{"id":"https://openalex.org/W3203670538","doi":"https://doi.org/10.3389/fgene.2021.753352","title":"Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-Directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis","display_name":"Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-Directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis","publication_year":2021,"publication_date":"2021-10-04","ids":{"openalex":"https://openalex.org/W3203670538","doi":"https://doi.org/10.3389/fgene.2021.753352","mag":"3203670538","pmid":"https://pubmed.ncbi.nlm.nih.gov/34671386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8521021"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2021.753352","doi":"https://doi.org/10.3389/fgene.2021.753352","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2021.753352","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fgene.2021.753352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100327172","display_name":"Yanjun Wang","orcid":"https://orcid.org/0000-0001-7465-7687","observed_orcids":["https://orcid.org/0000-0001-7465-7687"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjun Wang","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638839","display_name":"Ping Guo","orcid":"https://orcid.org/0000-0003-1313-107X","observed_orcids":["https://orcid.org/0000-0003-1313-107X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Guo","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415540","display_name":"Yanan Zhang","orcid":"https://orcid.org/0009-0004-9388-1202","observed_orcids":["https://orcid.org/0009-0004-9388-1202"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Zhang","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396554","display_name":"Lu Liu","orcid":"https://orcid.org/0000-0003-3289-8671","observed_orcids":["https://orcid.org/0000-0003-3289-8671"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Liu","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065549764","display_name":"Ran Yan","orcid":"https://orcid.org/0000-0001-8204-8654","observed_orcids":["https://orcid.org/0000-0001-8204-8654"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Yan","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034068671","display_name":"Zhongshang Yuan","orcid":"https://orcid.org/0000-0002-3527-4488","observed_orcids":["https://orcid.org/0000-0002-3527-4488"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhongshang Yuan","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100651802","display_name":"Yongfeng Song","orcid":"https://orcid.org/0000-0001-8934-3154","observed_orcids":["https://orcid.org/0000-0001-8934-3154"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongfeng Song","raw_affiliation_strings":["Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China","Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, China","Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]},{"raw_affiliation_string":"Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, China","institution_ids":[]},{"raw_affiliation_string":"Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034068671","https://openalex.org/A5100651802"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.7047,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.64483472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"12","issue":null,"first_page":"753352","last_page":"753352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4683000147342682,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":1.0},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bidirectional-causality","display_name":"bidirectional causality","score":0.8080000281333923},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/shared-genetic-architecture","display_name":"genetic overlap","score":0.753000020980835},{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.5299999713897705},{"id":"https://openalex.org/keywords/colocalization","display_name":"colocalization","score":0.8140000104904175},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.5799999833106995},{"id":"https://openalex.org/keywords/disease-co-occurrence","display_name":"disease co-occurrence","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9201554656028748},{"id":"https://openalex.org/C2780366471","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Primary biliary cirrhosis","level":2,"score":0.7288100719451904},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6273119449615479},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5771483778953552},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.5607398748397827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4758595824241638},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3932138979434967},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3811001181602478},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33161208033561707},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28103935718536377},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.27362024784088135},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11274769902229309},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.10563910007476807},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fgene.2021.753352","doi":"https://doi.org/10.3389/fgene.2021.753352","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2021.753352","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8521021","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8521021/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8521021/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Genet","raw_type":"Text"},{"id":"pmid:34671386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34671386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e508bbe752884e88bf8814966054393f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e508bbe752884e88bf8814966054393f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2021.753352","doi":"https://doi.org/10.3389/fgene.2021.753352","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2021.753352","pdf_url":null,"source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1035193065","display_name":null,"funder_award_id":"81922016","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G1698184477","display_name":null,"funder_award_id":"81870607","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1763820084","display_name":null,"funder_award_id":"81870607","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G2471398926","display_name":null,"funder_award_id":"81872712","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2687629545","display_name":null,"funder_award_id":"81673272","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3202158750","display_name":null,"funder_award_id":"81872712","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G3914063901","display_name":null,"funder_award_id":"ZR2020ZD14","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G3919631681","display_name":null,"funder_award_id":"82173624","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4071207704","display_name":null,"funder_award_id":"82173624","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G4712484246","display_name":null,"funder_award_id":"ZR2019ZD02","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5191628035","display_name":null,"funder_award_id":"81922016","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6618379725","display_name":null,"funder_award_id":"ZR2019JQ25","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7024561729","display_name":null,"funder_award_id":"ZR2019JQ25","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G7454280855","display_name":null,"funder_award_id":"2016WLJH23","funder_id":"https://openalex.org/F4320311026","funder_display_name":"Shandong University"},{"id":"https://openalex.org/G8547344099","display_name":null,"funder_award_id":"ZR2019ZD02","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320311026","display_name":"Shandong University","ror":"https://ror.org/0207yh398"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3203670538.pdf","grobid_xml":"https://content.openalex.org/works/W3203670538.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W110585975","https://openalex.org/W1489301770","https://openalex.org/W1966824338","https://openalex.org/W1980881293","https://openalex.org/W1981929456","https://openalex.org/W1984273763","https://openalex.org/W2000472698","https://openalex.org/W2001564798","https://openalex.org/W2032387601","https://openalex.org/W2038317844","https://openalex.org/W2066605252","https://openalex.org/W2073836327","https://openalex.org/W2084763031","https://openalex.org/W2087260664","https://openalex.org/W2093292173","https://openalex.org/W2108461633","https://openalex.org/W2113699335","https://openalex.org/W2116868464","https://openalex.org/W2118008714","https://openalex.org/W2132086750","https://openalex.org/W2141267824","https://openalex.org/W2144596601","https://openalex.org/W2153174384","https://openalex.org/W2153860431","https://openalex.org/W2156641499","https://openalex.org/W2161633633","https://openalex.org/W2195783463","https://openalex.org/W2232908523","https://openalex.org/W2244701831","https://openalex.org/W2295447825","https://openalex.org/W2324862792","https://openalex.org/W2435453484","https://openalex.org/W2464470020","https://openalex.org/W2508534964","https://openalex.org/W2539356209","https://openalex.org/W2572479089","https://openalex.org/W2581245397","https://openalex.org/W2601430401","https://openalex.org/W2605729742","https://openalex.org/W2613603864","https://openalex.org/W2735817229","https://openalex.org/W2745721913","https://openalex.org/W2766912018","https://openalex.org/W2766948492","https://openalex.org/W2777791186","https://openalex.org/W2792411929","https://openalex.org/W2802118207","https://openalex.org/W2802962038","https://openalex.org/W2803072880","https://openalex.org/W2804992454","https://openalex.org/W2886703787","https://openalex.org/W2948487606","https://openalex.org/W2952420414","https://openalex.org/W2969996045","https://openalex.org/W2973915145","https://openalex.org/W3014191903","https://openalex.org/W3020477396","https://openalex.org/W3024224717","https://openalex.org/W3042936392","https://openalex.org/W3046567422","https://openalex.org/W3118379951","https://openalex.org/W3182225677"],"related_works":["https://openalex.org/W4412506220","https://openalex.org/W4200490170","https://openalex.org/W4387780669","https://openalex.org/W4403891462","https://openalex.org/W4399524201","https://openalex.org/W4399850596","https://openalex.org/W4389096187","https://openalex.org/W4388479047","https://openalex.org/W6977446068","https://openalex.org/W7166704936"],"abstract_inverted_index":{"Background:":[0],"Hypothyroidism":[1],"and":[2,28,41,62,83,145,185,203,224,235,242],"primary":[3],"biliary":[4],"cirrhosis":[5],"(PBC)":[6],"are":[7],"often":[8],"co-existed":[9],"in":[10,112],"observational":[11],"epidemiological":[12],"studies.":[13,51],"However,":[14],"the":[15,35,60,63,66,86,123,141,148,182,207,210,218,231],"causal":[16,37,199,220],"relationship":[17],"between":[18,39,81,201,222],"them":[19],"remains":[20],"unclear.":[21],"Methods:":[22],"Genetic":[23],"correlation,":[24],"Mendelian":[25],"randomization":[26],"(MR)":[27],"colocalization":[29,192],"analysis":[30,114,187,193],"were":[31,133,143,188],"combined":[32],"to":[33,58,90],"assess":[34,59],"potential":[36],"association":[38,50,221],"hypothyroidism":[40,82,99,157,202,223,234],"PBC":[42,101,151,236],"by":[43],"using":[44],"summary":[45],"statistics":[46],"from":[47,125,174],"large-scale":[48],"genome-wide":[49],"Various":[52,178],"sensitivity":[53,179],"analyses":[54,180],"had":[55],"been":[56],"conducted":[57],"robustness":[61,208],"consistency":[64],"of":[65,77,98,138,209,233],"findings.":[67],"Results:":[68],"The":[69,96],"linkage":[70],"disequilibrium":[71],"score":[72],"regression":[73],"demonstrated":[74],"significant":[75],"evidence":[76,216],"shared":[78,198],"genetic":[79,87],"architecture":[80],"PBC,":[84,204,225],"with":[85,115,129,136,156],"correlation":[88],"estimated":[89],"be":[91,172],"0.117":[92],"(p":[93],"=":[94,108,164],"0.006).":[95],"OR":[97],"on":[100],"was":[102,152],"1.223":[103],"(95%":[104],"CI,":[105,161],"1.072\u20131.396;":[106],"p":[107,163],"2.76":[109],"\u00d7":[110],"10\u22123)":[111],"MR":[113,176],"inverse":[116],"variance":[117],"weighted":[118],"(IVW)":[119],"method.":[120],"More":[121],"importantly,":[122],"results":[124,169,214],"other":[126,149,175],"7MR":[127],"methods":[128],"different":[130],"model":[131],"assumptions,":[132],"almost":[134],"identical":[135],"that":[137,195],"IVW,":[139],"suggesting":[140],"findings":[142],"robust":[144],"convincing.":[146],"On":[147],"hand,":[150],"also":[153,171,189],"causally":[154],"associated":[155],"(OR,":[158],"1.049;":[159],"95%":[160],"1.010\u20131.089;":[162],"0.012),":[165],"and,":[166],"again,":[167],"similar":[168],"can":[170],"obtained":[173],"methods.":[177],"regarding":[181],"outlier":[183],"detection":[184],"leave-one-out":[186],"performed.":[190],"Besides,":[191],"suggested":[194],"there":[196],"existed":[197],"variants":[200],"further":[205],"highlighting":[206],"results.":[211],"Conclusion:":[212],"Our":[213],"suggest":[215],"for":[217],"bi-directional":[219],"which":[226],"may":[227],"provide":[228],"insights":[229],"into":[230],"etiology":[232],"as":[237,239],"well":[238],"inform":[240],"prevention":[241],"intervention":[243],"strategies":[244],"directed":[245],"toward":[246],"both":[247],"diseases.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-10-11T00:00:00"}