{"id":"https://openalex.org/W3203753697","doi":"https://doi.org/10.1042/cs20210462","title":"Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury","display_name":"Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3203753697","doi":"https://doi.org/10.1042/cs20210462","mag":"3203753697","pmid":"https://pubmed.ncbi.nlm.nih.gov/34622918"},"language":"en","primary_location":{"id":"doi:10.1042/cs20210462","doi":"https://doi.org/10.1042/cs20210462","is_oa":true,"landing_page_url":"https://doi.org/10.1042/cs20210462","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1042/cs20210462","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069194310","display_name":"Thiele Osvaldt Rosales","orcid":"https://orcid.org/0000-0002-5409-1716","observed_orcids":["https://orcid.org/0000-0002-5409-1716"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thiele\u00a0Osvaldt Rosales","raw_affiliation_strings":["Department of Pharmacology, Universidade Federal de Santa Catarina, SC, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Universidade Federal de Santa Catarina, SC, Brazil","institution_ids":["https://openalex.org/I4104125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029001046","display_name":"Ver\u00f4nica Vargas Horewicz","orcid":"https://orcid.org/0000-0003-0702-8375","observed_orcids":["https://orcid.org/0000-0003-0702-8375"]},"institutions":[{"id":"https://openalex.org/I4210088382","display_name":"Universidade do Sul de Santa Catarina","ror":"https://ror.org/006qssd78","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210088382"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ver\u00f4nica\u00a0Vargas Horewicz","raw_affiliation_strings":["Department of Health Sciences, Universidade do Sul de Santa Catarina, SC, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Universidade do Sul de Santa Catarina, SC, Brazil","institution_ids":["https://openalex.org/I4210088382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066549661","display_name":"Marcella de Amorim Ferreira","orcid":"https://orcid.org/0000-0003-3804-9662","observed_orcids":["https://orcid.org/0000-0003-3804-9662"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcella\u00a0Amorim Ferreira","raw_affiliation_strings":["Department of Pharmacology, Universidade Federal de Santa Catarina, SC, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Universidade Federal de Santa Catarina, SC, Brazil","institution_ids":["https://openalex.org/I4104125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004658394","display_name":"Geisson Marcos Nardi","orcid":"https://orcid.org/0000-0003-0484-8490","observed_orcids":["https://orcid.org/0000-0003-0484-8490"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Geisson\u00a0Marcos Nardi","raw_affiliation_strings":["Department of Morphological Sciences, Universidade Federal de Santa Catarina, SC, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphological Sciences, Universidade Federal de Santa Catarina, SC, Brazil","institution_ids":["https://openalex.org/I4104125"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005886154","display_name":"Jamil Assreuy","orcid":"https://orcid.org/0000-0001-8582-1569","observed_orcids":["https://orcid.org/0000-0001-8582-1569"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Jamil Assreuy","raw_affiliation_strings":["Department of Pharmacology, Universidade Federal de Santa Catarina, SC, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8582-1569","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Universidade Federal de Santa Catarina, SC, Brazil","institution_ids":["https://openalex.org/I4104125"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005886154"],"corresponding_institution_ids":["https://openalex.org/I4104125"],"apc_list":null,"apc_paid":null,"fwci":1.1785,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.76450836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"135","issue":"20","first_page":"2341","last_page":"2356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.39500001072883606,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.39500001072883606,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.32739999890327454,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.13289999961853027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-kinase-2","display_name":"G protein-coupled receptor kinase 2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/sepsis-associated-acute-kidney-injury","display_name":"sepsis-associated acute kidney injury","score":0.8569999933242798},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.7900000214576721},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9380000233650208},{"id":"https://openalex.org/keywords/renal-vasoconstriction","display_name":"renal vasoconstriction","score":0.8050000071525574},{"id":"https://openalex.org/keywords/renal-vascular-reactivity","display_name":"renal vascular reactivity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/prazosin","display_name":"prazosin","score":0.753000020980835},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-2","display_name":"nitric oxide synthase 2","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.8949999809265137},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.8999999761581421},{"id":"https://openalex.org/keywords/phenylephrine-induced-vasoconstriction","display_name":"phenylephrine vasoconstriction","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8109704852104187},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6401269435882568},{"id":"https://openalex.org/C78976303","wikidata":"https://www.wikidata.org/wiki/Q14907967","display_name":"Beta adrenergic receptor kinase","level":4,"score":0.6154007315635681},{"id":"https://openalex.org/C2780648677","wikidata":"https://www.wikidata.org/wiki/Q425296","display_name":"Prazosin","level":4,"score":0.6066368222236633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5901163816452026},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5503243803977966},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.5345385074615479},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.46253517270088196},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4229316711425781},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.41611015796661377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38361650705337524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3750855326652527},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3511356711387634},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33681318163871765},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.1322607398033142},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.09023812413215637}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018340","descriptor_name":"Receptors, Adrenergic, alpha-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054769","descriptor_name":"G-Protein-Coupled Receptor Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/cs20210462","doi":"https://doi.org/10.1042/cs20210462","is_oa":true,"landing_page_url":"https://doi.org/10.1042/cs20210462","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmid:34622918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34622918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science (London, England : 1979)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/cs20210462","doi":"https://doi.org/10.1042/cs20210462","is_oa":true,"landing_page_url":"https://doi.org/10.1042/cs20210462","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1536093676","https://openalex.org/W1644644121","https://openalex.org/W1846247956","https://openalex.org/W1940965673","https://openalex.org/W1964171066","https://openalex.org/W1968234843","https://openalex.org/W1969795252","https://openalex.org/W1970885673","https://openalex.org/W1977190827","https://openalex.org/W1987036848","https://openalex.org/W1996777399","https://openalex.org/W2007199396","https://openalex.org/W2009945632","https://openalex.org/W2015213851","https://openalex.org/W2018302467","https://openalex.org/W2023945291","https://openalex.org/W2024357735","https://openalex.org/W2033892651","https://openalex.org/W2035475900","https://openalex.org/W2043238124","https://openalex.org/W2046193597","https://openalex.org/W2049927822","https://openalex.org/W2051061580","https://openalex.org/W2052833946","https://openalex.org/W2063053685","https://openalex.org/W2085351880","https://openalex.org/W2093292798","https://openalex.org/W2107277218","https://openalex.org/W2110075486","https://openalex.org/W2118008806","https://openalex.org/W2127159528","https://openalex.org/W2138625702","https://openalex.org/W2142378238","https://openalex.org/W2149592972","https://openalex.org/W2163814324","https://openalex.org/W2171058482","https://openalex.org/W2171144560","https://openalex.org/W2173021033","https://openalex.org/W2230256109","https://openalex.org/W2278600110","https://openalex.org/W2280404143","https://openalex.org/W2299924659","https://openalex.org/W2308161836","https://openalex.org/W2396212074","https://openalex.org/W2410519949","https://openalex.org/W2410979878","https://openalex.org/W2520610051","https://openalex.org/W2523997822","https://openalex.org/W2615566422","https://openalex.org/W2734817732","https://openalex.org/W2769149806","https://openalex.org/W2788251575","https://openalex.org/W2808694326","https://openalex.org/W2910674778","https://openalex.org/W2916627882","https://openalex.org/W2950811882","https://openalex.org/W3120431381","https://openalex.org/W3216465316","https://openalex.org/W4245690870","https://openalex.org/W6714862286"],"related_works":["https://openalex.org/W4377020514","https://openalex.org/W7125156258","https://openalex.org/W2118008806","https://openalex.org/W2070525609","https://openalex.org/W2615566422","https://openalex.org/W2105313166","https://openalex.org/W2200075960","https://openalex.org/W3082194436","https://openalex.org/W2299924659","https://openalex.org/W1970885673"],"abstract_inverted_index":{"Renal":[0],"vascular":[1,106],"reactivity":[2,107],"to":[3,11,26,108,126,190,222,241,245],"vasoconstrictors":[4],"is":[5],"preserved":[6],"in":[7,9,14,48,130,137,142,152,172,183,186,210,219],"sepsis":[8,220],"opposition":[10],"what":[12],"happens":[13],"the":[15,38,98,105,143,173,187,191,203,211,225,233,239],"systemic":[16,99],"circulation.":[17],"We":[18],"studied":[19],"whether":[20],"this":[21,208],"distinct":[22],"behavior":[23],"was":[24,46,118,150],"related":[25],"\u03b11":[27,138,196],"adrenergic":[28,139,197],"receptor":[29,33,140,198,209],"density,":[30],"G":[31],"protein-coupled":[32],"kinase":[34],"2":[35,71],"(GRK2)":[36],"and":[37,54,77,79,87,104],"putative":[39],"role":[40],"of":[41,147,162,193,202,207,228,238],"nitric":[42,68],"oxide":[43,69],"(NO).":[44],"Sepsis":[45,96,110,124],"induced":[47],"female":[49],"mice":[50,58,154,156,164],"by":[51,120],"cecal":[52],"ligation":[53],"puncture":[55],"(CLP).":[56],"Wildtype":[57],"were":[59,90],"treated":[60,157],"with":[61,122,134,158,165,214,232],"prazosin":[62],"12":[63,80],"h":[64,81,93],"after":[65,82,94],"CLP":[66],"or":[67,155],"synthase":[70],"(NOS-2)":[72],"inhibitor,":[73],"30":[74],"min":[75],"before":[76],"6":[78],"CLP.":[83,95],"In":[84],"vivo":[85],"experiments":[86],"biochemistry":[88],"assays":[89],"performed":[91],"24":[92],"decreased":[97],"mean":[100],"arterial":[101],"pressure":[102],"(MAP)":[103],"phenylephrine.":[109],"also":[111],"reduced":[112,169],"basal":[113],"renal":[114,148],"blood":[115],"flow":[116],"which":[117],"normalized":[119],"treatment":[121],"prazosin.":[123],"led":[125],"a":[127,194,215],"substantial":[128],"decrease":[129],"GRK2":[131,149,170,184],"level":[132,185],"associated":[133],"an":[135,166,180],"increase":[136],"density":[141,204],"kidney.":[144,174],"The":[145,200],"disappearance":[146],"prevented":[151],"NOS-2-KO":[153],"1400":[159],"W.":[160],"Treatment":[161],"non-septic":[163],"NO":[167],"donor":[168],"content":[171],"Therefore,":[175],"our":[176],"results":[177],"show":[178],"that":[179],"NO-dependent":[181],"reduction":[182],"kidney":[188,212,249],"leads":[189],"maintenance":[192],"normal":[195],"density.":[199],"preservation":[201,234],"and/or":[205],"functionality":[206],"together":[213,231],"higher":[216],"vasoconstrictor":[217,229],"tonus":[218],"lead":[221],"vasoconstriction.":[223],"Thus,":[224],"increased":[226],"concentration":[227],"mediators":[230],"(and":[235],"even":[236],"increase)":[237],"response":[240],"them":[242],"may":[243],"help":[244],"explain":[246],"sepsis-induced":[247],"acute":[248],"injury.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-11T00:00:00"}