{"id":"https://openalex.org/W3203829385","doi":null,"title":"Towards a minimal model of the nuclear pore complex","display_name":"Towards a minimal model of the nuclear pore complex","publication_year":2021,"publication_date":"2021-01-28","ids":{"openalex":"https://openalex.org/W3203829385","mag":"3203829385"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10118968","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10118968/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061141787","display_name":"Luke K. Davis","orcid":"https://orcid.org/0000-0003-4487-4159","observed_orcids":["https://orcid.org/0000-0003-4487-4159"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Luke K. Davis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4487-4159","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061141787"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-pore-complex","display_name":"nuclear pore complex","score":1.0},{"id":"https://openalex.org/keywords/fg-nucleoporins","display_name":"FG-nucleoporins","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nuclear-transport-receptors","display_name":"nuclear transport receptors","score":0.8270000219345093},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"nuclear transport","score":0.8870000243186951},{"id":"https://openalex.org/keywords/phase-separation","display_name":"phase separation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sequence-heterogeneity","display_name":"sequence heterogeneity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/surface-heterogeneity","display_name":"surface heterogeneity","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C126725582","wikidata":"https://www.wikidata.org/wiki/Q30679","display_name":"Nuclear pore","level":3,"score":0.8930392265319824},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.7628042697906494},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.7562330961227417},{"id":"https://openalex.org/C68556195","wikidata":"https://www.wikidata.org/wiki/Q3571630","display_name":"Nucleoporin","level":5,"score":0.7146257162094116},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5727318525314331},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5196258425712585},{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.49764683842658997},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4835490882396698},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.4410806894302368},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3625774681568146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35643070936203003},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3070458471775055},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.15952059626579285},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12302029132843018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10708314180374146},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.07898524403572083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07136529684066772}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10118968","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10118968/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:3203829385","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10118968/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391657351","https://openalex.org/W340448289","https://openalex.org/W4391657876","https://openalex.org/W3004676160","https://openalex.org/W3131743970","https://openalex.org/W3199471798","https://openalex.org/W2884714681","https://openalex.org/W6889524977","https://openalex.org/W2612765580","https://openalex.org/W2148292198"],"abstract_inverted_index":{"The":[0,21,219],"transport":[1,42,66,103,213],"of":[2,36,43,49,93,111,201,208,240,243,253,258,299],"macromolecules":[3],"between":[4],"the":[5,18,37,41,47,58,74,78,86,109,125,147,187,198,202,238,251,259,300],"nucleus":[6,38],"and":[7,34,97,114,128,135,142,152,235,255,262,272],"cytoplasm":[8],"is":[9,116,160,176,222],"controlled":[10],"by":[11],"nuclear":[12,19,65],"pore":[13,60],"complexes":[14],"(NPC)":[15],"that":[16,56,123,136,163,282],"permeate":[17],"envelope.":[20],"NPC":[22,87],"allows":[23],"small":[24],"(\u223c":[25],"5":[26],"nm":[27],"diameter)":[28],"molecules":[29],"to":[30,73,84,101,168,178,225],"passively":[31],"diffuse":[32],"in":[33,77,130,139,191,229,267,274],"out":[35],"but":[39],"hinders":[40],"larger":[44],"material":[45],"through":[46],"presence":[48],"sticky":[50],"intrinsically":[51],"disordered":[52],"proteins":[53],"(FG":[54],"Nups)":[55],"occlude":[57],"inner":[59],"channel.":[61],"Through":[62],"complexation":[63],"with":[64,155],"receptors":[67],"(NTRs),":[68],"which":[69],"have":[70],"an":[71,230,268],"affinity":[72],"FG":[75,95,112,126,148,203,231,260,269],"motifs":[76],"Nups,":[79],"large":[80],"cargoes":[81],"are":[82,137,277],"able":[83],"overcome":[85],"permeability":[88],"barrier.":[89],"Our":[90],"physical":[91,120],"understanding":[92],"how":[94],"Nups":[96,113,127,149,204,261],"NTRs":[98,115,129,228,245,263],"give":[99],"rise":[100],"selective":[102],"remains":[104],"incomplete.":[105],"In":[106,194],"this":[107,174,195,291],"thesis,":[108],"behaviour":[110],"probed":[117],"using":[118,279],"coarse-grained":[119],"modelling":[121,280],"approaches":[122,281],"treat":[124],"a":[131,275,296],"rather":[132],"minimal":[133,288,297],"fashion,":[134],"implemented":[138],"computer":[140],"simulations":[141,154,236],"analytical":[143],"models.":[144],"By":[145],"treating":[146],"as":[150,189],"homopolymers":[151],"comparing":[153],"various":[156,227],"experimental":[157],"data":[158],"it":[159,183],"here":[161],"found":[162],"they":[164],"behave":[165],"very":[166],"similarly":[167],"idealized":[169],"polymer":[170,233],"chains.":[171],"Secondly,":[172],"when":[173],"model":[175,221,298],"extended":[177],"recently":[179],"developed":[180],"biomimetic":[181],"nanopores":[182],"can":[184],"account":[185,283],"for":[186,284],"morphology":[188],"seen":[190],"those":[192],"experiments.":[193],"nanopore":[196,276],"system,":[197],"resealing":[199],"dynamics":[200],"were":[205],"three":[206],"orders":[207],"magnitude":[209],"faster":[210],"than":[211],"typical":[212],"event":[214],"times":[215],"(~":[216],"1":[217],"ms).":[218],"homopolymer":[220],"further":[223],"expanded":[224],"include":[226],"Nup":[232,270],"film,":[234],"reveal":[237],"emergence":[239],"phase":[241],"separation":[242],"different":[244],"at":[246,287],"physiologically":[247],"relevant":[248],"densities.":[249],"Finally,":[250],"roles":[252],"sequence":[254],"surface":[256],"heterogeneity":[257,286],"on":[264],"binding,":[265],"diffusion":[266],"melt,":[271],"uptake":[273],"explored":[278],"such":[285],"complexity.":[289],"Overall,":[290],"thesis":[292],"makes":[293],"progress":[294],"towards":[295],"NPC.":[301]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2021-10-11T00:00:00"}
