{"id":"https://openalex.org/W3203691189","doi":"https://doi.org/10.1103/physreve.104.034414","title":"Protein dynamics implications of the low- and high-temperature denaturation of myoglobin","display_name":"Protein dynamics implications of the low- and high-temperature denaturation of myoglobin","publication_year":2021,"publication_date":"2021-09-24","ids":{"openalex":"https://openalex.org/W3203691189","doi":"https://doi.org/10.1103/physreve.104.034414","mag":"3203691189","pmid":"https://pubmed.ncbi.nlm.nih.gov/34654144"},"language":"en","primary_location":{"id":"doi:10.1103/physreve.104.034414","doi":"https://doi.org/10.1103/physreve.104.034414","is_oa":false,"landing_page_url":"https://doi.org/10.1103/physreve.104.034414","pdf_url":null,"source":{"id":"https://openalex.org/S4210235286","display_name":"Physical review. E","issn_l":"2470-0045","issn":["2470-0045","2470-0053","2470-0061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Review E","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029043346","display_name":"Ramzi Khuri","orcid":"https://orcid.org/0000-0001-9823-1576","observed_orcids":["https://orcid.org/0000-0001-9823-1576"]},"institutions":[{"id":"https://openalex.org/I141810926","display_name":"Baruch College","ror":"https://ror.org/023qavy03","country_code":"US","type":"education","lineage":["https://openalex.org/I141810926"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramzi R. Khuri","raw_affiliation_strings":["Department of Natural Sciences, Baruch College, City University of New York, New York, New York 10010, USA"],"raw_orcid":"https://orcid.org/0000-0001-9823-1576","affiliations":[{"raw_affiliation_string":"Department of Natural Sciences, Baruch College, City University of New York, New York, New York 10010, USA","institution_ids":["https://openalex.org/I141810926","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030390898","display_name":"Trung V. Phan","orcid":"https://orcid.org/0000-0001-7891-8119","observed_orcids":["https://orcid.org/0000-0001-7891-8119"]},"institutions":[{"id":"https://openalex.org/I141810926","display_name":"Baruch College","ror":"https://ror.org/023qavy03","country_code":"US","type":"education","lineage":["https://openalex.org/I141810926"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trung V. Phan","raw_affiliation_strings":["Department of Physics, Princeton University, Princeton, New Jersey 08544, USA","Department of Natural Sciences, Baruch College, City University of New York, New York, New York 10010, USA"],"raw_orcid":"https://orcid.org/0000-0001-7891-8119","affiliations":[{"raw_affiliation_string":"Department of Physics, Princeton University, Princeton, New Jersey 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Natural Sciences, Baruch College, City University of New York, New York, New York 10010, USA","institution_ids":["https://openalex.org/I141810926","https://openalex.org/I174216632"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081117311","display_name":"Robert H. Austin","orcid":"https://orcid.org/0000-0002-4269-6793","observed_orcids":["https://orcid.org/0000-0002-4269-6793"]},"institutions":[{"id":"https://openalex.org/I141810926","display_name":"Baruch College","ror":"https://ror.org/023qavy03","country_code":"US","type":"education","lineage":["https://openalex.org/I141810926"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Austin","raw_affiliation_strings":["Department of Physics, Princeton University, Princeton, New Jersey 08544, USA","Department of Natural Sciences, Baruch College, City University of New York, New York, New York 10010, USA"],"raw_orcid":"https://orcid.org/0000-0002-4269-6793","affiliations":[{"raw_affiliation_string":"Department of Physics, Princeton University, Princeton, New Jersey 08544, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Natural Sciences, Baruch College, City University of New York, New York, New York 10010, USA","institution_ids":["https://openalex.org/I141810926","https://openalex.org/I174216632"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3923,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52225051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"104","issue":"3","first_page":"034414","last_page":"034414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myoglobin","display_name":"myoglobin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cold-denaturation","display_name":"cold denaturation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.597000002861023},{"id":"https://openalex.org/keywords/two-state-model","display_name":"two-state model","score":0.9390000104904175},{"id":"https://openalex.org/keywords/thermodynamic-analysis","display_name":"thermodynamic analysis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/protein-thermostability","display_name":"protein thermal stability","score":0.6159999966621399},{"id":"https://openalex.org/keywords/temperature-dependent-dynamics","display_name":"temperature-dependent dynamics","score":0.5609999895095825},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C2778063876","wikidata":"https://www.wikidata.org/wiki/Q192642","display_name":"Myoglobin","level":2,"score":0.9316049814224243},{"id":"https://openalex.org/C2776923230","wikidata":"https://www.wikidata.org/wiki/Q16955798","display_name":"Denaturation (fissile materials)","level":2,"score":0.8675090074539185},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.5765913128852844},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.573737621307373},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5566533207893372},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.5389599800109863},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.48661574721336365},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4663362503051758},{"id":"https://openalex.org/C39353612","wikidata":"https://www.wikidata.org/wiki/Q5283759","display_name":"Atmospheric temperature range","level":2,"score":0.41432368755340576},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.336290180683136},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20599165558815002},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.12265652418136597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09902697801589966},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009211","descriptor_name":"Myoglobin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1103/physreve.104.034414","doi":"https://doi.org/10.1103/physreve.104.034414","is_oa":false,"landing_page_url":"https://doi.org/10.1103/physreve.104.034414","pdf_url":null,"source":{"id":"https://openalex.org/S4210235286","display_name":"Physical review. E","issn_l":"2470-0045","issn":["2470-0045","2470-0053","2470-0061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Review E","raw_type":"journal-article"},{"id":"pmid:34654144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34654144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical review. E","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5687007761","display_name":"Evolution Game Theory Modeling of Tumor Dormancy","funder_award_id":"1659940","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W58993228","https://openalex.org/W113688923","https://openalex.org/W1530042113","https://openalex.org/W1978824833","https://openalex.org/W1981855553","https://openalex.org/W1989720463","https://openalex.org/W2003713109","https://openalex.org/W2031667006","https://openalex.org/W2035602472","https://openalex.org/W2040355223","https://openalex.org/W2041871841","https://openalex.org/W2043267657","https://openalex.org/W2052571571","https://openalex.org/W2053552643","https://openalex.org/W2068728923","https://openalex.org/W2092000257","https://openalex.org/W2128795465","https://openalex.org/W2158476854","https://openalex.org/W2313807595","https://openalex.org/W2328807407","https://openalex.org/W2411904527","https://openalex.org/W2513388048","https://openalex.org/W2521219762","https://openalex.org/W2934079625","https://openalex.org/W2957617864","https://openalex.org/W4244442010","https://openalex.org/W4300439579"],"related_works":["https://openalex.org/W1485019793","https://openalex.org/W2082819325","https://openalex.org/W2002381028","https://openalex.org/W2075925702","https://openalex.org/W2513693349","https://openalex.org/W2074215797","https://openalex.org/W2070987084","https://openalex.org/W1967384871","https://openalex.org/W7100747451","https://openalex.org/W2108023227"],"abstract_inverted_index":{"We":[0,17,45],"reinvestigate":[1],"a":[2,28],"simple":[3],"model":[4],"used":[5],"in":[6,33,41],"the":[7,10,34,42,47,67,74],"literature":[8,35],"concerning":[9],"thermodynamic":[11,21],"analysis":[12],"of":[13,50,71,78],"protein":[14,56],"cold":[15,24,38],"denaturation.":[16],"derive":[18],"an":[19],"exact":[20],"expression":[22],"for":[23,36,53],"denaturation":[25,39],"and":[26,59],"give":[27],"better":[29],"approximation":[30],"than":[31],"exists":[32],"predicting":[37],"temperatures":[40],"two-state":[43],"model.":[44],"discuss":[46,60],"\"dark-side\"":[48],"implications":[49],"this":[51],"work":[52],"previous":[54],"temperature-dependent":[55],"dynamics":[57],"experiments":[58],"microfluidic":[61],"experimental":[62],"technologies,":[63],"which":[64],"could":[65],"explore":[66],"thermal":[68],"stability":[69],"range":[70],"proteins":[72],"below":[73],"bulk":[75],"freezing":[76],"point":[77],"water.":[79]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-11T00:00:00"}