalex.org/W2018633688","https://openalex.org/W2018655482","https://openalex.org/W2019145949","https://openalex.org/W2021267750","https://openalex.org/W2021977313","https://openalex.org/W2022170924","https://openalex.org/W2022614447","https://openalex.org/W2022794788","https://openalex.org/W2023245921","https://openalex.org/W2023529808","https://openalex.org/W2023661276","https://openalex.org/W2025153638","https://openalex.org/W2026667182","https://openalex.org/W2028491819","https://openalex.org/W2028652101","https://openalex.org/W2030325989","https://openalex.org/W2030802264","https://openalex.org/W2031273125","https://openalex.org/W2031982078","https://openalex.org/W2032392617","https://openalex.org/W2032487213","https://openalex.org/W2033827101","https://openalex.org/W2034147064","https://openalex.org/W2036423396","https://openalex.org/W2037948191","https://openalex.org/W2040504472","https://openalex.org/W2040706104","https://openalex.org/W2040753345","https://openalex.org/W2041023371","https://openalex.org/W2044407202","https://openalex.org/W2044663741","https://openalex.org/W2045147326","https://openalex.org/W2045777307","https://openalex.org/W2046014998","https://openalex.org/W2048058691","https://openalex.org/W2050005958","https://openalex.org/W2050375429","https://openalex.org/W2050647292","https://openalex.org/W2050786534","https://openalex.org/W2052011437","https://openalex.org/W2052054514","https://openalex.org/W2053577594","https://openalex.org/W2054737424","https://openalex.org/W2054868321","https://openalex.org/W2057784346","https://openalex.org/W2058674503","https://openalex.org/W2059261643","https://openalex.org/W2059382925","https://openalex.org/W2059804089","https://openalex.org/W2060038717","https://openalex.org/W2063679630","https://openalex.org/W2064132534","https://openalex.org/W2064284597","https://openalex.org/W2064681168","https://openalex.org/W2064722614","https://openalex.org/W2064963539","https://openalex.org/W2065878937","https://openalex.org/W2066809905","https://openalex.org/W2066998511","https://openalex.org/W2067682626","https://openalex.org/W2068495410","https://openalex.org/W2069491212","https://openalex.org/W2071087722","https://openalex.org/W2071847921","https://openalex.org/W2072427499","https://openalex.org/W2072509284","https://openalex.org/W2072675976","https://openalex.org/W2073222492","https://openalex.org/W2073449985","https://openalex.org/W2074649216","https://openalex.org/W2075927534","https://openalex.org/W2076204506","https://openalex.org/W2076453977","https://openalex.org/W2080751623","https://openalex.org/W2081966615","https://openalex.org/W2082766785","https://openalex.org/W2082843999","https://openalex.org/W2085899859","https://openalex.org/W2086120642","https://openalex.org/W2087357689","https://openalex.org/W2088694143","https://openalex.org/W2089215677","https://openalex.org/W2090285539","https://openalex.org/W2091265794","https://openalex.org/W2091586455","https://openalex.org/W2094881767","https://openalex.org/W2101614182","https://openalex.org/W2102572922","https://openalex.org/W2104534466","https://openalex.org/W2111216320","https://openalex.org/W2116766274","https://openalex.org/W2117141964","https://openalex.org/W2117380355","https://openalex.org/W2117537971","https://openalex.org/W2121977115","https://openalex.org/W2122564376","https://openalex.org/W2123103049","https://openalex.org/W2123431154","https://openalex.org/W2123714584","https://openalex.org/W2127099411","https://openalex.org/W2130323165","https://openalex.org/W2131222480","https://openalex.org/W2131522485","https://openalex.org/W2131710583","https://openalex.org/W2132767365","https://openalex.org/W2132787281","https://openalex.org/W2133068803","https://openalex.org/W2134272142","https://openalex.org/W2134462664","https://openalex.org/W2134575001","https://openalex.org/W2134703773","https://openalex.org/W2136012285","https://openalex.org/W2136659930","https://openalex.org/W2138468217","https://openalex.org/W2139066576","https://openalex.org/W2139506875","https://openalex.org/W2142483035","https://openalex.org/W2143906078","https://openalex.org/W2145954079","https://openalex.org/W2146656482","https://openalex.org/W2150656456","https://openalex.org/W2150860983","https://openalex.org/W2154737306","https://openalex.org/W2154763071","https://openalex.org/W2155477793","https://openalex.org/W2155654820","https://openalex.org/W2156606243","https://openalex.org/W2157096553","https://openalex.org/W2157102136","https://openalex.org/W2158089391","https://openalex.org/W2158490078","https://openalex.org/W2158977717","https://openalex.org/W2159340140","https://openalex.org/W2161334375","https://openalex.org/W2161584970","https://openalex.org/W2163210644","https://openalex.org/W2163245612","https://openalex.org/W2166789153","https://openalex.org/W2167775119","https://openalex.org/W2172055093","https://openalex.org/W2202268813","https://openalex.org/W2207016061","https://openalex.org/W2225712950","https://openalex.org/W2293372195","https://openalex.org/W2317462515","https://openalex.org/W2317980294","https://openalex.org/W2320681495","https://openalex.org/W2324660492","https://openalex.org/W2337252009","https://openalex.org/W2338815822","https://openalex.org/W2403526287","https://openalex.org/W2420794398","https://openalex.org/W2486618134","https://openalex.org/W2491672559","https://openalex.org/W2507685477","https://openalex.org/W2510545519","https://openalex.org/W2512757939","https://openalex.org/W2531051110","https://openalex.org/W2531850510","https://openalex.org/W2548909731","https://openalex.org/W2555807150","https://openalex.org/W2559809511","https://openalex.org/W2560746397","https://openalex.org/W2563994952","https://openalex.org/W2584311212","https://openalex.org/W2588841770","https://openalex.org/W2589302738","https://openalex.org/W2590568317","https://openalex.org/W2591620984","https://openalex.org/W2614974832","https://openalex.org/W2620272913","https://openalex.org/W2623521763","https://openalex.org/W2727929522","https://openalex.org/W2731085381","https://openalex.org/W2732036329","https://openalex.org/W2735511773","https://openalex.org/W2738605841","https://openalex.org/W2740690576","https://openalex.org/W2753398780","https://openalex.org/W2753860285","https://openalex.org/W2756821926","https://openalex.org/W2768578200","https://openalex.org/W2785526679","https://openalex.org/W2787932029","https://openalex.org/W2788764523","https://openalex.org/W2788827529","https://openalex.org/W2791232057","https://openalex.org/W2793431243","https://openalex.org/W2794654572","https://openalex.org/W2795733020","https://openalex.org/W2796455233","https://openalex.org/W2796637563","https://openalex.org/W2800043594","https://openalex.org/W2801990904","https://openalex.org/W2802062315","https://openalex.org/W2804405581","https://openalex.org/W2805466047","https://openalex.org/W2808551426","https://openalex.org/W2810672236","https://openalex.org/W2810978155","https://openalex.org/W2829376677","https://openalex.org/W2884160828","https://openalex.org/W2885863704","https://openalex.org/W2889082939","https://openalex.org/W2891796239","https://openalex.org/W2896624492","https://openalex.org/W2900691417","https://openalex.org/W2903562030","https://openalex.org/W2914111884","https://openalex.org/W2916646997","https://openalex.org/W2917090762","https://openalex.org/W2921561422","https://openalex.org/W2939921565","https://openalex.org/W2952510015","https://openalex.org/W2953014442","https://openalex.org/W2955413884","https://openalex.org/W2969383918","https://openalex.org/W2975976749","https://openalex.org/W2982620303","https://openalex.org/W2987602584","https://openalex.org/W2989595882","https://openalex.org/W2990946693","https://openalex.org/W2993466834","https://openalex.org/W2994123659","https://openalex.org/W2997280667","https://openalex.org/W3003432126","https://openalex.org/W3003740698","https://openalex.org/W3004441218","https://openalex.org/W3005252823","https://openalex.org/W3006261429","https://openalex.org/W3006477212","https://openalex.org/W3006508969","https://openalex.org/W3008786370","https://openalex.org/W3011301824","https://openalex.org/W3011477582","https://openalex.org/W3011478793","https://openalex.org/W3030540323","https://openalex.org/W3031912651","https://openalex.org/W3033847448","https://openalex.org/W3033860402","https://openalex.org/W3035823399","https://openalex.org/W3045412459","https://openalex.org/W3049273506","https://openalex.org/W3081159427","https://openalex.org/W3090901529","https://openalex.org/W3091506997","https://openalex.org/W3118586567","https://openalex.org/W3160209187","https://openalex.org/W3160415038","https://openalex.org/W3163254926","https://openalex.org/W3173766271","https://openalex.org/W3193806555","https://openalex.org/W3202815206","https://openalex.org/W4211123396","https://openalex.org/W4248888255","https://openalex.org/W4250295396","https://openalex.org/W4288070024","https://openalex.org/W4322388710","https://openalex.org/W6630743218","https://openalex.org/W6832261992"],"related_works":["https://openalex.org/W4320481482","https://openalex.org/W7038227412","https://openalex.org/W3021415691","https://openalex.org/W2994123659","https://openalex.org/W2158089391","https://openalex.org/W2738605841","https://openalex.org/W2997515518","https://openalex.org/W7203961308","https://openalex.org/W3042041012","https://openalex.org/W4386161886"],"abstract_inverted_index":{"Abnormal":[0],"accumulation":[1],"of":[2,11,34,52,117,124,145],"aggregated":[3],"\u03b1-synuclein":[4],"(\u03b1-Syn)":[5],"is":[6],"seen":[7],"in":[8,45,67,70,100,112,140,159],"a":[9],"variety":[10],"neurodegenerative":[12],"diseases,":[13],"including":[14,121],"Parkinson's":[15,27],"disease":[16,28,36],"(PD),":[17],"multiple":[18],"system":[19],"atrophy":[20],"(MSA),":[21],"dementia":[22,29],"with":[23],"Lewy":[24],"body":[25],"(DLB),":[26],"(PDD),":[30],"and":[31,48,61,69,89,109,114,128,147],"even":[32],"subsets":[33],"Alzheimer's":[35],"(AD)":[37],"showing":[38],"Lewy-body-like":[39],"pathology.":[40],"These":[41,75],"synucleinopathies":[42,113],"exhibit":[43,85],"differences":[44],"their":[46,98],"clinical":[47,108,157],"pathological":[49,95,110],"representations,":[50],"reminiscent":[51],"prion":[53],"disorders.":[54],"Emerging":[55],"evidence":[56],"suggests":[57],"that":[58],"\u03b1-Syn":[59,76,118,146,150],"self-assembles":[60],"polymerizes":[62],"into":[63],"conformationally":[64],"diverse":[65,149],"polymorphs":[66,77,152],"vitro":[68],"vivo,":[71],"similar":[72],"to":[73,92,154],"prions.":[74],"arising":[78],"from":[79],"the":[80,90,122,137,142,155],"same":[81],"precursor":[82],"protein":[83],"may":[84],"strain-specific":[86],"biochemical":[87],"properties":[88],"ability":[91],"induce":[93],"distinct":[94],"phenotypes":[96],"upon":[97],"inoculation":[99],"animal":[101],"models.":[102],"In":[103],"this":[104],"review,":[105],"we":[106],"discuss":[107],"variability":[111],"several":[115],"aspects":[116],"fibril":[119],"polymorphism,":[120],"existence":[123],"high-resolution":[125],"molecular":[126,151],"structures":[127],"brain-derived":[129],"strains.":[130],"The":[131],"current":[132],"review":[133],"sheds":[134],"light":[135],"on":[136],"recent":[138],"advances":[139],"delineating":[141],"structure-pathogenic":[143],"relationship":[144],"how":[148],"contribute":[153],"existing":[156],"heterogeneity":[158],"synucleinopathies.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-10-11T00:00:00"}